Mandibular cortical index in the screening of postmenopausal at low mineral density risk: a systematic review

2021 ◽  
pp. 20200514
Author(s):  
Luciana Munhoz ◽  
Lucas Morita ◽  
Aline Yukari Nagai ◽  
Julia Moreira ◽  
Emiko Saito Arita
Keyword(s):  
Systematic Review ◽  
At Risk ◽  
English Language ◽  
Panoramic Radiography ◽  
Original Research ◽  
Mineral Density ◽  
Cortical Index ◽  
The Subject ◽  
Mandibular Cortical Width ◽  
Mandibular Cortical Index

Objectives: This systematic literature review addressed the use of mandibular cortical index (MCI), assessed by panoramic radiography, for the identification of postmenopausal women at risk of osteoporosis. Methods: Databases were searched for original research studies published from September 2010 to September 2020 using the following keywords: “postmenopausal osteoporosis” and synonyms combined with “panoramic radiography” and synonyms. Only English language manuscripts and studies pertaining to the MCI were selected. Results: A total of 24 studies were included. The publications were highly heterogeneous in terms of the subject of interest, i.e. the MCI, with some studies comparing the usefulness of the MCI using panoramic radiography and using cone beam computed tomography, and others comparing different radiomorphometric indexes developed for panoramic radiography. Conclusions: Based on the literature included in this systematic review, we conclude that the MCI is useful as an auxiliary tool for identifying postmenopausal females at risk of low bone mineral density (BMD), as it correlates with skeletal BMD measured by dual X-ray absorptiometry. Nevertheless, other radiomorphometric indexes obtained from panoramic radiographs, such as panoramic mandibular index, mental index, and mandibular cortical width, are also valuable as auxiliary tools in the identification of postmenopausal females at risk, as they also correlate with BMD. Thus, it is not possible to affirm which index is the most reliable for the identification of postmenopausal females considering the literature screened. PROSPERO registration systematic review CRD42020208152.

scholarly journals The accuracy of panoramic radiography as a screening of bone mineral density in women: a systematic review

2020 ◽  
Vol 49 (2) ◽  
pp. 20190149
Author(s):  
Mateus Azevedo Kinalski ◽  
Noeli Boscato ◽  
Melissa Feres Damian
Keyword(s):  
Bone Mineral Density ◽  
Systematic Review ◽  
Bone Mineral ◽  
Panoramic Radiography ◽  
Meta Analysis ◽  
High Sensitivity ◽  
Test Accuracy ◽  
Mineral Density ◽  
Cortical Width ◽  
Mandibular Cortical Width

Objectives: A systematic review and meta-analysis of diagnostic test accuracy studies was conducted to assess if the radiomorphometric indexes observed in panoramic radiographies could estimate reduced bone mineral density (BMD) similarly to standard technique the bone densitometry (dual energy X-ray absorptiometry) in females older than 30 years. Methods: A systematic search in four databases was conducted until January 2019. Two evaluators performed data extraction and evaluation of risk of bias independently, and agreement was achieved by consensus. Data were synthesized on a subgroup meta-analysis with a random effect model and the hierarchical summary receiver-operating characteristic curve was used to calculate pooled estimates of studies. Results: Thirty three studies were included and 12 different radiomorphometric indexes identified, including Mandibular Cortical Index (MCI). The final number of cases pooled for the analysis was 5266 females.The MCI for BMD loss (osteopenia) presented values of sensitivity 0.81 [95% confidence interval (CI), 0.78–0.84] and specificity 0.48 (95% CI, 0.45–0.50), while for osteoporosis sensitivity 0.35 (95% CI, 0.30–0.40) and specificity 0.88 (95% CI, 0.86–0.90). The mandibular cortical width presented values of sensitivity 0.58 (95% CI, 0.40–0.73), specificity 0.73 (95% CI, 0.60–0.83) for osteopenia, while for osteoporosis sensitivity 0.57 (95% CI, 0.36–0.76) and specificity 0.83 (95% CI, 0.68–0.92). Due to the high sensitivity, MCI presented a potential value as a screening tool for initial BMD loss (osteopenia), once tests presenting high sensitivity are described as rarely missing subjects with the disease. To the other hand, MCI to osteoporosis and Mandibular Cortical Width for both conditions are not recommended because presented specificity higher than sensitivity. Conclusion: The MCI can be recommended as a feasible tool to screen initial BMD loss (osteopenia) in females above 30 years old using panoramic radiography exams.

Randomized Controlled Trials of Headache Treatments in Pregnancy: A Systematic Review

2020 ◽  
Author(s):  
Elisa T. Bushman ◽  
Gabriella Cozzi ◽  
Rachel G. Sinkey ◽  
Catherine H. Smith ◽  
Michael W. Varner ◽  
...  
Keyword(s):  
Systematic Review ◽  
At Risk ◽  
English Language ◽  
Statistical Significance ◽  
Cochrane Library ◽  
Control Group ◽  
Inclusion Criteria ◽  
Headache Diagnosis ◽  
Registration Number ◽  
In Pregnancy

Abstract Objective Headaches affect 88% of reproductive-aged women. Yet data are limited addressing treatment of headache in pregnancy. While many women experience improvement in pregnancy, primary and secondary headaches can develop. Consequently, pregnancy is a time when headache diagnosis can influence maternal and fetal interventions. This study was aimed to summarize existing randomized control trials (RCTs) addressing headache treatment in pregnancy. Study Design We searched PubMed, CINAHL, EMBASE, ClinicalTrials.gov, Cochrane Library, CINAHL, and SCOPUS from January 1, 1970 through June 31, 2019. Studies were eligible if they were English-language RCTs addressing treatment of headache in pregnancy. Conference abstracts and studies investigating postpartum headache were excluded. Three authors reviewed English-language RCTs addressing treatment of antepartum headache. To be included, all authors agreed each article to meet the following criteria: predefined control group, participants underwent randomization, and treatment of headache occurred in the antepartum period. If inclusion criteria were met no exclusions were made. Our systematic review registration number was CRD42019135874. Results A total of 193 studies were reviewed. Of the three that met inclusion criteria all were small, with follow-up designed to measure pain reduction and showed statistical significance. Conclusion Our systematic review of RCTs evaluating treatment of headache in pregnancy revealed only three studies. This paucity of data limits treatment, puts women at risk for worsening headache disorders, and delays diagnosis placing both the mother and fetus at risk for complications.

Biosafety Evaluation of Nanoparticles in View of Genotoxicity and Carcinogenicity Studies: A Systematic Review

2013 ◽  
Vol 543 ◽  
pp. 200-203 ◽  
Author(s):  
Hasan Turkez ◽  
Kubra Celik ◽  
Bulent Cakmak
Keyword(s):  
Systematic Review ◽  
Food Packaging ◽  
English Language ◽  
Keyword Search ◽  
Consumer Products ◽  
Original Research ◽  
Carcinogenic Potential ◽  
Water Cleaning

Nanoparticles (NPs) are used in various forms in consumer products including, cosmetics, food packaging, textiles and also in air and water cleaning, production of electro chromic windows, or smart windows and gas sensors. Many NPs have also been evaluated for potential use in biomedical applications as efficient delivery carriers for cancer diagnosis and therapy. Nowadays, NPs are being developed to create fascinating nanotechnology products. To develop NPs for broad applications, potential risks to human health and the environment should be evaluated and taken into consideration. Again, to translate these nanomaterials to the clinic and industrial domains, their biosafety needs to be verified, particularly in terms of genotoxic and carcinogenic effects. To evaluate evidenced-based practices for NPs safety, we performed a systematic review of the published English-language literature. We performed a systematic keyword search of PubMed for original research articles pertaining to reports on assessment of risks due to carcinogenic and mutagenic effects by different NPs. We identified 362 original articles available for analysis. The included studies were published between 1993 and 2012. The in vivo or in vitro genotoxicity studies were performed on only 18 out of 148 kinds of NPs in industry today. Likewise, the carcinogenicity investigations were performed on only 14 out of 148 NPs. The 10 types of the NPs including some titanium, aluminium, carbon black and silver molecules were found to have both mutagenic and carcinogenic potential. The important finding was also that there is a lack of systematic assessment of the DNA damaging and carcinogenic potential of NPs in spite of their extensive use in nanotechnological applications.

scholarly journals Interventions to Mitigate COVID-19 Misinformation: Protocol for a Scoping Review

2021 ◽  
Author(s):  
Navin Kumar ◽  
Nathan Walter ◽  
Kate Nyhan ◽  
Kaveh Khoshnood ◽  
Joseph D Tucker ◽  
...  
Keyword(s):  
Systematic Review ◽  
Scoping Review ◽  
English Language ◽  
Current Knowledge ◽  
Grey Literature ◽  
Open Science ◽  
Original Research ◽  
Study Selection ◽  
Scoping Reviews ◽  
Science Framework

Abstract Background: The duration and impact of the COVID-19 pandemic depends in a large part on individual and societal actions which is influenced by the quality and salience of the information to which they are exposed. Unfortunately, COVID-19 misinformation has proliferated. To date, no systematic efforts have been made to evaluate interventions that mitigate COVID-19-related misinformation. We plan to conduct a scoping review that seeks to fill several of the gaps in the current knowledge of interventions that mitigate COVID-19-related misinformation.Methods: A scoping review focusing on interventions that mitigate COVID-19 misinformation will be conducted. We will search (from January 2020 onwards) MEDLINE, EMBASE, CINAHL, PsycINFO, Web of Science Core Collection, Africa-Wide Information, Global Health, WHO Global Literature on Coronavirus Disease Database, WHO Global Index Medicus, and Sociological Abstracts. Grey literature will be identified using Disaster Lit, Google Scholar, Open Science Framework, governmental websites and preprint servers (e.g. EuropePMC, PsyArXiv, MedRxiv, JMIR Preprints). Study selection will conform to Joanna Briggs Institute Reviewers’ Manual 2020 Methodology for JBI Scoping Reviews. Only English language, original studies will be considered for inclusion. Two reviewers will independently screen all citations, full-text articles, and abstract data. A narrative summary of findings will be conducted. Data analysis will involve quantitative (e.g. frequencies) and qualitative (e.g. content and thematic analysis) methods.Discussion: Original research is urgently needed to design interventions to mitigate COVID-19 misinformation. The planned scoping review will help to address this gap.Systematic Review registrations: Systematic Review Registration: Open Science Framework (osf/io/etw9d).

scholarly journals Does type 2 diabetic osteoporotic patients present more periodontal risks than non-osteoporotic patients? An evaluation with mandibular cortical index (Klemetti)

2018 ◽  
Vol 17 ◽  
pp. e181211
Author(s):  
Wladimir Gushiken de Campos ◽  
Gonzalo André Montesinos ◽  
Rosa Cristina Peinado Agudo ◽  
Kaisermann Costa ◽  
Luciana Munhoz ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Bone Loss ◽  
Periodontal Disease ◽  
Diabetic Patients ◽  
Mineral Density ◽  
Cortical Index ◽  
Increased Risk ◽  
Type 2 Diabetic ◽  
Mandibular Cortical Index

Aim: This study aim was to evaluate if patients with type 2 diabetes and osteoporosis have an increased risk of periodontal disease (horizontal and vertical bone loss) when compared to diabetic patients without osteoporosis. Additionally, to assess if patients with diabetes and osteoporosis have a greater risk of reduction of bone mineral density in the mandible, expressed by mandibular cortical index (MCI) when compared to diabetic patients without osteoporosis. Methods: 59 patients (39 diagnosed with type 2 diabetes and osteoporosis; 20 diagnosed with type 2 diabetes and without osteoporosis) were selected. Type 2 diabetes was previously diagnosed by glycated hemoglobin examination and osteoporosis by peripheral dual-energy x-ray absorptiometry. Mandibular cortical index, as well as the presence of vertical and horizontal bone loss was verified on panoramic radiographs. Adjusted odds ratio analyses were performed on presence of periodontal disease and MCI considering the effect of osteoporosis. Results: Absence of statistical significance between variables was found. Conclusions: There is no difference between the risk of periodontal disease or low MCI among osteoporotic and non-osteoporotic type 2 diabetic patients.

scholarly journals Do HIV patients have mandibular osteoporotic alterations? A mandibular cortical index case-control study

2020 ◽  
Vol 24 (1) ◽  
Author(s):  
Aline Nagai ◽  
Lucas Morita ◽  
Luciana Munhoz ◽  
Emiko Arita
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Panoramic Radiograph ◽  
Control Group ◽  
Mineral Density ◽  
Significance Level ◽  
Panoramic Radiographs ◽  
Cortical Index ◽  
Control Study ◽  
Mandibular Cortical Index

Objective: The objective of this study was to evaluate mandibular osteoporotic alterations in patients with HIV infection in comparison to non-HIV-infected patients using panoramic radiographs. Material and Methods: 26 HIV-infected patients and 142 non-HIV-infected patients (control group) were included in this study. Panoramic radiographs of the participants were assessed considering mandibular cortical index (MCI). Non-parametric comparisons between groups were performed, using Mann-Whitney test, at a level significance level of p= 0.05. Results: HIV-infected patients presented lower bone mineral density (BMD) at mandible, assessed by MCI in panoramic radiographs when compared to non-HIV-infected patients. The medication intake of HIV-infected patients was highly heterogeneous and could not be associated to the low BMD presented in the mandibular cortex. Conclusions:  HIV-infected patients may present lower mandibular BMD than non-HIV-infected patients.   Keywords Panoramic radiograph; osteoporosis; bone mineral density; HIV.

scholarly journals MANDIBULAR BONE QUALITY OF PANORAMIC RADIOGRAPHS IN HIV-INFECTED CHILDREN

2020 ◽  
Vol 5 (1) ◽  
pp. 85
Author(s):  
Ria Noerianingsih Firman ◽  
Irna Sufiawati ◽  
Risti Saptarini Primarti ◽  
Aga Satria Nurrachman ◽  
Merry Annisa Damayanti
Keyword(s):  
Bone Quality ◽  
Mental Foramen ◽  
People Living With Hiv ◽  
Mineral Density ◽  
Cross Sectional ◽  
Mandibular Bone ◽  
Panoramic Radiographs ◽  
Cortical Index ◽  
Inferior Border ◽  
Mandibular Cortical Index

Background: People living with HIV may have several pathologic conditions in its body and bone is one of the organs affected by HIV infection. HIV-infected patients have been associated frequently with osteoporosis and lower bone mineral density (BMD) which may lead to the increasing risk of bone fracture. This situation may become more complicated in children and young age as it will affect the long-term bone quality and development later in life until the peak BMD is reached. Objectives: The aim of this study was to measure the mandibular bone quality using the mandibular cortical index (MCI) and panoramic mandibular index (PMI) in panoramic radiographs of HIV-infected children. Method: This study used descriptive cross sectional research design which analyzed panoramic radiographs of HIV-infected children and measured its mandibular bone quality. Total 43 panoramic radiographs of HIV-infected children were observed and analyzed qualitatively using mandibular cortical index (MCI) and panoramic mandibular index (PMI) were used for the quantitave measurement, as it have been widely used for assesing mandibular bone quality in previous studies. Mandibular cortical index (MCI) has 3 categories of cortical bone quality: C1 (normal cortex), C2 (mildly to moderately eroded cortex), and C3 (severely eroded cortex), while the normal ratio of mental foramen-inferior border of mandible to mandibular cortical length in panoramic mandibuIar index is about 0.3. Result: Mandibular cortical index (MCI) of 43 HIV-infected children consist of 4 samples in C1, 38 in  C2, 1 in C3, while the panoramic mandibular index (PMI) of 43 HIV-infected children consist of 23 less than normal, 5 normal, 15 more than normal. Conclusions: The most number of mandibular cortical index (MCI) was C2 (mildly to moderately eroded cortex) and the most number of panoramic mandibular index (PMI) was less than normal of HIV-infected children.

scholarly journals Outcomes of Renal Stone Surgery Performed Either as Predonation or Ex Vivo Bench Procedure in Renal Grafts from Living Donors: A Systematic Review

2020 ◽  
Vol 2020 ◽  
pp. 1-9
Author(s):  
Nicola Longo ◽  
Armando Calogero ◽  
Massimiliano Creta ◽  
Giuseppe Celentano ◽  
Luigi Napolitano ◽  
...  
Keyword(s):  
Systematic Review ◽  
Success Rate ◽  
Complication Rate ◽  
English Language ◽  
Ex Vivo ◽  
Living Donors ◽  
Original Research ◽  
Extracorporeal Shock Wave ◽  
Renal Grafts ◽  
Bench Surgery

Aims. We aimed to summarize available evidence about intraoperative and postoperative donors’ and recipients’ outcomes following stone surgery in renal grafts from living donors performed either before donation or as ex vivo bench surgery at the time of living-donor nephrectomy. Methods. A systematic review of PubMed, ISI Web of Knowledge, and Scopus databases was performed in September 2020. We included full papers that met the following criteria: original research, English language, human studies, and describing the results of stone surgery in renal grafts from living donors performed either before transplantation or as ex vivo bench surgery. Results. We identified 11 studies involving 106 patients aged between 22 and 72 years. Predonation and bench stone surgery was performed in 9 (8.5%) and 96 (90.6%) patients, respectively. Predonation stone surgery involved extracorporeal shock wave lithotripsy, retrograde intrarenal surgery, and percutaneous nephrolithotomy in 8, 1, and 1 patient, respectively. The overall success rate of predonation stone surgery was 78%, and the complication rate was 0%. Bench stone surgery involved ureteroscopy, pyelolithotomy, or a combination of both in 79 (82.3%), 10 (10.4%), and 7 (7.3%) cases, respectively, with an overall success rate of 95.8% and an overall complication rate of 9.37%. Conclusions. Predonation and bench stone surgery in grafts from living donors represents efficacious and safe procedures. Further studies on wider series with a longer follow-up are required.

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