Innovative method of alopecia treatment by autologous adipose-derived SVF

Abstract Background Alopecia refers to a condition developed by gradual reduction of hair loss by various abnormal causes such as endocrine system, genetic factors, and stress. Stromal vascular fraction (SVF) isolated from the fat is one of the latest innovative solutions in the field of regeneration therapy. We focused on presenting effectiveness of clinical cases to improve AGA through transplantation of autologous SVF into the scalp. Objective To confirm the efficacy of the autologous SVF usage to the patients with AGA. Methods Nine patients (age range 43–64 years; 4 men, grade IV to V and 5 women, grade I to III), who are suffering from androgenic alopecia (AGA), were treated with single transplantation of autologous SVF in the upper scalp. Autologous SVF was isolated and characterized prior to the injection of live 7–9 × 106 cells into the patients’ treatment site. The hair loss improvement effect was assessed by three test criteria: hair skin quality, hair thickness and hair density 3 and 6 months after post-injection compared to pre-injection status. Results Hair density of SVF-treated side was significantly increased after 3 and 6 months of transplantation compared to non-treated side (P = 0.01 and P = 0.009 per each). And significant improvement in the score of the keratin on the scalp was seen in the injected area as compared to the non-injected area 6 months after transplantation (P = 0.032). Although thickness increase was observed at 3 and 6 months after transplantation, there was no statistical significance (P = 0.142 and 0.155, respectively). Conclusions One transplantation of autologous SVF for the AGA patients, hair density and score for the keratin were significantly increased within 6 months. This study shows that SVF is a very effective way to treat hair loss and most of subjects are satisfied with the result after treatment.

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Innovative Method of Alopecia Treatment by Using Adipose-derived Stromal Vascular Fraction (SVF) Cells

10.21203/rs.3.rs-533152/v1 ◽

2021 ◽

Author(s):

sun jong kim ◽

MyungJin Kim ◽

YoungJun Lee ◽

Joochan Lee ◽

Ji Hyang Kim ◽

...

Keyword(s):

Stromal Vascular Fraction ◽

Post Injection ◽

Clinical Tests ◽

Hair Density ◽

Aesthetic Field ◽

The Aesthetic ◽

Vellus Hairs ◽

Age Range ◽

Skin Quality

Abstract BackgroundAndrogenetic alopecia (AGA) is characterized by progressive reduction of hair density on the scalp through gradual conversion of terminal hairs into vellus hairs. Stromal vascular fraction (SVF) cells harvested from fat cells are one of the latest breakthroughs in the aesthetic field. This study aimed to present clinical cases for the treatment of alopecia areata by transplantation of SVF into the scalp.Objective To evaluate the efficacy of the use of the stromal vascular fraction (SVF) in androgenetic alopecia patients.Methods9 patients (age range 43-64 years; 4 men, grade IV to V and 5 women, grade I to III), who are suffering from AGA, have been treated with a single injection of autologous SVF in the upper scalp. Autologous SVF was generated and characterized before the injection of 7-8 × 106 cells into the scalp of the patient. Hair regeneration was assessed by three clinical tests: hair skin quality, hair thickness, and hair density at 3 and 6 months post-injection and compared to pre-injection results.ResultsHair density was significantly increased after 3 and 6 months post injection (P = 0.01 and P=0.009). The increase in thickness was notably seen at 6 months post injection (P = 0.02). Furthermore, a significant improvement in the score of keratin of scalp was seen in the treated side as compared to the nontreated side (p=0.032). No side effects were noted after treatment.ConclusionsA single treatment of SVF injected into the scalp of patients with AGA significantly increased hair density within 3 to 6 months. The obtained results prove the efficacy and the safety of the treatment, and satisfaction of the patients confirm the quality of the results.

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Comparison of efficacy of topical 5% minoxidil alone versus topical 5% minoxidil with autologous Platelet Rich Plasma (PRP) therapy in treatment of androgenetic alopecia: A randomised open label study

IP Indian Journal of Clinical and Experimental Dermatology ◽

10.18231/j.ijced.2021.021 ◽

2021 ◽

Vol 7 (2) ◽

pp. 107-114

Author(s):

Bela Padhiar ◽

Sruthy Raveendran

Keyword(s):

Platelet Rich Plasma ◽

Androgenetic Alopecia ◽

Androgenic Alopecia ◽

Open Label ◽

Hair Density ◽

Convenience Sample ◽

Double Spin ◽

Autologous Platelet Rich Plasma ◽

Group B ◽

Autologous Platelet

Androgenic alopecia (AGA) is a type of progressive hairloss, where there is androgen mediated conversion of susceptible terminal hairs into vellus hairs, in genetically predisposed individuals. To compare efficacy of Topical 5% Minoxidil alone versus Topical 5% Minoxidil with Autologous Platelet Rich Plasma (PRP) therapy in patients with Androgenetic Alopecia.This is aProspective study conducted in Department of Dermatology GMERS Medical College, Gandhinagar, Gujarat. A convenience sample of 62 men in the age group of 20-40 with Grade 2-5 AGA according to Hamilton- Norwood Grading were selected and was divided into 2 groups of 31 each. Presitting digital photographs and dermoscopic photos were taken. Autologous PRP was prepared using 18 ml of patients blood after double spin centrifugation and injected by Nappage technique. Results were assessed at the baseline and at the end of each sitting on the basis of change in hair density, photographic evaluation and patient’s self satisfaction. Highly significant increase in hair density was achieved after 4 months of treatment. At T4 (Fourth Session of treatment) Group B showed higher hair density (42.97± 8.96) as compared to Group A (36.94 ± 11.57) which was statistically significant at P = 0.03Group B showed better improvement as compared to Group A.PRP treatment has a positive therapeutic effect on male Androgenetic alopecia without major side effects.

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Relación entre conducta prosocial, resolución de problemas y consumo de drogas en adolescentes

Anales de Psicología ◽

10.6018/analesps.32.2.204941 ◽

2016 ◽

Vol 32 (2) ◽

pp. 609 ◽

Cited By ~ 3

Author(s):

Olga Hernández-Serrano ◽

José P. Espada ◽

Alejandro Guillén-Riquelme

Keyword(s):

Problem Solving ◽

Statistical Significance ◽

Cross Sectional Study ◽

Prosocial Behaviour ◽

Cross Sectional ◽

Problem Solving Skills ◽

Problem Solving Strategies ◽

And Gender ◽

Prosocial Behaviours ◽

Age Range

The objectives of the present study are the following ones: 1) to study the use of drugs, the prosocial behaviour and the problem-solving skills with respect to age and gender, and 2) to analyze the association of both the prosocial behaviour and the problem-solving skills with the use of drugs. An exploratory cross-sectional study was performed, amongst a sample of 567 students in Spanish Compulsory Secondary Education (48.14% males) with an age range from 14 to 17 years (M = 14.92; SD = 0.90). Statistically significant differences were found concerning alcohol use and the prosocial behaviour with respect to gender, as well as concerning alcohol and cannabis use with respect to age. Logistic regression analyses revealed statistical significance of the prosocial behaviour with respect to the use of alcohol and cannabis. The ability in problem-solving was the most important protective predictor with respect to the abuse of cannabis. The results from this study enhance the importance of tailored interventions based on the promotion of prosocial behaviours and/or problem-solving strategies as fundamental protective factors for substance use amongst adolescents.

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ULTRASOUND PREDICTABILITY OF LOWER UTERINE SEGMENT CESAREAN SECTION SCAR THICKNESS

10.36106/ijsr/3520656 ◽

2020 ◽

pp. 9-11

Author(s):

Madhu Kumari ◽

Kumari Bibha ◽

Abha Sinha ◽

Debarshi Jana

Keyword(s):

Cesarean Section ◽

Gestational Age ◽

Statistical Significance ◽

P Value ◽

Chi Square ◽

Medical College ◽

Chi Square Test ◽

Uterine Scar ◽

Age Range ◽

The Given

Objective: The objective of this study is to find out association between scar thickness, assessed sonographically, and intraoperative findings (IOF). Study Design: Descriptive study. Place and Duration of Study: Department of Obstetrics and Gynecology, Sri Krishna Medical College and Hospital, Muzaffarpur, Bihar from June 2019 to May 2020. Methodology: A total of 70 pregnant patients were included in this study. Transabdominal ultrasound was done for scarred uteri. Sonographic findings were co-related with introperative findings. All the given data were entered on SPSS version 23. Age was expressed as mean ± SD. Parity, gestational age, and interval between cesarean sections were expressed as frequencies with percentages. Statistical analysis was done by using Chi-square test for categorical data for association between sonographic scar thickness and intraoperative findings. The statistical significance was set at p-value <0.05. Results: The age range of the patients was 20- 36 years with a mean of 27.91 ±3.690 years. Gestational age at the time of cesarean section was between 27-40 weeks of gestation with a mean of 37 ±2.126 weeks. The interval from previous cesarean was 10 months at the minimum, and 6 years at the maximum with a mean of 2.29 ±1.0 months. Mean scar thickness was 2.5 mm. Association between scar thickness (<1-3 mm) and intaoperative findings of dehiscence and rupture showed a p-value of <0.001. Conclusion: Sonographic assessment of a uterine scar has a practical application to determine the thickness of previous scar, and assess its integrity.

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Hair Loss During Menopause: Ways of the Problem Solution

Effective Pharmacotherapy ◽

10.33978/2307-3586-2020-16-27-10-14 ◽

2020 ◽

Vol 16 (27) ◽

pp. 10-14

Author(s):

Yu.A. Gallyamova ◽

◽

O.A. Korableva ◽

Ye.V. Doskina ◽

O.O. Khodova ◽

...

Keyword(s):

Hair Loss ◽

Growth Stage ◽

Problem Solution ◽

Hair Density ◽

Peptide Complex ◽

Female Type

Provided data on the effectiveness of a new peptide complex in the treatment of female-type hair loss in postmenopausal patients. Thus, the use of the complex contributed to the transition of follicles from the resting stage to the growth stage. As a result, the hair density increased

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Olfactory perception in women with physiologically altered hormonal status (during pregnancy and postmenopause)

Medicinski pregled ◽

10.2298/mpns0210380s ◽

2002 ◽

Vol 55 (9-10) ◽

pp. 380-383 ◽

Cited By ~ 6

Author(s):

Slobodan Savovic ◽

Dejan Nincic ◽

Slobodanka Lemajic ◽

Vladimir Pilija ◽

Aljosa Mandic ◽

...

Keyword(s):

Statistical Significance ◽

Endocrine System ◽

Premenopausal Women ◽

First Trimester ◽

Olfactory Function ◽

Hormonal Status ◽

Emotional States ◽

Olfactory Ability ◽

Novi Sad ◽

In Pregnancy

Introduction Olfaction is considered to be the ability to: perceive, conduct and recognize scents and odors. With its numerous connections to the limbic system and reticular formation, the olfactory system affects regulation of numerous vegetative functions, visceral functions and sexual behavior. Since estrogen and progesterone protect the olfactory function, changes in their levels in particular physiological states in women (in pregnancy and postmenopause) exert an influence on the ability to feel and recognize smells. It has its role in creating emotions and adjustment of visceral and vegetative response to particular emotional states. Also, it represents the connection between higher cortical functions and the endocrine system. Material and methods Our investigation was performed at the Ear, Nose and Throat Clinic in Novi Sad. The research included 80 healthy women classified into 4 groups; 20 women aged between 20 and 30; 20 women in the first trimester of pregnancy aged between 20 and 30; 20 premenopausal women aged between 41 and 50; and 20 women at least 3 years in postmenopause, aged between 41 and 50. For our research we used an olfactometer and the Fortunato-Niccolini method. Results and discussion In pregnancy the thresholds of perception (TP) and identification (TI) of examined substances were slightly lower in comparison to nonpregnant women of the same ages, but without any statistical significance (p>0.05). In climacteric-postmenopausal women there was a significant decrease of olfactory ability in comparison to nonmenopausal women of the same ages (p<0.01). Conclusion All changes of the olfactory function in pregnancy are explained by mental changes of pregnant women as well as their hormonal status. Significant decrease of olfactory ability in postmenopause is explained by decline in sexual hormone levels.

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Androgenic alopecia in post-menopausal female: a clinical presentation

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20201824 ◽

2020 ◽

Vol 9 (5) ◽

pp. 2157

Author(s):

Kirty Nahar ◽

Usha Bohra ◽

Vivek Arya

Keyword(s):

Hair Loss ◽

Histopathological Examination ◽

Clinical Signs ◽

Signs And Symptoms ◽

Abdominal Hysterectomy ◽

Androgenic Alopecia ◽

Clinical Signs And Symptoms ◽

Significant Regression ◽

Post Menopausal ◽

Work Up

Androgenic alopecia is a patterned hair loss occurring due to systemic androgens and genetic factors. It is the most common cause of hair loss in both genders. The appearance of this condition is the cause of significant stress and psychological problems, making appropriate management important. A 68-year-old postmenopausal female presented with complaints of increased hair loss from scalp, excessive hair growth at undesired sites and hirsutism not corrected with medications. On thorough investigations, CT scan whole abdomen and endocrinological workup, a clinical diagnosis of alopecia and hirsutism due to hyperandrogenemia secondary to ovarian tumor made. Abdominal hysterectomy with B/L salpingo-oophorectomy was done. Histopathological examination revealed an encapsulated tumor in right ovary-sex cord stromal tumor consistent with Leydig cell tumor in right ovary, no evidence of malignancy. Left ovary was normal. Patient showed significant regression of clinical signs and symptoms on follow up after 1 month. All women with severe hirsutism or androgenic alopecia needs further work up to locate the source of androgen over production.

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Hair Growth Promotion by Extracts of Inula Helenium and Caesalpinia Sappan Bark in Patients with Androgenetic Alopecia: A Pre-clinical Study Using Phototrichogram Analysis

Cosmetics ◽

10.3390/cosmetics6040066 ◽

2019 ◽

Vol 6 (4) ◽

pp. 66

Author(s):

Hyoung Chul Choi ◽

Gae Won Nam ◽

Noh Hee Jeong ◽

Bu Young Choi

Keyword(s):

Clinical Study ◽

Hair Loss ◽

Hair Growth ◽

Blood Circulation ◽

Growth Promotion ◽

Test Group ◽

Androgenetic Alopecia ◽

Hair Density ◽

Caesalpinia Sappan ◽

Inula Helenium

Inula helenium (IH) is known to possess antifungal, anti-bacterial, anti-helminthic, and anti-proliferation activities. Caesalpinia Sappan (CS) is known to reduce inflammation and improve blood circulation. Based on their folkloric use, these plants are expected to be promising candidates for promoting hair growth and preventing hair loss. Moreover, these plants are rich sources of certain phytochemicals, which have been reported to promote hair growth. In this clinical trial, we investigate the efficacy of a scalp shampoo formulated by mixing extracts of IH and CS in preventing hair loss and promoting hair growth in patients with androgenetic alopecia. Using a phototrichogram (Folliscope 2.8, LeadM, Korea), we compared the hair density and total hair counts in patients receiving the scalp shampoo at baseline, and at 8, 16, and 24 weeks after use of the shampoo. We found a statistically significant increase in the total hair count in the test group (n = 23) after 16 and 24 weeks of using the scalp shampoo (2.17 n/cm2 ± 5.72, p < 0.05; and 4.30 n/cm2 ± 6.37, p < 0.01, respectively) as compared to the control subjects. Based on the results of this clinical study, we conclude that the IH and CS extract complex is a promising remedy for preventing hair loss and promoting hair growth.

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Assessing Developmental Environmental Risk Factor Exposure in Clinical High Risk for Psychosis Individuals: Preliminary Results Using the Individual and Structural Exposure to Stress in Psychosis-Risk States Scale

Journal of Clinical Medicine ◽

10.3390/jcm8070994 ◽

2019 ◽

Vol 8 (7) ◽

pp. 994

Author(s):

Teresa Vargas ◽

Denise S. Zou ◽

Rachel E. Conley ◽

Vijay A. Mittal

Keyword(s):

Risk Factors ◽

High Risk ◽

Environmental Risk ◽

Statistical Significance ◽

Environmental Risk Factors ◽

Group Differences ◽

Clinical High Risk ◽

Significant Group ◽

Psychosis Risk ◽

Age Range

Introduction: Exposure to cumulative environmental risk factors across development has been linked to a host of adverse health/functional outcomes. This perspective incorporating information regarding exposure at differing developmental periods is lacking in research surrounding individuals at Clinical High Risk (CHR) for developing a psychotic disorder. Methods: CHR individuals (n = 35) and healthy volunteers (n = 28) completed structured clinical interviews as well as our group’s newly developed Individual and Structural Exposure to Stress in Psychosis-risk-states (ISESP) interview. Lifetime cumulative scores were calculated, and severity of stress was reported for multiple developmental periods/ages. Group differences were tested, and associations with current symptom domains were examined. Results: Significant group differences were not observed for lifetime cumulative events, though CHR trended toward endorsing more events and greater stress severity. For stress severity across development, there were trending group differences for the 11–13 age range, and significant group differences for the 14–18 age range; notably, comparisons for earlier time points did not approach statistical significance. Associations between negative symptoms and cumulative severity of exposure were observed. Discussion: Results suggest exploring exposure to cumulative environmental risk factors/stressors and stress severity across developmental periods is generally informative and possibly specifically so for predictive models and diathesis-stress psychosis risk conceptualizations.

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Tooth extraction: Pattern and etiology from extreme Northwestern Nigeria

European Journal of Dentistry ◽

10.4103/ejd.ejd_160_17 ◽

2017 ◽

Vol 11 (03) ◽

pp. 335-339 ◽

Cited By ~ 6

Author(s):

Abdurrazaq Olanrewaju Taiwo ◽

Adebayo Aremu Ibikunle ◽

Ramat Oyebunmi Braimah ◽

Omotayo Amidu Sulaiman ◽

Olalekan Micah Gbotolorun

Keyword(s):

Periodontal Disease ◽

Tooth Extraction ◽

Statistical Significance ◽

Age Groups ◽

Urban Region ◽

Geographical Regions ◽

Extraction Pattern ◽

The Difference ◽

And Gender ◽

Age Range

ABSTRACT Objective: Tooth extraction is a commonly performed procedure in dental clinics. It has been shown that the reasons for and pattern of tooth extraction vary across geographical regions. Few reports on the pattern of extraction among a semi-urban populace exist. To the best of our knowledge, there is no study on the pattern and reasons for tooth mortality from Sokoto, Northwestern Nigeria, which is a semi-urban region. Materials and Methods: A review of the records of patients that had tooth extraction at our center between January 2009 and January 2016, was done. Data such as the age, gender, type of tooth extracted, and reasons for extraction were retrieved and analyzed. Cross tabulations for age and gender were also made. The level of statistical significance was set at P < 0.05. Results: A total of 1167 extractions were performed in 984 patients. An age range of 18–107 years with a mean (±standard deviation) of 34.8 (13.3) was observed. Most of the patients were in the 21–30 years age group accounting for 35.7% of cases. Dental caries and its sequelae (DCS) (631, 54.1%) were the most common reasons for extraction, followed by periodontal disease (192, 16.5%). The difference in proportions of reasons for tooth extraction between the gender was statistically significant (P = 0.02; df = 24). The difference in the reasons for extraction among the age groups was statistically significant (P < 0.001; df = 132). Conclusion: DCS along with periodontal disease were the major reasons for extractions. These are largely preventable causes of tooth extraction; therefore, there is a need for commencement of far-reaching preventative actions.

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