scholarly journals Investigation of circulating lncRNAs as potential biomarkers in chronic respiratory diseases

2020 ◽  
Vol 18 (1) ◽  
Author(s):  
Zsófia Gál ◽  
András Gézsi ◽  
Ágnes F. Semsei ◽  
Adrienne Nagy ◽  
Monika Sultész ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Allergic Asthma ◽  
Respiratory Diseases ◽  
Expression Level ◽  
Healthy Children ◽  
Healthy Controls ◽  
Replication Cohort ◽  
Discovery Cohort ◽  
Chronic Respiratory Diseases ◽  
The Mean

Abstract Background In the present study the blood expression level of inflammatory response and autoimmunity associated long non-coding RNAs (lncRNAs) were compared in patients with different chronic respiratory diseases and investigated whether they could be used as biomarkers in these diseases. Methods In the discovery cohort, the gene expression level of 84 lncRNAs were measured in the blood of 24 adult patients including healthy controls and patients with asthma and COPD. In the replication cohort the expression of 6 selected lncRNAs were measured in 163 subjects including healthy controls and adults with allergic rhinitis, asthma, COPD and children with asthma. It was evaluated whether these lncRNAs can be used as diagnostic biomarkers for any studied disease. With systems biology analysis the biological functions of the selected lncRNAs were predicted. Results In the discovery cohort, the mean expression of 27 lncRNAs showed nominally significant differences in at least one comparison. OIP5-AS1, HNRNPU, RP11-325K4.3, JPX, RP11-282O18.3, MZF1-AS1 were selected for measurement in the replication cohort. Three lncRNAs (HNRNPU, RP11-325K4.3, JPX) expressed significantly higher in healthy children than in adult controls. All the mean expression level of the 6 lncRNAs differed significantly between adult allergic rhinitis patients and controls. RP11-325K4.3, HNRNPU and OIP5-AS1 expressed higher in allergic asthma than in non-allergic asthma. COPD and asthma differed in the expression of RP11-325K4.3 from each other. In examining of the lncRNAs as biomarkers the weighted accuracy (WA) values were especially high in the comparison of healthy controls and patients with allergic rhinitis. OIP5-AS1 and JPX achieved 0.98 and 0.9 WA values, respectively, and the combination of the selected lncRNAs also resulted in a high performance (WA = 0.98). Altogether, OIP5-AS1 had the highest discriminative power in case of three out of six comparisons. Conclusion Differences were detected in the expression of circulating lncRNAs in chronic respiratory diseases. Some of these differences might be utilized as biomarkers and also suggest a possible role of these lncRNAs in the pathomechanism of these diseases. The lncRNAs and the associated pathways are potential therapeutic targets in these diseases, but naturally additional studies are needed for the confirmation of these results.

scholarly journals Comparison of serum interleukin-33 levels in children with allergic respiratory diseases

2020 ◽  
Vol 73 (3-4) ◽  
pp. 88-93
Author(s):  
Borko Milanovic ◽  
Gordana Vijatov-Djuric ◽  
Mirjana Stojsic ◽  
Aleksandra Milutinovic ◽  
Jelena Stojcevic-Maletic
Keyword(s):  
Allergic Rhinitis ◽  
Allergic Asthma ◽  
Respiratory Diseases ◽  
Serum Levels ◽  
Asthma Severity ◽  
Control Group ◽  
Healthy Children ◽  
Interleukin 33 ◽  
Relationship Of ◽  
The Relationship

Introduction. Recent studies point to the importance of interleukin-33 in the pathogenesis of allergic respiratory diseases. The relationship of interleukin-33 and certain allergic respiratory diseases as well as their characteristics is not fully elucidated. The basic aim of this research was to determine interleukin-33 serum levels in children with allergic asthma and allergic rhinitis, as well as to examine the relationship between obtained interleukin-33 levels and individual clinical characteristics of these patients. Material and Methods. Serum interleukin- 33 levels were measured in a total of 91 children. The study group included 39 children with both allergic asthma and allergic rhinitis, and also 22 children with allergic asthma without allergic rhinitis. The control group included 30 healthy children. Results. Serum levels of interleukin-33 in children with both allergic asthma and allergic rhinitis were significantly higher compared to those in children with allergic asthma only (?2 = 7.01; p = 0.008; p < 0.01). Both groups of patients had significantly higher interleukin-33 serum levels compared to healthy children (?2 = 7.01; p = 0.008; p < 0.01). The correlation between serum interleukin-33 levels and allergic asthma severity was statistically significant (rs = 0.289; p = 0.024; p < 0.05). Conclusion. Serum levels of interleukin-33 were significantly higher in children with allergic respiratory diseases compared to healthy examinees. Significantly higher levels of serum interleukin-33 levels were found in children with both allergic asthma and allergic rhinitis, compared to children with allergic asthma only. Patients with higher interleukin- 33 serum levels also had a more severe type of allergic asthma.

scholarly journals Asthma prevalence and associated factors among lebanese adults: the first national survey

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Zeina Akiki ◽  
Danielle Saadeh ◽  
Rita Farah ◽  
Souheil Hallit ◽  
Hala Sacre ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Family History ◽  
Respiratory Diseases ◽  
Fruits And Vegetables ◽  
Asthma Prevalence ◽  
Cluster Sampling ◽  
Cross Sectional ◽  
Current Asthma ◽  
Chronic Respiratory Diseases ◽  
History Of

Abstract Background No national research has yet explored the prevalence of asthma among adults in Lebanon. This study aims to evaluate the prevalence of physician-diagnosed asthma and current asthma, and their determinants among Lebanese adults 16 years old or above. Methods A cross-sectional study was carried out using a multistage cluster sampling. The questionnaire used collected information on asthma, respiratory symptoms, and risk factors. Results The prevalence of physician-diagnosed asthma was 6.7% (95% CI 5–8.7%), and that of current asthma was 5% (95% CI 3.6–6.9%). Chronic symptoms such as cough, wheezing, and shortness of breath were worst at night. Factors positively associated with physician-diagnosed asthma were a secondary educational level (adjusted OR, aOR = 4.45), a family history of chronic respiratory diseases (aOR = 2.78), lung problems during childhood (15.9), and allergic rhinitis (4.19). Additionally, consuming fruits and vegetables less than once per week (3.36), a family history of chronic respiratory diseases (3.92), lung problems during childhood (9.43), and allergic rhinitis (8.12) were positively associated with current asthma. Conclusions The prevalence of asthma was within the range reported from surrounding countries. However, repeated cross-sectional studies are necessary to evaluate trends in asthma prevalence in the Lebanese population.

scholarly journals Is suicidal ideation associated with allergic asthma and allergic rhinitis?

2018 ◽  
Vol 44 (1) ◽  
pp. 31-35 ◽  
Author(s):  
Martín Bedolla-Barajas ◽  
Norma Angélica Pulido-Guillén ◽  
Bolívar Vivar-Aburto ◽  
Jaime Morales-Romero ◽  
José Raúl Ortiz-Peregrina ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Suicidal Ideation ◽  
Allergic Asthma ◽  
Allergic Diseases ◽  
Cross Sectional Study ◽  
University Hospital ◽  
Control Group ◽  
Healthy Controls ◽  
Cross Sectional ◽  
And Control

ABSTRACT Objective: To investigate whether there is an association between suicidal ideation (SI) and allergic diseases in adults. Methods: This was a comparative cross-sectional study involving individuals ranging from 20 to 50 years of age recruited from a university hospital in the city of Guadalajara, Mexico. We included patients with a confirmed diagnosis of allergic asthma, those with a confirmed diagnosis of allergic rhinitis, and healthy controls. All subjects completed the Beck Depression Inventory-II (BDI-II), which includes an item that evaluates the presence of suicidal thoughts or desires within the last two weeks, in order to identify SI. Results: The sample comprised 115 patients with allergic asthma, 111 patients with allergic rhinitis, and 96 healthy controls. The number of individuals identified with SI in the three groups were, respectively, 17 (14.8%), 13 (11.7%), and 8 (8.3%). Regarding the presence of SI, no statistically significant association was found in the allergic asthma group (OR = 1.98; 95% CI: 0.78-4.64; p = 0.154) or in the allergic rhinitis group (OR = 1.46; 95% CI: 0.58-3.68; p = 0.424) when they were compared with the control group. However, the presence of depression was associated with SI in the three groups: allergic asthma (OR = 12.36; 95% CI: 2.67-57.15; p = 0.001); allergic rhinitis (OR = 6.20; 95% CI: 1.66-23.14; p = 0.006); and control (OR = 21.0; 95% CI: 3.75-117.36; p < 0,001). Conclusions: In comparison with the control group, no association was found between SI and the groups with allergic diseases. In contrast, there was association between SI and depression in the three groups.

scholarly journals Chronic respiratory diseases at primary health care level in Georgia: the results of the pilot study

2016 ◽  
Vol 71 (4) ◽  
Author(s):  
I. Chkhaidze ◽  
T. Maglakelidze ◽  
N. Khaltaev
Keyword(s):  
Allergic Rhinitis ◽  
Respiratory Diseases ◽  
Chronic Obstructive ◽  
Official Statistics ◽  
Global Alliance ◽  
Care Level ◽  
Obstructive Pulmonary Disease ◽  
Chronic Respiratory Diseases ◽  
Chronic Morbidity ◽  
Official Data

Background and aim. Millions of people suffer from chronic respiratory diseases (CRD). To address this serious global health problem WHO formed the Global Alliance against Chronic Respiratory Diseases (GARD). Chronic obstructive pulmonary disease (COPD) is a major priority of GARD due to high chronic morbidity and mortality; however, there is still little prevalence data available. The prevalence of COPD in Georgia, as well as other CRD, is suspected to be high. Methods. GARD Pilot Survey (GAPS) in Georgia had been carried out by the Georgian Respiratory Association. The survey was conducted in the Sagarejo and Mtskheta districts with total population of about 70.000. All subjects provided information on asthma, bronchitis, respiratory symptoms, smoking, allergic conditions, CRD comorbidity and lifestyle via an interviewer-administered questionnaire. A total of 3,646 questionnaires were analysed. Results. It was discovered that official data concerning allergic rhinitis, TB and asthma are almost equal, but readings in relation to CRD are about five times lower according to official data of the Ministry of Health of Georgia. The data results: for allergic rhinitis - 218 in GAPS vs. 177 in the official statistics (for 100.000 population); for TB -105 in GAPS vs. 147 in the official statistics; for asthma -250 in GAPS vs. 374 in the official statistics; the data about CRD according to our survey is almost five times higher - 365 in GAPS vs. 84 in the official statistics (for 100.000 population). Conclusions. It is necessary to expand the survey to the entire country population. Country results are likely to be useful and interesting for local doctors and managers, as well as for officials.

scholarly journals Assessing service availability and readiness to manage Chronic Respiratory Diseases (CRDs) in Bangladesh

PLoS ONE ◽  
2021 ◽  
Vol 16 (3) ◽  
pp. e0247700
Author(s):  
Progga Paromita ◽  
Hasina Akhter Chowdhury ◽  
Cinderella Akbar Mayaboti ◽  
Shagoofa Rakhshanda ◽  
A. K. M. Fazlur Rahman ◽  
...  
Keyword(s):  
Respiratory Diseases ◽  
Tertiary Care ◽  
Health Facilities ◽  
Essential Medicines ◽  
World Health ◽  
Service Availability ◽  
Cross Sectional ◽  
Chronic Respiratory Diseases ◽  
District Hospitals ◽  
The Mean

Introduction Chronic Respiratory Diseases (CRDs) are some of the most prevailing non-communicable diseases (NCDs) worldwide and cause three times higher morbidity and mortality in low- and middle-income countries (LMIC) than in developed nations. In Bangladesh, there is a dearth of data about the quality of CRD management in health facilities. This study aims to describe CRD service availability and readiness at all tiers of health facilities using the World Health Organization’s (WHO) Service Availability and Readiness Assessment (SARA) tool. Methods A cross-sectional study was conducted from December 2017 to June 2018 in a total of 262 health facilities in Bangladesh using the WHO SARA Standard Tool. Surveys were conducted with facility management personnel by trained data collectors using REDCap software. Descriptive statistics for the availability of CRD services were calculated. Composite scores for facility readiness (Readiness Index ‘RI’) were created which included four domains: staff and guideline, basic equipment, diagnostic capacity, and essential medicines. RI was calculated for each domain as the mean score of items expressed as a percentage. Indices were compared to a cutoff of70% which means that a facility index above 70% is considered ‘ready’ to manage CRDs at that level. Data analysis was conducted using SPSS Vr 21.0. Results It was found, tertiary hospitals were the only hospitals that surpassed the readiness index cutoff of 70%, indicating that they had adequate capacity and were ready to manage CRDs (RI 78.3%). The mean readiness scores for the other hospital tiers in descending order were District Hospitals (DH): 40.6%, Upazila Health Complexes (UHC): 33.3% and Private NGOs: 39.5%). Conclusion Only tertiary care hospitals, constituting 3.1% of sampled health facilities, were found ready to manage CRD. Inadequate and unequal supplies of medicine as well as a lack of trained staff, guidelines on the diagnosis and treatment of CRDs, equipment, and diagnostic facilities contributed to low readiness index scores in all other tiers of health facilities.

scholarly journals New Technologies for Promoting Physical Activity in Healthy Children and in Children with Chronic Respiratory Diseases: A Narrative Review

2021 ◽  
Vol 13 (21) ◽  
pp. 11661
Author(s):  
Velia Malizia ◽  
Giuliana Ferrante ◽  
Salvatore Fasola ◽  
Laura Montalbano ◽  
Giovanna Cilluffo ◽  
...  
Keyword(s):  
Physical Activity ◽  
Urban Areas ◽  
Respiratory Diseases ◽  
New Technologies ◽  
Mobile Apps ◽  
Narrative Review ◽  
Healthy Children ◽  
Chronic Respiratory Diseases ◽  
Fitness Programs

Physical activity (PA) is proven to benefit children and adolescents in several ways. New technologies may provide children with stimulating modalities for organizing their leisure time, accessing fitness programs, and obtaining daily goal reminders and peer support. Due to the current COVID-19 pandemic, following WHO recommendations for PA is difficult for many children, especially for those living in urban areas. Therefore, the use of digital tools to support and maintain PA could be useful in healthy children, as well as in those with chronic respiratory diseases (CRDs). This narrative review aims to summarize the most recent evidence about the role of new technologies in promoting PA in healthy children and in those with CRDs, in supporting PA during the COVID-19 pandemic, and in enhancing psychological wellbeing in this age group. The use of technological devices for promoting PA, such as web/mobile apps and games, has been proven to be effective both in healthy children and in those with CRDs. In conclusion, new technologies are very promising in terms of feasibility, acceptability, and efficacy in promoting PA. Further studies are required to evaluate the long-term health benefits of using these technologies.

scholarly journals Lymphocyte phenotyping in untreated children patients with chronic allergic asthma

2010 ◽  
Vol 7 (1) ◽  
pp. 382-388
Author(s):  
Baghdad Science Journal
Keyword(s):  
Allergic Asthma ◽  
Peripheral Blood ◽  
Control Group ◽  
Healthy Children ◽  
T Helper ◽  
Cd4 Cells ◽  
Cd8 Cells ◽  
T Helper Lymphocytes ◽  
The Mean ◽  
Lymphocyte Phenotyping

This study aimed to isolate and phenotype lymphocytes in untreated children patients with chronic allergic asthma. To reach such aim the study involved (25) patients from children (17 male and 9 female) whom their ages where between (3-10) years, in addition to (15) apparently healthy children (9 male and 6 female) in the same ages involved as control group. The data demonstrated that there was a significant increase in the mean percentages of T-lymphocytes (CD3+ cells) in the peripheral blood of patients (66.75±0.29)**, in comparison with control group (43.58±0.19), a significant increase in the mean percentages of T-helper lymphocytes (CD4+ cells) in the peripheral blood of patients (51.14±0.55), in comparison with control group (39.17±0.23) and the mean percentages of B-lymphocytes (CD20+ cells) was also increased significantly in the peripheral blood of patients (29.63±0.20) when it compared with the mean percentages of the same cells in control group (18.60±0.80). Besides a significant decrease in the mean percentages of T-suppressor lymphocytes (CD8+ cells) in the peripheral blood of patients (11.31±0.05), in comparison with control group (16.42±0.15). Finally the results of this study showed a significant increase in the mean percentages of the ratio of (CD4+ cells/CD8+ cells) in the peripheral blood of patients (55.34±0.41), in comparison with control group (31.25±0.09).

Physical Activity in Children and Adolescents With Chronic Respiratory Diseases: A Systematic Review and Meta-Analysis

2021 ◽  
Vol 18 (2) ◽  
pp. 219-229
Author(s):  
Rodrigo Torres-Castro ◽  
Luis Vasconcello-Castillo ◽  
Roberto Acosta-Dighero ◽  
Nicolás Sepúlveda-Cáceres ◽  
Marisol Barros-Poblete ◽  
...  
Keyword(s):  
Physical Activity ◽  
Systematic Review ◽  
Children And Adolescents ◽  
Respiratory Diseases ◽  
Sedentary Time ◽  
Meta Analysis ◽  
Mean Difference ◽  
Slight Reduction ◽  
Healthy Controls ◽  
Chronic Respiratory Diseases

Background: The literature is unclear as to whether children and adolescents with chronic respiratory diseases (CRDs) differ from their healthy peers in physical activity (PA). Objective: To determine the PA levels measured through accelerometers in children and adolescents with CRDs. Methods: The authors conducted a systematic review using five databases. The authors included studies that assessed the PA measured by accelerometers in children and adolescents with CRDs. Two independent reviewers analyzed the studies, extracted the data, and assessed the quality of evidence. Results: From 11,497 reports returned by the initial search, 29 articles reporting on 4381 patients were included. In the sensitivity analysis, the authors found that children and adolescents with CRDs had a moderate-to-vigorous PA (MVPA) of −0.08 hours per day (95% confidence interval [CI], −0.12 to −0.03 h/d; P = .001), which was lower than the healthy controls; the values for sedentary time (mean difference −0.47 h/d; 95% CI, −1.29 to 0.36 h/d; P = .27) and steps/d (mean difference 361 steps/d; 95% CI −385 to 1707 steps/d; P = .45) were similar for both. Conclusion: Children and adolescents with CRDs have a slight reduction in MVPA in comparison with healthy controls, but sedentary time and steps/d were similar for both.

Facial and Auditory Recognition Abilities of Implanted Primary Schoolers

2021 ◽  
pp. 1-6
Author(s):  
Selma Yilar ◽  
Ilknur Tasdemir ◽  
Betul Koska ◽  
Esra Belen ◽  
Buse Cetinkaya ◽  
...  
Keyword(s):  
Healthy Children ◽  
Healthy Controls ◽  
Facial Emotions ◽  
School Aged Children ◽  
Rehabilitation Programs ◽  
Auditory Recognition ◽  
The Mean ◽  
Children With Hearing Loss ◽  
Emotion Recognition Training ◽  
Accuracy Rates

<b><i>Objective:</i></b> Emotions are often conveyed via visual and together with the auditory mode in social interaction. We aimed to investigate the ability to recognize facial and/or auditory emotions in school-aged children with cochlear implantation and healthy controls. <b><i>Methods:</i></b> All participants were asked to respond to facial emotions of Ekman and Friesen’s pictures, then auditory emotions, and last, they were asked to respond to video-based dynamic synchronous facial and auditory emotions. <b><i>Results:</i></b> The mean accuracy rates in recognizing anger (<i>p</i> = 0.025), surprise (<i>p</i> = 0.029), and neutral (<i>p</i> = 0.029) faces were significantly worse in children with cochlear implants (CIs) than in healthy controls. They were significantly worse than healthy controls in recognizing all auditory emotions except auditory emotion of fear (<i>p</i> = 0.067). The mean accuracy rates in recognizing video-based auditory/facial emotions of surprise (<i>p</i> = 0.031) and neutral (<i>p</i> = 0.029) emotions were significantly worse in children with CIs. <b><i>Conclusion:</i></b> The children with hearing loss were poorer in recognizing surprise, anger, and neutral facial emotions than healthy children; they had similar performance in recognizing anger emotions when both stimuli were given synchronously which may have a positive effect on social behaviors. It seems beneficial that emotion recognition training should be included in rehabilitation programs.

scholarly journals Nitric oxide as a biomarker of allergic inflammation in children

2007 ◽  
pp. 69-78
Author(s):  
S. E. Tsyplenkova ◽  
Yu. L. Mizernitsky
Keyword(s):  
Nitric Oxide ◽  
Differential Diagnosis ◽  
Respiratory Diseases ◽  
Allergic Inflammation ◽  
Clinical Importance ◽  
Diagnostic Methods ◽  
Control Group ◽  
Healthy Children ◽  
Chronic Respiratory Diseases ◽  
Asthmatic Children

The aim of this study was to analyze clinical importance of exhaled nitric oxide (NOex) measurement for early detection, differential diagnosis and control of treatment of chronic respiratory pathology in children. The study involved 412 children of 5 to 18 years old with different chronic bronchopulmonary diseases. Apart from a typical clinical, laboratory, and instrumental diagnostic methods, NOex was measured in all the children using the chemiluminescent gas analyzer 280i (Sievers, USA). The control group included 30 healthy children aged 5 to 18 with mean NOex 14.8 ± 1.4 ррb (9.2 ÷ 21.4 ррb). The majority of asthmatic children had high NOex (> 20 ppb in 284 (90 %) asthmatic children), р < 0.01, both in stable asthma and exacerbation. The NOex level was directly correlated to the severity and period of the disease (frequency of asthma attacks, time from the last asthma attack, lung function parameters), and blood levels of allergic markers (eosinophils, total IgE, circulating immune complexes, IL-4). Therefore, NOex monitoring was useful in evaluating the efficacy of different treatment modes. In other chronic respiratory diseases, NOex level was also elevated but to lesser degree. In children with primary ciliary dyskinesia, NOex was significantly below the normal level that could be used as a preliminary screening tool. In conclusion, NOex measurement is a reliable and objective method to control allergic inflammation in the airways. It is of great clinical importance and is helpful in differential diagnosis of chronic respiratory diseases and confirmation of the diagnosis. It allows individual choice of therapy, control of the patient's adherence to treatment and prognosis of future exacerbations.

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