Breast sarcomas: Is now the time to change our mind?

e21524 Background: Primary breast sarcoma usually was considered a rare malignant disease [Adem et al., 2004]. The aim of this study is to show the incidence of breast sarcoma in the region with female population of about 600,000. Methods: Retrospective comparative analysis of breast sarcoma and breast cancer incidence in female of Ternopil region for 2000 - 2008. Descriptive statistical method was used. Results: The total of 101 cases of breast sarcoma was diagnosed in female of 39 - 76 years of age. Every year about 11 (6–18) primary breast sarcomas and 256 (233–279) patients with primary breast cancer were detected. The incidence rate of breast sarcoma was 1.14 per 100,000 women in 2000, 2.94 (in 2001), 1.48 (2002), 0.99 (2003), 2.16 (2004), 1.67 (2005), 2.53 (2006), 2.03 (2007) and 1.87/100,000 in 2008. The incidence of breast cancer was ranged from 37.3 to 46.4 per 100,000 of female population. Breast sarcoma consisted of 2.5% of the breast malignancies in 2000, 6.5% (in 2001), 3.3% (2002), 2.6% (2003), 5.4% (2004), 4.1% (2005), 5.9% (2006), 4.4% (2007) and 4.7% in 2008. Pathohistologic examination revealed angiosarcoma in 92.1% of cases. Thus, our findings are significantly different than data of other authors: f.e., the incidence of primary breast sarcoma is at 45 new cases per 10 million women [Confavreux et al., 2003], or 17 new cases per million women [Moore and Kinne, 1996], and breast sarcoma accounting for 0.0006% of breast malignancies which were diagnosed in 1910–2000 [Adem, 2004]. Taking into account all historical and recent data we can suggest beginning of biological changing in correlation between breast malignant tumors–carcinoma and sarcoma. Conclusions: Our statistical finding shows that incidence of breast sarcoma is 1.87 (0.99–2.94) per of 100,000 female population, and now sarcomas consist of 4.4% (2.5–6.5%) of all malignant breast tumors. Angiosarcoma is a most common (92.1%) morphological type of breast sarcomas. No significant financial relationships to disclose.

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Breast Cancer in Megapolises of Kazakhstan: Epidemiological Assessment of Incidence and Mortality

Iranian Journal of Public Health ◽

10.18502/ijph.v48i7.2948 ◽

2020 ◽

Author(s):

Nurbek IGISSINOV ◽

Assem TOGUZBAYEVA ◽

Botagoz TURDALIYEVA ◽

Gulnur IGISSINOVA ◽

Zarina BILYALOVA ◽

...

Keyword(s):

Breast Cancer ◽

Cancer Incidence ◽

Western Europe ◽

Malignant Disease ◽

Breast Cancer Incidence ◽

Developed Countries ◽

Population Increase ◽

Female Population ◽

Incidence And Mortality ◽

The Government

Background: Breast cancer is the most common malignant disease among the female population of Kazakhstan like in many developed countries of the world (Canada, UK, US, Western Europe), and it accounts for every 5th tumor. We aimed to assess the epidemiological aspects of breast cancer incidence and mortality among Almaty and Astana (Now Nur-Sultan), Kazakhstan residents in 2009-2018. Methods: A retrospective study using modern descriptive and analytical methods of epidemiology was conducted to evaluate the breast cancer incidence and mortality in megapolises of Kazakhstan. Results: The average annual age-standardized incidence rate of breast cancer amounted to 61.90/0000 (95% CI=56.2-67.6) in Almaty and 61.20/0000 (95% CI=56.765.7) in Astana. The average age-standardized mortality was 19.20/0000 (95% CI=17.3-21.1) in Almaty and 19.30/0000 (95% CI=17.1-21.4) in Astana. The standardized incidence in the megapolises tended to increase (Тgr=+0.8% in Almaty and Тgr=+1.4% in Astana), while the mortality was decreasing (Тdec=−4.2% in Almaty and Тdec=−1.1% in Astana). According to the component analysis, the growth in the number of breast cancer cases was due to a population increase (ΔP=+130.4% in Almaty and ΔP=+93.2% in Astana), with a notable decrease of factors related to the risk of getting sick (ΔR=−27.9% in Almaty, ΔR=−6.1% in Astana). Conclusion: This is the first epidemiological study to assess the changes in incidence and mortality from breast cancer in megapolises of Kazakhstan because of screening. The results of this study can be used to improve the government program to combat breast cancer.

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Prognostic analysis of epidemiological indicators of the breast cancer among women in the Udmurt Republic

Kazan medical journal ◽

10.17816/kmj2019-975 ◽

2019 ◽

Vol 100 (6) ◽

Author(s):

S V Batov ◽

V M Napol'skikh ◽

N A Svirin ◽

I V Tchurakov ◽

I I Batova ◽

...

Keyword(s):

Breast Cancer ◽

Russian Federation ◽

Malignant Tumors ◽

Breast Cancer Incidence ◽

Female Population ◽

Prognostic Analysis ◽

Udmurt Republic ◽

The Russian Federation ◽

The Republic ◽

The Moment

Aim. To study a number of epidemiological indicators of a breast cancer in the Udmurt Republic for their assessment and prediction of dynamics. Methods. A retrospective analysis of data on a breast cancer of the population cancer register of the Udmurt Republic was performed in comparison with the corresponding statistics in the Russian Federation in 2017. For assessment of the received results the software BIOSTAT 4.3 was used. The forecast of epidemiological intensive indicators was calculated by methods of linear and polynomial trends. Results. The ratio of breast cancer (17.8% in 2017) among the female population of the Republic was the highest among all malignant tumors. In 2017 the crude indicator of breast cancer morbidity equaled 69.80 per 100 000, and standardized one 40.50 per 100 000. The standardized indicator of breast cancer incidence in Udmurtia was one of the lowest in Russia (77th rank place among 85 territorial entities). Crude mortality rate was 19.10 per 100 000, and standardized one 10.00 per 100 000 (82nd rank place in the Russian Federation). The ratio of the patients actively revealed (among registered numbre) was 45.8% (the average Russian value, 38.7%). Early diagnostics of tumor was carried out in 71.6% of patients, stage 1 of the disease was revealed in 34.3% of cases (in the Russian Federation average data, 69.9% and 26.0%, respectively). Forecasting till 2022 shows a trend of further growth of detectability of malignant tumors of breast at early stages among female population in the Udmurt Republic. Lethality of patients during the first year from the moment of diagnosis was 5.4% (the average Russian indicator, 6.0%). Conclusion. Morbidity and mortality rates of breast cancer in the Udmurt Republic in 2017 were lower than the average Russian indicators, and the statistical analysis does not show a negative trend till 2022.

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Analysis of the Incidence of the Female Population Omsk Region with Breast Cancer for Ten Years of (2003 - 2012)

Epidemiology and Vaccinal Prevention ◽

10.31631/2073-3046-2016-15-1-34-38 ◽

2016 ◽

Vol 15 (1) ◽

pp. 34-38

Author(s):

N. G. Shirlina ◽

V. L. Stasenko ◽

V. A. Shirinsky

Keyword(s):

Breast Cancer ◽

Rural Areas ◽

Malignant Tumors ◽

Breast Cancer Incidence ◽

Incidence Rates ◽

Female Population ◽

Regional Center ◽

Urban And Rural Residents ◽

Epidemiological Characteristics ◽

Cancer Incidence Rates

The paper presents the epidemiological characteristics of diseases of the female population of the Omsk region of breast cancer (BC) from 2003 to 2012, Determined the dynamics of morbidity. A comparative analysis of breast cancer incidence rates in urban and rural residents of the area. In the structure of malignant tumors of the female population of the Omsk region the proportion of breast cancer was 23.3% and was lower than the national average (20.0%). In rural areas, compared with the regional center had higher growth rates of incidence of breast cancer (1.5-fold).

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THE MORBIDITY OF MAMMARY GLAND CANCER OF FEMALE POPULATION OF THE SIBERIAN FEDERAL DISTRICT

Health Care of the Russian Federation ◽

10.18821/0044-197x-2017-61-3-123-128 ◽

2019 ◽

Vol 61 (3) ◽

pp. 123-128

Author(s):

Irina N. Odintsova ◽

L. F. Pisareva ◽

O. A. Ananina ◽

E. V. Panferova

Keyword(s):

Breast Cancer ◽

Mammary Gland ◽

Birth Rate ◽

Malignant Tumors ◽

Divorce Rate ◽

Federal District ◽

Demographic Characteristics ◽

Siberian Federal District ◽

Female Population ◽

Mammary Gland Cancer

The breast cancer is one of main localizations among malignant tumors in women of the Siberian Federal District. In the structure of morbidity it holds first place with such percentage as 20.4% and index of morbidity makes up to 51.2 per 100 000 of female population. The territories with increased and decreased risk are established. The features of prevalence of disease in a certain degree are conditioned by differences in demographic characteristics of populations. The indices of life-span, birth-rate in fertile age and divorce rate effect the level of morbidity of breast cancer in population.

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The relationship between dairy products intake and breast cancer incidence: a meta-analysis of observational studies

BMC Cancer ◽

10.1186/s12885-021-08854-w ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Yujing He ◽

Qinghua Tao ◽

Feifei Zhou ◽

Yuexiu Si ◽

Rongrong Fu ◽

...

Keyword(s):

Breast Cancer ◽

Protective Effect ◽

Dairy Products ◽

Meta Analysis ◽

Breast Cancer Incidence ◽

Cochrane Library ◽

Female Population ◽

Fermented Dairy Products ◽

Fermented Dairy ◽

The Relationship

Abstract Background The effect of dairy products intake on breast cancer (BC) is highly controversial. This study aims to investigate the relationship between dairy intake and BC incidence. Methods A search was carried out in PubMed, EBSCO, Web of Science, and Cochrane Library databases before January 2021. The primary objective was the risk of BC and intake of dairy products were exposure variables. Results The meta-analysis comprised 36 articles with 1,019,232 participants. Total dairy products have a protective effect on female population (hazard ratio (HR) =0.95, 95% confidence interval (CI) =0.91–0.99, p = 0.019), especially for estrogen receptor-positive (ER+) (HR = 0.79, p = 0.002) and progesterone receptor-positive (PR+) BC (HR = 0.75, p = 0.027). For ER+/PR+ BC, there is a trend of protection, but it has not reached statistical significance (HR = 0.92, p = 0.075). Fermented dairy products can reduce BC risk in postmenopausal population (HR = 0.96, 95%CI = 0.93–0.99, p = 0.021), but have no protective effect on premenopausal population (HR = 0.98, 95%CI = 0.94–1.03, p = 0.52). Non-fermented dairy products have no significant effect on BC occurrence (p > 0.05). High-fat dairy products are harmful to women, without statistical difference (HR = 1.06, 95%CI = 1.00–1.13, p = 0.066). On the contrary, low-fat dairy products can protect the premenopausal population (HR = 0.94, 95%CI = 0.89–1.00, p = 0.048). Conclusion The intake of dairy products can overall reduce BC risk in the female population, but different dairy products have varying effects on different BC subtypes and menopausal status.

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Breast cancer screening programmes in selected European countries and Poland

Journal of Education, Health and Sport ◽

10.12775/34598 ◽

2021 ◽

Vol 11 (7) ◽

pp. 11-21

Author(s):

Adam Jasiura ◽

Izabela Dera ◽

Karolina Szlachcic ◽

Mateusz Gorzel ◽

Joanna Zmonarska

Keyword(s):

Breast Cancer ◽

Cancer Screening ◽

Mortality Rate ◽

Breast Cancer Screening ◽

Malignant Tumors ◽

Breast Cancer Mortality ◽

Breast Cancer Incidence ◽

Screening Tests ◽

The European Union ◽

Screening Programs

Breast neoplasms are the most common malignant tumors among women. In recent years breast cancer incidence rate has increased. Due to this fact the European Union presents evidence-based guidelines on breast cancer screening and diagnosis. Recommended and commonly used screening test is mammography. The effectiveness of prophylaxis is measured by a decrease in breast cancer mortality rate. Detailed recommendations in EU member countries differ from those presented by the EU institutions. This paper compares the screening programme in Poland to screening programmes in other EU members. The evaluation considers compliance with European screening guidelines and changes in mortality rates since the introduction of the screening programs. General guidelines in Poland are close to European ones. However, some Polish health centers still use analog mammography instead of recommended digital mammography. Furthermore, mortality rate changes in Poland maintain on a constant level due to women’s reluctant participation in screening tests.

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Significance of serum colony-stimulating factor-1 as a breast cancer marker

Journal of Clinical Oncology ◽

10.1200/jco.2009.27.15_suppl.11071 ◽

2009 ◽

Vol 27 (15_suppl) ◽

pp. 11071-11071

Author(s):

S. Aharinejad ◽

A. Thomas ◽

C. Singer ◽

E. Kubista ◽

P. Paulus ◽

...

Keyword(s):

Breast Cancer ◽

Logistic Regression ◽

Tumor Size ◽

Malignant Disease ◽

Operating Characteristic ◽

Malignant Tumors ◽

Benign Tumors ◽

Colony Stimulating Factor ◽

Cancer Marker ◽

Stimulating Factor

11071 Background: A specific and sensitive biomarker that indicates the presence of breast cancer is highly desirable, yet available markers are of limited value. Colony-stimulating factor-1 (CSF-1) is involved in mammary gland development and mediates breast cancer progression. Earlier work indicated correlation of serum CSF-1 with breast cancer staging, and a recent report suggests that CSF-1 is a potential breast cancer marker, however the data reported so far await validation. Methods: In a prospective study in 799 women with no history of malignant disease undergoing surgery, serum CSF-1 levels were measured by a commercially available ELISA. In this cohort, 312 patients had breast cancer and 487 age-matched women had benign tumors. The tumor size, nodal and metastasis status, histological tumor type, hormone and human epidermal growth factor receptor 2 (HER2) and menopausal status were evaluated. Mean CSF-1 serum concentrations were compared between the patient groups by non-parametric Wilcoxon two-sample and Kruskal-Wallis test. The area under the receiver operating characteristic curve was calculated by logistic regression. Results: Mean serum CSF-1 concentrations were significantly higher in all patients with malignant tumors (502±429 pg/mL) as compared to those with benign tumors (382±344 pg/mL) (p<0.0001, Wilcoxon). Increased CSF-1 concentrations were significantly related to malignant versus non-malignant disease in logistic regression and receiver operating characteristic analysis (p<0.0001, AUC=0.6). Increased CSF-1 levels in patients with malignant tumors were associated with postmenopausal (p=0.0038) but not premenopausal (p=0.94) status (Wilcoxon). Serum CSF-1 concentrations did not correlate significantly with tumor size, nodal and metastasis status, hormone receptor and HER2 status of patients (Kruskal-Wallis). Conclusions: Our data suggest that serum CSF-1 could serve as a breast cancer marker in postmenopausal women. While its serum levels are not related to breast cancer stage at diagnosis, they might be useful for breast cancer screening in postmenopausal women. No significant financial relationships to disclose.

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Incidence of Breast Cancer in Eritrea: A Retrospective Study from 2011 to 2017

International Journal of Breast Cancer ◽

10.1155/2019/8536548 ◽

2019 ◽

Vol 2019 ◽

pp. 1-5

Author(s):

Lidia B. Medhin ◽

Lia A. Tekle ◽

Daniel T. Fikadu ◽

Danait B. Sibhatu ◽

Samson F. Gebreyohans ◽

...

Keyword(s):

Breast Cancer ◽

Breast Cancer Incidence ◽

Incidence Rates ◽

Total Incidence ◽

Breast Cancer Epidemiology ◽

Icd 10 ◽

Malignant Breast ◽

Standard Rate ◽

Low Prevalence

In Africa, breast cancer closely compares with cervical cancer as the most common malignancy affecting women and the incidence rates appear to be rising. Eritrea is experiencing a growing breast cancer problem, but little is presently known on tumor patterns, breast cancer epidemiology, and risk factors. The main objective of this study is to provide baseline data on breast cancer incidence in both sexes in Eritrea. This study was carried out retrospectively and quantitatively by collecting, abstracting, analyzing, coding, and interpreting data recorded in National Health Laboratory (NHL) using CanReg5 ver. 5.00.35. Extracting and classification of the tumor data was done using topography, morphology together with the ICD-10. To generate the incidence rate for the seven years the Eritrean population dataset was used from the population pyramid net for 2014. After we entered all the data from Pathology department in NHL, data was analyzed using the predetermined and developed built-in analysis tools of CanReg5 software and Microsoft Excel 2010. A total number of 9,403 pathology cases were recorded from 2011 to 2017. Out of these 1,497 cases were confirmed as cytology and histology of breast cases. From 1,497 confirmed breast cases in both sexes, the incidence of benign cases was higher than incidence of malignant cases with the case number of 1, 149, and 348, respectively. Out of the 1,497 cases, 1,447 (96.66%) were females; this included a total incidence cases of female benign and malignant breast cases 1,111 (76.78%), and 336 (23.22%), respectively. In both female and male age group the highest positive cases were found in the age greater than 85. The incidence age standard rate per 100,000 in females and male was 3.3 and 0.2, respectively. In sum, the age standardized incidence of breast cancer was relatively low. However, it is our opinion that the low prevalence may be due to low awareness and a highly centralized screening and diagnostic services. This limits access. Altogether, it is our opinion that breast cancer presents a burden to Eritrean ministry of health.

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The Relationship between Dairy Products Intake and Breast Cancer Incidence: A Meta-analysis of Observational Studies.

10.21203/rs.3.rs-548714/v1 ◽

2021 ◽

Author(s):

Yujing He ◽

Ping Chen ◽

Feifei Zhou ◽

Yuexiu Si ◽

Rongrong Fu ◽

...

Keyword(s):

Breast Cancer ◽

Protective Effect ◽

Dairy Products ◽

Meta Analysis ◽

Breast Cancer Incidence ◽

Cochrane Library ◽

Female Population ◽

Fermented Dairy Products ◽

Fermented Dairy ◽

The Relationship

Abstract Background: The effect of dairy products intake on breast cancer (BC) is highly controversial. This study aims to investigate the relationship between dairy intake and BC incidence.Methods: A search was carried out in PubMed, EBSCO, Web of Science, and Cochrane Library databases before January 2021. The primary endpoint was the relationship between intake of dairy products and BC risk. Results: The meta-analysis comprised 36 articles with 1,019,232 participants. Total dairy products have a protective effect on female population (hazard ratio (HR) =0.95, 95% confidence interval (CI) =0.91-0.99, p=0.019), especially for estrogen receptor-positive (ER+) (HR=0.79, p=0.002) and progesterone receptor-positive (PR+) BC (HR=0.75, p=0.027). For ER+/PR+ BC, there is a trend of protection, but it has not reached statistical significance (HR=0.92, p=0.075). Fermented dairy products can reduce BC risk in postmenopausal population (HR=0.96, 95%CI=0.93-0.99, p=0.021), but have no protective effect on premenopausal population (HR=0.98, 95%CI=0.94-1.03, p=0.52). Non-fermented dairy products have no significant effect on BC occurrence (p>0.05). High-fat dairy products are harmful to women, without statistical difference (HR=1.06, 95%CI=1.00-1.13, p=0.066). On the contrary, low-fat dairy products can protect the premenopausal population (HR=0.94, 95%CI=0.89-1.00, p=0.048).Conclusion: The intake of dairy products can overall reduce BC risk in the female population, but different dairy products have varying effects on different BC subtypes and menopausal status.

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