scholarly journals Dynamic capacity allocation in a radiology service considering different types of patients, individual no-show probabilities, and overbooking

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Rodolfo Benedito Zattar da Silva ◽  
Flávio Sanson Fogliatto ◽  
André Krindges ◽  
Moiseis dos Santos Cecconello
Keyword(s):  
Optimal Policy ◽  
Real Data ◽  
Capacity Allocation ◽  
Radiology Department ◽  
Radiology Service ◽  
Penalty Costs ◽  
Number Of Patients ◽  
Different Types ◽  
Markov Decision ◽  
The One

Abstract Background We propose a mathematical model formulated as a finite-horizon Markov Decision Process (MDP) to allocate capacity in a radiology department that serves different types of patients. To the best of our knowledge, this is the first attempt at considering radiology resources with different capacities and individual no-show probabilities of ambulatory patients in an MDP model. To mitigate the negative impacts of no-show, overbooking rules are also investigated. Methods The model’s main objective is to identify an optimal policy for allocating the available capacity such that waiting, overtime, and penalty costs are minimized. Optimization is carried out using traditional dynamic programming (DP). The model was applied to real data from a radiology department of a large Brazilian public hospital. The optimal policy is compared with five alternative policies, one of which resembles the one currently used by the department. We identify among alternative policies the one that performs closest to the optimal. Results The optimal policy presented the best performance (smallest total daily cost) in the majority of analyzed scenarios (212 out of 216). Numerical analyses allowed us to recommend the use of the optimal policy for capacity allocation with a double overbooking rule and two resources available in overtime periods. An alternative policy in which outpatients are prioritized for service (rather than inpatients) displayed results closest to the optimal policy, being also recommended due to its easy implementation. Conclusions Based on such recommendation and observing the state of the system at any given period (representing the number of patients waiting for service), radiology department managers should be able to make a decision (i.e., define number and type of patients) that should be selected for service such that the system’s cost is minimized.

Markov Branching Decision Chains with Interest-Rate-Dependent Rewards

1995 ◽  
Vol 9 (1) ◽  
pp. 99-121 ◽  
Author(s):  
Ying Huang ◽  
Arthur F. Veinott
Keyword(s):  
Interest Rate ◽  
Interest Rates ◽  
Optimal Policy ◽  
Linear Program ◽  
Present Value ◽  
Constraint Matrix ◽  
Rate Dependent ◽  
Markov Decision ◽  
The Interest Rate ◽  
The One

Finite-state-and-action Markov branching decision chains are studied with bounded endogenous expected population sizes and interest-rate-dependent one-period rewards that are analytic in the interest rate at zero. The existence of a stationary strong-maximum-present-value policy is established. Miller and Veinott's [1969] strong policy-improvement method is generalized to find in finite time a stationary n-present-value optimal policy and, when the one-period rewards are rational in the interest rate, a stationary strong-maximum-present-value policy. This extends previous studies of Blackwell [1962], Miller and Veinott [1969], Veinott [1974], and Rothblum [1974, 1975], in which the one-period rewards are independent of the interest rate, and Denardo [1971] in which semi-Markov decision chains with small interest rates are studied. The problem of finding a stationary n-present-value optimal policy is also formulated as a staircase linear program in which the objective function and right-hand sides, but not the constraint matrix, depend on the interest rate, and solutions for all small enough positive interest rates are sought. The optimal solutions of the primal and dual are polynomials in the reciprocal of the interest rate. A constructive rule is given for finding a stationary n-present-value optimal policy from an optimal solution of the asymptotic linear program. This generalizes the linear programming approaches for finding maximum-reward-rate and maximum-present-value policies for Markov decision chains studied by Manne [1960], d'Epenoux [1960, 1963], Balinski [1961], Derman [1962], Denardo and Fox [1968], Denardo [1970], Derman and Veinott [1972], Veinott [1973], and Hordijk and Kallenberg [1979, 1984].

Intuitionistic fuzzy two-factor variance analysis of movie ticket sales

2021 ◽  
pp. 1-11
Author(s):  
Velichka Traneva ◽  
Stoyan Tranev
Keyword(s):  
Comparative Analysis ◽  
Real Data ◽  
Intuitionistic Fuzzy Sets ◽  
Real Numbers ◽  
Data Set ◽  
Important Method ◽  
Ticket Sales ◽  
Intuitionistic Fuzzy ◽  
The One ◽  
First Time

Analysis of variance (ANOVA) is an important method in data analysis, which was developed by Fisher. There are situations when there is impreciseness in data In order to analyze such data, the aim of this paper is to introduce for the first time an intuitionistic fuzzy two-factor ANOVA (2-D IFANOVA) without replication as an extension of the classical ANOVA and the one-way IFANOVA for a case where the data are intuitionistic fuzzy rather than real numbers. The proposed approach employs the apparatus of intuitionistic fuzzy sets (IFSs) and index matrices (IMs). The paper also analyzes a unique set of data on daily ticket sales for a year in a multiplex of Cinema City Bulgaria, part of Cineworld PLC Group, applying the two-factor ANOVA and the proposed 2-D IFANOVA to study the influence of “ season ” and “ ticket price ” factors. A comparative analysis of the results, obtained after the application of ANOVA and 2-D IFANOVA over the real data set, is also presented.

scholarly journals Constructing Large-Scale Genetic Maps Using an Evolutionary Strategy Algorithm

Genetics ◽  
2003 ◽  
Vol 165 (4) ◽  
pp. 2269-2282
Author(s):  
D Mester ◽  
Y Ronin ◽  
D Minkov ◽  
E Nevo ◽  
A Korol
Keyword(s):  
Discrete Optimization ◽  
High Performance ◽  
Large Scale ◽  
Simulated Data ◽  
Real Data ◽  
Genetic Maps ◽  
Chromosome 1 ◽  
Evolutionary Strategy ◽  
Group A ◽  
The One

Abstract This article is devoted to the problem of ordering in linkage groups with many dozens or even hundreds of markers. The ordering problem belongs to the field of discrete optimization on a set of all possible orders, amounting to n!/2 for n loci; hence it is considered an NP-hard problem. Several authors attempted to employ the methods developed in the well-known traveling salesman problem (TSP) for multilocus ordering, using the assumption that for a set of linked loci the true order will be the one that minimizes the total length of the linkage group. A novel, fast, and reliable algorithm developed for the TSP and based on evolution-strategy discrete optimization was applied in this study for multilocus ordering on the basis of pairwise recombination frequencies. The quality of derived maps under various complications (dominant vs. codominant markers, marker misclassification, negative and positive interference, and missing data) was analyzed using simulated data with ∼50-400 markers. High performance of the employed algorithm allows systematic treatment of the problem of verification of the obtained multilocus orders on the basis of computing-intensive bootstrap and/or jackknife approaches for detecting and removing questionable marker scores, thereby stabilizing the resulting maps. Parallel calculation technology can easily be adopted for further acceleration of the proposed algorithm. Real data analysis (on maize chromosome 1 with 230 markers) is provided to illustrate the proposed methodology.

scholarly journals A Bird’s-Eye View of Cell Sources for Cell-Based Therapies in Blood Cancers

Cancers ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 1333
Author(s):  
Benjamin Motais ◽  
Sandra Charvátová ◽  
Matouš Hrdinka ◽  
Michal Šimíček ◽  
Tomáš Jelínek ◽  
...  
Keyword(s):  
Hematological Malignancies ◽  
Antigen Receptors ◽  
Chimeric Antigen Receptors ◽  
Blood Cancer ◽  
Cell Based Therapy ◽  
Cell Source ◽  
Different Types ◽  
Cell Sources ◽  
The One ◽  
Initial Results

Hematological malignancies comprise over a hundred different types of cancers and account for around 6.5% of all cancers. Despite the significant improvements in diagnosis and treatment, many of those cancers remain incurable. In recent years, cancer cell-based therapy has become a promising approach to treat those incurable hematological malignancies with striking results in different clinical trials. The most investigated, and the one that has advanced the most, is the cell-based therapy with T lymphocytes modified with chimeric antigen receptors. Those promising initial results prepared the ground to explore other cell-based therapies to treat patients with blood cancer. In this review, we want to provide an overview of the different types of cell-based therapies in blood cancer, describing them according to the cell source.

Plausibility and Aesthetic Interpretation

1977 ◽  
Vol 7 (2) ◽  
pp. 327-340 ◽  
Author(s):  
Denis Dutton
Keyword(s):  
Scientific Inquiry ◽  
The Other ◽  
Inquiry Science ◽  
Works Of Art ◽  
Different Types ◽  
Logical Structures ◽  
The One

If a catalogue were made of terms commonly used to affirm the adequacy of critical interpretations of works of art, one word certain to be included would be “plausible.” Yet this term is one which has received precious little attention in the literature of aesthetics. This is odd, inasmuch as I find the notion of plausibility central to an understanding of the nature of criticism. “Plausible” is a perplexing term because it can have radically different meanings depending on the circumstances of its employment. ln the following discussion, I will make some observations about the logic of this concept in connection with its uses in two rather different contexts: the context of scientific inquiry on the one hand, and that of aesthetic interpretation on the other. In distinguishing separate senses of “plausible,” I shall provide reason to resist the temptation to imagine that because logical aspects of two different types of inquiry—science and criticism—happen to be designated by the same term, they may to that extent be considered to have similar logical structures.

Fluid turbulence simulations of divertor heat load for ITER hybrid scenario using BOUT++

2021 ◽  
Author(s):  
Xueyun Wang ◽  
Xueqiao Xu ◽  
Philip B Snyder ◽  
Zeyu Li
Keyword(s):  
Heat Flux ◽  
Steady State ◽  
Energy Loss ◽  
Heat Load ◽  
Type I ◽  
Fluid Turbulence ◽  
Drift Model ◽  
Steady State Operation ◽  
Different Types ◽  
The One

Abstract The BOUT++ six-field turbulence code is used to simulate the ITER 11.5MA hybrid scenario and a brief comparison is made among ITER baseline, hybrid and steady-state operation (SSO) scenarios. Peeling-ballooning instabilities with different toroidal mode numbers dominate in different scenarios and consequently yield different types of ELMs. The energy loss fractions (ΔWped/Wped) caused by unmitigated ELMs in the baseline and hybrid scenarios are large (~2%) while the one in the SSO scenario is dramatically smaller (~1%), which are consistent with the features of type-I ELMs and grassy ELMs respectively. The intra ELM divertor heat flux width in the three scenarios given by the simulations is larger than the estimations for inter ELM phase based on Goldston’s heuristic drift model. The toroidal gap edge melting limit of tungsten monoblocks of divertor targets imposes constraints on ELM energy loss, giving that the ELM energy loss fraction should be smaller than 0.4%, 1.0%, and 1.2% for ITER baseline, hybrid and SSO scenarios, correspondingly. The simulation shows that only the SSO scenario with grassy ELMs may satisfy the constraint.

Comparison of two different types of fractional-order COVID-19 distributed time-delay models with real data application

2021 ◽  
pp. 2150219
Author(s):  
Liangli Yang ◽  
Yongmei Su ◽  
Xinjian Zhuo
Keyword(s):  
Time Delay ◽  
Fractional Order ◽  
Distributed Delay ◽  
Real Data ◽  
Least Square ◽  
Order Model ◽  
The Real ◽  
Fractional Order Model ◽  
Different Types ◽  
Distributed Time Delay

The outbreak of COVID-19 has a great impact on the world. Considering that there are different infection delays among different populations, which can be expressed as distributed delay, and the distributed time-delay is rarely used in fractional-order model to simulate the real data, here we establish two different types of fractional order (Caputo and Caputo–Fabrizio) COVID-19 models with distributed time-delay. Parameters are estimated by the least-square method according to the report data of China and other 12 countries. The results of Caputo and Caputo–Fabrizio model with distributed time-delay and without delay, the integer-order model with distributed delay are compared. These show that the fractional-order model can be better in fitting the real data. Moreover, Caputo order is better in short-term time fitting, Caputo–Fabrizio order is better in long-term fitting and prediction. Finally, the influence of several parameters is simulated in Caputo order model, which further verifies the importance of taking strict quarantine measures and paying close attention to the incubation period population.

Analysis of statistical indicators of the population of Saint Petersburg with malignant neoplasms of pancreas

2021 ◽  
Vol 23 (2) ◽  
pp. 155-164
Author(s):  
Vladislav E. Moiseenko ◽  
Alexander V. Pavlovsky ◽  
Dmitry A. Granov ◽  
Larisa V. Kochorova ◽  
Inna V. Dodonova ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Stage Iv ◽  
Malignant Neoplasms ◽  
Number Of Patients ◽  
Incidence And Mortality ◽  
Significant Downward Trend ◽  
Accumulation Index ◽  
One Year ◽  
The One ◽  
Statistical Indicators

Morbidity and mortality from pancreatic cancer is an urgent medical and social problem. Evaluation of statistical indicators in dynamics makes it possible to identify organizational and clinical problems in providing care to patients with malignant neoplasms of the pancreas. Medical and statistical indicators of incidence of malignant pancreatic neoplasms in St. Petersburg residents are evaluated. The assessment of medical and statistical indicators of the incidence of malignant neoplasms of the pancreas in residents of St. Petersburg. Statistical data were studied for the period from 2014 to 2019. The increase in the "rough" indicator of primary morbidity changed from 417.99 per 100 thousand population in 2014 to 505.6 in 2019. In the structure of primary cancer incidence, the indicator of active detection of pancreatic cancer glands in 2014 amounted to 3.6%, in 2019 3.8%. The proportion of patients with diagnoses confirmed morphologically increased from 48.9% to 61.4%. The proportion of patients with newly diagnosed stage IV of the disease changed from 39.5% in 2014 to 51.4% in 2019, and in patients with stage III in 2019 it was 33.3% (a decrease in comparison with 2014 15.3%). In 2019, the disease was diagnosed at stage II in 15.2% of patients. The proportion of patients with stage I in 2019 was 6.6%, this indicator in 2014 was registered at the level of 19.2%. From 2014 to 2019, the one-year mortality rate did not change and amounted to 67.9 and 67.4%, respectively (the decrease was 0.7%). Over the past 5 years, there has been no significant downward trend in the "rough" incidence and mortality rates from pancreatic cancer. However, in the dynamics, there was an increase in the number of patients registered for 5 or more years, and an increase in the accumulation index of the contingent of patients with pancreatic cancer.

Incidence of various dental anomalies in population of Taxilla, Pakistan

2021 ◽  
Vol 15 (10) ◽  
pp. 2710-2711
Author(s):  
Saman Malik ◽  
Faiqa Hassan ◽  
Muhammad Farooq ◽  
Usman ul Haq ◽  
Amna Faisal ◽  
...  
Keyword(s):  
Gender Discrimination ◽  
Radiology Department ◽  
Dental Radiology ◽  
Dental Anomalies ◽  
Supernumerary Teeth ◽  
Missing Teeth ◽  
Impacted Teeth ◽  
The People ◽  
Dental Procedures ◽  
Different Types

Background: There are different types of teeth anomalies that effects the people of different regional populations. Aim: To determine the occurrence of dental anomalies in patients of Taxila that visit our college for routine dental procedures. Methods: The study was retrospective and was conducted on periapical intraoral radiographs of patients between the ages of 15 to 35 years, with no gender discrimination at Dental College HITEC-IMS. Results: We collected data from 450 periapical intraoral radiographs that were taken in last six months (i.e. 15th January 2021 till 15th July 2021) in dental radiology department. Conclusion: The dental anomalies that were found in the population of taxila were impacted teeth, missing teeth, rotated tooth, supernumerary teeth (mesiodens), root dilacerations, peg lateral, taurodontism and hypercementosis. Keywords: Root anomalies, dental anomalies, periapical radiograph

Treatment of frostbite in an open way (without dressings)

1937 ◽  
Vol 33 (1) ◽  
pp. 84-86
Author(s):  
V. A. Petrovykh
Keyword(s):  
Recovery Period ◽  
Climatic Conditions ◽  
The Other ◽  
Critical Approach ◽  
Tatar Strait ◽  
Other Hand ◽  
Number Of Patients ◽  
The One ◽  
Apparent Similarity ◽  
Methods Of Treatment

The harsh climatic conditions of the coast of the Tatar Strait make explainable the large number of patients with frostbite who passed under our supervision during the winter of 1935-36 and amounted to 2.8% (26 people) of the total contingent of inpatients. The variety of recommended methods for treating frostbite, on the one hand, and the relatively long recovery period for all of them, on the other hand, made us take a critical approach to the proposed methods of treatment. All currently existing methods are reduced to the treatment of frostbite areas with bandages; and on the locus morbi apply indifferent or slightly disinfecting ointments, or a similar property of a powder, or wipes moistened with slightly disinfecting solutions, for example, Sol. kalii hyperm. 1: 1000. The apparent similarity of the external manifestations of frostbite and burns inspired us with the idea of ​​conducting frostbite therapy in an "open way", which has long occupied a well-deserved place in the treatment of burns.

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