Genome–wide SNP-by air pollution interaction and airflow obstruction development in the Dutch population-based Lifelines cohort

BackgroundGenetic vulnerability to coronary heart disease (CHD) is well established, but little is known whether these effects are mediated or modified by equally well-established social determinants of CHD. We estimate the joint associations of the polygenetic risk score (PRS) for CHD and education on CHD events.MethodsThe data are from the 1992, 1997, 2002, 2007 and 2012 surveys of the population-based FINRISK Study including measures of social, behavioural and metabolic factors and genome-wide genotypes (N=26 203). Follow-up of fatal and non-fatal incident CHD events (N=2063) was based on nationwide registers.ResultsAllowing for age, sex, study year, region of residence, study batch and principal components, those in the highest quartile of PRS for CHD had strongly increased risk of CHD events compared with the lowest quartile (HR=2.26; 95% CI: 1.97 to 2.59); associations were also observed for low education (HR=1.58; 95% CI: 1.32 to 1.89). These effects were largely independent of each other. Adjustment for baseline smoking, alcohol use, body mass index, igh-density lipoprotein (HDL) and total cholesterol, blood pressure and diabetes attenuated the PRS associations by 10% and the education associations by 50%. We do not find strong evidence of interactions between PRS and education.ConclusionsPRS and education predict CHD events, and these associations are independent of each other. Both can improve CHD prediction beyond behavioural risks. The results imply that observational studies that do not have information on genetic risk factors for CHD do not provide confounded estimates for the association between education and CHD.

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Long-Term Exposure to PM2.5 and Cognitive Decline: A Longitudinal Population-Based Study

Journal of Alzheimer s Disease ◽

10.3233/jad-200852 ◽

2021 ◽

pp. 1-9

Author(s):

Giulia Grande ◽

Jing Wu ◽

Petter L.S. Ljungman ◽

Massimo Stafoggia ◽

Tom Bellander ◽

...

Keyword(s):

Air Pollution ◽

Cognitive Decline ◽

Population Based ◽

Cerebrovascular Diseases ◽

Air Pollutant ◽

National Study ◽

Piecewise Regression ◽

Risk Increase ◽

Restricted Cubic Splines

Background: A growing but contrasting evidence relates air pollution to cognitive decline. The role of cerebrovascular diseases in amplifying this risk is unclear. Objectives: 1) Investigate the association between long-term exposure to air pollution and cognitive decline; 2) Test whether cerebrovascular diseases amplify this association. Methods: We examined 2,253 participants of the Swedish National study on Aging and Care in Kungsholmen (SNAC-K). One major air pollutant (particulate matter ≤2.5μm, PM2.5) was assessed yearly from 1990, using dispersion models for outdoor levels at residential addresses. The speed of cognitive decline (Mini-Mental State Examination, MMSE) was estimated as the rate of MMSE decline (linear mixed models) and further dichotomized into the upper (25%fastest cognitive decline), versus the three lower quartiles. The cognitive scores were used to calculate the odds of fast cognitive decline per levels of PM2.5 using regression models and considering linear and restricted cubic splines of 10 years exposure before the baseline. The potential modifier effect of cerebrovascular diseases was tested by adding an interaction term in the model. Results: We observed an inverted U-shape relationship between PM2.5 and cognitive decline. The multi-adjusted piecewise regression model showed an increased OR of fast cognitive decline of 81%(95%CI = 1.2–3.2) per interquartile range difference up to mean PM2.5 level (8.6μg/m3) for individuals older than 80. Above such level we observed no further risk increase (OR = 0.89;95%CI = 0.74–1.06). The presence of cerebrovascular diseases further increased such risk by 6%. Conclusion: Low to mean PM2.5 levels were associated with higher risk of accelerated cognitive decline. Cerebrovascular diseases further amplified such risk.

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Impact of short- and long-term exposure to air pollution on blood pressure: A two-decade population-based study in Tehran

International Journal of Hygiene and Environmental Health ◽

10.1016/j.ijheh.2021.113719 ◽

2021 ◽

Vol 234 ◽

pp. 113719

Author(s):

Alireza Khajavi ◽

Seyed Saeed Tamehri Zadeh ◽

Fereidoun Azizi ◽

Robert D. Brook ◽

Hengameh Abdi ◽

...

Keyword(s):

Blood Pressure ◽

Air Pollution ◽

Population Based ◽

Population Based Study ◽

Short And Long Term

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Rising incidence rates and unaltered survival for primary upper urinary tract urothelial carcinoma: a Dutch population‐based study from 1993 to 2017.

BJU International ◽

10.1111/bju.15389 ◽

2021 ◽

Author(s):

Thomas van Doeveren ◽

Marianne van der Mark ◽

Pim J. van Leeuwen ◽

Joost L. Boormans ◽

Katja K.H. Aben

Keyword(s):

Urinary Tract ◽

Urothelial Carcinoma ◽

Population Based ◽

Upper Urinary Tract ◽

Incidence Rates ◽

Dutch Population ◽

Population Based Study ◽

Rising Incidence ◽

Urinary Tract Urothelial Carcinoma

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Outdoor Air Pollution and Depression in Canada: A Population-Based Cross-Sectional Study from 2011 to 2016

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph18052450 ◽

2021 ◽

Vol 18 (5) ◽

pp. 2450

Author(s):

Ashley K. Dores ◽

Gordon H. Fick ◽

Frank P. MacMaster ◽

Jeanne V. A. Williams ◽

Andrew G. M. Bulloch ◽

...

Keyword(s):

Air Pollution ◽

Fine Particulate Matter ◽

Canadian Community Health Survey ◽

Population Based ◽

Cross Sectional Study ◽

Future Research ◽

Outdoor Air ◽

Cross Sectional ◽

Outdoor Air Pollution ◽

Environmental Health Research

To assess whether exposure to increased levels of outdoor air pollution is associated with psychological depression, six annual iterations of the Canadian Community Health Survey (n ≈ 127,050) were used to estimate the prevalence of a major depressive episode (2011–2014) or severity of depressive symptoms (2015–2016). Survey data were linked with outdoor air pollution data obtained from the Canadian Urban Environmental Health Research Consortium, with outdoor air pollution represented by fine particulate matter ≤2.5 micrometers (μm) in diameter (PM2.5), ozone (O3), sulfur dioxide (SO2), and nitrogen dioxide (NO2). Log-binomial models were used to estimate the association between outdoor air pollution and depression, and included adjustment for age, sex, marital status, income, education, employment status, urban versus rural households, cigarette smoking, and chronic illness. No evidence of associations for either depression outcomes were found. Given the generally low levels of outdoor air pollution in Canada, these findings should be generalized with caution. It is possible that a meaningful association with major depression may be observed in regions of the world where the levels of outdoor air pollution are greater, or during high pollution events over brief time intervals. Future research is needed to replicate these findings and to further investigate these associations in other regions and populations.

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A High Lymph Node Yield is Associated with Prolonged Survival in Elderly Patients Undergoing Curative Gastrectomy for Cancer: A Dutch Population-Based Cohort Study

Annals of Surgical Oncology ◽

10.1245/s10434-017-5815-5 ◽

2017 ◽

Vol 24 (8) ◽

pp. 2213-2223 ◽

Cited By ~ 6

Author(s):

Hylke J. F. Brenkman ◽

Lucas Goense ◽

Lodewijk A. Brosens ◽

Nadia Haj Mohammad ◽

Frank P. Vleggaar ◽

...

Keyword(s):

Cohort Study ◽

Lymph Node ◽

Elderly Patients ◽

Population Based ◽

Prolonged Survival ◽

Dutch Population ◽

Curative Gastrectomy ◽

Lymph Node Yield ◽

High Lymph Node ◽

Node Yield

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Prevalence and burden of chronic bronchitis symptoms: results from the BOLD study

European Respiratory Journal ◽

10.1183/13993003.00621-2017 ◽

2017 ◽

Vol 50 (5) ◽

pp. 1700621 ◽

Cited By ~ 19

Author(s):

Filip Mejza ◽

Louisa Gnatiuc ◽

A. Sonia Buist ◽

William M. Vollmer ◽

Bernd Lamprecht ◽

...

Keyword(s):

Lung Function ◽

Lung Disease ◽

Chronic Bronchitis ◽

Airflow Obstruction ◽

Population Based ◽

Normal Lung ◽

Increased Risk ◽

Potential Risk Factors ◽

Definition Of ◽

Disease Study

We studied the prevalence, burden and potential risk factors for chronic bronchitis symptoms in the Burden of Obstructive Lung Disease study.Representative population-based samples of adults aged ≥40 years were selected in participating sites. Participants completed questionnaires and spirometry. Chronic bronchitis symptoms were defined as chronic cough and phlegm on most days for ≥3 months each year for ≥2 years.Data from 24 855 subjects from 33 sites in 29 countries were analysed. There were significant differences in the prevalence of self-reported symptoms meeting our definition of chronic bronchitis across sites, from 10.8% in Lexington (KY, USA), to 0% in Ile-Ife (Nigeria) and Blantyre (Malawi). Older age, less education, current smoking, occupational exposure to fumes, self-reported diagnosis of asthma or lung cancer and family history of chronic lung disease were all associated with increased risk of chronic bronchitis. Chronic bronchitis symptoms were associated with worse lung function, more dyspnoea, increased risk of respiratory exacerbations and reduced quality of life, independent of the presence of other lung diseases.The prevalence of chronic bronchitis symptoms varied widely across the studied sites. Chronic bronchitis symptoms were associated with significant burden both in individuals with chronic airflow obstruction and those with normal lung function.

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