scholarly journals The microbiota-related coinfections in COVID-19 patients: a real challenge

2021 ◽  
Vol 10 (1) ◽  
Author(s):  
Ranjan K. Mohapatra ◽  
Kuldeep Dhama ◽  
Snehasish Mishra ◽  
Ashish K. Sarangi ◽  
Venkataramana Kandi ◽  
...  
Keyword(s):  
Transmission Rate ◽  
Adaptive Immune System ◽  
The Elderly ◽  
Main Body ◽  
Local Immunity ◽  
The Public ◽  
Global Pandemic ◽  
Severity Of The Disease ◽  
Health Situation

Abstract Background The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of ongoing global pandemic of coronavirus disease 2019 (COVID-19), has infected millions of people around the world, especially the elderly and immunocompromised individuals. The infection transmission rate is considered more rapid than other deadly pandemics and severe epidemics encountered earlier, such as Ebola, Zika, Influenza, Marburg, SARS, and MERS. The public health situation therefore is really at a challenging crossroads. Main body The internal and external and resident microbiota community is crucial in human health and is essential for immune responses. This community tends to be altered due to pathogenic infections which would lead to severity of the disease as it progresses. Few of these resident microflora become negatively active during infectious diseases leading to coinfection, especially the opportunistic pathogens. Once such a condition sets in, it is difficult to diagnose, treat, and manage COVID-19 in a patient. Conclusion This review highlights the various reported possible coinfections that arise in COVID-19 patients vis-à-vis other serious pathological conditions. The local immunity in lungs, nasal passages, oral cavity, and salivary glands are involved with different aspects of COVID-19 transmission and pathology. Also, the role of adaptive immune system is discussed at the site of infection to control the infection along with the proinflammatory cytokine therapy.

Hidden Threat During Quarantine and Transition Phase in Elderly: The Need for Special Precautions

2020 ◽  
Vol 70 (10) ◽  
pp. 190-193
Author(s):  
Maggie Nathania ◽  
Diana Sunardi
Keyword(s):  
Case Fatality Rate ◽  
Middle Age ◽  
Transmission Rate ◽  
Case Fatality ◽  
Risk Groups ◽  
The Elderly ◽  
Age Group ◽  
Global Pandemic ◽  
The World ◽  
Severity Of The Disease

A global pandemic, COVID-19, has struck 216 countries with more than 9 million cases and 420.000 deaths. In Indonesia alone, 49.000 people have been infected with more than 2.000 deaths. To reduce the transmission rate and break the chain of transmission, various countries in the world require people to limit and mitigate activities outside the house, especially for high-risk groups: the elderly and groups with comorbidities. Although there is no age group protected from SARS-CoV-2 infection, the elderly group shows significantly higher mortality and severity of the disease when compared with young and middle age. Case fatality rate in the elderly ranges between 8% in patients aged ≥80 years, 8% in patients aged 70-79 years, and up to 49% in critical cases. Other studies also show that the average age of patients who need the intensive care unit (ICU) is older than patients who do not require ICU.

PARTISIPASI MASYARAKAT MELALUI PROGRAM GERAKAN MEMBANGUN MASYARAKAT SEHAT PADA PELAYANAN KESEHATAN DI POSYANDU (GERBANGMAS SIAGA) DI KABUPATEN LUMAJANG ( STUDI KASUS PADA GERBANGMAS BOUGENVILLE RW 20 KELURAHAN CITRODIWANGSAN, KABUPATEN LUMAJANG)

Publika ◽  
2021 ◽  
pp. 215-226
Author(s):  
MUHAMMAD RIZAL FIRDAUS ◽  
Muhammad Farid Ma'ruf
Keyword(s):  
Social Media ◽  
Health Information ◽  
The Elderly ◽  
Community Empowerment ◽  
The Public ◽  
Inhibiting Factors ◽  
Inhibiting Factor ◽  
Empowerment Program

Penelitian ini bertujuan untuk mengetahui masalah Partisipasi dalam Program Pemberdayaan Masyarakat yang ada di RW 20 Kelurahan Citrodiwangsan. Peneliti menggunakan metode riset kualitatif . Responden dalam penelitian ini yaitu kader dan warga RW 20 Kelurahan Citrodiwangsan. Data dikumpulkan dengan wawancara dan observasi. Penelitian ini menghasilkan tiga temuan. Pertama, partisipasi perencanaan masih tergolong kurang pro aktif dalam mengedukasi warga dikarenakan masih banyak RT yang tidak bisa mewadahi dan mengedukasi masyarakat untuk aktif dalam kegiatan Posyandu Gerbangmas. Kedua, terkait partisipasi pelaksanaan kegiatan masih banyak masyarakat yang memandang sebelah mata kegiatan ini meskipun seluruh warga telah diikutkan secara menyeluruh, hal ini karena kurangnya sosialisasi dari pengurus kader. Ketiga, faktor penghambat yaitu kurangnya memahami arti partisipasi yang rendah dimana masyarakat masih sibuk dengan kesibukannya sendiri serta kurangnya peran RT untuk mendorong masyarakatnya dalam memberikan pengertian akan pentingnya kegiatan posyandu. Oleh karena itu, dari beberapa masalah-masalah yang telah peneliti temukan maka peneliti memiliki saran yang bertujuan untuk memaksimalkan kader maupun RT dalam mengajak masyarakat. Saran tersebut diantaranya adalah pelaksanaan posyandu dilaksanakan pada hari libur, kegiatan posyandu tidak hanya ditempatkan pada satu titik tetapi dijadwalkan untuk berpindah ketempat kawasan lainnya dan memanfaatkan fasilitas media sosial untuk memberikan sosialisasi dan informasi kesehatan balita dan lansia. Kata kunci: masalah partisipasi, program pemberdayaan masyarakat, partisipasi perencanaan, partisipasi pelaksanaan, faktor penghambat partisipasi   This study aims to determine the problem of participation in the Community Empowerment Program in RW 20 Citrodiwangsan Village. Respondents in this study were cadres and residents of RW 20 Citrodiwangsan Village. Data were collected by interview and observation. This study resulted in three findings. First, planning participation is still classified as less proactive in educating residents because there are still many RTs that cannot accommodate and educate the public to be active in Gerbangmas Posyandu activities. Second, with regard to participation in the implementation of activities, there are still many people who underestimate this activity even though all residents have been included as a whole, this is due to the lack of socialization from the cadre management. Third, the inhibiting factor is the lack of understanding of the meaning of low participation where the community is still busy with their own activities and the lack of the role of the RT in encouraging the community to provide an understanding of the importance of posyandu activities. Therefore, from some of the problems that researchers have found, the researcher has suggestions that aim to maximize cadres and RTs in inviting the community. These suggestions include that the implementation of posyandu is carried out on holidays, posyandu activities are not only placed at one point but are scheduled to move to another area and utilizing social media facilities to provide socilization and health information for toddlers and the elderly. Keywords: participation problems, community empowerment programs, planning participation, implementation participation, inhibiting factors for participation

An Updated Review on the Role of Single Nucleotide Polymorphisms in COVID-19 Disease Severity: A Global Aspect

2022 ◽  
Vol 23 ◽  
Author(s):  
Jun Wei Ng ◽  
Eric Tzyy Jiann Chong ◽  
Ping-Chin Lee
Keyword(s):  
Single Nucleotide Polymorphisms ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Angiotensin Converting Enzyme 2 ◽  
Global Pandemic ◽  
Global Aspect ◽  
Common Risk Factors ◽  
Severity Of The Disease ◽  
Ace2 Gene

Abstract: Coronavirus disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and recently has become a serious global pandemic. Age, gender, and comorbidities are known to be common risk factors for severe COVID-19 but are not enough to fully explain the magnitude of their effect on the risk of severity of the disease. Single nucleotide polymorphisms (SNPs) in several genes have been reported as a genetic factor contributing to COVID-19 severity. This comprehensive review focuses on the association between SNPs in four important genes and COVID-19 severity in a global aspect. We discuss a total of 39 SNPs in this review: five SNPs in the ABO gene, nine SNPs in the angiotensin-converting enzyme 2 (ACE2) gene, 19 SNPs in the transmembrane protease serine 2 (TMPRSS2) gene, and six SNPs in the toll-like receptor 7 (TLR7) gene. These SNPs data could assist in monitoring an individual's risk of severe COVID-19 disease, and therefore personalized management and pharmaceutical treatment could be planned in COVID-19 patients.

scholarly journals HIV/AIDS among the elderly: stigmas in healthcare work and training

2016 ◽  
Vol 19 (5) ◽  
pp. 733-744 ◽  
Author(s):  
Júnia Brunelli Cassétte ◽  
Leandro César da Silva ◽  
Ezequiel Elias Azevedo Alves Felício ◽  
Lissa Araújo Soares ◽  
Rhariany Alves de Morais ◽  
...  
Keyword(s):  
Health Professionals ◽  
The Elderly ◽  
Sexual Practices ◽  
Work Processes ◽  
The Public ◽  
Health And Illness ◽  
Healthcare Work ◽  
And Training ◽  
Hiv Aids

Abstract The number of HIV/AIDs diagnoses among the elderly is currently increasing both in Brazil and on a global level. The present article describes the results of a qualitative study which aimed to assess the role of health professionals on elderly patients diagnosed with HIV/AIDS receiving treatment via the public health service. Nine professionals who made up a specialized HIV/AIDS service in a medium-sized city in the state of Minas Gerais were interviewed. Their statements were subjected to content analysis, and the results suggested that according to the perceptions of the health professionals, the main impacts of the diagnosis of HIV/AIDS are linked to isolation, loneliness, prejudice, fear of revealing the diagnosis and the decrease or interruption of sexual practices. The professionals reported being overburdened both psychologically and in terms of workload, having difficulty addressing aspects of sexuality and sexual practices with the elderly, and admitted to possessing certain stereotypes and prejudices related to HIV/AIDS and the sexuality of the elderly. Through results analysis, it was concluded that the stigma and prejudice related to HIV and the sexuality of the elderly are intimately present in the work processes of the professionals interviewed, impacting on the treatment of such individuals and interfering with their health and illness processes. The discussion of these aspects should be included in health training strategies.

scholarly journals Sweden

2006 ◽  
Vol 3 (1) ◽  
pp. 9-12 ◽  
Author(s):  
Helena Silfverhielm ◽  
Claes Göran Stefansson
Keyword(s):  
Western Europe ◽  
Psychiatric Care ◽  
The Elderly ◽  
Living Standards ◽  
Chronic Mental Illness ◽  
High Productivity ◽  
The Public ◽  
Parliamentary Government ◽  
Good Living

With an area of 450 000 km2, Sweden is one of the largest countries in Western Europe. It is 1500 km from north to south. It has nearly 9 million inhabitants (20 per km2). It is a constitutional, hereditary monarchy with a parliamentary government. Sweden is highly dependent on international trade to maintain its high productivity and good living standards. Many public services are provided by Sweden's 289 municipalities and 21 county councils. Municipal responsibilities include schools, child care and care of the elderly, as well as social support for people with a chronic mental illness. The county councils are mainly responsible for healthcare, including psychiatric care, and public transport at the regional level. Sweden is characterised by an even distribution of incomes and wealth. This is partly a result of the comparatively large role of the public sector.

scholarly journals Role of Senescence and Aging in SARS-CoV-2 Infection and COVID-19 Disease

Cells ◽  
2021 ◽  
Vol 10 (12) ◽  
pp. 3367
Author(s):  
Seodhna M. Lynch ◽  
Guangran Guo ◽  
David S. Gibson ◽  
Anthony J. Bjourson ◽  
Taranjit Singh Rai
Keyword(s):  
Immune System ◽  
Severe Disease ◽  
Severe Infection ◽  
The Elderly ◽  
System Response ◽  
Aging Research ◽  
Global Pandemic ◽  
Immune System Response ◽  
Response Current

Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has resulted in a global pandemic associated with substantial morbidity and mortality worldwide, with particular risk for severe disease and mortality in the elderly population. SARS-CoV-2 infection is driven by a pathological hyperinflammatory response which results in a dysregulated immune response. Current advancements in aging research indicates that aging pathways have fundamental roles in dictating healthspan in addition to lifespan. Our review discusses the aging immune system and highlights that senescence and aging together, play a central role in COVID-19 pathogenesis. In our review, we primarily focus on the immune system response to SARS-CoV-2 infection, the interconnection between severe COVID-19, immunosenescence, aging, vaccination, and the emerging problem of Long-COVID. We hope to highlight the importance of identifying specific senescent endotypes (or “sendotypes”), which can used as determinants of COVID-19 severity and mortality. Indeed, identified sendotypes could be therapeutically exploited for therapeutic intervention. We highlight that senolytics, which eliminate senescent cells, can target aging-associated pathways and therefore are proving attractive as potential therapeutic options to alleviate symptoms, prevent severe infection, and reduce mortality burden in COVID-19 and thus ultimately enhance healthspan.

scholarly journals Religion and Covid-19 in the Era of Post-Truth: The Case of Indonesia

2020 ◽  
Vol 12 (1) ◽  
pp. 1-12
Author(s):  
Asfa Widiyanto
Keyword(s):  
Content Analysis ◽  
Public Space ◽  
Significant Contribution ◽  
The Public ◽  
Religious Conservatism ◽  
Knowledge Culture ◽  
Global Pandemic ◽  
The World ◽  
Role Of Religion

Coronavirus disease (Covid-19) has become global pandemic, which affects all countries in the world including Indonesia. The mitigation of covid-19 pandemic in Indonesia cannot neglect the role of religion, since religion constitutes the main identity of most people. Hence, religion becomes value reference and ‘system of knowing’, including in addressing the covid-19 pandemic. By employing comparative and content analysis, it is hoped that this paper will constitute a significant contribution in unravelling the complex role of religion in dealing with covid-19 pandemic, most particularly in the context of post-truth. There are three concerns of this paper. First, it examines the challenges of religious conservatism towards covid-19 mitigation among Indonesian Muslims, most particularly in the context of post-truth which in some ways intensifies the emergence of conservativism in the public space. Second, it explores the possibility of ‘new spirituality’ which is pertinent for the mitigation of Covid-19. Third, it explores the contribution of Indonesian Muslim knowledge culture to the fight against covid-19.

The role of the police in anti-money laundering

2019 ◽  
Vol 22 (1) ◽  
pp. 145-157
Author(s):  
Nikola Dujovski ◽  
Snezana Mojsoska
Keyword(s):  
Money Laundering ◽  
Social Life ◽  
Annual Reports ◽  
Comparative Approach ◽  
Main Body ◽  
Content Type ◽  
The Public ◽  
Republic Of Macedonia ◽  
The Republic

Purpose This paper aims to describe and discuss the role of the police in anti-money laundering, with particular reference to the situation in the Republic of Macedonia. Design/methodology/approach A doctrinal approach is used to describe the role of the police in anti-money laundering policy, as well as to discuss whether the police is the central and main body in the fight against this crime. Deductive and inductive methods are used to analyze the collected data about Macedonian activities, provided by domestic and international organizations and institutions. Government agencies, institutions and bodies with different capacities for identifying and combating money laundering are included. Findings According to global statistics, about $2tn is laundered annually. Money laundering directly affects general economic and social life and the entire development, which shows why the concerns about this phenomenon have been growing worldwide. The most important issue in combating money laundering refers to preventing and detecting the problem. The police have the central role in combating money laundering in the Republic of Macedonia, but they must co-operate with public prosecutors and other agencies to fight this crime with more success. Even though Macedonian legislation is harmonized with European Union (EU) directives, there are a lot of activities in the field of money laundering to be done to fulfill EU standards. Relevant collected data were acquired from MONEYVAL reports, annual reports from the Ministry of Interior, Public Bureau of Statistics and statistics from the public prosecutor’s office, including all published documents. Originality/value The paper answers questions related to the role and effectiveness of the police by examining different authorizations and powers. Different approaches in implementing the law are specified and suggestions to overcome “two voices” are given. A comparative approach is also used to demonstrate the number of criminal charges per year, mainly collected by the public prosecutor’s office. The authors analyze whether additional training is needed for the police. All institutions should collaborate with the police because money laundering offences may be disclosed during investigations of other offences.

scholarly journals Senescent Remodeling of the Innate and Adaptive Immune System in the Elderly Men with Prostate Cancer

2014 ◽  
Vol 2014 ◽  
pp. 1-11 ◽  
Author(s):  
Gianluigi Taverna ◽  
Mauro Seveso ◽  
Guido Giusti ◽  
Rodolfo Hurle ◽  
Pierpaolo Graziotti ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Expression Patterns ◽  
Adaptive Immune System ◽  
The Elderly ◽  
Elderly Men ◽  
Redox Stress ◽  
Adaptive Immune ◽  
Cellular Events ◽  
Intensive Investigation

Despite years of intensive investigation that has been made in understanding prostate cancer, it remains a major cause of death in men worldwide. Prostate cancer emerges from multiple alterations that induce changes in expression patterns of genes and proteins that function in networks controlling critical cellular events. Based on the exponential aging of the population and the increasing life expectancy in industrialized Western countries, prostate cancer in the elderly men is becoming a disease of increasing significance. Aging is a progressive degenerative process strictly integrated with inflammation. Several theories have been proposed that attempt to define the role of chronic inflammation in aging including redox stress, mitochondrial damage, immunosenescence, and epigenetic modifications. Here, we review the innate and adaptive immune systems and their senescent remodeling in elderly men with prostate cancer.

scholarly journals Immunosenescence of Polymorphonuclear Neutrophils

2010 ◽  
Vol 10 ◽  
pp. 145-160 ◽  
Author(s):  
Inga Wessels ◽  
Judith Jansen ◽  
Lothar Rink ◽  
Peter Uciechowski
Keyword(s):  
Molecular Mechanisms ◽  
Adaptive Immune System ◽  
The Elderly ◽  
Polymorphonuclear Neutrophils ◽  
Traditional Role ◽  
Functional Changes ◽  
The Public ◽  
Age Related

All immune cells are affected by aging, contributing to the high susceptibility to infections and increased mortality observed in the elderly. The effect of aging on cells of the adaptive immune system is well documented. In contrast, knowledge concerning age-related defects of polymorphonuclear neutrophils (PMN) is limited. During the past decade, it has become evident that in addition to their traditional role as phagocytes, neutrophils are able to secrete a wide array of immunomodulating molecules. Their importance is underlined by the finding that genetic defects that lead to neutropenia increase susceptibility to infections. Whereas there is consistence about the constant circulating number of PMN throughout aging, the abilities of tissue infiltration, phagocytosis, and oxidative burst of PMN from aged donors are discussed controversially. Furthermore, there are numerous discrepancies betweenin vivoandin vitroresults, as well as between results for murine and human PMN. Most of the reported functional changes can be explained by defective signaling pathways, but further research is required to get a detailed insight into the underlying molecular mechanisms. This could form the basis for drug development in order to prevent or treat age-related diseases, and thus to unburden the public health systems.

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