scholarly journals POLYMORPHISM OF PARAOXONASE-1 GENE (PON1) AND ITS ASSOCIATION WITH ECONOMIC TRAITS OF HOLSTEIN CATTLE

2020 ◽  
Vol 15 (3) ◽  
pp. 43-48
Author(s):  
Natal'ya Safina ◽  
Shamil' Shakirov ◽  
El'za Gaynutdinova ◽  
Ziliya Fattahova

The purpose of the research was to study the polymorphism of the paraoxonase-1 gene with the replacement of A with G in the promoter region, as well as to evaluate the growth, milk productivity and reproductive ability of Holstein heifers with different genotypes on this gene. The work was performed in 2018–2019 in the Republic of Tatarstan on 148 first-calf cows. Genotyping was conducted by PCR-RFLP in Bsc4I locus of PON1 gene. The studied population was polymorphic, the genetic balance was not disturbed. The distribution of alleles and genotypes was as follows: A – 0.564 and G – 0.436; AA – 31.8 % (48 animals), GA – 49.3 % (75 animals), GG – 18.9 % (28 animals). Animals with GA genotype of PON1 gene were not significantly better in terms of growth dynamics (kg) in control weighing from 6 to 18 months and of daily gain (g) in 6-18 months period. The cows from the same group were statistically significantly superior to heifers with AA and GG in terms of reproductive ability: fertility index of Dohi (56.2), calving interval (395.7 days), service period (122 days), and were distinguished by the early age of the first successful insemination (17.1 months). It was found that first-calf heifers with the GG genotype were better in milk yield per 305 days of lactation (7339.6 kg), milk fat yield (291.1 kg) and milk protein yield (254.6 kg). The identified associations of PON1 gene polymorphism can be used for the selection of parental pairs for targeted breeding to improve economically useful signs of Holstein cattle

2021 ◽  
Vol 282 ◽  
pp. 02007
Author(s):  
Natalia Safina ◽  
Shamil Shakirov ◽  
Elza Gaynutdinova ◽  
Ziliya Fattakhova

The aim of the work was to study the traits of dairy productivity of Holstein heifers with different genotypes of the paraoxonase-1 (PON1) gene. The research was conducted in 148 animals of Integrated Agricultural Production Centre “Stud farm named after Lenin” of Atninsky district of the Republic of Tatarstan. Genotyping of cattle was carried out by the PCR-RFLP method at the laboratory of the Department of Agrobiological Research of Tatar Scientific Research Institute of Agriculture, FRC Kazan Scientific Center, Russian Academy of Sciences. The results of allele and genotype calling of the PON1 gene showed that the study population is polymorphic and differs in genetic biodiversity. During the analysis of daity productivity, qualitative composition of milk and lactational activity, it was found that cow-heifers with the GG genotype of the PON1 gene were superior to animals with other genotypes in all the test parameters. Thus, it follows that the GG genotype of the PON1 gene has a positive effect on the economic characters of cattle, which can be used in breeding in the future.


Author(s):  
M. I. Kuziv ◽  
E. I. Fedorovych

The major components of economically useful traits in cattle dairy productivity, which conducted the selection is milk productivity and reproductive ability of cows. Studies conducted on animals Ukrainian black and white dairy cattle in the «Milk River» farm in the Sokal and Brody offices breeding reproducers «Breeder» Lviv region and plant breeding «Yamnytsya» Ivano–Frankivsk region. Ukrainian black and white dairy breed in the western region of Ukraine is characterized by good reproductive ability. Depending on the husbandry and lactation duration, service period lasted within 87.4 – 121.5 day, intercalving period – within 364 – 402.6 day, dry period within – 47.3 – 72.9 day, the fertility index was 46.3 – 48.0, coefficient of reproductive ability – within 0.92–0.99,  output of calves per 100 cows – within 91.8 – 98.8. The duration of pregnancy in cows of different  farms and lactations were in range 277 – 283.5 day and meet the requirements of the physiological norm. It has been shown that the milk yield of cows depends on the parameters of reproductive capacity. The correlation between duration of service–period and intercalving period, and milk yield, milk fat in most cases was positive. Correlation dry period duration and parameters of milk yield changed from negative to positive. Depending on the husbandry, lactation and index the impact share of service–period duration on milk yield was 7.0 – 29.7, for intercalving period – 8.8 – 31.8, for dry period – 9.2 – 23.8% respectively.


2007 ◽  
Vol 23 (3-4) ◽  
pp. 11-17
Author(s):  
Vlada Pantelic ◽  
Z. Skalicki ◽  
M.M. Petrovic ◽  
S. Aleksic ◽  
B. Miscevic ◽  
...  

Research included 3.461 first calving Simmental cows in control, with lactations concluded within one year. All first calving cows were reared by private/individual farmers on the territory of the Republic of Serbia. Phenotypic correlations between following milk and fertility traits have been investigated: duration of lactation DL, milk yield MY, milk fat content MFC, milk fat yield MFY, yield of 4% FCM, age at first calving AFC and duration of service period DSP. Results of the investigation of phenotypic correlations are obtained using mixed models LSMLMW (Harvey 1990). This method enables optimal consideration of numerous effects on investigated traits (bull sires, region, calving season, and calving year). Phenotypic correlation of traits in cattle breeding relates to presence of mutual positive or negative covariance which is result of the effect of genetic and factors of the environment. Information on phenotypic correlations between milk and fertility traits can be of great importance in selection of cows, since it provides possibility to choose/select heads based on several traits at the same time. .


2019 ◽  
Vol 35 (3) ◽  
pp. 219-228
Author(s):  
Vlada Pantelic ◽  
Dragan Niksic ◽  
Nevena Maksimovic ◽  
Dusica Ostojic-Andric ◽  
Marina Lazarevic ◽  
...  

The main goal of this research was to examine, using modern methods, the variability of phenotypic correlations of production performances and reproductive properties of Simmental cows reared on the farms of individual agricultural producers, in different breeding areas of the Republic of Serbia. The study of phenotypic correlations of milk performance and fertility properties in different regions of Serbia was carried out on a total of 3.056 primi parous Simmental heifers under control, with lactations completed within one year. The examined animals were reared on different individual farms, and mainly in very different conditions of housing and nutrition, depending on the breeding area. The study of phenotypic correlations included the following milk performance traits: milk yield, milk fat content, milk fat yield, yield of 4% corrected milk; and fertility properties: age at first calving and service period. The results of the study among other things indicate that although the phenotypic correlations between the fertility and milk performance properties show different degrees of variation, they should be taken into account in the final assessment of the breeding value of the animal, so that the breeding selection programs are more comprehensively designes.


Author(s):  
V. V. Fedorovych ◽  
T. V. Orihivskyy ◽  
N. P. Babik ◽  
E. I. Fedorovych ◽  
R. S. Oseredchuk

There are indicators data of body weight, body parts measurements, reproductive ability, milk production, morphological and functional properties of udder, the duration of use and economic reasons of disposal of Simmental cows in terms of Lviv oblast. It was established that the experimental cows by live weight during their growth in all ages have been prevailing minimum requirements of breed standard. They are marked by peculiar to combined breed type of body structure with well–defined not only milk but also meat forms, they had strong skeleton and were quite tall (withers height – 131.1 cm). However, the width of the breast in most cows, that is not enough for combined breed (on an average 41.4 cm). Simmentals age at the moment of the 1st insemination was 19.7, while during the 1st calving – 29.0 months, the duration of the service–period, depending on lactation, was within 96.8 – 112.0, of inter–calving period – within 381.6 – 396.9 day. They were characterized by an average fertility and high adaptablity. Simmentals milk yield, depending on lactation, was 3026,4–3810,2 kg, fat content in milk – 3.76 – 3.81% and quantity of milk fat 113.6 – 145.0 kg. Cows after the 4th calving had the highest milk productivity. During the all studied lactations cows milk yield and quantity of milk fat predominated breed standard. They had a well developed udder. 68.2% cows after the first calving had cupped udder, 25.9% – wash–tub and 6.9% – round udder. Their intensity of milk yield was 1.53 kg/min. Simmental cows duration of economic use in the conditions of Lviv oblast was 1.904.1 day or 5.3 lactations, lifetime yield – 18011, lifetime quantity of milk fat – 688 kg. Most reasons for dropped out of the herd was dysfunction of reproduction (35.7%) and low productivity (21.3%).


Author(s):  
A. Bolgov ◽  
S. Shterkel ◽  
N. Grishina

The purpose of the study is to study the relationship between the rates of dairy productivity and reproduction of cows in the highly productive Ayrshire herds of the Republic of Karelia.Materials and methods. The work was performed on the basis of the four Stud of the Airshire rock at the "Megrega" trivial, "Ilyinskoe", Mayak LLC, Agrocomplex OJSC. V. M. Zaitseva "(Republic of Karelia). Data on dairy productivity and reproductive ability are collected and processed in 24,720 cows. Materials of zootechnical accounting and bonitations for 2004-2020 were used. At the end of the observation period, the productivity of the Stud was 7500-8500 kg of milk.From indicators of the productivity of cows, the amount of fishing, fat products for full lactation and 305 days of lactation, from the reproduction indicators - the duration of the service period, a dry period, an interstitial period (MOP), the age of the first calf, the age of cows during the selection, the causes of the selection are taken.The main biometric constants (X ̅, ϭ, CV) were calculated, the grouping method was used to characterize the signs of signs calculated the correlation coefficients.Results. The relationship between milk productivity and reproduction was studied in 4 Ayrshire herds of 24,720 cows with an average productivity of 7500-8500 kg of milk. A high positive relationship of milk yield and milk fat production with the duration of the service period (SP) was established, the correlation coefficient was up to 0.929 (P<0.001), which is consistent with the data of other researchers of this problem. It is shown that in herds with a milk yield of 8500-9000 kg of milk, the SP duration of 135-140 days is justified. It was noted that the decrease in the age of the first calving of cows led to an increase in the milk yield of the entire herd (r =-0.676; -0.686; P<0.05).A relatively short period of use of cows in herds was recorded – 3.5-3.7 lactations, while the milk yield of cows aged six lactations and older significantly exceeded the average milk yield for the herd. This leads to a positive correlation of the period of use of cows (r =0.935; P<0.001) and the proportion of cows with six lactation and older (r =0.788; P<0.05) with the milk yield of the herd. Cows with six lactations and older can stay in the herd, provided that their performance exceeds the average level of the herd. The influence of milk yield on the length of the service period and the MOP is manifested not only within one lactation, but also in adjacent lactation. It was found that with an increase in milk yield from less than 6000 kg of milk to 9500-10000 kg or more in the previous lactation, the duration of SP in the subsequent lactation increased from 112 to 170 days, MOP – from 391 to 436 (correlation coefficients from 0.138 (P<0.01) to 0.870 (P<0.001).Conclusion. The results obtained indicate the need to develop operating conditions for cows that provide a combination of high and record milk yield with normal reproductive abilities. In particular, to ensure maximum optimization of feeding conditions, maintenance, breeding and veterinary services, and control of animal health.


2018 ◽  
Vol 7 (4.38) ◽  
pp. 1115
Author(s):  
Feyzullah Ramazanovich Feyzullayev ◽  
Vadim Anatolyevich Babushkin1, Anatoly Vladimirovich ◽  
Anatoly Vladimirovich Bakai ◽  
Tatiana Viktorovna Lepekhina

During its formation and improvement, cattle acquired a number of biological and economic-useful qualities, which allowed identifying separate groups of animals with high productivity and productive longevity. One of the main criteria for cow selection for further breeding is the quantity and quality of dairy products [4]. Profitability of dairy farming largely depends on both milk yield and the reproductive ability of cows. Troubled calving and subsequent diseases and complications affect the state of the animal organism; preservation and restoration of the health of a cow after troubled calving require considerable expenses. This research was aimed at examining milk production in cows with easy and troubled calving. To achieve this goal, in the studied number of cows with easy and troubled calving, the authors analyzed the following parameters: milk yield during the first lactation, fat and protein mass fraction, the amount of milk fat and milk protein; milk productivity was also studied, depending on the age at first insemination and the duration of the service period. It has been found that milk yields in the cows with troubled calving were higher than in the cows with easy calving. The influence of the age at the first fruitful insemination on the further milk productivity has been determined: the highest yields were obtained from the cows with the age at the first fruitful insemination in the interval between 15.1 and 17.0 months. The maximum milk yields during the first lactation – 6,206 kg - were observed in the cows with relatively short service period (61 to 90 days).  


2020 ◽  
Vol 21 (4) ◽  
pp. 434-442
Author(s):  
S. V. Titova ◽  
V. A. Zabiyakin

The article presents the results of the research on the comparative study of the main economically valuable traits of dairy cattle of various origin. The population of Holstein cows of black-and-white breed was taken as the object of the study. Source material for the research was provided by data of breeding records (n = 4848) of cows from breeding plant "Semyonovsky", Medvedevsky district, Mari El Republic. The breeding stock of the herd was presented by four lines: Vis Bek Idial 1013415 – 55.6 %, Reflection Sovering 198998 – 36.9 %, Montvik Chieftain 95679 – 6.7 % and Siling Trijun Rokit 252803 – 0.3 %. Animals of V. B. Idial line were most productive. They were superior to the representatives of other lines: in milk yield by 448-891 kg of milk (7.1-15.2 %) (p>0.99), in milk fat yield – by 17.5-35.0 kg (7.3-15.7 %) (p>0.99), in milk protein – by 4.7-28.6 kg (7.4-15.5 %) (p>0.99) and they had a high coefficient of milking capacity of 1323 kg. Animals of all lines except S. T Rokit line were characterized by a uniform (stable) lactation curve, the coefficient of lactation stability was 93 %. The lowest age of the first calving was observed in animals of the R. Sovering line (26.5 months), the highest – in the S. T. Rokit line (30.7 months). The duration of the service period in the V.B. Idial line was 129.4 days, that was higher than this indicator for other lines by 8.3-11 days (6.8-9.3 %) (p>0.95-0.99). The duration of the calving interval in all studied lines exceeded the optimal one (365 days) and changed in accordance with the change of the service period. A high index of fecundity was in cows of V. B. Ideal line (45.3), a low index - in S. T. Rokit line (37.2). In the studied lines, the coefficient of reproductive ability that characterizes the fertility of cows was 0.90-0.92, in S. T. Rokit line – 0.84.


2020 ◽  
Vol 60 ◽  
pp. 61-70
Author(s):  
N. Pelekhaty ◽  
D. Kucher ◽  
O. Kochuk-Yashchenko ◽  
A. Lypianets

The results of the studies carried out highlight the assessment of the adaptive ability of Jersey cows. The conditions of keeping Jersey cows in the Dan Milk subsidiary contribute to the realization of high milk productivity, which is due to heredity, but cause a deterioration in their reproductive capacity. At the same time, a high manifestation of milk productivity and satisfactory reproductive ability have observed only in the daughters of DJ Jante 302761 – whose adaptation index was closer to zero and amounted to -2.7. The force of influence (ηx2) of paternal origin on the signs of milk production in first-calf calfs was 21.1% versus 5.9% of the generalized mean value for cows belonging to the line. It has been founded that according to the adaptation index, the state of animals those characterized by the absence of harmonious interaction with the environment – cows show high productivity with a significant deterioration in reproductive capacity, which indicates the presence of a feedback between these characteristics. It was found not high enough, but statistically significant influence (P < 0.01 – P < 0.001) on the adaptation level of first-calf cows by milk yield for 305 days of lactation (8.0%), milk fat and protein (7.0%). A statistically significant effect (ηx2 = 82%) of the signs of reproductive ability of cows (service period and period between calving) was found depending on their level of adaptation (P < 0.001). With an increase in the level of milk production of cows, was established a clear connection between the deterioration of the adaptive qualities of livestock. So with an increase in milk yield for the entire lactation from 6000 to 10000 kg of milk, the adaptation index decreases from -0.5 to -9.5, which is confirmed by a statistically significant difference between the extreme groups of animals with different levels of productivity (P < 0.001). According to the adaptation index, the condition of animals were characterize by the lack of harmonious interaction with the environment - cows show high milk productivity with a significant deterioration in reproductive capacity, which indicates the inverse relationship between these traits. The influence of the father and belonging to the lines on such indicators of milk productivity as: yield for 305 days of lactation, milk fat and protein (P < 0.05 – P < 0.001) was statistically significant. Significant effect of increasing the level of milk yield of cows was observed on such signs of reproductive capacity as: service period, period between calves and reproductive ability coefficient (P < 0,001). There was no statistically significant effect of belonging to the lines and offspring of specific breeders on the signs of reproduction of cows in general (P > 0.05). We found that the reproductive quality of cows is more influenced by the level of milk yield of cows during lactation (23.1%, at P < 0.001), which is confirmed by our previous studies. The conditions of keeping Jersey cows in the Dan Milk State Enterprise contribute to the realization of high milk productivity, which is due to heredity, but causes a deterioration in their reproductive capacity.


Author(s):  
Soloveva Yu.A. ◽  
Borisova N.V.

Polymorphisms of different genes can predispose people to various diseases. They can influence the body's physiological response to exogenous risk factors. Polymorphisms of the endothelial dysfunction genes NOS3 and CYBA contribute to the development of socially significant diseases, such as acute coronary syndrome, stroke, as well as diseases accompanied by fibrotic changes (cirrhosis of the liver, pulmonary fibrosis, etc.). Therefore, the study of these genes in the Yakut population seems relevant. The present study involved 124 healthy volunteers, their ethnicity is Yakuts (including Yakuts in the third generation, living in the Republic of Sakha (Yakutia)). Genetic analysis of polymorphisms was performed by the method of polymerase chain reaction of restriction fragment length polymorphisms (PCR-RFLP). The study found that healthy Yakuts have GG homozygote of rs1799983 of the NOS3 gene in 83.87%, GT - 15.32%, TT - 0.81%. The frequency of the G allele was 91.53%, the T allele - 8.47%. The study found that healthy Yakuts have CC homozygote of rs4673 of the CYBA gene in 75.0%, CT - 21.77%, TT - 3.23%. The frequency of C allele was 91.44%, T - 8.56%. These results are consistent with the literature data. Thus, the research of the polymorphism rs1799983 of the NOS3 gene and rs4673 of the CYBA gene in various ethnic groups could have encouraging prospects in the personalized medicine for predicting pathological conditions associated with endothelial dysfunction: liver fibrosis, cardiovascular diseases, obstetric and gynecological pathologies, dysfunctions of various organs and systems.


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