The quality of phase I trial (P1T) abstracts submitted to ASCO meetings

2007 ◽  
Vol 25 (18_suppl) ◽  
pp. 6532-6532
Author(s):  
E. L. Strevel ◽  
N. Chau ◽  
G. R. Pond ◽  
A. J. Murgo ◽  
S. P. Ivy ◽  
...  
Keyword(s):  
Drug Development ◽  
Maximum Tolerated Dose ◽  
Quality Score ◽  
Electronic Survey ◽  
Governmental Agencies ◽  
Expert Rating ◽  
Expert Ratings ◽  
Oral Presentations ◽  
Abstract Reporting

6532 Background: Conference abstracts of P1T communicate important information of anticancer drug development. Our objectives were to determine elements considered by experts as essential for good P1T abstract reporting, to assess the quality of P1T abstracts submitted to ASCO meetings, and to propose guidelines for future reporting. Methods: Elements important for P1T abstract reporting were determined by a survey of experts in developmental therapeutics, and a scoring system for abstract quality was generated. All P1T abstracts published in ASCO Proceedings from 2002–2006 were reviewed, and a quality score was assigned. Results: An electronic survey was sent twice to 69 experts, with a response rate of 39% (27/69). Characteristics of the 27 experts were: average age = 48; male = 74%, USA:Europe:Canada = 78%:15%:7%; 89% had 10+ years experience in drug development; 93% from academic institutions versus 7% from governmental agencies; 56% currently involved in clinical research versus 44% in translational research. Experts were asked to rate each of 37 elements using a five-point Like rt scale, and elements with average expert ratings over 3.75 were included in the final quality score calculations. A total of 920 P1T abstracts over 5 years were reviewed. A positive and linear association was observed between average expert rating of the elements and proportion of P1T abstracts that included those elements (Spearman correlation coefficient, ρ=0.65). The median quality score for all 920 abstracts was 65% (range 26%–95%, SD 12.6%). Deficiencies existed in abstract reporting; for instance, dose-limiting toxicity was described in only 63% of abstracts, while recommended dose or maximum tolerated dose was reported in only 38%. A significant association between year of presentation was found (ρ=0.36, P<0.001), with later years possessing better quality scores. The quality score was also statistically significant as a predictor of type of presentation (odds ratio 0.20, 95% CI 0.08–0.54, P=0.002), with oral presentations having the highest scores. Conclusion: The quality of P1T abstract reporting at ASCO has improved over time, although there is room for optimization. The quality of P1T abstract reporting may be enhanced using guidelines derived from our expert consensus. No significant financial relationships to disclose.

Improving the quality of abstract reporting for economic analyses in oncology.

2012 ◽  
Vol 30 (34_suppl) ◽  
pp. 109-109
Author(s):  
Maria Yi Ho ◽  
Kelvin Chan ◽  
Stuart Peacock ◽  
Winson Y. Cheung
Keyword(s):  
Health Economic ◽  
Time Horizon ◽  
Quality Score ◽  
Costs And Benefits ◽  
Expert Rating ◽  
Economic Analyses ◽  
The Cost ◽  
Abstract Reporting ◽  
Over Time

109 Background: Increasing costs of cancer drugs underscore the importance of EA, which convey key information about the relative costs and benefits of new interventions. Although guidelines for abstracts exist for phase I, II, and III oncology trials, similar recommendations for EA are lacking. Our objectives were to 1) identify items considered to be essential for EA abstracts; 2) evaluate the quality of EA abstracts submitted to ASCO, ASH, and ISPOR meetings; and 3) propose guidelines for future reporting. Methods: Health economic experts were surveyed and asked to rate each of 24 possible EA elements on a 5-point Likert scale. A scoring system for abstract quality (0=poor and 100=excellent) was devised based on EA elements with an average expert rating ≥ 3.5. All EA abstracts from ASCO (‘97–‘09), ASH (‘04–‘09) and ISPOR (‘97–‘09) were reviewed and assigned a quality score. Results: Of 99 experts surveyed, 50 (51%) responded. Characteristics of respondents: average age = 53; male = 78%; US / Europe / Canada = 54% / 28% / 18%. A total of 216 abstracts were reviewed: ASCO 53%, ASH 14% and ISPOR 33%. Median quality score was 75 (range 48 to 93), but notable deficiencies were observed. For instance, the cost perspective of the EA was reported in only 61% of abstracts, while the time horizon was described in only 47%. An association was seen between year of presentation and overall quality of abstracts (p=0.001), with those from recent years demonstrating better quality scores. There were also disparities in quality scores among EA of different cancer sites (p=0.005). Conclusions: Quality of EA abstracts for oncology has improved over time, but there is room for improvement. Abstracts may be enhanced using guidelines derived from our survey of experts (see table). [Table: see text]

scholarly journals Online Videos as a Source of Physiotherapy Exercise Tutorials for Patients with Lumbar Disc Herniation—A Quality Assessment

2021 ◽  
Vol 18 (11) ◽  
pp. 5815
Author(s):  
Stephan Heisinger ◽  
Dominikus Huber ◽  
Michael Paul Matzner ◽  
Timothy Hasenoehrl ◽  
Stefano Palma ◽  
...  
Keyword(s):  
Lumbar Disc Herniation ◽  
Disc Herniation ◽  
Lumbar Disc ◽  
Quality Score ◽  
Global Quality ◽  
Wide Range ◽  
Youtube Videos ◽  
Socioeconomic Burden ◽  
Therapy Advice

Background: During the last few decades the prevalence of lumbar disc herniation has been increasing constantly, thereby imposing a significant socioeconomic burden. Physiotherapy plays a crucial role in both surgical and conservative treatment of lumbar disc herniation, consequently the current COVID-19 pandemic with concomitant lockdowns has led to a shortage of physiotherapeutical care. In the light of these recent events publicly available physiotherapy tutorials may be a useful tool to address this problem. Aim: The main aim of this study was to assess the quality of online physiotherapy exercise tutorials for lumbar disc herniation. Materials & Methods: With YouTube being a widely known and used platform we screened 240 of the most viewed videos. A total of 76 videos met the inclusion criteria and were statistically analyzed. The videos were assessed using Global Quality Score, DISCERN Score and JAMA benchmark criteria and in regard to their applicability. Results: They displayed a wide range of views (44,969 to 5,448,717), likes (66 to 155,079) and dislikes (6 to 2339). The videos were assessed using Global Quality Score, DISCERN Score and JAMA benchmark criteria and in regard to their applicability. Neither the number of “Views”, “Likes”, nor “Dislikes” was found to have a significant association with any of the quality measures used in this study. Conclusion: Overall quality grade was determined as “moderate”. Based on the data examined in this study, the use of YouTube videos as a source of therapy advice for lumbar spine disc herniation cannot be recommended universally.

scholarly journals A Novel Approach for Comparison of Reception Performance in a Technique Test and Small-Sided Games

Sports ◽  
2021 ◽  
Vol 9 (5) ◽  
pp. 66
Author(s):  
Arne Sørensen ◽  
Vidar Sørensen ◽  
Terje Dalen
Keyword(s):  
Correlation Coefficient ◽  
Rank Order ◽  
Technical Skills ◽  
Quality Score ◽  
Soccer Players ◽  
Moderate Correlation ◽  
Technical Aspects ◽  
Youth Soccer ◽  
Novel Approach

The purpose of this study was to evaluate the correlation between soccer players’ performance of receptions of passes in tests of both isolated technical skills and more match-realistic situations in small-sided games (SSGs). In addition, this study investigated whether the involvement in SSGs (number of receptions) correlated with the quality of receptions in the respective SSGs. The participants were 13 male outfield youth soccer players from teams in the first division of the regional U18 league. The quality of receptions was scored by educated coaches according to set criteria of performance. Statistical analyses of correlations were determined using Spearman’s rank-order correlation coefficient (rs). The main results were (1) a significant correlation in the quality of ball reception between 4vs1 SSGs and 5vs5 SSGs (rs = −0.61, p < 0.01) and (2) a trend towards moderate correlation between the quality of ball reception using a ball projection machine and 5vs5 SSGs (rs = −0.48, p = 0.10). (3) A significant correlation was found between the number of receptions in 5vs5 SSGs and the quality score of receptions in 5vs5 SSGs (rs = −0.70, p < 0.01). The trend towards moderate correlations between 5vs5 SSGs and the isolated technical reception test could imply the importance of training in the technical aspects of ball reception. Moreover, it seems as though the players with the best reception performance are the players who are most involved in SSGs, that is, having the most receptions.

Toward Eloquentia Perfecta in the History and Systems Course

1994 ◽  
Vol 21 (2) ◽  
pp. 91-93 ◽  
Author(s):  
C. James Goodwin
Keyword(s):  
Oral Presentation ◽  
Peer Feedback ◽  
Course Content ◽  
Oral Presentations

A technique for improving the quality of student oral presentations is described. Throughout the semester, students in my History and Systems course delivered minilectures covering specific course content. Peers evaluated their lectures, and students were tested on minilecture information. In a replication, the lectures were videotaped. Lecturers also wrote a paper that elaborated the content of their talks and self-evaluated their performance based on peer feedback and (in the replication) the videotape. The result was a distinct improvement over the typical oral presentation assignment.

Comprehensive Nursing can Relieve the Negative Emotions of Patients undergoing Breast Cancer Resection and Reduce Postoperative

2021 ◽  
Vol 7 (5) ◽  
pp. 4234-4243
Author(s):  
Xiaoxia Lv ◽  
Lihua Wang ◽  
Yan Zhai
Keyword(s):  
Breast Cancer ◽  
Postoperative Complications ◽  
Quality Score ◽  
Cancer Resection ◽  
Upper Limb Function ◽  
Sf 36 ◽  
Group A ◽  
Group B ◽  
Nursing Quality

To explore the effect of comprehensive nursing on adverse emotions and postoperative complications of breast cancer patients undergoing mastectomy. Altogether 180 patients who received treatment in our hospital from May 2017 to May 2019 were selected as the research participants and divided into group A and group B. Among them, 100 cases in group A received comprehensive nursing, 80 cases in group B received routine nursing. The surgical indications, upper limb function, serum NGF, TK1 and CA15-3 expression level, VAS score, SAS, SDS score, quality of life SF-36 score were detected, and the incidence rate of postoperative complications and nursing quality score were compared. Compared with group B, group A had less postoperative bed time, intraoperative blood loss, length of hospital stay, better recovery of upper limb function, lower expression levels of serum NGF, TK1 and CA15-3, lower VAS score, SAS and SDS score, higher quality of life SF-36 score, lower incidence of postoperative complications and higher nursing quality score. Comprehensive nursing can relieve the negative emotions of patients undergoing breast cancer resection and reduce the incidence of postoperative complications.

HOUSING AFFORDABILITY IN THE STATE OF MELAKA

2017 ◽  
Vol 15 ◽  
Author(s):  
Mariana Mohamed Osman ◽  
Noor Suzilawati Rabe ◽  
Muhammad Faris Abdullah ◽  
Nur Farhanah Rosli ◽  
Farah Eleena Zainudin
Keyword(s):  
Quality Of Life ◽  
Secondary Data ◽  
Housing Affordability ◽  
The State ◽  
Improve Quality ◽  
Governmental Agencies ◽  
Income Ratio ◽  
Basic Need

Housing is a basic need to man. It provides shelter and comfort from the elements and improve quality of life of the residents. Hence, housing should be affordable to all. This paper assesses the housing affordability for the districts in Melaka. This was achieved by calculating the median multiple of the price income ratio and comparing the score to the housing affordability index. Secondary data were obtained from reports published by the governmental agencies. The results show that housing is mostly moderately unaffordable in the districts of Melaka. Additionally, housing affordability has improved from 2012 to 2014 in majority of the districts.

scholarly journals Precision Medicine: From “Omics” to Economics towards Data-Driven Healthcare - Time for European Transformation

2017 ◽  
Vol 2 (Suppl. 1) ◽  
pp. 1-10 ◽  
Author(s):  
Denis Lacombe ◽  
Lifang Liu ◽  
Françoise Meunier ◽  
Vassilis Golfinopoulos
Keyword(s):  
Drug Development ◽  
Development Process ◽  
Precision Oncology ◽  
Drug Development Process ◽  
Cancer Treatments ◽  
True Value ◽  
Efficient Access ◽  
Funding Agencies ◽  
Anti Cancer

There is room for improvement for optimally bringing the latest science to the patient while taking into account patient priorities such as quality of life. Too often, regulatory agencies, governments, and funding agencies do not stimulate the integration of research into care and vice versa. Re-engineering the drug development process is a priority, and healthcare systems are long due for transformation. On one hand, patients need efficient access to treatments, but despite precision oncology approaches, efficiently shared screening platforms for sorting patients based on the biology of their tumour for trial access are lacking and, on the other hand, the true value of cancer care is poorly addressed as central questions such as dose, scheduling, duration, and combination are not or sub-optimally addressed by registration trials. Solid evidence on those parameters could potentially lead to a rational and wiser use of anti-cancer treatments. Together, optimally targeting patient population and robust comparative effectiveness data could lead to more affordable and economically sound approaches. The drug development process and healthcare models need to be interconnected through redesigned systems taking into account the full math from drug development into affordable care.

scholarly journals An Effective feature set in Quality Estimation of Natural Scene Statistics Images

2019 ◽  
Vol 9 (2) ◽  
pp. 2881-2888
Keyword(s):  
Image Quality Assessment ◽  
Image Features ◽  
Quality Score ◽  
Natural Image ◽  
Natural Scene ◽  
Natural Scene Statistics ◽  
Quality Estimation ◽  
Objective Quality ◽  
Quality Value

Quality estimation in images is an area which demands high attention of researchers. Many recent algorithms in Image quality assessment relies on the computation of definite values from the image or comparison with the original pristine image. Here, we propose the extraction of a set of specific features from image and processing is done on these extracted features to obtain the objective quality score. The detailed inspection of behaviour of this set of highly specific image features extracted through less complex mathematical procedure from a collection good quality and low quality set of Natural Scene Statistics images available in LIVE dataset is elaborated in this work. Our studies and results are compared with the subjective opinion value and is proven to be accurate. The obtained results are demonstrated using statistical and graphical manner for promptness in understanding the nature of quality of the image. Thus the proposed feature set is proven to be complete in assessing the quantitative quality value of any Natural image.

scholarly journals Assessing automated CMR contouring algorithms using systematic contour quality scoring analysis

2021 ◽  
Vol 22 (Supplement_1) ◽  
Author(s):  
M Omer ◽  
A Amir-Khalili ◽  
A Sojoudi ◽  
T Thao Le ◽  
S A Cook ◽  
...  
Keyword(s):  
Machine Learning ◽  
Learning Algorithm ◽  
Random Order ◽  
Standard Operating Procedure ◽  
Left Ventricular ◽  
Quality Score ◽  
Machine Learning Algorithms ◽  
Dice Similarity Coefficient ◽  
National Budget

Abstract Funding Acknowledgements Type of funding sources: Public grant(s) – National budget only. Main funding source(s): SmartHeart EPSRC programme grant (www.nihr.ac.uk), London Medical Imaging and AI Centre for Value-Based Healthcare Background Quality measures for machine learning algorithms include clinical measures such as end-diastolic (ED) and end-systolic (ES) volume, volumetric overlaps such as Dice similarity coefficient and surface distances such as Hausdorff distance. These measures capture differences between manually drawn and automated contours but fail to capture the trust of a clinician to an automatically generated contour. Purpose We propose to directly capture clinicians’ trust in a systematic way. We display manual and automated contours sequentially in random order and ask the clinicians to score the contour quality. We then perform statistical analysis for both sources of contours and stratify results based on contour type. Data The data selected for this experiment came from the National Health Center Singapore. It constitutes CMR scans from 313 patients with diverse pathologies including: healthy, dilated cardiomyopathy (DCM), hypertension (HTN), hypertrophic cardiomyopathy (HCM), ischemic heart disease (IHD), left ventricular non-compaction (LVNC), and myocarditis. Each study contains a short axis (SAX) stack, with ED and ES phases manually annotated. Automated contours are generated for each SAX image for which manual annotation is available. For this, a machine learning algorithm trained at Circle Cardiovascular Imaging Inc. is applied and the resulting predictions are saved to be displayed in the contour quality scoring (CQS) application. Methods: The CQS application displays manual and automated contours in a random order and presents the user an option to assign a contour quality score 1: Unacceptable, 2: Bad, 3: Fair, 4: Good. The UK Biobank standard operating procedure is used for assessing the quality of the contoured images. Quality scores are assigned based on how the contour affects clinical outcomes. However, as images are presented independent of spatiotemporal context, contour quality is assessed based on how well the area of the delineated structure is approximated. Consequently, small contours and small deviations are rarely assigned a quality score of less than 2, as they are not clinically relevant. Special attention is given to the RV-endo contours as often, mostly in basal images, two separate contours appear. In such cases, a score of 3 is given if the two disjoint contours sufficiently encompass the underlying anatomy; otherwise they are scored as 2 or 1. Results A total of 50991 quality scores (24208 manual and 26783 automated) are generated by five expert raters. The mean score for all manual and automated contours are 3.77 ± 0.48 and 3.77 ± 0.52, respectively. The breakdown of mean quality scores by contour type is included in Fig. 1a while the distribution of quality scores for various raters are shown in Fig. 1b. Conclusion We proposed a method of comparing the quality of manual versus automated contouring methods. Results suggest similar statistics in quality scores for both sources of contours. Abstract Figure 1

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