scholarly journals Varieties of the state of exchange of nitrogenous metabolites (creatinine, urea, uric acid and bilirubin) and their immune accompaniment at rats

2021 ◽  
Vol 11 (7) ◽  
pp. 228-238
Author(s):  
Igor Kuchma ◽  
Igor-Severyn Flyunt ◽  
Sofiya Ruzhylo ◽  
Walery Zukow ◽  
Volodymyra Bilas ◽  
...  
Keyword(s):  
Uric Acid ◽  
Mineral Waters ◽  
Plasma Urea ◽  
Immune Parameters ◽  
Wide Range ◽  
Female Wistar Rats ◽  
Blood Neutrophils ◽  
Characteristic Features ◽  
The Individual ◽  
Nitrogenous Metabolism

Background. Earlier we found that even in intact rats, certain parameters of nitrogenous metabolism and immunity fluctuate in a fairly wide range, which further expands in cases of prolonged water loads. The links between the individual parameters of metabolism and immunity were revealed. Based on this, the aim of this study was to create groups that are homogeneous in the parameters of nitrogenous metabolism, followed by a search for the characteristic parameters of immunity. Material and methods. Experiment was performed on 60 healthy female Wistar rats, both intact and loaded with different mineral waters. The plasma levels and urinary excretion of the nitrogenous metabolites (creatinine, urea, uric acid and bilirubin) were determined. Immune status was assessed by thymocytogram, splenocytogram, blood leukocytogram and immunocytogram, as well as by phagocytosis parameters of blood neutrophils and monocytes. Results. The characteristic features of the members of the most numerous (29 animals) of the first cluster are moderately elevated plasma urea and upper borderline creatinineemia in combination with lower borderline uricemia. In members of the third cluster (22 animals), all seven parameters are in the range of normal. In contrast, rats of the second cluster (n=9) were found to have significantly increased levels of urea and creatinine excretion, as well as uricemia. Each cluster is accompanied by a specific constellation of immune parameters. The overall accuracy of the classification is 95%. Conclusion. The variety of states of exchange of nitrogenous metabolites is accompanied by specific constellations of immune parameters.

scholarly journals Neuroendocrine-immune complex as the mirror of the state of exchange of nitrogenous metabolites at rats

2021 ◽  
Vol 11 (8) ◽  
pp. 55-65
Author(s):  
Igor Popovych ◽  
Igor Kuchma ◽  
Sofiya Ruzhylo ◽  
Walery Zukow ◽  
Anatoliy Gozhenko
Keyword(s):  
Immune Complex ◽  
The State ◽  
Mineral Waters ◽  
Immune Parameters ◽  
Autonomous Regulation ◽  
Wide Range ◽  
Healthy Female ◽  
Female Wistar Rats ◽  
Blood Neutrophils ◽  
Nitrogenous Metabolism

Background. Earlier we found that even in intact rats, certain parameters of nitrogenous metabolism fluctuate in a fairly wide range, which further expands in cases of prolonged water loads. Based on this, we have been created three groups that are homogeneous in the parameters of nitrogenous metabolism. We have been shown that each cluster is accompanied by a specific constellation of immune parameters. In this study, an attempt will be made to supplement the immune accompaniment of each constellation of nitrogenous metabolites with parameters of the autonomic nervous and endocrine systems. Material and methods. Experiment was performed on 60 healthy female Wistar rats, both intact and loaded with different mineral waters. Immune status was assessed by thymocytogram, splenocytogram, blood leukocytogram and immunocytogram, as well as by phagocytosis parameters of blood neutrophils and monocytes. The state of autonomous regulation assessed by HRV. The plasma levels of the hormones of adaptation: corticosterone, triiodothyronine and testosterone (by the ELISA) were determined as well as mineralocorticoid, calcitonin and parathyroid activity calculated by their electrolyte markers. Results. 9 neuro-endocrine and 17 immune parameters were identified, the set of which three clusters of nitrogen metabolism clearly differ from each other. The overall accuracy of the classification is 93,3%. Conclusion. The variety of states of exchange of nitrogenous metabolites is accompanied by specific constellations of 26 parameters of neuro-endocrine-immune complex.

Dynamics of the Level Formation of Style Hierarchy in Musical Art

2021 ◽  
Vol 66 (1) ◽  
pp. 109-124
Author(s):  
Yuliya Kapliyenko-Iliuk
Keyword(s):  
Social Factors ◽  
Information Sources ◽  
Scientific Information ◽  
Folk Traditions ◽  
Wide Range ◽  
The Subject ◽  
Characteristic Features ◽  
The Individual ◽  
Individual Style ◽  
National Style

"Style, as a category of musicology, has been studied by scholars of different times. It has a wide range of questions under inquire. The problems of forming a system of style levels have repeatedly been the subject of scientific research. The article is devoted to the study of scientific information sources that consider the principles of style hierarchy, individual, national levels, and their importance in higher systems – the style of genres and eras. Based on research of scholars’ opinions in the field of music style, conclusions about features of hierarchy of style levels, dynamics of their formation are made. Individual style is dominant in the formation of other style levels, in particular styles of genres and era. At the heart of the problem of the individual style study is the personality of the composer with the characteristic features of individual oeuvre. The national style is formed based on social factors, professional national creativity, and folk traditions. The national style manifests the features of the historical category, therefore over time it acquires new characteristic features. Epochal style is a complex coexistence of national music cultures; it subordinates the styles of genres. Thus, the study of the category of style, its theoretical problems, in particular the dynamics of the formation of style levels, demonstrates the timeliness and the need for further exploration. Keywords: music style, individual style, national style, genre, era. "

scholarly journals Peculiarities of neuroendocrine and metabolic effects of sulfate-chloride sodium-magnesium mineral waters "Myroslava" and "Khrystyna" of Truskavets’ spa in healthy female rats

2021 ◽  
Vol 11 (9) ◽  
pp. 862-875
Author(s):  
Myroslava Hrytsak ◽  
Dariya Popovych ◽  
Nataliya Badiuk ◽  
Ivanna Hrytsan
Keyword(s):  
Uric Acid ◽  
Tap Water ◽  
Mineral Waters ◽  
Female Rats ◽  
Metabolic Effects ◽  
Control Group ◽  
Healthy Female ◽  
Sodium Magnesium ◽  
Female Wistar Rats ◽  
Daily Urine

Background. Earlier we found that the newly created sulfate-chloride sodium-magnesium drinking mineral waters of Truskavets’ spa have similar neuroendocrine and metabolic effects on healthy old female rats significantly different from daily water. The aim of this study is to elucidate the effects of these mineral waters on the neuroendocrine status and metabolism of these animals. Materials and Methods. Experiment was performed on 50 healthy female Wistar rats. Animals of the first group remained intact, using tap water from drinking ad libitum. Rats of the control group for 6 days injected a tap water through the tube at a dose of 1,5 mL/100 g of body mass. The rats of the main groups received the water "Myroslava" and "Khrystyna". The day after the completion of the drinking course in all rats, at first, assessed the state of autonomous regulation by parameters of the HRV. The plasma levels of the hormones of adaptation were determined: corticosterone, triiodothyronine and testosterone (by the ELISA) as well as electrolytes: calcium, magnesium, phosphates, chloride, sodium and potassium; nitric metabolites: creatinine, urea, uric acid, medium molecular polypeptides, bilirubin; lipid peroxidation products and antioxidant enzymes, as well as cholesterol, amylase and glucose. Most of the listed parameters of metabolism were also determined in daily urine. In the adrenals the thickness of glomerular, fascicular, reticular and medullar zones was measured. Results. To identify exactly those parameters, the set of which all four groups of animals differ significantly from each other, the information field of the registered parameters was subjected to discriminant analysis. The program included in the model 8 endocrine and 16 metabolic parameters, information about which is condensed into three roots. The first root reflects directly the SOD and corticosterone and inversely the reticular zone as well as plasma uric acid and glucose. The second root contains information about Nap/Kp ratio, natrihistia, amylasemia, magnesiumuria as well as inversely about kaliemia. The third root reflects directly the triiodothyronine, parathyroid activity, plasma Ca, natriuria and chloriduria as well as urine malondyaldehide. Inversely displays the root information about the testosterone, Ku/Nau ratio, glomerular zone, plasma katalase and Na as well as uricosuria and amylasuria. In the information space of the three discriminant roots, all four groups are quite clearly distinguished. Classification accuracy is 94% (three errors). Conclusion. The newly created sulfate-chloride sodium-magnesium drinking mineral waters of Truskavets resort have specific endocrine and metabolic effects on healthy old female rats with weekly use. This provides a basis for preclinical studies.

scholarly journals Relationships of urolithogenicity index with some components of urine composition in healthy old female rats

2021 ◽  
Vol 11 (10) ◽  
pp. 357-372
Author(s):  
Viktor Flyunt ◽  
Igor-Severyn Flyunt ◽  
Sofiya Ruzhylo ◽  
Oksana Fihura ◽  
Dariya Popovych ◽  
...  
Keyword(s):  
Uric Acid ◽  
Chemical Composition ◽  
Mineral Waters ◽  
Female Rats ◽  
Number Of Components ◽  
Composition Materials ◽  
Female Wistar Rats ◽  
Daily Urine ◽  
Sodium Phosphates ◽  
The Impact

Background. Despite the long history, the results of studies of the impact of balneotherapy in the resort of Truskavets on the lithogenicity of urine are ambiguous, so the topic remains relevant. The aim of this study was to determine the relationship between the lithogenicity index of urine and a number of components of its composition. Materials and Methods. Experiment was performed on 60 healthy old female Wistar rats 220-300 g. Ten animals remained intact, using daily water from drinking ad libitum. Other animals for 6 days were loaded through the tube with daily and various mineral waters at a dose of 1,5 mL/100 g of body mass. The day after the completion of the drinking course collected daily urine, which determined the content of a number of components of the composition. We calculated urine lithogenicity index (Lith) by the formula: Lith = (Uric acid•Calcium/Magnesium•Creatinine)0,25. Results. The most significant effect on the Lith is the concentration of magnesium (r=-0,730), followed by uric acid (r=0,583), calcium (r=0,352) and creatinine (r=-0,298). Medium molecular polypeptides, catalase, sodium, phosphates and urea has been identified as prolithogenic factors while tubular reabsorption of water as litholytic factor. The chemical composition of the fluids consumed by animals has little effect on the lithogenicity index of urine. Conclusion. Both prolithogenic and litholytic factors are present in the urine, which depend little on the chemical composition of the fluid used.

scholarly journals The concept of "Contemporary Dance": cultural, philosophical, and artistic approaches

2021 ◽  
Author(s):  
Natalia Fedotova
Keyword(s):  
The Body ◽  
Contemporary Dance ◽  
Contemporary Culture ◽  
Avant Garde ◽  
Wide Range ◽  
Wide Circle ◽  
Characteristic Features ◽  
Definition Of ◽  
The Individual ◽  
Historical Methods

The purpose of the article is to analyze and systematize approaches to the definition of the concept of "contemporary dance". Methodology. The research methodology is based on the analysis of scientific sources related to the topic, approaches to the interpretation of the concept of "Contemporary Dance", using terminological and historical methods. Scientific novelty. For the first time, the main approaches to the definition of contemporary dance are revealed and its characteristic features are revealed. Conclusions. Contemporary dance has taken a prominent place among the directions of choreographic art, has a wide circle of admirers, is recognized as a stage phenomenon and cultural and artistic practice. Currently, there is a wide range of approaches to understanding contemporary dance, which leads to terminological differences in scientific works. Among the main positions in contemporary dance, one can single out its consideration as an avant-garde form of choreographic art that evolved from modern dance; as a dramatic virtuoso dance originating from ballet and jazz; as an intellectual dance that originated in Europe and America, based on various techniques and techniques, it is perceived as a tool for the development of the dancer's body. We adhere to the position that contemporary dance is a direction of choreographic art that arose in the late XX – early XXI centuries in Europe and America, based on techniques and techniques that act as tools for the development of the body, the formation of awareness and the individual choreographic language of the dancer. Keywords: contemporary dance, contemporary culture, choreography, contemporary dance, terminological approach.

MULTIDIMENSIONAL MANAGEMENT CONTEMPORARY: GENERATION OF SOCIAL MEANINGS FOR A NEW COLLECTIVE IDENTITIES

2018 ◽  
Vol 1 (14) ◽  
pp. 264-273
Author(s):  
Inna Andriivna Semenets-Orlova ◽  
Yaroslava Yaroslavivna Kyselova
Keyword(s):  
Social Activity ◽  
Professional Activity ◽  
Collective Identities ◽  
Dominant Type ◽  
Civil Responsibility ◽  
European Area ◽  
Social Meanings ◽  
Characteristic Features ◽  
Decentralization Reform ◽  
The Individual

The article is devoted to the analysis of the process of generating social meanings on the area of European civilization. Authors assign a separate place to the research of the tendency of increasing social activity in local communities, which accompanies decentralization processes in modern Ukraine. The article analyzes the characteristic features of non-tribes, based on the M. Maffesoli’s concept of “neo-tribalism”, and traces the tendency of reactualization a partly transformed communal way of life of modern tribes. The authors investigate the retrieval of the request for a valuable education in society. It is emphasized on the growing tendency of the filling of the meaning of the professional activity of public administrators, according to the significant request of providing public interests and collective goals by citizens. The authors singled out a new role of public administration — providing public education. In the context of this problem, the authors substantiate the critical need for a successful completion of the authority decentralization reform in Ukraine. Proceeding from the process of neo-tribalism that covers modern Europe, the authors predict the emergence of a new collective identities on the European area. The authors point to a characteristic tendency: Ukrainians are deeply embedded in solving internal problems of society, which manifests in the correction of gaps in cultural and educational policies of past years, self-organization (through volunteer and volunteer movements), civil responsibility for the welfare of their communities, and participation in the management of local affairs. According to the authors, this tendency influences the dominant type of future sociality (it is not the individual “Me”, but “Me as a part of community”).

THE VALUE OF LOVE IN THE SYSTEM OF FORMATION OF THE PROFESSIONAL MATURITY OF THE EDUCATOR

2020 ◽  
Vol 1 (10(79)) ◽  
pp. 12-18
Author(s):  
G. Bubyreva
Keyword(s):  
Russian Federation ◽  
The State ◽  
Educational Process ◽  
Wide Range ◽  
The Family ◽  
The Russian Federation ◽  
The Government ◽  
The Individual ◽  
The Right

The existing legislation determines the education as "an integral and focused process of teaching and upbringing, which represents a socially important value and shall be implemented so as to meet the interests of the individual, the family, the society and the state". However, even in this part, the meaning of the notion ‘socially significant benefit is not specified and allows for a wide range of interpretation [2]. Yet the more inconcrete is the answer to the question – "who and how should determine the interests of the individual, the family and even the state?" The national doctrine of education in the Russian Federation, which determined the goals of teaching and upbringing, the ways to attain them by means of the state policy regulating the field of education, the target achievements of the development of the educational system for the period up to 2025, approved by the Decree of the Government of the Russian Federation of October 4, 2000 #751, was abrogated by the Decree of the Government of the Russian Federation of March 29, 2014 #245 [7]. The new doctrine has not been developed so far. The RAE Academician A.B. Khutorsky believes that the absence of the national doctrine of education presents a threat to national security and a violation of the right of citizens to quality education. Accordingly, the teacher has to solve the problem of achieving the harmony of interests of the individual, the family, the society and the government on their own, which, however, judging by the officially published results, is the task that exceeds the abilities of the participants of the educational process.  The particular concern about the results of the patriotic upbringing served as a basis for the legislative initiative of the RF President V. V. Putin, who introduced the project of an amendment to the Law of RF "About Education of the Russian Federation" to the State Duma in 2020, regarding the quality of patriotic upbringing [3]. Patriotism, considered by the President of RF V. V. Putin as the only possible idea to unite the nation is "THE FEELING OF LOVE OF THE MOTHERLAND" and the readiness for every sacrifice and heroic deed for the sake of the interests of your Motherland. However, the practicing educators experience shortfalls in efficient methodologies of patriotic upbringing, which should let them bring up citizens, loving their Motherland more than themselves. The article is dedicated to solution to this problem based on the Value-sense paradigm of upbringing educational dynasty of the Kurbatovs [15].

Chain-breaking/Preventive Antioxidant, Urate-lowering, and Anti-inflammatory Effects of Pure Curcumin

2020 ◽  
Vol 17 (1) ◽  
pp. 66-74
Author(s):  
Seghira Bisset ◽  
Widad Sobhi ◽  
Chawki Bensouici ◽  
Abdelhalim Khenchouche
Keyword(s):  
Uric Acid ◽  
Xanthine Oxidase ◽  
Acid Production ◽  
Biological Activities ◽  
Antioxidant Effect ◽  
Metal Chelating ◽  
Wide Range ◽  
Chain Breaking ◽  
Pharmaceutical Industries ◽  
Anti Inflammatory

Background: Several researches have shown that therapeutic compounds or phytochemicals from natural sources are important in the food as it is valuable in pharmaceutical industries due to their fewer side effects and potent against various diseases. Curcumin, a major polyphenol derived from turmeric spice, which used in many foods, has a wide range of biological activities, with quite a safety. Objective: The goal of this study was to investigate the antioxidant, urate-lowering, and antiinflammatory effects of pure curcumin. Methods: The antioxidant activity was evaluated for chain-breaking antioxidant effect (radicalscavenging and reducing abilities assays) and for preventive antioxidant effect with metal chelating assay, the urate-lowering was assayed on aspectrophotometer by measuring the inhibition of uric acid production by xanthine oxidase (XO) enzyme, and the anti-inflammatory effect was estimated using in vitro albumin denaturation inhibition. Results: Curcumin showed a significant and good chain-breaking antioxidant effect, both in free radical- scavenging assays (Galvinoxyl radical, ABTS, and hydroxyl radical), and in reducing abilities methods (reducing power, Cupric ion reducing antioxidant capacity and O-phenanthroline assays). In preventive antioxidant effect, assessed with the metal chelating assay, curcumin showed significant effect but with high concentration compared with standard. In the xanthine/xanthine oxidase system, curcumin significantly inhibited uric acid production (IC50=0.71 ± 0.06 mg/mL). Regarding antiinflammatory activity, curcumin showed significant inhibition of albumin denaturation with an IC50 value of 1181.69 ± 1.11μg/mL. Conclusion: These results indicated that curcumin showed promising antioxidant, anti-gout and antiinflammatory properties and might be used as potential, natural drugs against oxidative and inflammation- related diseases.

Punk as Folk: Continuities and Tensions in the UK and Beyond

2020 ◽  
Author(s):  
Pete Dale
Keyword(s):  
Folk Music ◽  
Music Making ◽  
Collective Creativity ◽  
Living Tradition ◽  
Wide Range ◽  
The Us ◽  
The Common ◽  
The Individual ◽  
The Uk

Numerous claims have been made by a wide range of commentators that punk is somehow “a folk music” of some kind. Doubtless there are several continuities. Indeed, both tend to encourage amateur music-making, both often have affiliations with the Left, and both emerge at least partly from a collective/anti-competitive approach to music-making. However, there are also significant tensions between punk and folk as ideas/ideals and as applied in practice. Most obviously, punk makes claims to a “year zero” creativity (despite inevitably offering re-presentation of at least some existing elements in every instance), whereas folk music is supposed to carry forward a tradition (which, thankfully, is more recognized in recent decades as a subject-to-change “living tradition” than was the case in folk’s more purist periods). Politically, meanwhile, postwar folk has tended more toward a socialist and/or Marxist orientation, both in the US and UK, whereas punk has at least rhetorically claimed to be in favor of “anarchy” (in the UK, in particular). Collective creativity and competitive tendencies also differ between the two (perceived) genre areas. Although the folk scene’s “floor singer” tradition offers a dispersal of expressive opportunity comparable in some ways to the “anyone can do it” idea that gets associated with punk, the creative expectation of the individual within the group differs between the two. Punk has some similarities to folk, then, but there are tensions, too, and these are well worth examining if one is serious about testing out the common claim, in both folk and punk, that “anyone can do it.”

scholarly journals The OsERF115/AP2EREBP110 Transcription Factor Is Involved in the Multiple Stress Tolerance to Heat and Drought in Rice Plants

2021 ◽  
Vol 22 (13) ◽  
pp. 7181
Author(s):  
Seong-Im Park ◽  
Hyeok Jin Kwon ◽  
Mi Hyeon Cho ◽  
Ji Sun Song ◽  
Beom-Gi Kim ◽  
...  
Keyword(s):  
Stress Tolerance ◽  
Transcriptional Activation ◽  
Individual Plant ◽  
Hormone Signaling ◽  
Combined Stress ◽  
Drought Treatment ◽  
Wide Range ◽  
The Individual ◽  
Potential Use ◽  
Multiple Stress Tolerance

The AP2/EREBP family transcription factors play important roles in a wide range of stress tolerance and hormone signaling. In this study, a heat-inducible rice ERF gene was isolated and functionally characterized. The OsERF115/AP2EREBP110 was categorized to Group-IIIc of the rice AP2/EREBP family and strongly induced by heat and drought treatment. The OsERF115/AP2EREBP110 protein targeted to nuclei and suppressed the ABA-induced transcriptional activation of Rab16A promoter in rice protoplasts. Overexpression of OsERF115/AP2EREBP110 enhanced thermotolerance of seeds and vegetative growth stage plants. The OsERF115/AP2EREBP110 overexpressing (OE) plants exhibited higher proline level and increased expression of a proline biosynthesis P5CS1 gene. Phenotyping of water use dynamics of the individual plant indicates that the OsERF115/AP2EREBP110-OE plant exhibited better water saving traits under heat and drought combined stress. Our combined results suggest the potential use of OsERF115/AP2EREBP110 as a candidate gene for genetic engineering approaches to develop heat and drought stress-tolerant crops.

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