scholarly journals Effect of oral isotretinoin on muscle strength in patients with acne vulgaris: a prospective controlled study

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Cevriye Mülkoğlu ◽  
Nermin Karaosmanoğlu
Keyword(s):  
Muscle Strength ◽  
Acne Vulgaris ◽  
Local Treatment ◽  
Quadriceps Muscle ◽  
The Body ◽  
Controlled Study ◽  
Control Group ◽  
Specific Marker ◽  
Significant Difference ◽  
Oral Isotretinoin

Abstract Background Musculoskeletal side effects related to isotretinoin are frequently reported. This study aimed to investigate the effect of oral isotretinoin treatment on muscle strength. Our second aim was to evaluate whether there was a correlation between the serum creatine phosphokinase (CPK) level, a specific marker of muscle breakdown, and muscle strength. Methods This study included 30 patients who presented to our hospital and were started on oral isotretinoin treatment for acne vulgaris and 30 patients in the control group who were given local treatment. Age, sex, height and weight of the patients were recorded, and the body mass index (BMI) was calculated. The hamstring and quadriceps muscle strengths of the non-dominant side were evaluated in all patients using an isokinetic dynamometer, and the peak torque (PT) values ​​were recorded. In the isotretinoin group, isokinetic measurements were performed again in those that completed six-month drug treatment and compared with the initial PT values. Results The two groups were similar in terms of age, sex, and BMI (p > 0.05). There was no significant difference between the isotretinoin and control groups in terms of muscle strength at the beginning of the treatment (p > 0.05). No significant change was observed in hamstring and quadriceps PT values in the isotretinoin group after 6 months of treatment compared to baseline (p > 0.05). No statistically significant correlation was found between the serum CPK level and hamstring and quadriceps muscle strength (p > 0.05). Conclusion Oral isotretinoin doesn’t alter muscle strength. There is no relationship between the serum CPK levels and muscle strength.

Efficiency of correction of autonomic disorders in the conditions of meteo-climatic maladaptation by the methods of reflex and crystal therapy

2015 ◽  
Vol 9 (4) ◽  
pp. 0-0
Author(s):  
Михайлова ◽  
A. Mikhaylova ◽  
Круглянин ◽  
K. Kruglyanin ◽  
Файзуллоев ◽  
...  
Keyword(s):  
Nervous System ◽  
Environmental Changes ◽  
Climatic Conditions ◽  
The Body ◽  
Controlled Study ◽  
Health Improvement ◽  
Control Group ◽  
Vegetative Nervous System ◽  
Significant Difference ◽  
Autonomic Disorders

The change of climatic conditions often leads to stress and sometimes failure of adaptive resources. Vegetative nervous system is one of the main participants of adaptation to environmental changes. Its functions inevitably decline in cases of short-term change of meteorological and climatic conditions, especially, in people with history of vascular dystonia. The article presents the results of correction of the autonomic function by the methods of reflex- and crystal therapy in the conditions of maladaptation due to meteo-climatic changes. Due to its popularization in world medical practice and absence of research within evidence-based medicine, non-drug therapy, used in complementary medicine, in particular crystal therapy, require evaluation of its effectiveness for correction of autonomic disorders in cases of maladaptation and comparing with the generally accepted method of reflexology. Crystal therapy is a method of health improvement, which involves applying precious and semiprecious minerals to various parts of the body. Assessment of vegetative nervous system in healthy men and women with the diagnosis of vascular dystonia was carried out on the first day and 7-8 days after the arrival to Anapa. Randomized, blind, placebo controlled study has shown significant difference of the effect of reflex- and crystal therapy from the control group and the placebo group, in the correction of vegetative disturbances according to the heart rate variability and a number of mental health indicators. It has proven the effectiveness of reflexotherapy in the case of a high degree of maladaptation and crystal therapy in case of mild to moderate severity of maladaptation, identified according to the coefficient of weather variability in traffic along various routes.

scholarly journals The Effect Of Biofeedback On The Motor– Muscular Situation In Rehabilitation Of Stroke Patients

2017 ◽  
pp. 35 ◽  
Author(s):  
Zohre Najafi ◽  
Zahra sadat Manzari ◽  
Fariborz Rezaeitalab ◽  
Amin Azhari
Keyword(s):  
Muscle Strength ◽  
Intervention Group ◽  
Group Versus ◽  
Muscle Stiffness ◽  
The Body ◽  
Control Group ◽  
Check List ◽  
Post Intervention ◽  
Significant Difference ◽  
And Control

Background:Stroke is the most common debilitating neurological disease in adults. Therefore, rehabilitation is a major consideration to reduce costs and relief disabilities. Biofeedback, a newly recommended method is claimed to be able to improve the consequences following stroke by enhancement the understanding of the psychological functions of the body.  Objectives: The purpose of this study was to investigate the effect of biofeedback on the motor– muscular situation in rehabilitation of stroke patientsMethods:The present study was a randomized clinical trial that was started in May 2016 and completed in September 2016. The sample of this study included all the patients with stroke attending the physiotherapy center of Imam Raza hospital in Mashhad, Iran. The participants were randomly divided into 2 groups (case and control group) after considering the inclusion and exclusion criteria. In the intervention group, biofeedback (2 times a week for 15 sessions, each session lasting 20 minutes) was performed.Before the intervention demographic information questionnaire was complete by all participants. Then a check list of main variables such as hands muscle strength, muscle stiffness (spasticity), balance and ability to walk was complete by a physician. In the 7th session of the exercise and in the end of intervention (14th session), again, the main variables of the check list were reassessed by the researcher. The statistical analysis was done by Statistical Package for the Social Sciences (SPSS) software version 16.Results:the mean score of balance evaluation in pre-intervention had not any significant differences (p=0.503), but in post intervention evaluation, this score in intervention group versus control group showed significant differences (p=0.014).the mean score of muscle strength,Results showed that by eliminating the effects of muscular strength before the intervention, this variable in both intervention and control groups after the intervention, had improvement and significant difference (p=0.005).Comparison the average spasticity, showed that spasticity evaluation score before and after intervention had no significant difference between the two groups (p=1.00)Conclusion: Considering the findings of this study, the biofeedback therapy is a promising treatment modality in improvement the motor– muscular condition following stroke.  

Transmen Individuals Have Hyperandrogenism Related Metabolic Changes Compared Ciswomen: Case Controlled Study

2021 ◽  
Author(s):  
Pınar Erel ◽  
Onur Elbasan ◽  
Neşe Yorguner ◽  
Eren İmre ◽  
Özlem ÜSTAY
Keyword(s):  
Muscle Strength ◽  
Metabolic Parameters ◽  
Controlled Study ◽  
Control Group ◽  
Total Testosterone ◽  
First Case ◽  
Significant Difference ◽  
Observational Cohort ◽  
Drug Naïve ◽  
Rotterdam Criteria

Abstract Introduction : This study aims to evaluate metabolic parameters and hormonal profiles of transmen individuals who are referred from psychiatry outpatient clinic, compared to natal women. Method This study is designed as a single-center observational cohort study. Seventy drug-naive female to male transgender individuals (FtoM) and 34 healthy natal women for the control group were included. Hormone profile and metabolic parameters were measured and compared between the two groups. Results Sixteen of the 70 FtoM individuals meet Rotterdam criteria and are diagnosed with PCOS (22,85%), on the other hand in 4 individuals in the control group meet the criteria (11,7%). Although there wasn't any significant difference between the two groups weight and BMI; total testosterone, triglyceride, FAI, androstenedione, 17-OH progesterone, muscle strength, HOMA-IR levels were significantly higher in the transmen group and HDL levels were significantly higher in the control group (p values 0.001, 0.007, 0.013, 0.011, 0.001, 0.004 respectively.) Conclusion This is the first case-controlled study that compared anthropometric, metabolic, and endocrinological parameters of transmen individuals with cis women. In our study, we showed that even when PCOS patients were excluded, hyperandrogenemia continues in these individuals compared to cis women. It is clear that transmen individuals have higher androgen levels which may have been the reason for increased muscle strength, insulin resistance, and dyslipidemia compared to natal women. But the main reason for hyperandrogenism in drug-naïve transmen individuals is still not known and more comprehensive further studies are needed.

Effectiveness Of Toilet Training Education On Mother's Behavior And Toddler Age Toilet Training Ability (18-36 Months)

2020 ◽  
Vol 5 (2) ◽  
pp. 49-55
Author(s):  
Hafiko Andresni ◽  
Zahtamal Zahtamal ◽  
Winda Septiani ◽  
Mitra Mitra ◽  
Lita Lita
Keyword(s):  
Sampling Technique ◽  
T Test ◽  
The Body ◽  
Toilet Training ◽  
Wilcoxon Test ◽  
Control Group ◽  
Maternal Knowledge ◽  
Control Group Design ◽  
Significant Difference

ABSTRACT Toilet training is an effort to train children to be able to control and urinate (BAK) and defecate (BAB). Toilet training is one of the main tasks of children at toddler age. Toilet training is one of the main tasks of children in toddler age which is very important to be done to create independence in children in controlling BAK and BAB and children know the parts of the body and their functions. Data in 2012 shows that ± 60% of parents do not teach toilet training to children from an early age. The aim of the study was to find out the effectiveness of toilet training education on maternal behavior and toilet skills in toddler age training (18-36 months). The study was conducted in July-August 2018. This type of quantitative research used the design of the Quasy pretest and posttest experiment with non-equivalent control group design. Samples were 36 mothers and 36 children with purposive sampling technique. Data analysis used Paired t test, Wilcoxon test, Man-Whitney test an Independent t test. The results showed that toilet training education through lecture methods, modules and maze games was more effective than toilet training education through lecture and leaflet methods on children's knowledge and abilities. Conversely, for the role of mothers in supervision there is no significant difference in effectiveness. Health education is recommended in health promotion programs to increase maternal knowledge, the role of mothers and the ability of toilet training children independently. Keywords: Toilet training, Lecture method, Module, Maze game, Leaflet, Knowledge, Role of mother, Children's ability.

scholarly journals Effects of whole-body vibration on quadriceps and hamstring muscle strength, endurance, and power in children with hemiparetic cerebral palsy: a randomized controlled study

2021 ◽  
Vol 26 (1) ◽  
Author(s):  
Rania G. Hegazy ◽  
Amr Almaz Abdel-aziem ◽  
Eman I. El Hadidy ◽  
Yosra M. Ali
Keyword(s):  
Cerebral Palsy ◽  
Physical Therapy ◽  
Muscle Strength ◽  
Whole Body Vibration ◽  
Whole Body ◽  
Controlled Study ◽  
Control Group ◽  
Hamstring Muscle ◽  
Post Intervention ◽  
Body Vibration

Abstract Background Hemiplegic cerebral palsy (CP) enormously affects the quadriceps and hamstring muscles. It causes weakness in the affected lower-extremity muscles in addition to muscle imbalance and inadequate power production, especially in the ankle plantar-flexor and knee extensor muscles. It also causes anomalous delayed myoelectrical action of the medial hamstring. A whole-body vibration (WBV) exercise can diminish muscle spasticity and improve walking speed, muscle strength, and gross motor function without causing unfavorable impacts in adults suffering from CP. Thus, the aim of this study is to investigate the impacts of WBV training associated with conventional physical therapy on the quadriceps and hamstring muscle strength, endurance, and power in children with hemiparetic CP. Results The post-intervention values of the quadriceps and hamstring muscle force, endurance, and power were significantly higher than the pre-intervention values for both groups (p = 0.001). The post-intervention values of the study group were significantly higher than the control group (quadriceps force, p = 0.015; hamstring force, p = 0.030; endurance, p = 0.025; power, p = 0.014). Conclusion The 8 weeks of WBV training that was added to traditional physical therapy was more successful in improving the quadriceps and hamstring muscle strength, endurance, and power in children with hemiparetic CP when compared to traditional physical therapy alone.

Self-Managed Music-Guided Exercise Intervention Improved Upper and Lower Extremity Muscle Strength for ICU Survivors—A Pilot Randomized Controlled Study

2021 ◽  
pp. 109980042110502
Author(s):  
Zhan Liang ◽  
Hilary Yip ◽  
Kimberly Sena Moore ◽  
Tanira Ferreira ◽  
Ming Ji ◽  
...  
Keyword(s):  
Muscle Strength ◽  
Lower Extremity ◽  
Active Control ◽  
Exercise Intervention ◽  
Controlled Study ◽  
Control Group ◽  
Active Control Group ◽  
Randomized Controlled ◽  
Left And Right ◽  
The Mean

Objective The objective of this study was to evaluate effects of a self-managed music-guided exercise intervention on muscle strength among intensive care unit (ICU) survivors. Methods We used a two-arm randomized-controlled trial. Following ICU discharge, eligible participants were assigned to one of two groups: music group ( n = 13) or active control group ( n = 13). The music group was taught to self-manage upper and lower extremity exercise movements by listening to an individualized music-guided playlist twice daily for 5 days. The active control group was provided an exercise brochure and advised to perform the same exercises at the same intervals. Dynamometers were used to measure muscle strength. T-tests and Weighted GEE models were used for testing the intervention effect between groups. Results Twenty-six subjects were enrolled. The mean age was 62.8 ( SD = 13.8), 53.8% were male, 65.4% were Caucasian, and the mean APACHE severity of illness score was 59 ( SD = 23.4). Reasons for ICU admission were mainly cardiac and medical. The music group showed significant improvements in handgrip, plantar flexion, leg extension, elbow flexion, and shoulder adduction strengths on left and right sides. Additionally, left and right leg extensor and left plantar flexor strengths showed significant post-differences, and small to moderately large effect sizes, between the music group and control group. Conclusion These findings suggest that a music-guided exercise intervention has the potential to improve muscle strength in ICU survivors and prevent further post-ICU deterioration in ICU survivors. Future trials should build upon these preliminary findings.

Arthroscopic Imaging Treatment and Clinical Rehabilitation of Knee Sports Injuries

2021 ◽  
Vol 11 (6) ◽  
pp. 1780-1788
Author(s):  
Habaxi Kaken ◽  
Shanshan Wang ◽  
Wei Zhao ◽  
Baoerjiang Asihaer ◽  
Li Wang
Keyword(s):  
Muscle Strength ◽  
Knee Joint ◽  
Sports Injuries ◽  
Cruciate Ligament ◽  
Quadriceps Muscle ◽  
Lower Limbs ◽  
Continuous Passive Motion ◽  
Control Group ◽  
Pressure Therapy ◽  
Quick Recovery

This article studies the effects of arthroscopic imaging treatment and clinical rehabilitation of knee sports injuries. Arthroscopy was used to perform meniscus trimming and resection for 40 patients with knee sports injuries. The ages of the patients ranged from 20 to 60 years old. All patients received routine rehabilitation training such as continuous passive motion of the knee joint, biofeedback of the lower limbs, and air pressure therapy of the lower limbs. In addition, the control group was given muscle strength training, and the training began after the patients received the quadriceps muscle strength test. The removal of the joint cavity and the joint debridement has achieved satisfactory treatment results. In the experiment, the test cases were divided into two groups, and the sensor test platform was used for signal collection. Normal activities can be resumed 2 weeks after the operation. After a follow-up of 6 to 24 months, the knee joint pain disappeared, the joint was free of swelling, and the knee function was normal up to 93%. Arthroscopic reconstruction of the anterior and posterior cruciate ligament joint repair/reconstruction of the medial and posterolateral ligament knots is safe and feasible for the treatment of multiple ligament injuries of the knee joint. It has the advantages of less trauma and quick recovery. Early postoperative systemic and standardized rehabilitation exercises can obtain good knee joint function.

A study on the safety evaluation of buphrenorphine administered through an autoinjector compared with manual injection using haematological and biochemical variables in rats

2016 ◽  
Vol 36 (9) ◽  
pp. 901-909 ◽  
Author(s):  
D Sheela ◽  
R Vijayaraghavan ◽  
S Senthilkumar
Keyword(s):  
Body Weight ◽  
Research Work ◽  
Safety Evaluation ◽  
Weight Ratio ◽  
The Body ◽  
Control Group ◽  
Body Weight Ratio ◽  
Significant Difference ◽  
Manual Group ◽  
Significant Change

Buprenorphine drug cartridge was made for autoinjector device for use in emergency and critical situations to reduce the morbidity and mortality. Water-filled cartridges were prepared and buprenorphine was injected aseptically in the cartridge, to make 0.05 and 0.10 mg/mL. Rats were injected intraperitoneally, buprenorphine (0.3 and 0.6 mg/kg), repeatedly with the autoinjector and compared with manual injection (7 days and 14 days) using various haematological and biochemical parameters. No significant change was observed in the body weight, organ to body weight ratio and haematological variables in any of the experimental groups compared with the control group. Except serum urea and aspartate aminotransferase, no significant change was observed in glucose, cholesterol, triglycerides, bilirubin, protein, albumin, creatinine, uric acid, alanine aminotransferase, gamma glutamyltransferase and alkaline phosphatase. The autoinjectors deliver the drugs with spray effect and force for faster absorption. In the present study, the autoinjector meant for intramuscular injection was injected intraperitoneally in rats, and the drug was delivered with force on the vital organs. No significant difference was observed in the autoinjector group compared to the manual group showing tolerability and safety of the buphrenorphine autoinjector. This study shows that buprenorphine autoinjector can be considered for further research work.

Congenital Heart Disease and Childhood Adjustment

1971 ◽  
Vol 2 (1) ◽  
pp. 23-30 ◽  
Author(s):  
Edward T. Auer ◽  
Audrey G. Senturia ◽  
Moisy Shopper ◽  
Ralph L. Biddy
Keyword(s):  
Body Image ◽  
Surgical Intervention ◽  
Intellectual Functioning ◽  
Emotional Disturbances ◽  
The Body ◽  
Psychiatric Clinic ◽  
Control Group ◽  
Significant Difference ◽  
Figure Drawings ◽  
Childhood Adjustment

This report deals with the findings from a study of twenty-eight children, all of whom had ventricular septal defects and were studied by the same cardiovascular team. One-half of the group had a surgical procedure for correction of the defect. The study investigated three problems in children with ventricular septal defect ( VSD). (1) Do children with surgical intervention for VSD show greater impairment of intellectual functioning than non-operated children? (2) Do children with surgical intervention show greater emotional disturbance than non-operated children? (3) Do children with surgical intervention show greater alteration of body image than do non-operated children? Data were collected using questionnaires, family interviews, subject interviews, medical records, school reports, physicians' reports and Human Figure Drawings, both inside and outside the body. The findings conclude that ( a) operated children do demonstrate significantly more impairment of intellectual functioning; ( b) there was no significant difference in the incidence of emotional disturbances between the two groups but that these twenty-eight children with VSD were more similar emotionally to children in a psychiatric clinic group than in a control group; and ( c) the only indication of altered body image was found in the greater frequency with which bones were drawn by the operated group.

scholarly journals Optimalisasi Pertumbuhan Bayi dengan Baby Massage and Spa

2019 ◽  
Vol 10 (2) ◽  
pp. 276
Author(s):  
Yusari Asih ◽  
I Gusti Ayu Mirah WS
Keyword(s):  
Body Length ◽  
Head Circumference ◽  
Intervention Group ◽  
Sampling Technique ◽  
Holistic Approach ◽  
The Body ◽  
Control Group ◽  
P Value ◽  
Control Group Design ◽  
Significant Difference

<p><span>Baby Massage and Spa was a traditional effort that uses a holistic approach through comprehensive care using a combination of massage and water therapy methods that are carried out in an integrated manner to balance the body, mind, and feelings. Age 3-6 months is the right time for babies to do massage and spa. The purpose of this study was to determine the effect of baby massage and spa on the growth of infants aged 3-5 months in Pringsewu District in 2018. This study uses a quasi-experimental approach with research design pre and post-test with control group design. The purposive sampling technique was taken with a sample of 30 infants as the intervention group and 30 infants as the control group. Data were processed using computerization and analyzed using the T-Test. The results showed that there were significant differences between body weight, body length and baby head circumference in the pre and post-treatment. There was no significant difference in the average increase in infant weight between babies who were carried out by baby massage and spa with babies who were not carried out by baby massage and spa with p-value 0.116. There is a significant difference in the baby's body length and head circumference performed by baby massage and spa with those not carried out by baby massage and spa with p-value 0.000. Baby Massage and Spa has a significant effect on increasing the growth of babies aged 3-5 months.</span></p><p><span> </span></p>

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