scholarly journals TRICHOLOGY FEATURES OF ALOPECIA IN WOMEN OF REPRODUCTIVE AGE PATIENTS WITH POLYCYSTIC OVARY SYNDROM

2018 ◽  
Vol 2 (5) ◽  
pp. 9-14
Author(s):  
Лилия Беленькая ◽  
Liliya Belenkaya ◽  
Олег Иванов ◽  
Oleg Ivanov ◽  
Ольга Панарина ◽  
...  
Keyword(s):  
Polycystic Ovary ◽  
Reproductive Age ◽  
Endocrine Disorders ◽  
Androgenic Alopecia ◽  
General Physical Examination ◽  
General Physical ◽  
Systemic Examination ◽  
Dermatologic Manifestations ◽  
Reproductive Aged Women ◽  
The Impact

Background. Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders, affecting 5–10 % of reproductive-aged women. The dermatologic manifestations of PCOS play a significant role in diagnosis. The purpose of the present study was to examine the impact of androgenic alopecia among patients with PCOS and to define their most significant trichological features. Because the data on dermatologic changes associated with PCOS are rather scarce, the present study was designed to determine the incidence and prevalence of androgenic alopecia. Materials and methods. We conducted a prospective observational study of patients with PCOS. The diagnosis of PCOS was made according to the consensus criteria adopted in May 2003 in Rotterdam. Each patient signed informed consent, and then a general physical examination, systemic examination, breast and pelvic examination, as well as a detailed trichological examination were carried out. Results. Twenty women with PCOS participated in the study. The median age was 28.7 ± 6.2 years. Oligo/anovulation frequency was 63.2 %, hirsutism frequency – 68.4 %. In our study, the prevalence of androgenic alopecia was found to be 30 %, telogenic hair loss – 55 %, absence of alopecia signs in 15 % of cases. Conclusions. Androgenic alopecia is a prevalent but unreliable marker of biochemical hyperandrogenism. It is therefore imperative for the treating physicians to understand the adverse effects associated with PCOS, recognize these potential health risks in patients, and treat them accordingly.

scholarly journals A Prospective Study of the Prevalence of the Polycystic Ovary Syndrome in Unselected Caucasian Women from Spain1

2000 ◽  
Vol 85 (7) ◽  
pp. 2434-2438 ◽  
Author(s):  
Miryam Asunción ◽  
Rosa M. Calvo ◽  
José L. San Millán ◽  
José Sancho ◽  
Sergio Avila ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Blood Donation ◽  
Polycystic Ovary ◽  
Reproductive Age ◽  
Endocrine Disorders ◽  
Androgenic Alopecia ◽  
Hydroxylase Deficiency ◽  
Ovary Syndrome ◽  
Caucasian Women ◽  
21 Hydroxylase Deficiency

We prospectively estimated the prevalence of the polycystic ovary syndrome (PCOS), as defined by the NIH/NICHHD 1990 endocrine criteria, in a population of 154 Caucasian women of reproductive age reporting spontaneously for blood donation. Anthropometric data; the presence of hirsutism, acne, and androgenic alopecia; and the menstrual history were recorded by a single investigator. In 145 women, blood samples were also obtained for measurement of serum androgen levels. PCOS was defined by the presence of 1) oligomenorrhea, 2) clinical and/or biochemical hyperandrogenism, and 3) exclusion of hyperprolactinemia, thyroid disorders, and nonclassic 21-hydroxylase deficiency. Hirsutism was defined by a modified Ferriman- Gallwey score of 8 or more, acne was considered as a sign of hyperandrogenism when persistent after the second decade of life, and hyperandrogenemia was defined by an increase in circulating testosterone or dehydroepiandrosterone sulfate or an increase in the free androgen index above the 95th percentile of the control values derived from the nonhirsute, nonacneic women having regular menses who were not receiving hormonal therapy. PCOS was present in 10 (6.5%), hirsutism was present in 11 (7.1%), and acne was present in 19 (12.3%) of the 154 women. Our results demonstrate a 6.5% prevalence of PCOS, as defined, in a minimally biased population of Caucasian women from Spain. The polycystic ovary syndrome, hirsutism, and acne are common endocrine disorders in women.

scholarly journals Fish Consumption: A Review of Its Effects on Metabolic and Hormonal Health

2021 ◽  
Vol 14 ◽  
pp. 117863882110223
Author(s):  
Carlos O Mendivil
Keyword(s):  
Metabolic Syndrome ◽  
Fish Consumption ◽  
Dietary Habits ◽  
Positive Impact ◽  
Polycystic Ovary ◽  
Scientific Evidence ◽  
Endocrine Disorders ◽  
Omega 3 ◽  
The Metabolic Syndrome ◽  
The Impact

Dietary habits are a major determinant of the risk of chronic disease, particularly metabolic and endocrine disorders. Fish as a food group are a unique source of nutrients with metabolic and hormonal importance including omega-3 fatty acids, iodine, selenium, vitamin D, taurine and carnitine. Fish are also a source of high quality protein and have in general low caloric density. The impact of these nutrients on cardiovascular risk has been extensively reviewed, but the impact of fish on the broader field of endocrine and metabolic health is sometimes not sufficiently appreciated. This article aimed to summarize the impact the effect of regular fish consumption on conditions like the metabolic syndrome, obesity, diabetes, hypothyroidism, polycystic ovary syndrome and the menopausal transition, which are in and of themselves significant causes of morbidity and mortality worldwide. The review revealed that scientific evidence from food science, translational research, epidemiologic studies and interventional trials shows that regular fish consumption has a positive impact on thyroid homeostasis, facilitates maintenance of a healthy body weight, reduces the magnitude of age-associated increases in blood pressure, improves glucose homeostasis helping prevent diabetes and the metabolic syndrome, and has a positive impact on muscle mass preservation among the elderly. These effects are mediated by multiple mechanisms, only some of which have been identified. For most of these effects it holds true that the potential benefits are more substantial when baseline fish consumption is low.

scholarly journals Simultaneous alterations in ovaries and bone as a result of Polycystic Ovary Syndrome

2021 ◽  
Vol 3 (2) ◽  
pp. 2-14
Author(s):  
Ana Lúcia de Oliveira Bonfá ◽  
Eduardo Donato Alves ◽  
Víctor Fabrício ◽  
Keico Okino Nonaka ◽  
Janete Aparecida Anselmo-Franci ◽  
...  
Keyword(s):  
Cell Culture ◽  
Animal Model ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Reproductive Age ◽  
Estradiol Valerate ◽  
Endocrine Disorders ◽  
Ovary Syndrome ◽  
Bone Properties ◽  
In Vivo Animal Model

Polycystic ovary syndrome (PCOS) is one of the most widely recognized endocrine disorders affecting reproductive-age women. The etiopathogenesis and mechanisms of this syndrome remain unclear. Diagnosis requires two of the following: polycystic ovaries, oligo- or anovulation, and hyperandrogenism. Most women with PCOS display conditions such as metabolic abnormalities, diabetes, obesity, cardiovascular disease, and/or bone dysfunction. Considering the ethical limitations of human studies, animal and cell culture models that reflect some features of PCOS are important for investigation of this syndrome. The aim of the present work was to study some of the endocrine relationships between ovaries and bone tissue in a polycystic ovary syndrome animal model. The study was performed using an estradiol valerate PCOS-induced rat model (n = 30) and bone mesenchymal stem cell cultured from bone marrow of those animals. It was hypothesized that changes of the endocrine relationship between ovaries and bones could be observed in from in vivo animal model and in vitro cell culture assays. The ovarian morphological and endocrine changes seem to be correlated with endocrine, biophysical, and biomechanical changes in bone properties. Mesenchymal stem cells obtained from PCOS-induced rats, cultured for up to 21 days and differentiated into osteoblasts, presented lower viability and reduced mineralization of the extracellular matrix. Taken together, these results indicate important endocrine and structural effects of PCOS in ovaries and bones, contributing to part of the understanding of the pathophysiological mechanisms of PCOS.

Polycystic ovary syndrome

2020 ◽  
pp. 528-535
Author(s):  
Zhongwei Huang ◽  
Eu Leong Yong
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Endometrial Hyperplasia ◽  
Polycystic Ovary ◽  
Reproductive Age ◽  
Endocrine Disorders ◽  
Age Group ◽  
Ovary Syndrome ◽  
Reproductive Ageing ◽  
Reproductive Age Group

Polycystic ovary syndrome (PCOS) is an enigmatic condition and its pathophysiology remains to be determined but it is likely to involve the androgen, insulin, and anti-Mullerian hormone pathways. PCOS is diagnosed in women in the reproductive age group based on the Rotterdam criteria. The spectrum of disease involves various phenotypes based on the current diagnostic criteria and this may have reproductive, metabolic, and endocrine consequences. Reproductive issues include that of irregular menstrual cycles and anovulation. Metabolic disorders such as insulin resistance, obesity, dyslipidaemia, and hypertension must be screened for in all women who are diagnosed with PCOS. Long-term risks of metabolic and endocrine disorders in women with PCOS still need further confirmation with more robust data. Reproductive ageing appears to be increased in women with PCOS and they seem to menopause at a later age. Thus far, PCOS appears to be associated with endometrial hyperplasia and cancer.

scholarly journals Impact of hypocaloric dietary intervention on ovulation in obese women with PCOS

Reproduction ◽  
2017 ◽  
Vol 153 (1) ◽  
pp. R15-R27 ◽  
Author(s):  
Brittany Y Jarrett ◽  
Marla E Lujan
Keyword(s):  
Weight Loss ◽  
Dietary Intervention ◽  
Polycystic Ovary ◽  
Reproductive Function ◽  
Antral Follicle ◽  
Reproductive Age ◽  
Obese Women ◽  
Dietary Interventions ◽  
Wide Range ◽  
The Impact

Polycystic ovary syndrome (PCOS) is a common cause of ovulatory dysfunction affecting women of reproductive age. Obesity and insulin resistance are thought to potentiate disruptions in antral follicle development that result in chronic anovulation, and as such, have become important therapeutic targets of dietary interventions aimed at weight loss. Caloric restriction has been shown to promote sporadic ovulation in obese women with PCOS, but improvements have occurred across a wide range of patients and little has been garnered about the factors that distinguish responders from non-responders. Further, few studies have evaluated the likelihood for modest weight loss to restore normal ovulatory cyclicity in PCOS. Consensus regarding the impact of dietary intervention on ovulation has been limited by variability in the measures used to characterize and report ovulatory status across studies. In response, this review provides an assessment of the evidence surrounding the effectiveness of hypocaloric dietary intervention to normalize ovulatory function in PCOS. The impact of physiological vs methodological factors on the evaluation of ovulatory status is discussed, and recommendations to strengthen future studies in this area are provided. Ultimately, further research is needed to understand the optimal dietary or lifestyle approaches that promote ovulation and sustained improvements in reproductive function in PCOS.

scholarly journals Hirsutism, Acne, and Hair Loss: Management of Hyperandrogenic Cutaneous Manifestations of Polycystic Ovary Syndrome

2016 ◽  
pp. 1
Author(s):  
Cenk Yasa ◽  
Özlem Dural ◽  
Ercan Bastu ◽  
Funda Güngör Uğurlucan
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Androgenic Alopecia ◽  
Ovary Syndrome ◽  
Cutaneous Manifestations ◽  
Insulin Sensitizers ◽  
Criteria For Diagnosis ◽  
Reproductive Aged Women ◽  
Topical Medications ◽  
Endocrine Abnormality

<p>PPolycystic ovary syndrome is the most common endocrine abnormality that affects reproductive-aged women. Diagnostic criteria of polycystic ovary syndrome have been established by different societies in recent years, and hyperandrogenism remains as one of the main criteria for diagnosis. Cutaneous manifestations of hyperandrogenism include hirsutism, acne and androgenic alopecia and are commonly observed in women with polycystic ovary syndrome. The major determinants of cutaneous manifestations are increased production of androgen and increased tissue availability. Cutaneous manifestations of hyperandrogenism are cosmetic problems, which produce significant emotional distress and psychological morbidity. Treatment includes a combination of combined oral contraceptives, antiandrogens, insulin sensitizers, gonadotropin releasing hormone agonists, topical medications, and cosmetic procedures. The diagnosis, management, and treatment approaches are described in detail in this review.</p>

scholarly journals Hormonal profile and characteristics of polychistic ovarium syndrome among Madurese tribe, Indonesia

2020 ◽  
Vol 9 (4) ◽  
pp. 333
Author(s):  
Zakkiyatus Zainiyah ◽  
Eny Susanti ◽  
Mustofa Haris
Keyword(s):  
Polycystic Ovary ◽  
Follicle Stimulating Hormone ◽  
Reproductive Age ◽  
Sex Hormone Binding Globulin ◽  
Endocrine Disorders ◽  
Biochemical Tests ◽  
Hormonal Profile ◽  
Serum Luteinizing Hormone ◽  
Control Study ◽  
Stimulating Hormone

Polycystic ovarium syndrome (PCOS), the most common endocrine disorders in women of reproductive age, characterized by menstrual disorders (amenorrhea/oligomenorrhea), hirsutism, the appearance of acne, alopecia and the results of biochemical tests that show increased androgens (testosterone). Increased serum luteinizing hormone (LH) and follicle stimulating hormone (FSH) serve as diagnostic tests for PCOS over the years, but from several research results obtained inconsistent results that need further research. The purpose of this study is to analyze the hormonal profile and characteristics of polycystic ovary syndrome (PCOS) in Madura. Case-control study conducted in March-August 2019 in the Madura tribe. There were 32 subjects with PCOS and 32 healthy women participated in this study. Hormonal examination was using a serum and followed by enzyme-linked immune sorbent assay (ELISA kit). Levels Follicle-stimulating hormone (FSH) average was 8.74 and SHBGs were 10.02 lower in PCOS patients and LH levels were higher in PCOS patients; ratio LH/FSH was 0.76. The results of the Madurese study showed that levels of FSH, LH, weight significantly related to PCOS sex hormone binding globulin (SHBG), however body mass index (BMI) levels were not related to PCOS.

scholarly journals Assessment of Psycho-emotional Distress Due to Age, Body Mass Index, and Marital Status in Polycystic Ovary Syndrome in North Indian Population

2020 ◽  
Vol 8 (4) ◽  
pp. 368-375
Author(s):  
Fauzia Tabassum ◽  
Hemali Heidi Sinha ◽  
Kavita Dhar ◽  
Chandra Jyoti ◽  
Md Sayeed Akhtar ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Body Weight ◽  
Polycystic Ovary Syndrome ◽  
Marital Status ◽  
Body Mass ◽  
Polycystic Ovary ◽  
Reproductive Age ◽  
Ovary Syndrome ◽  
Significant Difference ◽  
The Impact

Objectives: Polycystic ovary syndrome (PCOS) is a multifaceted endocrine disorder in reproductive age having a greater impact on health-related quality of life (HRQOL). The aim of this study was to find out PCOS demographics and its related HRQOL effects for improving psychological understanding in disease management. Materials and Methods: A prospective questionnaire-based study was conducted for a period of twelve months at All India Institute of Medical Sciences, Patna, India. The data of 100 PCOS cases were collected about socio-demographic status, clinical history, and dietary intake. Then, a validated PCOS questionnaire (PCOSQ) was used to observe the impact of PCOS symptoms on patients’ HRQOL. Results: The overall 57% and 48% of PCOS cases belonged to the age range of 20-30 years and had a body mass index (BMI) of >25-30, respectively. Based on the results, a significant difference was observed in the mean score of PCOSQ vs. marital status in PCOS cases with respect to emotion (P=0.039), body weight (P=0.002), and infertility (P=0.001). Furthermore, the result showed a significant difference in the domain of emotion (P=0.008), body hair (P=0.035), body weight (P<0.001), and infertility (P=0.018) among BMI group, and a high score was observed in the BMI group <18 in comparison to the other groups of BMI. Conclusions: In general, our findings indicated that infertility, emotions, and BMI had extremely higher impacts on the HRQOL of women suffering from PCOS although their educational status failed to affect HRQOL.

scholarly journals Study the Effect of Interleukin36 Gamma and AMH in Iraqi Women with PCOS

2018 ◽  
Vol 28 (3) ◽  
pp. 151
Author(s):  
Wafa R. AlFatlawi
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Transforming Growth Factor ◽  
Seminal Fluid ◽  
Polycystic Ovary ◽  
Surrogate Marker ◽  
Reproductive Age ◽  
Endocrine Disorders ◽  
Ovary Syndrome ◽  
Markers Of Inflammation ◽  
Significant Difference

Polycystic ovary syndrome (PCOS) is one of the most common female endocrine disorders and affect approximately (5-10) % of women of reproductive age. Anti-Müllerian hormone (AMH) is a homodimeric glycoprotein, a member of the transforming growth factor-β superfamily, it is secreted exclusively from women by granulose cells of ovarian follicles and it is considered as the precise marker of follicle pool size. AMH has been shown to be a good surrogate marker for polycystic ovary syndrome (PCOS). Interleukins are considered as strong risk markers of inflammation. Interleukin-36 gamma (IL36) also known as interleukin-1 family member 9 (IL1F9) is a protein that in humans is encoded by the IL36G gene. Serum samples were collected on day 2 of the menstrual cycle. Serum IL36ɣ, FSH and LH concentration were measured by using ELISA. This study aimed to evaluate the association between IL36ɣ and AMH and study the relationship between obesity and AMH of women in the age of reproductive (25-35) yrs. This study included 28 infertile women with PCOS their husbands were apparently normal (hormones and seminal fluid analysis), their aged (25-35) years, and 20 healthy women aged (25-33) years as control. All control women & patients were from outpatients unit of Alkadumia teaching hospital at Baghdad and all the parameters were measured in Sigma Laboratory. Serum IL-36 ɣ elevated in PCOS patients mainly those with high AMH levels. This hormone increased in PCOS patients compared with control. There was a non-significant difference between patients and control to LH and FSH levels.

scholarly journals Analysis of the informativeness of melatonin evaluation in polycystic ovary syndrome

2016 ◽  
Vol 13 (4) ◽  
pp. 15-20 ◽  
Author(s):  
Elena Andreeva ◽  
Yulia Absatarova ◽  
Ekaterina Sheremetyeva ◽  
Dmitriy Derkatch ◽  
Tatiana Ponomareva ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Sleep Disorders ◽  
Polycystic Ovary ◽  
Reproductive Function ◽  
Reproductive Age ◽  
Control Group ◽  
Endocrine Disorders ◽  
Ovary Syndrome ◽  
Subjective Sleep ◽  
Pcos Group

Background. Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in women of reproductive age. Recently, the role of melatonin in the pathogenesis of this syndrome became widely discussed among the scientists, because there is an evidence of its impact on the reproductive function and maturation of oocytes.Aim. To study a informativeness of melatonin determination and its relationship with sleep disorders in PCOS.Materials and methods. The study involved 120 women aged 17–35 years: 60 patients with PCOS and 60 women without this disorder as controls. The level of melatonin in the blood, saliva and its metabolite in urine – 6 sulfatoximelatonin were analyzed. To identify sleep disorders survey was conducted using a questionnaire scoring subjective sleep characteristics.Results. Sleep disorders based on subjective scoring profiles sleep characteristics were identified in PCOS group (up to 70% of patients) regardless of BMI. The level of 6-sulfatoximelatonin in urine, nocturnal melatonin levels in saliva (at 3:00 AM) and melatonin in the blood were significantly higher in patients with PCOS compared with the control group regardless of BMI. The level of melatonin in follicular fluid was lower in patients with PCOS. There was a significant correlation of melatonin levels in the blood and the degree of sleep disorders according to the questionnaire scoring subjective sleep characteristics, the level of melatonin in saliva at 3:00 AM and a 6-sulfatoximelatonin in daily urine (p = 0.046).Conclusions. PCOS is polyetiology disease, and an important role in the formation and progression in which plays melatonin. Correlation of levels of this hormone in different body fluids suggests its systemic action and direct involvement in the regulation of reproductive function.  

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