scholarly journals Neuroendocrine-immune complex as the mirror of the state of exchange of nitrogenous metabolites at rats

2021 ◽  
Vol 11 (8) ◽  
pp. 55-65
Author(s):  
Igor Popovych ◽  
Igor Kuchma ◽  
Sofiya Ruzhylo ◽  
Walery Zukow ◽  
Anatoliy Gozhenko
Keyword(s):  
Immune Complex ◽  
The State ◽  
Mineral Waters ◽  
Immune Parameters ◽  
Autonomous Regulation ◽  
Wide Range ◽  
Healthy Female ◽  
Female Wistar Rats ◽  
Blood Neutrophils ◽  
Nitrogenous Metabolism

Background. Earlier we found that even in intact rats, certain parameters of nitrogenous metabolism fluctuate in a fairly wide range, which further expands in cases of prolonged water loads. Based on this, we have been created three groups that are homogeneous in the parameters of nitrogenous metabolism. We have been shown that each cluster is accompanied by a specific constellation of immune parameters. In this study, an attempt will be made to supplement the immune accompaniment of each constellation of nitrogenous metabolites with parameters of the autonomic nervous and endocrine systems. Material and methods. Experiment was performed on 60 healthy female Wistar rats, both intact and loaded with different mineral waters. Immune status was assessed by thymocytogram, splenocytogram, blood leukocytogram and immunocytogram, as well as by phagocytosis parameters of blood neutrophils and monocytes. The state of autonomous regulation assessed by HRV. The plasma levels of the hormones of adaptation: corticosterone, triiodothyronine and testosterone (by the ELISA) were determined as well as mineralocorticoid, calcitonin and parathyroid activity calculated by their electrolyte markers. Results. 9 neuro-endocrine and 17 immune parameters were identified, the set of which three clusters of nitrogen metabolism clearly differ from each other. The overall accuracy of the classification is 93,3%. Conclusion. The variety of states of exchange of nitrogenous metabolites is accompanied by specific constellations of 26 parameters of neuro-endocrine-immune complex.

scholarly journals Varieties of the state of exchange of nitrogenous metabolites (creatinine, urea, uric acid and bilirubin) and their immune accompaniment at rats

2021 ◽  
Vol 11 (7) ◽  
pp. 228-238
Author(s):  
Igor Kuchma ◽  
Igor-Severyn Flyunt ◽  
Sofiya Ruzhylo ◽  
Walery Zukow ◽  
Volodymyra Bilas ◽  
...  
Keyword(s):  
Uric Acid ◽  
Mineral Waters ◽  
Plasma Urea ◽  
Immune Parameters ◽  
Wide Range ◽  
Female Wistar Rats ◽  
Blood Neutrophils ◽  
Characteristic Features ◽  
The Individual ◽  
Nitrogenous Metabolism

Background. Earlier we found that even in intact rats, certain parameters of nitrogenous metabolism and immunity fluctuate in a fairly wide range, which further expands in cases of prolonged water loads. The links between the individual parameters of metabolism and immunity were revealed. Based on this, the aim of this study was to create groups that are homogeneous in the parameters of nitrogenous metabolism, followed by a search for the characteristic parameters of immunity. Material and methods. Experiment was performed on 60 healthy female Wistar rats, both intact and loaded with different mineral waters. The plasma levels and urinary excretion of the nitrogenous metabolites (creatinine, urea, uric acid and bilirubin) were determined. Immune status was assessed by thymocytogram, splenocytogram, blood leukocytogram and immunocytogram, as well as by phagocytosis parameters of blood neutrophils and monocytes. Results. The characteristic features of the members of the most numerous (29 animals) of the first cluster are moderately elevated plasma urea and upper borderline creatinineemia in combination with lower borderline uricemia. In members of the third cluster (22 animals), all seven parameters are in the range of normal. In contrast, rats of the second cluster (n=9) were found to have significantly increased levels of urea and creatinine excretion, as well as uricemia. Each cluster is accompanied by a specific constellation of immune parameters. The overall accuracy of the classification is 95%. Conclusion. The variety of states of exchange of nitrogenous metabolites is accompanied by specific constellations of immune parameters.

scholarly journals Similar neuroendocrine and metabolic effects of sulfate-chloride sodium-magnesium mineral waters "Myroslava" and "Khrystyna" of Truskavets’ spa in healthy female rats

2021 ◽  
Vol 11 (6) ◽  
pp. 320-334
Author(s):  
Myroslava Hrytsak ◽  
Daria Popovych ◽  
Nataliya Badiuk ◽  
Ivanna Hrytsan ◽  
Walery Zukow
Keyword(s):  
Tap Water ◽  
Physiological Activity ◽  
Experimental Studies ◽  
Mineral Waters ◽  
Female Rats ◽  
Metabolic Effects ◽  
Control Group ◽  
Healthy Female ◽  
Sodium Magnesium ◽  
Female Wistar Rats

Background. In order to expand the hydro-mineral base of Truskavets’ spa by diluting brine (130 g/L), two new sulphate-chloride sodium-magnesium mineral waters "Myroslava" (5 g/L) and "Khrystyna" (10 g/L) were created. This report is the first in a series of experimental studies of their physiological activity in line with the concepts of neuroendocrine-immune complex and functional-metabolic continuum. Materials and Methods. Experiment was performed on 50 healthy female Wistar rats 220-300 g divided into 4 groups. Animals of the first group remained intact, using tap water from drinking ad libitum. Rats of the control group for 6 days administered a single tap water through the tube at a dose of 1,5 mL/100 g of body mass. The rats of the main groups received the water "Myroslava" and "Khrystyna". The day after the completion of the drinking course in all rats assessed the state of autonomous regulation by parameters of the HRV. The plasma levels of the hormones of adaptation were determined: corticosterone, triiodothyronine and testosterone (by the ELISA); as well as electrolytes, nitric metabolites, lipid peroxidation products and antioxidant enzymes as well as cholesterol, glucose, amylase and middle mass molecules. Most of the listed parameters of metabolism as well as 17-ketosteroids were determined in daily urine. In the adrenal glands the thickness of glomerular, fascicular, reticular and medullar zones was measured. Results. To identify exactly those parameters, the set of which three groups of animals differ significantly from each other, the information field of the registered parameters was subjected to discriminant analysis. The program included in the model 6 endocrine and 11 metabolic parameters, as well as glomerular filtration. Conclusion. The newly created sulfate-chloride sodium-magnesium drinking mineral waters of Truskavets’ spa have similar neuroendocrine and metabolic effects on healthy old female rats significantly different from daily water.

scholarly journals Peculiarities of neuroendocrine and metabolic effects of sulfate-chloride sodium-magnesium mineral waters "Myroslava" and "Khrystyna" of Truskavets’ spa in healthy female rats

2021 ◽  
Vol 11 (9) ◽  
pp. 862-875
Author(s):  
Myroslava Hrytsak ◽  
Dariya Popovych ◽  
Nataliya Badiuk ◽  
Ivanna Hrytsan
Keyword(s):  
Uric Acid ◽  
Tap Water ◽  
Mineral Waters ◽  
Female Rats ◽  
Metabolic Effects ◽  
Control Group ◽  
Healthy Female ◽  
Sodium Magnesium ◽  
Female Wistar Rats ◽  
Daily Urine

Background. Earlier we found that the newly created sulfate-chloride sodium-magnesium drinking mineral waters of Truskavets’ spa have similar neuroendocrine and metabolic effects on healthy old female rats significantly different from daily water. The aim of this study is to elucidate the effects of these mineral waters on the neuroendocrine status and metabolism of these animals. Materials and Methods. Experiment was performed on 50 healthy female Wistar rats. Animals of the first group remained intact, using tap water from drinking ad libitum. Rats of the control group for 6 days injected a tap water through the tube at a dose of 1,5 mL/100 g of body mass. The rats of the main groups received the water "Myroslava" and "Khrystyna". The day after the completion of the drinking course in all rats, at first, assessed the state of autonomous regulation by parameters of the HRV. The plasma levels of the hormones of adaptation were determined: corticosterone, triiodothyronine and testosterone (by the ELISA) as well as electrolytes: calcium, magnesium, phosphates, chloride, sodium and potassium; nitric metabolites: creatinine, urea, uric acid, medium molecular polypeptides, bilirubin; lipid peroxidation products and antioxidant enzymes, as well as cholesterol, amylase and glucose. Most of the listed parameters of metabolism were also determined in daily urine. In the adrenals the thickness of glomerular, fascicular, reticular and medullar zones was measured. Results. To identify exactly those parameters, the set of which all four groups of animals differ significantly from each other, the information field of the registered parameters was subjected to discriminant analysis. The program included in the model 8 endocrine and 16 metabolic parameters, information about which is condensed into three roots. The first root reflects directly the SOD and corticosterone and inversely the reticular zone as well as plasma uric acid and glucose. The second root contains information about Nap/Kp ratio, natrihistia, amylasemia, magnesiumuria as well as inversely about kaliemia. The third root reflects directly the triiodothyronine, parathyroid activity, plasma Ca, natriuria and chloriduria as well as urine malondyaldehide. Inversely displays the root information about the testosterone, Ku/Nau ratio, glomerular zone, plasma katalase and Na as well as uricosuria and amylasuria. In the information space of the three discriminant roots, all four groups are quite clearly distinguished. Classification accuracy is 94% (three errors). Conclusion. The newly created sulfate-chloride sodium-magnesium drinking mineral waters of Truskavets resort have specific endocrine and metabolic effects on healthy old female rats with weekly use. This provides a basis for preclinical studies.

RESEARCH ON INVESTMENT AND INNOVATION ACTIVITY IN UKRAINE: TRENDS AND PROBLEMS

2018 ◽  
Vol 1 (01) ◽  
pp. 5-73
Author(s):  
Anatoliy Ivanovich Bogdanenko
Keyword(s):  
State Policy ◽  
Innovation System ◽  
State Regulation ◽  
The State ◽  
Innovation Activity ◽  
Legal Principles ◽  
Innovation Activities ◽  
Wide Range ◽  
Intellectual Potential ◽  
Innovation Processes

In the monograph the theoretical identification of concepts and categorical series of state regulation of investment-innovation processes are investigated; the directions of optimization of the state policy of innovation and investment development management in Ukraine are determined; the organizational and legal principles of the state regulation of development of intellectual potential of the population are substantiated; the areas of development and improvement of the national innovation system as an object of state policy are highlighted and assessed. The monograph will be interesting for scholars, lecturers, doctoral and graduate students, and will also be useful to practical politicians, journalists and media workers and a wide range of readers interested in investment and innovation activities.

THE VALUE OF LOVE IN THE SYSTEM OF FORMATION OF THE PROFESSIONAL MATURITY OF THE EDUCATOR

2020 ◽  
Vol 1 (10(79)) ◽  
pp. 12-18
Author(s):  
G. Bubyreva
Keyword(s):  
Russian Federation ◽  
The State ◽  
Educational Process ◽  
Wide Range ◽  
The Family ◽  
The Russian Federation ◽  
The Government ◽  
The Individual ◽  
The Right

The existing legislation determines the education as "an integral and focused process of teaching and upbringing, which represents a socially important value and shall be implemented so as to meet the interests of the individual, the family, the society and the state". However, even in this part, the meaning of the notion ‘socially significant benefit is not specified and allows for a wide range of interpretation [2]. Yet the more inconcrete is the answer to the question – "who and how should determine the interests of the individual, the family and even the state?" The national doctrine of education in the Russian Federation, which determined the goals of teaching and upbringing, the ways to attain them by means of the state policy regulating the field of education, the target achievements of the development of the educational system for the period up to 2025, approved by the Decree of the Government of the Russian Federation of October 4, 2000 #751, was abrogated by the Decree of the Government of the Russian Federation of March 29, 2014 #245 [7]. The new doctrine has not been developed so far. The RAE Academician A.B. Khutorsky believes that the absence of the national doctrine of education presents a threat to national security and a violation of the right of citizens to quality education. Accordingly, the teacher has to solve the problem of achieving the harmony of interests of the individual, the family, the society and the government on their own, which, however, judging by the officially published results, is the task that exceeds the abilities of the participants of the educational process.  The particular concern about the results of the patriotic upbringing served as a basis for the legislative initiative of the RF President V. V. Putin, who introduced the project of an amendment to the Law of RF "About Education of the Russian Federation" to the State Duma in 2020, regarding the quality of patriotic upbringing [3]. Patriotism, considered by the President of RF V. V. Putin as the only possible idea to unite the nation is "THE FEELING OF LOVE OF THE MOTHERLAND" and the readiness for every sacrifice and heroic deed for the sake of the interests of your Motherland. However, the practicing educators experience shortfalls in efficient methodologies of patriotic upbringing, which should let them bring up citizens, loving their Motherland more than themselves. The article is dedicated to solution to this problem based on the Value-sense paradigm of upbringing educational dynasty of the Kurbatovs [15].

Safety assessment of biological raw materials in the system of medicines quality assurance

2020 ◽  
pp. 63-72
Author(s):  
Yu. Olefir ◽  
E. Sakanyan ◽  
I. Osipova ◽  
V. Dobrynin ◽  
M. Smirnova ◽  
...  
Keyword(s):  
Raw Materials ◽  
State Level ◽  
The State ◽  
Spongiform Encephalopathy ◽  
Safety Standards ◽  
Wide Range ◽  
The Russian Federation ◽  
Key Aspects ◽  
First Time ◽  
Medicines Quality

The entry of a wide range of biotechnological products into the pharmaceutical market calls for rein-forcement of the quality, efficacy and safety standards at the state level. The following general monographs have been elaborated for the first time to be included into the State Pharmacopoeia of the Russian Federation, XIV edition: "Viral safety" and "Reduction of the risk of transmitting animal spongiform encephalopathy via medicinal products". These general monographs were elaborated taking into account the requirements of foreign pharmacopoeias and the WHO recommendations. The present paper summarises the key aspects of the monographs.

The development of the movement for the communist labour at the Tyumen shipbuilding plant in days of the seven-year plan (1959-1965): the experience of microhistorical study

2019 ◽  
Vol 5 (2) ◽  
pp. 153-172
Author(s):  
Sergey S. Pashin ◽  
Natalia S. Vasikhovskaya
Keyword(s):  
Political History ◽  
The State ◽  
Historical Narrative ◽  
Industrial Enterprise ◽  
State Archive ◽  
Wide Range ◽  
Archival Documents ◽  
History Of

The article is devoted to the study of the movement for communist labour at the Tyumen Shipbuilding Plant during the period of the seven-year plan (1959-1965). The authors seek to fill a historical narrative with the particular facts connected with the peculiarities and specifics of such phenomenon as the movement for communist labour. They consider it in the context of microhistory and as the most important element of production routine. The employees of the largest industrial enterprise of Soviet Tyumen — Shipbuilding Plant in concrete historical circumstances came under the spotlight of the authors. The submitted article is written with attraction of a wide range of archival documents, taken from the funds of the State Archive of the Tyumen Region and also funds of the State Archive of Socio-Political History of the Tyumen Region. Having studied the documents the authors come to conclusion that the movement for communist labour had little effect on the production progress of the plant employees.

Aromatization of C2-C6 Aliphatic Hydrocarbons on Copper-Containing ZSM-5 Zeolites

1992 ◽  
Vol 57 (12) ◽  
pp. 2553-2560
Author(s):  
Zdravka Popova ◽  
Katia Aristirova ◽  
Christo Dimitrov
Keyword(s):  
Copper Content ◽  
Acid Strength ◽  
The State ◽  
Aliphatic Hydrocarbons ◽  
Bronsted Acid ◽  
Ion Formation ◽  
Brönsted Acid ◽  
Wide Range ◽  
Carbenium Ion ◽  
Acid Centers

The aromatization of a wide range of model aliphatic and cycloaliphatic hydrocarbons (ethene, ethane, propene, n-hexane, 1-hexene, methylcyclopentane, cyclohexane, cyclohexene) on copper-containing NaZSM-5 and HZSM-5 zeolites has been investigated. It was established that the degree of aromatization is related to carbenium ion formation and depends on the acid strength and copper content of zeolite. Experiments with copper-containing samples reduced prior to use indicated the possibility to enhance the selectivity to aromatization. The change of the state of Cu2+ ions during catalytic experiments confirmed the assumption about participation of Cu0 simultaneously with the Bronsted acid centers in the dehydrogenation/hydrogenation steps.

Sound-Politics in São Paulo

2019 ◽  
Author(s):  
Leonardo Cardoso
Keyword(s):  
Crime Control ◽  
State Intervention ◽  
Sao Paulo ◽  
The State ◽  
Ethnographic Study ◽  
São Paulo ◽  
Cultural Rights ◽  
Point Of Entry ◽  
Wide Range ◽  
Analytical Category

This book is an ethnographic study of controversial sounds and noise control debates in Latin America’s most populous city. It discusses the politics of collective living by following several threads linking sound-making practices to governance issues. Rather than discussing sound within a self-enclosed “cultural” field, I examine it as a point of entry for analyzing the state. At the same time, rather than portraying the state as a self-enclosed “apparatus” with seemingly inexhaustible homogeneous power, I describe it as a collection of unstable (and often contradictory) sectors, personnel, strategies, discourses, documents, and agencies. My goal is to approach sound as an analytical category that allows us to access citizenship issues. As I show, environmental noise in São Paulo has been entangled in a wide range of debates, including public health, religious intolerance, crime control, urban planning, cultural rights, and economic growth. The book’s guiding question can be summarized as follows: how do sounds enter and leave the sphere of state control? I answer this question by examining a multifaceted process I define as “sound-politics.” The term refers to sounds as objects that are susceptible to state intervention through specific regulatory, disciplinary, and punishment mechanisms. Both “sound” and “politics” in “sound-politics” are nouns, with the hyphen serving as a bridge that expresses the instability that each concept inserts into the other.

scholarly journals Density Guarantee on Finding Multiple Subgraphs and Subtensors

2021 ◽  
Vol 15 (5) ◽  
pp. 1-32
Author(s):  
Quang-huy Duong ◽  
Heri Ramampiaro ◽  
Kjetil Nørvåg ◽  
Thu-lan Dam
Keyword(s):  
Lower Bound ◽  
State Of The Art ◽  
The State ◽  
The Other ◽  
Exact Methods ◽  
Practical Solution ◽  
Novel Approach ◽  
Wide Range ◽  
Real World Datasets ◽  
Tensor Data

Dense subregion (subgraph & subtensor) detection is a well-studied area, with a wide range of applications, and numerous efficient approaches and algorithms have been proposed. Approximation approaches are commonly used for detecting dense subregions due to the complexity of the exact methods. Existing algorithms are generally efficient for dense subtensor and subgraph detection, and can perform well in many applications. However, most of the existing works utilize the state-or-the-art greedy 2-approximation algorithm to capably provide solutions with a loose theoretical density guarantee. The main drawback of most of these algorithms is that they can estimate only one subtensor, or subgraph, at a time, with a low guarantee on its density. While some methods can, on the other hand, estimate multiple subtensors, they can give a guarantee on the density with respect to the input tensor for the first estimated subsensor only. We address these drawbacks by providing both theoretical and practical solution for estimating multiple dense subtensors in tensor data and giving a higher lower bound of the density. In particular, we guarantee and prove a higher bound of the lower-bound density of the estimated subgraph and subtensors. We also propose a novel approach to show that there are multiple dense subtensors with a guarantee on its density that is greater than the lower bound used in the state-of-the-art algorithms. We evaluate our approach with extensive experiments on several real-world datasets, which demonstrates its efficiency and feasibility.

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