scholarly journals Q223R Polymorphism of the LEPR and obesity

2016 ◽  
Vol 1 (5) ◽  
pp. 170-174
Author(s):  
Шенеман ◽  
Ekaterina Sheneman ◽  
Иевлева ◽  
Kseniya Ievleva ◽  
Рычкова ◽  
...  
Keyword(s):  
Body Fat ◽  
Genetic Disorders ◽  
Adolescent Females ◽  
Normal Weight ◽  
Overweight And Obesity ◽  
Clinical Group ◽  
Body Fat Percentage ◽  
Fat Percentage ◽  
Hip Circumference ◽  
Leptin Receptors

The problem of overweight and obesity is one of the most urgent health issues in the world. 13% of girls and 21% of boys aged 11 suffer from overweight in the Russian Federation.The main causes of pubertal obesity are endocrine pathology, lifestyle and genetic disorders including mutation and polymorphisms of different metabolic pathways. Leptin produced in adipose tissue participates in reproduction regula-tion, glucose homeostasis, bone formation, etc. These effects are provided by leptin receptors coding LEPR gene. Q223R (rs1137101) polymorphism is associated with an increased serum level of leptin and overweight. There is no exact information about association between this polymorphism and obesity of adolescent females. The objective was to reveal LEPR Q223R polymorphism association between overweight and obesity in adolescent females.123 Caucasian adolescent females were involved in this study. All samples could be separated into two groups: the girls with normal weight (SDS BMI ±1.0; controlgroup), girls with overweight and obesity (SDS BMI≥ +1.0–2.0; studied group). Anthropometric measurements (weight, height, waist and hip circumference, body fat percentage) were taken, and genotyping was performed using polymerase chain reaction with electrophoresis detection.G-allele frequency was 43.1% in control and 40% in the clinical group. We found no significant differences of the prev-alence of polymorphism Q223Rbetween the studied groups (р=0,862). Furthermore, there was no association between the carriage of AG and GG with weight, BMI, body fat percentage, waist and hip circumference in both groups (р> 0.05).We have not found any association between LEPR Q223R and overweight and obesity in adolescent females.

Characterization and prevalence of obesity among normal weight college students

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Kara C. Anderson ◽  
Katie R. Hirsch ◽  
Austin M. Peterjohn ◽  
Malia N.M. Blue ◽  
Alexis A. Pihoker ◽  
...  
Keyword(s):  
College Students ◽  
Body Fat ◽  
Fat Mass ◽  
Vigorous Physical Activity ◽  
Normal Weight ◽  
High Density ◽  
High Density Lipoproteins ◽  
Cardiometabolic Health ◽  
Body Fat Percentage ◽  
Fat Percentage

AbstractNormal weight obesity (NWO) describes individuals who have a normal weight body mass index (BMI), but have an unhealthy amount of body fat. Based on the life-long habits that develop during college, exploring NWO among a college-aged population may be essential in identifying and preventing obesity that develops in early adulthood. This study aimed to characterize NWO among young adults with normal weight BMI. 94 college students (Mean ± SD: Age: 19.6 ± 1.5 yrs; BMI: 21.9 ± 1.8 kg/m2) enrolled during the Fall semester (Aug-Oct) were assessed for body composition by dual energy X-ray absorptiometry to determine body fat percentage, fat mass, lean mass and trunk fat; lifestyle habits were characterized from validated questionnaires. Mean arterial pressure and metabolic biomarkers [total cholesterol, high density lipoproteins, non-high density lipoproteins, and glucose] were evaluated for cardiometabolic health. NWO was defined using data from the National Health and Nutrition Examination Survey (NHANES) for body fat percentage. Data was analyzed by group (NWO vs NWL) and sex. with independent t-tests to investigate continuous data, and chi-square test of independence for categorical data. Rates of NWO for the total sample were 13.8%. Males (n=30) had a higher rate of NWO (26.7%) compared to females (n=64; 7.8%). NWO individuals had higher fat mass (p=0.024), trunk fat (p<0.001), and larger waist to hip ratio (p<0.001) than normal weight lean. NWO also engaged in less vigorous physical activity (p=0.043). The occurrence of NWO among otherwise healthy college students is evident. Identification of these individuals may be an effective component for obesity prevention and treatment. Determining feasible methods to measure body fat in this population is essential, as BMI may mask obesity in a young adult population.

scholarly journals Association of Non-alcoholic Fatty Liver Disease with Body Fat Percentage in Normal-Weight Individuals

2021 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Zeynab Hatamizargaran ◽  
Mohammadreza Sasani ◽  
Masoumeh Akhlaghi
Keyword(s):  
Risk Factors ◽  
Liver Disease ◽  
Fatty Liver ◽  
Body Fat ◽  
Fatty Liver Disease ◽  
Density Lipoprotein ◽  
Normal Weight ◽  
Body Fat Percentage ◽  
Fat Percentage ◽  
Study Results

Background: Recent data have suggested that nonalcoholic fatty liver disease (NAFLD) can occur in normal-weight subjects. This study examined the association of body fat percentage (BF%) with NAFLD and its risk factors in normal-weight individuals. Objectives: The present study aimed to explain the influence of body fat on the risk of NAFLD. Methods: A total of 59 subjects with body mass index (BMI) within the range of 18.5 - 24.9 kg/m2 were selected from referrals to two major university polyclinics in Shiraz, Iran, from April to June 2019. Fatty liver grade, anthropometric characteristics, body composition, and cardiometabolic risk factors were measured in this study. Results: Waist circumference (P = 0.012), fat mass (P < 0.001), triglycerides (TG) (P = 0.027), very-low-density lipoprotein (VLDL) (P = 0.007), and TG/high-density lipoprotein cholesterol (HDL-C) ratio (P = 0.003) increased; however, skeletal muscle mass decreased (P < 0.001) across the tertiles of BF%. The average of fatty liver grade was similar in the first and second tertiles; nevertheless, the fatty liver grade of participants in the third tertile was significantly higher (1.3 ± 0.9 vs. 0.4 ± 0.7; P = 0.005). In ordinal regression analysis, BF% (1.13; 95% CI: 1.04 - 1.22; P = 0.003), BMI (1.95; 95% CI: 1.02 - 3.74; P = 0.045), VLDL (1.77; 95% CI: 1.00 - 3.12; P = 0.049), and TG/HDL-C ratio (2.21; 95% CI: 1.26 - 3.86; P = 0.006) had positive associations with NAFLD; nonetheless, HDL-C (0.33; 95% CI: 0.16 - 0.67; P = 0.002) and dietary cholesterol (0.97; 95% CI: 0.95 - 0.997; P = 0.028) had inverse associations with NAFLD after the adjustments for age, gender, BMI, and physical activity. Conclusions: The results of this study suggested that within normal weight ranges, NAFLD occurs more frequently in individuals with higher BF%. In addition, BF% can be used as an important marker in NAFLD screening.

scholarly journals Accelerometer-determined peak cadence and weight status in children from São Caetano do Sul, Brazil

2017 ◽  
Vol 22 (11) ◽  
pp. 3689-3698
Author(s):  
Gerson Luis de Moraes Ferrari ◽  
Timóteo Araújo ◽  
Luis Carlos Oliveira ◽  
Victor Keihan Rodrigues Matsudo ◽  
Emily Mire ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Body Fat ◽  
Weight Status ◽  
Bioelectrical Impedance ◽  
Normal Weight ◽  
Body Fat Percentage ◽  
Obese Children ◽  
Fat Percentage ◽  
The Relationship ◽  
Brazilian Children

Abstract The purpose of this study was to determine the relationship between peak cadence indicators and body mass index (BMI) and body fat percentage (BF%)-defined weight status in children. The sample comprised 485 Brazilian children. Minute-by-minute step data from accelerometry were rank ordered for each day to identify the peak 1-minute, 30-minute and 60-minute cadence values. Data were described by BMI–defined and bioelectrical impedance-determined BF% weight status. BMI-defined normal weight children had higher peak 1-minute (115.5 versus 110.6 and 106.6 steps/min), 30-minute (81.0 versus 77.5 and 74.0 steps/min) and 60-minute cadence (67.1 versus 63.4 and 60.7 steps/min) than overweight and obese children (p<.0001), respectively. Defined using %BF, normal weight children had higher peak 1-minute (114.5 versus 106.1 steps/min), 30-minute (80.4 versus 73.1 steps/min) and 60-minute cadence (66.5 versus 59.9 steps/min) than obese children (p<.0001). Similar relationships were observed in boys; however, only peak 1- minute cadence differed significantly across BMI and %BF-defined weight status categories in girls. Peak cadence indicators were negatively associated with BMI and BF% in these schoolchildren and significantly higher among normal weight compared to overweight or obese children.

Abstract P028: Increased Cardiometabolic Risk And Autonomic Function Alterations In Normal Weight Obesity

Circulation ◽  
2021 ◽  
Vol 143 (Suppl_1) ◽  
Author(s):  
Alice P Duque ◽  
Isadora M Barbosa ◽  
Alessandra S Lins ◽  
Fernando G de Jesus ◽  
Christiane F Araújo ◽  
...  
Keyword(s):  
Body Fat ◽  
Cardiometabolic Risk ◽  
Autonomic Function ◽  
Normal Weight ◽  
Atherogenic Index ◽  
Body Fat Percentage ◽  
Fat Percentage ◽  
Double Product ◽  
Visceral Fat Area ◽  
High Body

Introduction: Normal weight obesity (NWO) is defined by the presence of normal body mass index (BMI) with high body fat percentage. In this setting, high body fat seems to affect even non-obese individuals, predicting cardiovascular risk. Hypothesis: High body fat percentage, in eutrophic individuals, affects anthropometry, hemodynamic, autonomic function and cardiometabolic risk. Methods: This cross-sectional study recruited workers of a public hospital from 2018 to 2020. Inclusion criteria: age ≥ 18 yr.; BMI: 18.5 to 24.9 Kg/m 2 . Exclusion criteria: pregnancy/lactating women; BMI < 18.5 Kg/m 2 or ≥ 25 Kg/m 2 . High body fat percentage was categorized, by sex and age, as: 20 to 39 years, >19.9% and >32.9%; 40 to 59 years, >21.9% and >33.9%; and 60 to 79 years, >24.9% and >35.9% for men and women, respectively. Blood assays: fasting glucose, lipid profile and C reactive protein; anthropometry: neck, waist and hip circumferences; bioimpedance: visceral fat area and body fat percentage; hemodynamic parameters: blood pressure and double product; autonomic function: orthostatic test (30:15 ratio), orthostatic hypotension test and heart rate variability (HRV): high and low frequency and sympathovagal index; cardiometabolic risk: body shape index, atherogenic dyslipidemia, atherogenic index, atherogenic index of plasma and Framingham score. Statistical analysis: Mann-Whitney and chi-squared test. P<0.05. Ethics: according to Helsinki declaration, revised in 2013. Results: A total of 52 from 241 volunteers were eutrophic: 23 were NWO, that exhibited higher visceral fat area, anthropometric measures, blood pressure and double product; and worse lipid profile, HRV frequency domain and cardiometabolic risk parameters compared to the 29 with normal body fat percentage (table 1) . Conclusions: NWO individuals have metabolic, hemodynamic, anthropometric and autonomic alterations that, associated with new indexes related to atherogenesis, confirm the early cardiometabolic risk of this profile.

scholarly journals Body Fat Percentage in Relation to Lung Function in Individuals with Normal Weight Obesity

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Yuan-Yuei Chen ◽  
Tung-Wei Kao ◽  
Wen-Hui Fang ◽  
Chung-Ching Wang ◽  
Yaw-Wen Chang ◽  
...  
Keyword(s):  
Lung Function ◽  
Body Fat ◽  
Normal Weight ◽  
Body Fat Percentage ◽  
Fat Percentage ◽  
Normal Weight Obesity

scholarly journals Comparison of predicted body fat percentage from anthropometric methods and from impedance in university students

2004 ◽  
Vol 92 (5) ◽  
pp. 827-832 ◽  
Author(s):  
Marta Arroyo ◽  
Ana M. Rocandio ◽  
Laura Ansotegui ◽  
Hector Herrera ◽  
Itziar Salces ◽  
...  
Keyword(s):  
University Students ◽  
Body Fat ◽  
Body Height ◽  
Reference Method ◽  
Bioelectrical Impedance ◽  
Impedance Analysis ◽  
Overweight And Obesity ◽  
Mean Difference ◽  
Body Fat Percentage ◽  
Fat Percentage

The objective of the present study was to compare different methods for evaluating body fat percentage (BF%) (anthropometric methods and bioelectrical impedance analysis) in university students. Subjects were 653 healthy students whose mean age, body height, body weight and BMI were 21·1 (SD 2·5) years, 166·0 (SD 8·4) cm, 62·8 (SD 11·0) kg and 22·7 (SD 3·1) kg/m2, respectively. Results showed that BMI is a poor predictor of body fatness since the sensitivity was low in comparison with the reference method (Siri equation). The lowest values of BF% were obtained using the reference method (Siri equation) (21·8 (SD 6·8)%). The two methods with the highest agreement were Siri and Lean (mean difference, −0·5), followed by Brozek (mean difference, −1·4) and Deurenberg (mean difference, −1·5). The largest mean difference for BF% was between Siri and impedance (−4·5). Although the methods and/or equations used in the present study have been commonly utilised to estimate BF% in young adults, the results must be interpreted with caution in the diagnosis and monitoring of overweight and obesity.

scholarly journals Serum IL-12 Is Increased in Mexican Obese Subjects and Associated with Low-Grade Inflammation and Obesity-Related Parameters

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
K. Suárez-Álvarez ◽  
L. Solís-Lozano ◽  
S. Leon-Cabrera ◽  
A. González-Chávez ◽  
G. Gómez-Hernández ◽  
...  
Keyword(s):  
Body Fat ◽  
Adult Population ◽  
Strong Relationship ◽  
Normal Weight ◽  
Low Grade ◽  
Body Fat Percentage ◽  
Fat Percentage ◽  
Necrosis Factor Alpha ◽  
Obese Subjects ◽  
Low Grade Inflammation

Interleukin-(IL-) 12 has been recently suggested to participate during development of insulin resistance in obese mice. Nevertheless, serum IL-12 levels have not been accurately determined in overweight and obese humans. We thus studied serum concentrations of IL-12 in Mexican adult individuals, examining their relationship with low-grade inflammation and obesity-related parameters. A total of 147 healthy individuals, 43 normal weight, 61 overweight, and 43 obese subjects participated in the study. Circulating levels of IL-12, tumor necrosis factor-alpha (TNF-α), leptin, insulin, glucose, total cholesterol, and triglyceride were measured after overnight fasting in all of the study subjects. Waist circumference and body fat percentage were recorded for all the participants. Serum IL-12 was significantly higher in overweight and obese individuals than in normal weight controls. Besides being strongly related with body mass index (r=0.5154), serum IL-12 exhibited a significant relationship with abdominal obesity (r=0.4481), body fat percentage (r=0.5625), serum glucose (r=0.3158), triglyceride (r=0.3714), and TNF-α(r=0.4717). Thus, serum levels of IL-12 are increased in overweight and obese individuals and show a strong relationship with markers of low-grade inflammation and obesity in the Mexican adult population. Further research is needed to understand the role of IL-12 in developing obesity-associated alterations in humans.

scholarly journals L Score as a Novel Anthropometric Measure for Obesity Screening in Adult Individuals: An Exploratory Study

2020 ◽  
Vol 8 (E) ◽  
pp. 60-64
Author(s):  
Devi Prasad Mohapatra ◽  
Jaya Prakash Sahoo ◽  
Madhusmita Mohanty Mohaptra ◽  
Sitanshu Sekhar Kar ◽  
Sridharan Kalyani ◽  
...  
Keyword(s):  
Statistical Analysis ◽  
Body Fat ◽  
Tertiary Care ◽  
Primary Objective ◽  
Overweight And Obesity ◽  
Rapid Screening ◽  
Body Fat Percentage ◽  
Fat Percentage ◽  
Secondary Objective ◽  
Total Body

BACKGROUND: Obesity is one of today’s most neglected public health problems, affecting every region of the world. Early identification of increased weight gain among the population is paramount to prevent the attendant complications associated with obesity. OBJECTIVES: The primary objective of this study was to measure the distribution of L score in the representative population and the secondary objective was to identify an association between L score values and other measures of obesity such as body mass index, waist circumference, waist-to-height ratio, neck circumference (NC), and total body fat percentage. METHODS: This study was conducted in the departments of plastic surgery and endocrinology of a tertiary care institute. The L score (a measure of fullness of the lateral retromalleolar fossa in the lower limb) was assessed in all the participating individuals. Statistical analysis was performed using the Statistical Package for the Social Sciences version 19.0. p < 0.05 was considered as statistically significant in statistical analysis. RESULTS: Among the 50 participants taken in this study, 24 had L score 0, 15 had score 1, and 11 had score 2. The participants with L score 1 and 2 had higher obesity, higher NC, and more body fat percentage compared to those having score 0. All the participants with L score 2 were overweight and had central obesity. CONCLUSIONS: The L score measure has a potential for simple and rapid screening of at-risk population for overweight and obesity.

scholarly journals Exploring the Relationship between Trunk Adiposity and Trunk Flexibility

2013 ◽  
Vol 2 (1) ◽  
pp. 22-28
Author(s):  
TaNiqua Ward
Keyword(s):  
Waist Circumference ◽  
Body Fat ◽  
Significant Relationship ◽  
Body Fat Percentage ◽  
Trunk Flexion ◽  
Fat Percentage ◽  
Hip Circumference ◽  
Trunk Extension ◽  
The Relationship ◽  
Trunk Flexibility

Abstract Purpose: The purpose of this study is to examine the relationship between trunk adiposity and trunk flexibility among adults.  Methods: A total of 29 participants, male (n=11) and female (n=18) participants between the ages of 19 and 84 years. The participants were recruited from the University of Central Oklahoma daily email news service. The bioelectrical impedance analyzer (BIA) was used to calculate percent body fat and body mass index (BMI). Three circumference measurements were taken on each participant: waist, abdomen, and hips. The two inclinometers were placed on the sacroiliac joint (S1) and thoracic 12 (T12) to measure trunk flexion and extension. Trunk flexibility was measured as the difference between the two reading at full flexion or extension. Results: The Pearson’s Product Moment Correlation was used to analyze the results. There was a significant negative relationship between trunk flexion correlated with abdomen circumference (r= -.49, p= .01) and hip circumference (r= -.39, p= .03). There was a non- significant relationship observed between trunk flexion and WHR (r= -.10, p= .62) and waist circumference (r= -.35, p= .06). There was a non-significant relationship observed between trunk extension and WHR (r= -.07, p= .71), waist circumference (r= .17, p= .38), abdomen circumference (r= .07, p= .71), and hip circumference (r= .29, p= .13). Trunk flexion was not correlated to BMI (r= -.27, p= .15) and body fat percentage (r= -.29, p= .14). A significant relationship was found between trunk extension and BMI (r= .38, p= .04). Trunk extension and body fat percentage (r= .02, p= .92) did not have a significant relationship. Conclusion: Abdomen and hips are most beneficial when measuring circumferences for trunk adiposity. It was found that trunk flexion has a greater relationship with trunk adiposity than trunk extension.  

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