scholarly journals Gut microbiome composition, not alpha diversity, is associated with survival in a natural vertebrate population

2021 ◽  
Vol 3 (1) ◽  
Author(s):  
Sarah F. Worsley ◽  
Charli S. Davies ◽  
Maria-Elena Mannarelli ◽  
Matthew I. Hutchings ◽  
Jan Komdeur ◽  
...  
Keyword(s):  
Natural Population ◽  
Breeding Season ◽  
Body Condition ◽  
Gut Microbiome ◽  
Alpha Diversity ◽  
Host Fitness ◽  
Community Membership ◽  
Long Term Study ◽  
In The Wild ◽  
Individual Body

Abstract Background The vertebrate gut microbiome (GM) can vary substantially across individuals within the same natural population. Although there is evidence linking the GM to health in captive animals, very little is known about the consequences of GM variation for host fitness in the wild. Here, we explore the relationship between faecal microbiome diversity, body condition, and survival using data from the long-term study of a discrete natural population of the Seychelles warbler (Acrocephalus sechellensis) on Cousin Island. To our knowledge, this is the first time that GM differences associated with survival have been fully characterised for a natural vertebrate species, across multiple age groups and breeding seasons. Results We identified substantial variation in GM community structure among sampled individuals, which was partially explained by breeding season (5% of the variance), and host age class (up to 1% of the variance). We also identified significant differences in GM community membership between adult birds that survived, versus those that had died by the following breeding season. Individuals that died carried increased abundances of taxa that are known to be opportunistic pathogens, including several ASVs in the genus Mycobacterium. However, there was no association between GM alpha diversity (the diversity of bacterial taxa within a sample) and survival to the next breeding season, or with individual body condition. Additionally, we found no association between GM community membership and individual body condition. Conclusions These results demonstrate that components of the vertebrate GM can be associated with host fitness in the wild. However, further research is needed to establish whether changes in bacterial abundance contribute to, or are only correlated with, differential survival; this will add to our understanding of the importance of the GM in the evolution of host species living in natural populations.

scholarly journals Gut microbiome composition, not alpha diversity, is associated with survival in a natural vertebrate population

2021 ◽  
Author(s):  
Sarah F Worsley ◽  
Charli S Davies ◽  
Maria-Elena Mannarelli ◽  
Matthew I Hutchings ◽  
Jan Komdeur ◽  
...  
Keyword(s):  
Natural Population ◽  
Breeding Season ◽  
Body Condition ◽  
Gut Microbiome ◽  
Alpha Diversity ◽  
Host Fitness ◽  
Community Membership ◽  
Long Term Study ◽  
In The Wild ◽  
Individual Body

Abstract Background: The vertebrate gut microbiome (GM) can vary substantially across individuals within the same natural population. Although there is evidence linking the GM to health in captive animals, very little is known about the consequences of GM variation for host fitness in the wild. Here, we explore the relationship between faecal microbiome diversity, body condition and survival using data from the long-term study of a discrete natural population of the Seychelles warbler ( Acrocephalus sechellensis ) on Cousin Island. To our knowledge, this is the first time that GM differences associated with survival have been fully characterised for a natural vertebrate species, across multiple age groups and breeding seasons. Results: We identified substantial variation in GM community structure among sampled individuals, which was partially explained by breeding season (7% of the variance), and host age class (up to 1% of the variance). We also identified significant differences in GM community membership between individuals that survived, versus those that had died by the following breeding season. Individuals that died carried reduced abundances of beneficial taxa in the bacterial order Clostridiales , but increased abundances of taxa that are known to be opportunistic pathogens (e.g. members of the Chloroflexi and Propionibacteriales ). However, there was no association between GM alpha diversity (the diversity of bacterial taxa within a sample) and survival to the next breeding season, or with individual body condition. Additionally, we found no association between GM community membership and individual body condition. Conclusions: These results demonstrate that components of the vertebrate GM can be associated with host fitness in the wild, although whether changes in bacterial abundance contribute to, or are only correlated with, the differential survival observed remains unclear. Importantly, it suggests that components of the GM may be under selection, and, thus, could have the potential to influence the evolution of host species living in natural populations.

Haemoproteusinfected birds have increased lifetime reproductive success

Parasitology ◽  
2015 ◽  
Vol 142 (8) ◽  
pp. 1033-1043 ◽  
Author(s):  
M. ZYLBERBERG ◽  
E. P. DERRYBERRY ◽  
C. W. BREUNER ◽  
E. A. MACDOUGALL-SHACKLETON ◽  
J. M. CORNELIUS ◽  
...  
Keyword(s):  
Reproductive Success ◽  
Lifetime Reproductive Success ◽  
Parasitic Infections ◽  
Host Fitness ◽  
Return Rates ◽  
Long Term Study ◽  
In The Wild ◽  
The Impact ◽  
The Relationship

SUMMARYThe impact of haematozoan infection on host fitness has received substantial attention since Hamilton and Zuk posited that parasites are important drivers of sexual selection. However, short-term studies testing the assumption that these parasites consistently reduce host fitness in the wild have produced contradictory results. To address this complex issue, we conducted a long-term study examining the relationship between naturally occurring infection withHaemoproteusandPlasmodium, and lifetime reproductive success and survival of Mountain White-crowned Sparrows. Specifically, we tested the hypothesis that birds infected with haematozoan parasites have reduced survival (as determined by overwinter return rates) and reproductive success. Contrary to expectation, there was no relationship betweenHaemoproteusandPlasmodiuminfection and reproduction or survival in males, nor was there a relationship betweenPlasmodiuminfection and reproduction in females. Interestingly,Haemoproteus-infected females had significantly higher overwinter return rates and these females fledged more than twice as many chicks during their lifetimes as did uninfected females. We discuss the impact of parasitic infections on host fitness in light of these findings and suggest that, in the case of less virulent pathogens, investment in excessive immune defence may decrease lifetime reproduction.

scholarly journals Immunogenetic Variation Shapes the Gut Microbiome in a Natural Vertebrate Population

2021 ◽  
Author(s):  
Charli S. Davies ◽  
Sarah F. Worsley ◽  
Kathryn H. Maher ◽  
Jan Komdeur ◽  
Terry Burke ◽  
...  
Keyword(s):  
Natural Population ◽  
Mhc Class Ii ◽  
Gut Microbiome ◽  
Host Genotype ◽  
Class I Mhc ◽  
Mhc I ◽  
Mhc Ii ◽  
Individual Fitness ◽  
In The Wild ◽  
Seychelles Warbler

Abstract Background: The gut microbiome (GM) can influence many biological processes in the host, impacting its health and survival, but the GM can also be influenced by the host’s traits. In vertebrates, Major Histocompatibility Complex (MHC) genes play a pivotal role in combatting pathogens and are thought to shape the host’s GM. However, despite this - and the documented importance of both GM and MHC variation to individual fitness - few studies have investigated the association between the GM and MHC in the wild. Results: We characterised MHC class I (MHC-I), MHC class II (MHC-II), and GM variation in individuals within a natural population of the Seychelles warbler, Acrocephalus sechellensis. We determined how the diversity and composition of the GM varied with MHC characteristics, in addition to environmental factors and other host intrinsic traits. Our results show that the presence of specific MHC alleles, but not MHC diversity, influences both the diversity and composition of the GM in this population. We found that MHC-I alleles, rather than MHC-II alleles, had the greatest impact on the GM. GM diversity was negatively associated with the presence of three MHC-I alleles (Ase-ua3, Ase-ua4, Ase-ua5), and one MHC-II allele (Ase-dab4), while changes in GM composition were associated with the presence of four different MHC-I alleles (Ase-ua1, Ase-ua7, Ase-ua10, Ase-ua11). GM diversity was also positively correlated with genome-wide heterozygosity and varied with host age and field period.Conclusions: These results suggest that components of the host’s immune system play a role in shaping the GM of wild animals. Host genotype – specifically, adaptive immune receptor MHC-I alleles – can modulate the GM, although whether this occurs directly, or indirectly through effects on host health is unclear. To our knowledge this is the first-time individual MHC-I variation has been shown to be associated with differences in GM characteristics in a natural population. Importantly, it suggests that host–microbiome coevolution may play a role in maintaining functional immunogenetic variation within natural vertebrate populations.

scholarly journals Biodiversity of protists and nematodes in the wild nonhuman primate gut

2019 ◽  
Vol 14 (2) ◽  
pp. 609-622 ◽  
Author(s):  
Allison E. Mann ◽  
Florent Mazel ◽  
Matthew A. Lemay ◽  
Evan Morien ◽  
Vincent Billy ◽  
...  
Keyword(s):  
Nonhuman Primate ◽  
Gut Microbiome ◽  
Alpha Diversity ◽  
18S Rrna Gene ◽  
Rrna Gene ◽  
Primate Phylogeny ◽  
Associated Bacteria ◽  
In The Wild ◽  
Health And Disease ◽  
Eukaryotic Organisms

Abstract Documenting the natural diversity of eukaryotic organisms in the nonhuman primate (NHP) gut is important for understanding the evolution of the mammalian gut microbiome, its role in digestion, health and disease, and the consequences of anthropogenic change on primate biology and conservation. Despite the ecological significance of gut-associated eukaryotes, little is known about the factors that influence their assembly and diversity in mammals. In this study, we used an 18S rRNA gene fragment metabarcoding approach to assess the eukaryotic assemblage of 62 individuals representing 16 NHP species. We find that cercopithecoids, and especially the cercopithecines, have substantially higher alpha diversity than other NHP groups. Gut-associated protists and nematodes are widespread among NHPs, consistent with their ancient association with NHP hosts. However, we do not find a consistent signal of phylosymbiosis or host-species specificity. Rather, gut eukaryotes are only weakly structured by primate phylogeny with minimal signal from diet, in contrast to previous reports of NHP gut bacteria. The results of this study indicate that gut-associated eukaryotes offer different information than gut-associated bacteria and add to our understanding of the structure of the gut microbiome.

scholarly journals Gut microbiome composition in the Hispanic Community Health Study/Study of Latinos is shaped by geographic relocation, environmental factors, and obesity

2019 ◽  
Vol 20 (1) ◽  
Author(s):  
Robert C. Kaplan ◽  
Zheng Wang ◽  
Mykhaylo Usyk ◽  
Daniela Sotres-Alvarez ◽  
Martha L. Daviglus ◽  
...  
Keyword(s):  
Community Health ◽  
Gut Microbiome ◽  
Alpha Diversity ◽  
Amplicon Sequencing ◽  
Shannon Index ◽  
Health Study ◽  
Rrna Gene ◽  
Cross Sectional ◽  
Hispanic Community ◽  
The Usa

Abstract Background Hispanics living in the USA may have unrecognized potential birthplace and lifestyle influences on the gut microbiome. We report a cross-sectional analysis of 1674 participants from four centers of the Hispanic Community Health Study/Study of Latinos (HCHS/SOL), aged 18 to 74 years old at recruitment. Results Amplicon sequencing of 16S rRNA gene V4 and fungal ITS1 fragments from self-collected stool samples indicate that the host microbiome is determined by sociodemographic and migration-related variables. Those who relocate from Latin America to the USA at an early age have reductions in Prevotella to Bacteroides ratios that persist across the life course. Shannon index of alpha diversity in fungi and bacteria is low in those who relocate to the USA in early life. In contrast, those who relocate to the USA during adulthood, over 45 years old, have high bacterial and fungal diversity and high Prevotella to Bacteroides ratios, compared to USA-born and childhood arrivals. Low bacterial diversity is associated in turn with obesity. Contrasting with prior studies, our study of the Latino population shows increasing Prevotella to Bacteroides ratio with greater obesity. Taxa within Acidaminococcus, Megasphaera, Ruminococcaceae, Coriobacteriaceae, Clostridiales, Christensenellaceae, YS2 (Cyanobacteria), and Victivallaceae are significantly associated with both obesity and earlier exposure to the USA, while Oscillospira and Anaerotruncus show paradoxical associations with both obesity and late-life introduction to the USA. Conclusions Our analysis of the gut microbiome of Latinos demonstrates unique features that might be responsible for health disparities affecting Hispanics living in the USA.

scholarly journals Possible Epigenetic Origin of a Recurrent Gynandromorph Pattern in Megachile Wild Bees

Insects ◽  
2021 ◽  
Vol 12 (5) ◽  
pp. 437
Author(s):  
Daniele Sommaggio ◽  
Giuseppe Fusco ◽  
Marco Uliana ◽  
Alessandro Minelli
Keyword(s):  
Current Knowledge ◽  
Sex Differentiation ◽  
General Pattern ◽  
Body Parts ◽  
Wild Bees ◽  
Male And Female ◽  
Female Phenotype ◽  
In The Wild ◽  
Gene Transcripts ◽  
Individual Body

Gynandromorphs, i.e., individuals with a mix of male and female traits, are common in the wild bees of the genus Megachile (Hymenoptera, Apoidea). We described new transverse gynandromorphs in Megachile pilidens Alfkeen, 1924 and analyze the spatial distribution of body parts with male vs. female phenotype hitherto recorded in the transverse gynandromorphs of the genus Megachile. We identified 10 different arrangements, nine of which are minor variants of a very general pattern, with a combination of male and female traits largely shared by the gynandromorphs recorded in 20 out of 21 Megachile species in our dataset. Based on the recurrence of the same gynandromorph pattern, the current knowledge on sex determination and sex differentiation in the honey bee, and the results of recent gene-knockdown experiments in these insects, we suggest that these composite phenotypes are possibly epigenetic, rather than genetic, mosaics, with individual body parts of either male or female phenotype according to the locally expressed product of the alternative splicing of sex-determining gene transcripts.

scholarly journals Endocannabinoid system mediates the association between gut-microbial diversity and anhedonia/amotivation in a general population cohort

2021 ◽  
Author(s):  
Amedeo Minichino ◽  
Matthew A. Jackson ◽  
Marta Francesconi ◽  
Claire J. Steves ◽  
Cristina Menni ◽  
...  
Keyword(s):  
General Population ◽  
Microbial Diversity ◽  
Gut Microbiome ◽  
Endocannabinoid System ◽  
Alpha Diversity ◽  
Serum Levels ◽  
Population Cohort ◽  
Random Intercept ◽  
General Population Cohort ◽  
Antidepressant Use

AbstractAnhedonia and amotivation are debilitating symptoms and represent unmet therapeutic needs in a range of clinical conditions. The gut-microbiome-endocannabinoid axis might represent a potential modifiable target for interventions. Based on results obtained from animal models, we tested the hypothesis that the endocannabinoid system mediates the association between gut-microbiome diversity and anhedonia/amotivation in a general population cohort. We used longitudinal data collected from 786 volunteer twins recruited as part the TwinsUK register. Our hypothesis was tested with a multilevel mediation model using family structure as random intercept. The model was set using alpha diversity (within-individual gut-microbial diversity) as predictor, serum and faecal levels of the endocannabinoid palmitoylethanolamide (PEA) as mediator, and anhedonia/amotivation as outcome. PEA is considered the endogenous equivalent of cannabidiol, with increased serum levels believed to have anti-depressive effects, while increased stool PEA levels, reflecting increased excretion, are believed to have opposite, detrimental, effects on mental health. We therefore expected that either reduced serum PEA or increased stool PEA would mediate the association between microbial diversity and anhedonia amotivation. Analyses were adjusted for obesity, diet, antidepressant use, sociodemographic and technical covariates. Data were imputed using multiple imputation by chained equations. Mean age was 65.2 ± 7.6; 93% of the sample were females. We found a direct, significant, association between alpha diversity and anhedonia/amotivation (β = −0.37; 95%CI: −0.71 to −0.03; P = 0.03). Faecal, but not serum, levels of the endocannabinoid palmitoylethanolamide (PEA) mediated this association: the indirect effect was significant (β = −0.13; 95%CI: −0.24 to −0.01; P = 0.03), as was the total effect (β = −0.38; 95%CI: −0.72 to −0.04; P = 0.03), whereas the direct effect of alpha diversity on anhedonia/amotivation was attenuated fully (β = −0.25; 95%CI: −0.60 to 0.09; P = 0.16). Our results suggest that gut-microbial diversity might contribute to anhedonia/amotivation via the endocannabinoid system. These findings shed light on the biological underpinnings of anhedonia/amotivation and suggest the gut microbiota-endocannabinoid axis as a promising therapeutic target in an area of unmet clinical need.

scholarly journals Within and between breeding-season changes in contaminant occurrence and body condition in the Antarctic breeding South polar skua

2021 ◽  
pp. 117434
Author(s):  
Hilde Karin Midthaug ◽  
Daniel J. Hitchcock ◽  
Jan Ove Bustnes ◽  
Anuschka Polder ◽  
Sébastien Descamps ◽  
...  
Keyword(s):  
Breeding Season ◽  
Body Condition ◽  
South Polar Skua ◽  
The Antarctic ◽  
South Polar

scholarly journals Gut Microbiome in Psoriasis: An Updated Review

Pathogens ◽  
2020 ◽  
Vol 9 (6) ◽  
pp. 463
Author(s):  
Mariusz Sikora ◽  
Albert Stec ◽  
Magdalena Chrabaszcz ◽  
Aleksandra Knot ◽  
Anna Waskiel-Burnat ◽  
...  
Keyword(s):  
Gut Microbiome ◽  
Beta Diversity ◽  
Large Scale ◽  
Skin Diseases ◽  
Intestinal Barrier ◽  
Alpha Diversity ◽  
Current Data ◽  
Intestinal Microbiome ◽  
Microbial Composition ◽  
Alpha And Beta Diversity

(1) Background: A growing body of evidence highlights that intestinal dysbiosis is associated with the development of psoriasis. The gut–skin axis is the novel concept of the interaction between skin diseases and microbiome through inflammatory mediators, metabolites and the intestinal barrier. The objective of this study was to synthesize current data on the gut microbial composition in psoriasis. (2) Methods: We conducted a systematic review of studies investigating intestinal microbiome in psoriasis, using the PRISMA checklist. We searched MEDLINE, EMBASE, and Web of Science databases for relevant published articles (2000–2020). (3) Results: All of the 10 retrieved studies reported alterations in the gut microbiome in patients with psoriasis. Eight studies assessed alpha- and beta-diversity. Four of them reported a lack of change in alpha-diversity, but all confirmed significant changes in beta-diversity. At the phylum-level, at least two or more studies reported a lower relative abundance of Bacteroidetes, and higher Firmicutes in psoriasis patients versus healthy controls. (4) Conclusions: There is a significant association between alterations in gut microbial composition and psoriasis; however, there is high heterogeneity between studies. More unified methodological standards in large-scale studies are needed to understand microbiota’s contribution to psoriasis pathogenesis and its modulation as a potential therapeutic strategy.

scholarly journals Non-breeding feather concentrations of testosterone, corticosterone and cortisol are associated with subsequent survival in wild house sparrows

2011 ◽  
Vol 279 (1733) ◽  
pp. 1560-1566 ◽  
Author(s):  
Lee Koren ◽  
Shinichi Nakagawa ◽  
Terry Burke ◽  
Kiran K. Soma ◽  
Katherine E. Wynne-Edwards ◽  
...  
Keyword(s):  
Stress Hormones ◽  
Passer Domesticus ◽  
House Sparrows ◽  
Long Term Study ◽  
Darwinian Fitness ◽  
Liquid Chromatography Tandem Mass ◽  
In The Wild ◽  
The Subject ◽  
As Stress

Potential mechanistic mediators of Darwinian fitness, such as stress hormones or sex hormones, have been the focus of many studies. An inverse relationship between fitness and stress or sex hormone concentrations has been widely assumed, although empirical evidence is scarce. Feathers gradually accumulate hormones during their growth and provide a novel way to measure hormone concentrations integrated over time. Using liquid chromatography–tandem mass spectrometry, we measured testosterone, corticosterone and cortisol in the feathers of house sparrows ( Passer domesticus ) in a wild population which is the subject of a long-term study. Although corticosterone is considered the dominant avian glucocorticoid, we unambiguously identified cortisol in feathers. In addition, we found that feathers grown during the post-nuptial moult in autumn contained testosterone, corticosterone and cortisol levels that were significantly higher in birds that subsequently died over the following winter than in birds that survived. Thus, feather steroids are candidate prospective biomarkers to predict the future survival of individuals in the wild.

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