scholarly journals Epidemiology and health outcomes of sarcoidosis in a universal healthcare population: a cohort study

2019 ◽  
Vol 54 (4) ◽  
pp. 1900444 ◽  
Author(s):  
Lee M. Fidler ◽  
Meyer Balter ◽  
Jolene H. Fisher ◽  
Teresa To ◽  
Matthew B. Stanbrook ◽  
...  
Keyword(s):  
Cohort Study ◽  
The Elderly ◽  
International Classification Of Diseases ◽  
Mortality Rates ◽  
Ontario Health Insurance Plan ◽  
Health Administrative Data ◽  
Universal Healthcare ◽  
Classification Of Diseases ◽  
Related Mortality

Sarcoidosis-related mortality appears to be rising in North America, with increasing rates in females and the elderly. We aimed to estimate trends in sarcoidosis incidence, prevalence and mortality in Ontario, Canada.We performed a cohort study using health administrative data from Ontario between 1996 and 2015. International Classification of Diseases and Ontario Health Insurance Plan codes were used for case detection. Three disease definitions were created: 1) sarcoidosis, two or more physician claims within 2 years; 2) chronic sarcoidosis, five or more physician claims within 3 years; and 3) sarcoidosis with histology, two or more physician claims with a tissue biopsy performed between claims.Overall, 18 550, 9199 and 3819 individuals with sarcoidosis, chronic sarcoidosis and sarcoidosis with histology, respectively, were identified. The prevalence of sarcoidosis was 143 per 100 000 in 2015, increasing by 116% (p<0.0001) from 1996. The increase in age-adjusted prevalence was higher in males than females (136% versus 99%; p<0.0001). The incidence of sarcoidosis declined from 7.9 to 6.8 per 100 000 between 1996 and 2014 (15% decrease; p=0.0009). A 30.3% decrease in incidence was seen among females (p<0.0001) compared with a 5.5% increase in males (p=0.47). Age- and sex-adjusted mortality rates of patients with sarcoidosis rose from 1.15% to 1.47% between 1996 and 2015 (28% increase; p=0.02), with the overall trend being nonsignificant (p=0.39). Mortality rates in patients with chronic sarcoidosis increased significantly over the study period (p=0.0008).The prevalence of sarcoidosis is rising in Ontario, with an apparent shifting trend in disease burden from females to males. Mortality is increasing in patients with chronic sarcoidosis.

Association of age with risk of major depression among patients with chronic kidney disease over midlife: a nationwide cohort study in Taiwan

2018 ◽  
Vol 31 (08) ◽  
pp. 1171-1179 ◽  
Author(s):  
Shih-Feng Chen ◽  
Yu-Huei Chien ◽  
Pau-Chung Chen ◽  
I-Jen Wang
Keyword(s):  
Chronic Kidney Disease ◽  
Cohort Study ◽  
Major Depression ◽  
Kidney Disease ◽  
Comparison Group ◽  
Age Groups ◽  
International Classification Of Diseases ◽  
Classification Of Diseases ◽  
The Impact

ABSTRACTBackground:The impact of age on the development of depression among patients with chronic kidney disease (CKD) at stages before dialysis is not well known. We aimed to explore the incidence of major depression among predialysis CKD patients of successively older ages through midlife.Methods:We conducted a retrospective cohort study using the longitudinal health insurance database 2005 in Taiwan. This study investigated 17,889 predialysis CKD patients who were further categorized into study (i.e. middle and old-aged) groups and comparison group aged 18–44. The International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) was applied for coding diseases.Results:The group aged 75 and over had the lowest (hazard ratio [HR] 0.47; 95% confidence interval [CI] 0.32–0.69) risk of developing major depression, followed by the group aged 65–74 (HR 0.67; 95% CI 0.49–0.92), using the comparison group as reference. The adjusted survival curves showed significant differences in cumulative major depression-free survival between different age groups. We observed that the risk of major depression development decreases with higher age. Females were at a higher risk of major depression than males among predialyasis CKD patients.Conclusions:The incidence of major depression declines with higher age in predialysis CKD patients over midlife. Among all age groups, patients aged 75 and over have the lowest risk of developing major depression. A female preponderance in major depression development is present. We suggest that depression prevention and therapy should be integrated into the standard care for predialysis CKD patients, especially for those young and female.

scholarly journals Non-specific diagnoses are frequent in patients hospitalized after calling 112 and their mortality is high – a register-based Danish cohort study

2020 ◽  
Author(s):  
Frederikke Vestergaard Nielsen ◽  
Mette Rønn Nielsen ◽  
Ida Lund Lorenzen ◽  
Jesper Amstrup ◽  
Torben Anders Kløjgaard ◽  
...  
Keyword(s):  
Cohort Study ◽  
International Classification Of Diseases ◽  
Rank Test ◽  
Test Results ◽  
Historical Cohort ◽  
Specific Diagnosis ◽  
Number Of Patients ◽  
Classification Of Diseases ◽  
Icd 10

Abstract Background The number of patients calling for an ambulance increases. A considerable number of patients receive a non-specific diagnosis at discharge from the hospital, and this could imply less serious acute conditions, but the mortality has only scarcely been studied. The aim of this study was to examine the most frequent sub-diagnoses among patients with hospital non-specific diagnoses after calling 112 and their subsequent mortality. Methods A historical cohort study of patients brought to the hospital by ambulance after calling 112 in 2007-2014 and diagnosed with a non-specific diagnosis, chapter R or Z, in the International Classification of Diseases, 10 th edition (ICD-10). 1-day and 30-day mortality was analyzed by survival analyses and compared by the log-rank test. Results We included 74,847 ambulance runs in 53,937 unique individuals. The most frequent diagnoses were ‘unspecified disease’ (Z039), constituting 47.0 % (n 35,279). In children 0-9 years old, ‘febrile convulsions’ was the most frequent non-specific diagnosis used in 54.3 % (n 1,602). Overall, 1- and 30-day mortality was 2.2 % (n 1,205) and 6.0 % (n 3,258). The highest mortality was in the diagnostic group ‘suspected cardiovascular disease’ (Z035) and ‘unspecified disease’ (Z039) with 1-day mortality 2.6 % (n 43) and 2.4 % (n 589), and 30 day mortality of 6.32 % (n 104) and 8.1 % (n 1,975). Conclusion Among patients calling an ambulance and discharged with non-specific diagnoses the 1- and 30-day mortality, despite modest mortality percentages lead to a high number of deaths.

scholarly journals Mortality from respiratory infections and chronic non-communicable diseases before the COVID-19 pandemic in Cali, Colombia.

2020 ◽  
pp. 1-10
Author(s):  
Luis Eduardo Bravo Ocaña ◽  
Paola Collazos ◽  
Elvia Karina Grillo Ardila ◽  
Luz Stella García ◽  
Erquinovaldo Millán ◽  
...  
Keyword(s):  
Respiratory Infections ◽  
Ventilatory Support ◽  
The Elderly ◽  
International Classification Of Diseases ◽  
Mortality Rates ◽  
Communicable Diseases ◽  
Noncommunicable Diseases ◽  
Non Communicable Diseases ◽  
Infected People ◽  
Classification Of Diseases

Introduction: The COVID-19 disease pandemic is a health emergency. Older people and those with chronic noncommunicable diseases are more likely to develop serious illnesses, equire ventilatory support, and die from complications. Objective: To establish deaths from respiratory infections and some chronic non-communicable diseases that occurred in Cali, before the SARS-CoV-2 disease pandemic. Methods: During the 2003-2019 period, 207,261 deaths were registered according to the general mortality database of the Municipal Secretary of Health of Cali. Deaths were coded with the International Classification of Diseases and causes of death were grouped according to WHO guidelines. Rates were standardized by age and are expressed per 100,000 people-year. Results: A direct relationship was observed between aging and mortality from respiratory infections and chronic non-communicable diseases. Age-specific mortality rates were highest in those older than 80 years for all diseases evaluated. Seasonal variation was evident in respiratory diseases in the elderly. Comments: Estimates of mortality rates from respiratory infections and chronic non-communicable diseases in Cali provide the baseline that will serve as a comparison to estimate the excess mortality caused by the COVID-19 pandemic. Health authorities and decision makers should be guided by reliable estimates of mortality and of the proportion of infected people who die from SARS-CoV-2 virus infection.

scholarly journals Severe COVID-19 among patients with asthma and COPD: a report from the Swedish National Airway Register

2021 ◽  
Vol 15 ◽  
pp. 175346662110497
Author(s):  
Johanna Karlsson Sundbaum ◽  
Lowie E.G.W. Vanfleteren ◽  
Jon R. Konradsen ◽  
Fredrik Nyberg ◽  
Ann Ekberg-Jansson ◽  
...  
Keyword(s):  
Intensive Care ◽  
Large Population ◽  
International Classification Of Diseases ◽  
Death Certificates ◽  
Classification Of Diseases ◽  
National Patient ◽  
Icd 10 ◽  
Discharge From Hospital ◽  
Related Mortality

Background: Patients with obstructive lung diseases may be at risk of hospitalization and/or death due to COVID-19. Aim: To estimate the frequency of severe COVID-19, and COVID-19-related mortality in a well-defined large population of patients with asthma and chronic inflammatory lung disease (COPD). Further to assess the frequency of asthma and COPD as registered comorbidities at discharge from hospital, and in death certificates. Methods: At the start of the pandemic, the Swedish National Airway Register (SNAR) included 271,404 patients with a physician diagnosis of asthma and/or COPD. In September 2020, after the first COVID-19 wave in Sweden, the database was linked with the National Patient Register (NPR), the Swedish Intensive Care Register and the Swedish Cause of Death Register, which all provide data about COVID-19 based on International Classification of Diseases (ICD-10) codes. Severe COVID-19 was defined as hospitalization and/or intensive care or death due to COVID-19. Results: Among patients in SNAR, 0.5% with asthma, and 1.2% with COPD were identified with severe COVID-19. Among patients  < 18 years with asthma, only 0.02% were severely infected. Of hospitalized adults, 14% with asthma and 29% with COPD died. Further, of patients in SNAR, 56% with asthma and 81% with COPD were also registered in the NPR, while on death certificates the agreement was lower (asthma 24% and COPD 71%). Conclusion: The frequency of severe COVID-19 in asthma and COPD was relative low. Mortality for those hospitalized was double as high in COPD compared to asthma. Comorbid asthma and COPD were not always identified among patients with severe COVID-19.

scholarly journals CAUSAS DE MORTALIDAD A CONSECUENCIA DE LA VEJEZ EN JEREZ DE LOS CABALLEROS (BADAJOZ, ESPAÑA) EN EL SIGLO XIX

2015 ◽  
Vol 63 (2) ◽  
pp. 229-234
Author(s):  
FRANCISCO JAVIER SUÁREZ GUZMÁN
Keyword(s):  
Mortality Rate ◽  
Cause Of Death ◽  
The Elderly ◽  
International Classification Of Diseases ◽  
Age Related ◽  
Historical Archives ◽  
Classification Of Diseases ◽  
Siglo Xix ◽  
Las Mujeres

<p><strong>RESUMEN</strong></p><p><strong>         </strong>Introducción:<strong> </strong>Según la Clasificación Internacional de Enfermedades de Bertillon de 1899, se han reunido las causas de defunción ocasionadas por la vejez en Jerez de los Caballeros (Badajoz) durante el siglo XIX.</p><p>Material y métodos: Se han recopilado un total de 26.203 defunciones de las cuales en 7.665 no consta la causa del fallecimiento, y sí en 18.538, para ello se han estudiado los Libros de Defunciones del Archivo Parroquial y legajos del Archivo Histórico.</p><p>Resultados: El primer difunto aparece el 28 de junio de 1808. Las tasas brutas de mortalidad específica promedian un 0,3‰. El término vejez fue cambiado a lo largo de los años, sobre todo al aumentar la esperanza de vida, pero continuaría la condición de marginado social del anciano.</p><p>Conclusiones: Las enfermedades relacionadas con el envejecimiento causaron 204 defunciones, el 1,1% del total de la mortalidad de la población durante el siglo XIX, correspondiendo a la decimosegunda causa de mortalidad en la población. La mayor mortalidad se da entre los 75 y 84 años con 85 defunciones (41,7%). Las mujeres presentan las cifras más elevadas 128 fallecimientos (62,7%). Enero es el mes con más óbitos.</p><p><strong>ABSTRACT</strong></p><p>Introduction: We have compiled the causes of age-related decease in Jerez de los Caballeros (Badajoz) during the 20th century following Bertillon’s International Classification of Diseases of 1899.</p><p>Materials and Methods: A total of 26.203 deceases has been found. For 7.665 of these no cause of death is recorded. We have consulted the Books of the Death, located in the Parish Archives, and files of the Historical Archives.</p><p>Results: The first decease appears on 28th June 1808. Gross specific mortality rates average 00,3‰. The application of the term old age changed with the passing of time, especially with the increase in life expectancy, but the elderly remain an object of social marginalization.</p><p>Conclusions: Age-related diseases caused 204 deceases, 1,1% of the total for the period under research, being the twelfth most frequent cause of death in the population. The highest mortality rate occurs between the ages of 75 and 84 (41%). Females have a higher mortality rate than males (128 deceases, 62,7%). January is the month with most deceases.</p><br /><p> </p><p> </p>

scholarly journals Gastrointestinal perforations in patients with rheumatoid arthritis treated with biological disease-modifying antirheumatic drugs in Sweden: a nationwide cohort study

RMD Open ◽  
2020 ◽  
Vol 6 (2) ◽  
pp. e001201 ◽  
Author(s):  
Andrei Barbulescu ◽  
Bénédicte Delcoigne ◽  
Johan Askling ◽  
Thomas Frisell
Keyword(s):  
Cohort Study ◽  
General Population ◽  
Treatment Guidelines ◽  
International Classification Of Diseases ◽  
Incidence Rates ◽  
Classification Of Diseases ◽  
Icd 10 ◽  
Population Controls ◽  
Necrosis Factor

ObjectivesTo compare incidence rates of gastrointestinal (GI) perforations between patients with RA and the general population, and between patients treated with tumour necrosis factor inhibitors (TNFi) and non-TNFi biologics.MethodsIn this nationwide cohort study, a total of 63 532 patients with RA, with 26 050 biological treatment episodes (TNFi, rituximab, abatacept or tocilizumab) and 76 304 general population controls, were followed between 2009 and 2017 until the first outcome event. The main outcome was hospitalisation or death due to lower GI perforations, identified according to a prespecified list of ICD-10 (International Classification of Diseases, 10th revision) codes. Inverse probability of treatment weighting was used for adjustment.ResultsThe sex-standardised and age-standardised incidence rates of lower GI perforations were 1.1 (95% CI 1.0 to 1.3) events per 1000 person-years among general population controls, 1.6 (1.5–1.7) among bionaïve patients and ranged from 1.8 (1.4–3.6) (TNFi) to 4.5 (2.7–10.4) (tocilizumab) among biologics-treated patients. After adjustment for glucocorticoid use, the risk in bionaïve, TNFi-treated, abatacept-treated or rituximab-treated patients with RA was no longer different from the general population, while for tocilizumab it remained significantly higher. Comparing tocilizumab to TNFi, the adjusted HR for lower GI perforations was 2.2 (1.3–3.8), corresponding to one additional GI perforation per 451 patient-years treated with tocilizumab instead of TNFi.ConclusionTocilizumab was associated with a higher risk of lower GI perforations compared with alternative biologics. In absolute numbers, the risk remained low on all biologics commonly used to treat RA, but the accumulated evidence across settings and outcome definitions supports that this risk should be considered in treatment guidelines for RA.

scholarly journals Time series of tuberculosis mortality in Brazil (1980-2001)

2007 ◽  
Vol 15 (5) ◽  
pp. 936-941 ◽  
Author(s):  
Paula Hino ◽  
Moacyr Lobo da Costa-Júnior ◽  
Cinthia Midori Sassaki ◽  
Mayra Fernanda Oliveira ◽  
Tereza Cristina Scatena Villa ◽  
...  
Keyword(s):  
Time Series ◽  
International Classification Of Diseases ◽  
Vulnerable Groups ◽  
Primary Health ◽  
Gender And Age ◽  
Classification Of Diseases ◽  
Icd 10 ◽  
Related Mortality ◽  
Tuberculosis Mortality

This descriptive study aimed to describe Tuberculosis-related mortality in Brazil between 1980 and 2001, through time series analysis of data from the DATASUS related to cases in which Tuberculosis was the basic cause of death. The mortality rates were calculated per 100,000 inhabitants according to gender and age. We found a decrease in Tuberculosis mortality of approximately 42% for men and 54% for women across the period analyzed. The International Classification of Diseases was used: ICD-9, for the period of 1980 to 1995; ICD-10 for 1996 to 2001. Deaths are related to late diagnosis, which is a problem of organization of the primary health care, as neither prevention actions nor case detections by active search for respiratory symptoms were incorporated into the health professionals' practice which contributes to higher death rates in more vulnerable groups.

scholarly journals Non-specific diagnoses are frequent in patients hospitalized after calling 112 and their mortality is high – a register-based Danish cohort study

2020 ◽  
Author(s):  
Frederikke Vestergaard Nielsen ◽  
Mette Rønn Nielsen ◽  
Ida Lund Lorenzen ◽  
Jesper Amstrup ◽  
Torben Anders Kløjgaard ◽  
...  
Keyword(s):  
Cohort Study ◽  
International Classification Of Diseases ◽  
Rank Test ◽  
Historical Cohort ◽  
Specific Diagnosis ◽  
Log Rank Test ◽  
Number Of Patients ◽  
Classification Of Diseases ◽  
Icd 10

Abstract Background The number of patients calling for an ambulance increases. A considerable number of patients receive a non-specific diagnosis at discharge from the hospital, and this could imply less serious acute conditions, but the mortality has only scarcely been studied. The aim of this study was to examine the most frequent sub-diagnoses among patients with hospital non-specific diagnoses after calling 112 and their subsequent mortality.Methods A historical cohort study of patients brought to the hospital by ambulance after calling 112 in 2007-2014 and diagnosed with a non-specific diagnosis, chapter R or Z, in the International Classification of Diseases, 10th edition (ICD-10). 1-day and 30-day mortality was analyzed by survival analyses and compared by the log-rank test. Results We included 74,847 ambulance runs in 53,937 unique individuals. The most frequent diagnoses were ‘unspecified disease’ (Z039), constituting 47.0 % (n 35,279). In children 0-9 years old, ‘febrile convulsions’ was the most frequent non-specific diagnosis used in 54.3 % (n 1,602). Overall, 1- and 30-day mortality was 2.2 % (n 1,205) and 6.0 % (n 3,258). The highest mortality was in the diagnostic group ‘suspected cardiovascular disease’ (Z035) and ‘unspecified disease’ (Z039) with 1-day mortality 2.6 % (n 43) and 2.4 % (n 589), and 30 day mortality of 6.32 % (n 104) and 8.1 % (n 1,975).Conclusion Among patients calling an ambulance and discharged with non-specific diagnoses the 1- and 30-day mortality, despite modest mortality percentages lead to a high number of deaths.

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