scholarly journals The effect of RHIZOMA COPTIDIS and COPTIS CHINENSIS aqueous extract on radiation-induced skin injury in a rat model

2013 ◽  
Vol 13 (1) ◽  
Author(s):  
Xi-Jing Wang ◽  
Shuai Lin ◽  
Hua-Feng Kang ◽  
Zhi-Jun Dai ◽  
Ming-Hua Bai ◽  
...  
Keyword(s):  
Aqueous Extract ◽  
Rat Model ◽  
Coptis Chinensis ◽  
Skin Injury ◽  
Rhizoma Coptidis ◽  
Radiation Induced

scholarly journals Will mesenchymal stem cells be future directions for treating radiation-induced skin injury?

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Zhuoqun Fang ◽  
Penghong Chen ◽  
Shijie Tang ◽  
Aizhen Chen ◽  
Chaoyu Zhang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Malignant Tumors ◽  
Skin Injury ◽  
Future Directions ◽  
Cytokines And Chemokines ◽  
Radiation Induced ◽  
The Common ◽  
Apoptotic Activity ◽  
Different Sources

AbstractRadiation-induced skin injury (RISI) is one of the common serious side effects of radiotherapy (RT) for patients with malignant tumors. Mesenchymal stem cells (MSCs) are applied to RISI repair in some clinical cases series except some traditional options. Though direct replacement of damaged cells may be achieved through differentiation capacity of MSCs, more recent data indicate that various cytokines and chemokines secreted by MSCs are involved in synergetic therapy of RISI by anti-inflammatory, immunomodulation, antioxidant, revascularization, and anti-apoptotic activity. In this paper, we not only discussed different sources of MSCs on the treatment of RISI both in preclinical studies and clinical trials, but also summarized the applications and mechanisms of MSCs in other related regenerative fields.

“Second hit” of Tsc2 gene in radiation induced renal tumors of Eker rat model

2002 ◽  
Vol 1236 ◽  
pp. 163-174 ◽  
Author(s):  
Okio Hino ◽  
Hiroaki Mitani ◽  
Junko Sakaurai
Keyword(s):  
Rat Model ◽  
Renal Tumors ◽  
Tsc2 Gene ◽  
Second Hit ◽  
Eker Rat ◽  
Radiation Induced

scholarly journals A novel role for bone marrow-derived cells to recover damaged keratinocytes from radiation-induced injury

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Junko Okano ◽  
Yuki Nakae ◽  
Takahiko Nakagawa ◽  
Miwako Katagi ◽  
Tomoya Terashima ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Underlying Mechanism ◽  
Basal Cells ◽  
Barrier Dysfunction ◽  
Skin Injury ◽  
Accelerated Proliferation ◽  
Radiation Induced ◽  
Bone Marrow Derived Cells ◽  
Injury Recovery

AbstractExposure to moderate doses of ionizing radiation (IR), which is sufficient for causing skin injury, can occur during radiation therapy as well as in radiation accidents. Radiation-induced skin injury occasionally recovers, although its underlying mechanism remains unclear. Moderate-dose IR is frequently utilized for bone marrow transplantation in mice; therefore, this mouse model can help understand the mechanism. We had previously reported that bone marrow-derived cells (BMDCs) migrate to the epidermis-dermis junction in response to IR, although their role remains unknown. Here, we investigated the role of BMDCs in radiation-induced skin injury in BMT mice and observed that BMDCs contributed to skin recovery after IR-induced barrier dysfunction. One of the important mechanisms involved the action of CCL17 secreted by BMDCs on irradiated basal cells, leading to accelerated proliferation and recovery of apoptosis caused by IR. Our findings suggest that BMDCs are key players in IR-induced skin injury recovery.

scholarly journals Sulforaphane-Mediated Nrf2 Activation Prevents Radiation-Induced Skin Injury through Inhibiting the Oxidative-Stress-Activated DNA Damage and NLRP3 Inflammasome

Antioxidants ◽  
2021 ◽  
Vol 10 (11) ◽  
pp. 1850
Author(s):  
Jinlong Wei ◽  
Qin Zhao ◽  
Yuyu Zhang ◽  
Weiyan Shi ◽  
Huanhuan Wang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Western Blotting ◽  
Nlrp3 Inflammasome ◽  
Fibrous Tissue ◽  
Mouse Skin ◽  
Control Group ◽  
Skin Injury ◽  
Antioxidant Genes ◽  
Radiation Induced

This article mainly observed the protective effect of sulforaphane (SFN) on radiation-induced skin injury (RISI). In addition, we will discuss the mechanism of SFN’s protection on RISI. The RISI model was established by the irradiation of the left thigh under intravenous anesthesia. Thirty-two C57/BL6 mice were randomly divided into control group (CON), SFN group, irradiation (IR) group, and IR plus SFN (IR/SFN) group. At eight weeks after irradiation, the morphological changes of mouse skin tissues were detected by H&E staining. Then, the oxidative stress and inflammatory response indexes in mouse skin tissues, as well as the expression of Nrf2 and its downstream antioxidant genes, were evaluated by ELISA, real-time PCR, and Western blotting. The H&E staining showed the hyperplasia of fibrous tissue in the mouse dermis and hypodermis of the IR group. Western blotting and ELISA results showed that the inflammasome of NLRP3, caspase-1, and IL-1β, as well as oxidative stress damage indicators ROS, 4-HNE, and 3-NT, in the skin tissues of mice in the IR group were significantly higher than those in the control group (p < 0.05). However, the above pathological changes declined sharply after SFN treatment (p < 0.05). In addition, the expressions of Nrf2 and its regulated antioxidant enzymes, including CAT and HO-1, were higher in the skin tissues of SFN and IR/SFN groups, but lower in the control and IR groups (p < 0.05). SFN may be able to suppress the oxidative stress by upregulating the expression and function of Nrf2, and subsequently inhibiting the activation of NLRP3 inflammasome and DNA damage, so as to prevent and alleviate the RISI.

The effect of L-carnitine in the prevention of ionizing radiation-induced cataracts: a rat model

2006 ◽  
Vol 245 (4) ◽  
pp. 588-594 ◽  
Author(s):  
Ibrahim Kocer ◽  
Seyithan Taysi ◽  
Mustafa Vecdi Ertekin ◽  
Ihsan Karslioglu ◽  
Akcahan Gepdiremen ◽  
...  
Keyword(s):  
Ionizing Radiation ◽  
Rat Model ◽  
Radiation Induced

Radiation Safety in Vascular Surgery

2015 ◽  
Author(s):  
Amy B. Reed ◽  
Melissa L Kirkwood
Keyword(s):  
Radiation Dose ◽  
Endovascular Procedures ◽  
Radiation Safety ◽  
National Council ◽  
Skin Injury ◽  
Air Kerma ◽  
Dose Limits ◽  
Radiation Induced ◽  
Effects Of Radiation ◽  
Harmful Effects

Modern vascular surgeons perform an ever-increasing number of complex endovascular procedures, largely based on patient preference, decreased length of stay, and improved outcome. With the upsurge of endovascular cases, concern has grown regarding the harmful effects of radiation exposure delivered to the patient and the operator. Surgeon education on the appropriate use of fluoroscopic operating factors coupled with appropriate training in radiation safety has been shown to decrease radiation dose. This review elucidates dose terminology and metrics, possible radiation-induced injuries, risk factors for deterministic injury, and radiation safety principles and techniques. Tables provide practical tips to lower patient and operator radiation dose during fluoroscopically guided intervention, and National Council on Radiation Protection & Measurements recommended dose limits for occupational exposure. Figures illustrate reference air kerma, radiation-induced skin injury, effects of image receptor and table position, and operator exposure. This review contains 4 figures, 3 tables, and 53 references.

scholarly journals Effect of Solanum macrocarpon Linn leaf aqueous extract on the brain of an alloxan-induced rat model of diabetes

2020 ◽  
Vol 48 (6) ◽  
pp. 030006052092264
Author(s):  
Mary A. Okesola ◽  
Basiru O. Ajiboye ◽  
Babatunji E. Oyinloye ◽  
Olukemi A. Osukoya ◽  
Ofogho S. Owero-ozeze ◽  
...  
Keyword(s):  
Aqueous Extract ◽  
Rat Model ◽  
Fasting Blood Glucose ◽  
Diabetes Control ◽  
Antioxidant Enzyme Activities ◽  
Diabetes Group ◽  
Leaf Aqueous Extract ◽  
The Brain ◽  
Different Doses ◽  
Control Diabetes

Objective This study was designed to evaluate the protective effect of aqueous extract of Solanum macrocarpon Linn leaf in the brain of an alloxan-induced rat model of diabetes. Methods The experimental model of diabetes was induced by a single intraperitoneal injection of freshly prepared alloxan. Rats were then divided into six groups: normal control, diabetes control, diabetes group treated with metformin, and three diabetes groups treated with different concentrations of S. macrocarpon. Rats were sacrificed on day 14 of the experiment and different brain biochemical parameters were assessed and compared between groups. Results Administration of different doses of S. macrocarpon leaf aqueous extract was associated with significantly reduced levels of fasting blood glucose, lipid peroxidation, neurotransmitters, cholinesterases, cyclooxygenase-2 and nitric oxide compared with diabetes control rats. In addition, antioxidant enzyme activities were significantly increased in diabetes rats administered 12.45, 24.9 and 49.8 mg/kg body weight of S. macrocarpon versus diabetes control rats. Conclusion Aqueous extract of S. macrocarpon Linn leaf may be useful in the management of diabetic neuropathy.

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