Development of a model emergency oncology response system (EORS): The California oncology emergency master plan (COEMP)

2006 ◽  
Vol 24 (18_suppl) ◽  
pp. 6142-6142
Author(s):  
R. Moss ◽  
P. Yu ◽  
C. Presant ◽  
J. Gonzalez ◽  
M. Lamb ◽  
...  
Keyword(s):  
Hurricane Katrina ◽  
Homeland Security ◽  
Support Network ◽  
Red Cross ◽  
Data Repository ◽  
Active Components ◽  
Educational Materials ◽  
Contact Data ◽  
Life Threatening ◽  
Pilot Implementation

6142 Background: Hurricane Katrina displaced patients (PT) and physicians (MD). Time & resources were needed to match displaced PT with oncology (ONC) practices (PRC) for ongoing care. Disruption of care can be life-threatening to ONC PT who need to adhere to schedules & monitoring. California (CA) is particular risk for natural disaster. In order to better support PT in a future emergency (E) MOASC & ANCO created a model EORS with pilot implementation of select elements. Methods: MOASC & ANCO prepared a multi-component COEMP. Joint calls & meetings yielded a draft EORS approved by both society boards. Initial & long-term funding is expected via granting mechanisms. Pilot implementation of specific elements began in 11/2005. Results: Goals of the COEMP are: Establish dedicated E ONC MD network; Create a voluntary ONC-specific PT medical record (MR) template & secure data repository; Create & test a functional E MD responder system for CA ONC MD; Develop liaison with relief providers (Homeland Security, FEMA, Red Cross); Strengthen existing role with Bio-Pharma (BP) for delivery of medicine (Rx) to displaced PT and PRC; Develop specific educational materials for the EORS (PT, MDs, Insurers, BP); Create & distribute an EORS “PT Wallet Card” with PT national digital record (NDR) and E responder contacts. To prioritize components of the COEMP, a needs assessment, reviewing past E experience, response, and current capacity, has been initiated. The specific active components of the EORS include: 1-E ONC MD support network: ONC MDs have been invited to volunteer via email and at regional meetings. 2-Secure PT MR repository: MDs and PT will coordinate relevant MR, insurance, and E contact data, in locations (home of PT, w/relatives, NDR). 3-E coordinator MDs & staff will respond to E calls from PT/MD via phone & email. 4-Open dialogue with BP for E access to Rx for displaced PT. 5-Educational & training for PRC and PT in printed & electronic form. Conclusions: COEMP provides an initial E model for ONC. It may be applicable for state societies or national ONC groups. At ASCO 2006, MDs will be invited to participate and expand COEMP capabilities. Although we hope COEMP/EORS need never be used, its development will enable ONC practices to be more prepared for loco-regional E. No significant financial relationships to disclose.

New Drug Discovery from Medicinal Plants and Phytoconstituents for Depressive Disorders

2019 ◽  
Vol 18 (2) ◽  
pp. 92-102 ◽  
Author(s):  
Fatma Tuğçe Gürağaç Dereli ◽  
Mert Ilhan ◽  
Esra Küpeli Akkol
Keyword(s):  
Medicinal Plants ◽  
Depressive Disorders ◽  
Living Standards ◽  
Side Effect Profile ◽  
Active Components ◽  
Synthetic Drugs ◽  
Traditional Medicinal Plants ◽  
Antidepressant Effects ◽  
Life Threatening ◽  
Culinary Herbs

Background & Objective: Depression, a risk factor for several serious diseases, is a highly prevalent and life-threatening psychiatric disorder. It can affect the individual’s position in life and reduce the living standards. The research on the use of medicinal plants in treating this disease has increased enormously because of the possible low rehabilitation rate and side effects of available synthetic drugs, such as sexual dysfunction, nausea, fatigue, insomnia, hypersomnia, and weight gain.Conclusion:Therefore, this review aimed to draw attention to the antidepressant effects of culinary herbs and traditional medicinal plants and their active components, thereby promoting their use in the development of more potent antidepressants with improved side effect profile.

scholarly journals EMERGENCY USE AUTHORIZATION: AT ZERO HOUR

2018 ◽  
Vol 3 (4) ◽  
pp. 18-23
Author(s):  
V. Balamuralidhara ◽  
Vaishnav A.M. ◽  
Bachu V. ◽  
Pramod Kumar T.M.
Keyword(s):  
Homeland Security ◽  
Ebola Virus ◽  
Hemorrhagic Fever ◽  
The United States ◽  
Vital Role ◽  
Test Device ◽  
Department Of Homeland Security ◽  
The Public ◽  
Life Threatening ◽  
Us Fda

The Emergency Use Authorisation (EUA) authority plays a vital role in US FDA. They provide the authority/permission to use the unregistered products/registered product with unregistered route to treat the life threatening damages to the patients in world in some emergency conditions. The aim of this work is to give an overview on EUA in life threatening conditions and there challenges in getting the permissions under regulations with example of E-bola virus. The e-bola is a virus. It is a hemorrhagic fever deadly disease caused by one of the E-bola viral strain, which is wide spread in West Africa. The -Secretary of the Department of homeland security (DHS), determined, pursuant to section 319F-2 of the Public Health Service Act, that the Ebola virus presents a material threat against the United States population sufficient to affect national security. Issuance of EUA by the FDA Commissioner requires several steps under section 564 of the FD&C Act. The FDA Commissioner, can only issue the EUA, if criteria for issuance under the statute are met. This study’s highlights the importance of the EUA in emergency when there is no medicine for disease/virus in the world. For example the FDA has issued a EUA to use the ReEBOV which is the Rapid Antigen Test device designed by Lusys lab co. Pvt. Ltd. for detecting the Zaire Ebola virus.

Local Government Homeland Security Information Systems

2010 ◽  
pp. 136-150
Author(s):  
Christopher G. Reddick
Keyword(s):  
Information Systems ◽  
Information Sharing ◽  
Hurricane Katrina ◽  
Homeland Security ◽  
Local Governments ◽  
Terrorist Attack ◽  
Background Information ◽  
Federal State ◽  
Security Information ◽  
State And Local

This chapter examines homeland security information systems (HSIS) with a focus on local governments. Local governments are typically the first at the scene when responding to an emergency or a terrorist attack. The most notable incidents are Hurricane Katrina and the terrorist attacks of September 11, 2001. In both of these incidents the first responders were the local governments, which faced dual issues of communication and information sharing. It is important to understand the current level of preparedness and use of HSIS in local governments. This chapter tries to discern the relative priority of HSIS compared to other priorities of local governments in the realm of homeland security. This chapter first outlines some background information on local governments with respect to their organizational structure and level of homeland security preparedness. The second section outlines the stages of e-government adoption, which is commonly discussed in the local e-government literature. Third, there is a discussion of homeland security information sharing between the federal, state, and local governments. There is some evidence presented from existing surveys of the impact of HSIS on local governments. Finally, there is survey results presented from a study conducted by the International City/ County Management Association (ICMA) on homeland security preparedness. This survey information is used to determine where HSIS fits into local priorities on homeland security.

scholarly journals Induction of blood-circulating bile acids supports recovery from myelosuppressive chemotherapy

2020 ◽  
Vol 4 (9) ◽  
pp. 1833-1843
Author(s):  
Valgardur Sigurdsson ◽  
Youichi Haga ◽  
Hajime Takei ◽  
Els Mansell ◽  
Chizuko Okamatsu-Haga ◽  
...  
Keyword(s):  
Bile Acids ◽  
Treatment Protocol ◽  
Recovery Process ◽  
Systemic Circulation ◽  
Chemotherapeutic Agents ◽  
Clinical Settings ◽  
Active Components ◽  
Pediatric Cancer Patients ◽  
Life Threatening ◽  
Natural Response

Abstract Chemotherapeutic agents can reduce bone marrow (BM) activity, causing myelosuppression, a common life-threatening complication of cancer treatment. It is challenging to predict the patients in whom prolonged myelosuppression will occur, resulting in a delay or discontinuation of the treatment protocol. An early indicator of recovery from myelosuppression would thus be highly beneficial in clinical settings. In this study, bile acids (BAs) were highly increased in the systemic circulation as a natural response during recovery from myelosuppression, supporting regeneration of BM cells. BA levels in the blood of pediatric cancer patients and mice treated with chemotherapeutic agents were increased, in synchrony with early proliferation of BM cells and recovery from myelosuppression. In a mouse model of altered BA composition, Cyp8b1 knockout mice, a subset of mice recovered poorly after chemotherapy. The poor recovery correlated with low levels and changes in composition of BAs in the liver and systemic circulation. Conversely, BA supplementation in chemotherapy-treated wild-type mice resulted in significantly improved recovery. The results suggest that part of the mechanism by which BAs support recovery is the suppression of endoplasmic reticulum stress pathways in expanding and recovering hematopoietic cells. The findings propose a novel role of BAs as early markers of recovery and active components of the recovery process after chemotherapy.

scholarly journals Surgical Needs at the End of the Battle of Mosul: Results from Mosul General Hospital

2019 ◽  
Vol 44 (3) ◽  
pp. 673-679
Author(s):  
Fredrik Bäckström ◽  
Denise Bäckström ◽  
Lin Sadi ◽  
Peter Andersson ◽  
Andreas Wladis
Keyword(s):  
General Hospital ◽  
Red Cross ◽  
Final Phase ◽  
Hospital Data ◽  
Related Condition ◽  
Northern Iraq ◽  
Number Of Children ◽  
Body Regions ◽  
Life Threatening ◽  
Official Declaration

Abstract Purpose The aim of the study was to analyze the surgical needs of patients seeking emergency care at the Mosul General Hospital in the final phase of the battle of Mosul in northern Iraq between an international military coalition and rebel forces. During the conflict, the International Red Committee of the Red Cross (ICRC) supported the hospital with staff and resources. Ceasefire in the conflict was declared at the end of July 2017. Methods Routinely collected hospital data from the ICRC-supported Mosul General Hospital from June 6, 2017, to October 1, 2017 were collected and analyzed retrospectively. All patients with weapon-related injuries as well as all patients with other types of injuries or acute surgical illness were included. Results Some 265 patients were admitted during the study period. Non-weapon-related conditions were more common than weapon-related (55.1%). The most common non-weapon-related condition was appendicitis followed by hernia and soft tissue wounds. Blast/fragment was the most frequent weapon-related injury mechanism followed by gunshot. The most commonly injured body regions were chest and abdomen. Children accounted for 35.3% of all weapon-related injuries. Patients presented at the hospital with weapon-related injuries more than 2 months after the official declaration of ceasefire. A majority of the non-weapon-related, as well as the weapon-related conditions, needed surgery (88.1% and 87.6%, respectively). Few postoperative complications were reported. Conclusions The number of children affected by the fighting seems to be higher in this cohort compared to previous reports. Even several months after the fighting officially ceased, patients with weapon-related injuries were presenting. Everyday illnesses or non-weapon-related injuries dominated. This finding underlines the importance of providing victims of conflicts with surgery for life-threatening conditions, whether weapon related or not.

How the next President of the United States can fix FEMA

2008 ◽  
Vol 6 (5) ◽  
pp. 13 ◽  
Author(s):  
Jane A. Bullock, BA ◽  
George D. Haddow, MURP
Keyword(s):  
Hurricane Katrina ◽  
Homeland Security ◽  
Local Governments ◽  
Current System ◽  
Hazard Mitigation ◽  
The United States ◽  
Federal State ◽  
Economic Damage ◽  
Department Of Homeland Security ◽  
State And Local

Our nation continues to experience increased frequency and severity of weather disasters. All of these risks demand that we look at the current system and assess if this system, which is predicated on strong Federal leadership in partnership with State and local governments and which failed so visibly in Hurricane Katrina, needs to be rebuilt on a new model. We are suggesting a plan of action that, we believe, is practical, achievable, and will reduce the costs in lives, property, environmental and economic damage from future disasters. The next President is the only person who can make this happen.We suggest that the next President undertake the following steps: (1) move FEMA out of the Department of Homeland Security; (2) appoint a FEMA Director, who is a trusted adviser to the President; (3) include the appointment of the FEMA Director in the first round of Presidential appointees to the Cabinet; (4) rebuild the Federal Response Plan; (5) remove the hazard mitigation and long-term recovery functions from FEMA; (6) invest $2.5 billion annually in hazard mitigation; (7) support community disaster resiliency efforts. The next President will have the opportunity to build the new partnership of Federal, State and local governments, voluntary agencies, nonprofits and the private sector that is needed to make our nation resilient. The question is will the next President take advantage of this opportunity?

The Department of Defense and Homeland Security relationship: Hurricane Katrina through Hurricane Irene

2015 ◽  
Vol 13 (3) ◽  
pp. 265 ◽  
Author(s):  
John Michael Weaver, DPA
Keyword(s):  
Hurricane Katrina ◽  
Homeland Security ◽  
Department Of Defense ◽  
Collaborative Relationship ◽  
Mixed Methods Approach ◽  
Federal Intervention ◽  
Hurricane Irene ◽  
Sequential Mixed Methods ◽  
Security Relationship ◽  
Primary Unit

This research explored federal intervention with the particular emphasis on examining how a collaborative relationship between Department of Defense (DOD) and Homeland Security (DHS) led to greater effectiveness between these two federal departments and their subordinates (United States Northern Command and Federal Emergency Management Agency, respectively) during the preparation and response phases of the disaster cycle regarding US continental-based hurricanes. Through the application of a two-phased, sequential mixed methods approach, this study determined how their relationship has led to longitudinal improvements in the years following Hurricane Katrina, focusing on hurricanes as the primary unit of analysis.

scholarly journals Triptolide’s anti-inflammatory effects on ARDS by down-regulating miR-9-5p and up-regulating LRG1 and CLDN5

2021 ◽  
Author(s):  
Junyong Han ◽  
Huiqing Que ◽  
Wei Li ◽  
Shijie Xue ◽  
Sui Lin ◽  
...  
Keyword(s):  
Target Genes ◽  
Distress Syndrome ◽  
Inhibitory Effect ◽  
Active Components ◽  
Whole Transcriptome Sequencing ◽  
Life Threatening ◽  
Anti Inflammatory ◽  
Whole Transcriptome ◽  
Inflammatory Effect

Abstract Background Acute respiratory distress syndrome (ARDS) is a life-threatening respiratory disease and its treatment is not fully established. Triptolide, one of Tripterygium wilfordii’s main active components, has been proved to alleviate Lipopolysaccharide (LPS)-induced ARDS. Imbalance of MicroRNAs (miRNAs) is recognized as the pathogenic mechanism of various diseases, including ARDS. However, the specific miRNAs that play a key regulatory role in the anti-inflammatory effect of triptolide in ARDS remain elusive. Methods In this study, we administered triptolide in a mouse model of ARDS, and whole transcriptome sequencing was applied to identify meaningful miRNAs and validate them in vitro. Results The results showed that triptolide may reduce the inflammatory response in ARDS by regulating miR-9-5p. The data further proved that LRG1 and CLDN5 expression are regulated by miR-9-5p, and triptolide can down-regulate the expression of miR-9-5p by regulating negatively the expression of LRG1 and CLDN5. Conclusion Our study revealed that miR-9-5p was the specific miRNAs that plays key role in triptolide’s alleviation of ARDS inflammation by regulating target genes, and its inhibitory effect on LRG1 and CLDN5 expression was verified.

scholarly journals Mr.Vc: a database of microarray and RNA-seq of Vibrio cholerae

Database ◽  
2019 ◽  
Vol 2019 ◽  
Author(s):  
Zhiyuan Zhang ◽  
Guozhong Chen ◽  
Jun Hu ◽  
Wajid Hussain ◽  
Fenxia Fan ◽  
...  
Keyword(s):  
Vibrio Cholerae ◽  
Diarrheal Disease ◽  
Gene Annotation ◽  
Relevant Information ◽  
Differentially Expressed ◽  
Data Repository ◽  
Rna Seq ◽  
Experimental Conditions ◽  
Life Threatening ◽  
Infectious Cycle

AbstractGram-negative bacterium Vibrio cholerae is the causative agent of cholera, a life-threatening diarrheal disease. During its infectious cycle, V. cholerae routinely switches niches between aquatic environment and host gastrointestinal tract, in which V. cholerae modulates its transcriptome pattern accordingly for better survival and proliferation. A comprehensive resource for V. cholerae transcriptome will be helpful for cholera research, including prevention, diagnosis and intervention strategies. In this study, we constructed a microarray and RNA-seq database of V. cholerae (Mr.Vc), containing gene transcriptional expression data of 145 experimental conditions of V. cholerae from various sources, covering 25 937 entries of differentially expressed genes. In addition, we collected relevant information including gene annotation, operons they may belong to and possible interaction partners of their protein products. With Mr.Vc, users can easily find transcriptome data they are interested in, such as the experimental conditions in which a gene of interest was differentially expressed in, or all genes that were differentially expressed in an experimental condition. We believe that Mr.Vc database is a comprehensive data repository dedicated to V. cholerae and could be a useful resource for all researchers in related fields. Mr.Vc is available for free at http://bioinfo.life.hust.edu.cn/mrvc.

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