EVALUATING THE EFFECTIVENESS OF FRUCTOSE-1,6-DIPHOSPHATE IN TREATING OF OCULAR ISCHEMIC SYNDROME

2015 ◽  
Vol 8 (2) ◽  
Author(s):  
Dilbar Makhkamova
Keyword(s):  
Visual Acuity ◽  
Standard Therapy ◽  
Main Group ◽  
Doppler Imaging ◽  
Nerve Tissue ◽  
Neuroprotective Activity ◽  
Control Group ◽  
Ocular Ischemic Syndrome ◽  
Comprehensive Therapy ◽  
Ischemic Syndrome

The purpose of this study was to evaluate the efficacy and safety of FDP in patients with ocular ischemic syndrome.Material and methods. The material for this study is based on results of a comprehensive examination and treatment of 53 patients with a diagnosis OIS. The average age of the patients was 57,8 ± 6,82 year. 19 of them women, 34 men.  27 patients entered to the main group (1) which received standard therapy in combination with intravenous FDP (fructose 1,6-bisphosphate). 26 patients in the control group (2) received standard treatment.Results.  In applying the FDP combined with comprehensive therapy in the main group resulted in increased of visual acuity by 32.8%, parameters of retinal sensitivity by 17.8%, reducing the area of scotomas compared with patients of the control group. Optical coherence tomography registered significant changes in the dynamics in patients of the main group - reducing the edema and restoration of  RNFL and ONH. Recovery of visual function may have contributed neuroprotective activity of the drug FDP by a protective effect on nerve tissue, reducing the effects of hypoxic stress.Conclusions. The use of standard therapy in combination with FDP in the treatment of ocular ischemic syndrome has a positive effect on the course of the disease, thereby, increase of visual acuity, a decrease in sectoral loss in vision fields, the positive dynamics OCT parameters, improving hemodynamic parameters at Doppler imaging in dynamics.

scholarly journals LEVEL OF MARKERS OF NEURODEGENERATION IN PATIENTS WITH OCULAR ISCHEMIC SYNDROME

2014 ◽  
Vol 7 (2) ◽  
Author(s):  
Halidjan Kamilov ◽  
Munirahon Kasimova ◽  
Dilbar Makhkamova
Keyword(s):  
Blood Serum ◽  
Protein S ◽  
Main Group ◽  
Tear Fluid ◽  
Control Group ◽  
Normal Range ◽  
Ocular Ischemic Syndrome ◽  
S 100 ◽  
Blood Serum Protein ◽  
Ischemic Syndrome

The purpose of this study was to investigate the content neurospecific markers protein S-100 and neuroenolaza in blood serum and tear fluid of patients with ocular ischemic syndrome.Material and methods. We observed 43 patients aged 57 to 79 years, mean age 67.3 ± 2.7 years. Control group consisted of 11 volunteers  without ophthalmic symptoms. The main group consisted of 32 patients with OIS. The neurospecific proteins S100 and NSE were investigated in blood serum and tear fluid.Results. The study found that in patients of the control group the content of protein were within the normal range: S- 100 in the tear fluid – 0,0662 ± 0,00335 mkg/l, in the blood serum 0,0508 ± 0,00241 mkg/l. In patients of the main group the indicators of protein in the tear fluid were elevated in all patients - 3,12 ± 0,246 mkg/l ( p<0.005). The normal levels in blood serum of marker S-100 was in 30 patients - 0,0589 ± 0,00303 mkg/l, while, in 2 patients protein S-100 were raised and averaged 0,2175±0,00725 mkg/l. It was found that in patients of the control group content of protein NSE in the tear fluid and blood serum were within normal values - 15,86 ± 0,148 Ng/ml, 15,60 ± 0,202 Ng/ml respectively. In the main group the amount of protein NSE tended to increase in the tear fluid in 23 patients and averaged 33,012 ± 3,2626 Ng/ml (p<0.005), a significant decrease the quantity of protein was observed in 9 patients, which amounted to 5,166 ± 0,8301 Ng/ml. At normal levels in the blood serum protein NSE detected in 30 patients and averaged 14,48 ± 0,263 Ng/ml, whereas, in 2 patients there was a significant increase of content of protein NSE and was 27,47 ± 3,068 Ng/ml.Conclusions. Thus, changes in the concentration of S100 and neuroenolaza in the tear fluid in patients with ocular ischemic syndrome allow to identify as marker of nerve cells damage of the eye, contributing to the definition in conjunction with other signs of stage and etiology of the disease.

scholarly journals Optimization of rehabilitation measures after artificial abortion as the result of immunomodulator aminodihydrophthalasindione sodium apply in comprehensive therapy

2019 ◽  
pp. 156-161
Author(s):  
E. A. Voroshilova
Keyword(s):  
Marked Reduction ◽  
Clinical Effect ◽  
Comparison Group ◽  
Clinical Symptoms ◽  
Randomized Study ◽  
Main Group ◽  
Control Group ◽  
Comprehensive Therapy ◽  
Effect Of Treatment ◽  
Artificial Abortion

The article presents the results of a comparative randomized study, the purpose of which was to evaluate the effectiveness of the use of aminodihydrophthalasindione sodium (Galavit, LLC SELVIM, Russia) in the treatment of patients undergoing an abortion. Included in the study, 48 women were divided into two groups, 24 patients of the main group in addition to the standard rehabilitation were treated with aminodihydrophthalasindione sodium in the comparison group – 24 patients underwent only standard rehabilitation. In this study, all patients (100%) of the main group who were treated with aminodihydrophthalasindione sodium in addition to the standard therapy marked reduction of the clinical symptoms of the disease and positive dynamics was observed at ultrasound. In the control group, the full clinical effect of treatment was observed only in 10 patients (52.6%). 9 women (47,4%) required repeated therapy. Ultrasound studies in 12 patients (63.2%) showed changes equivalent to endometritis.

scholarly journals Comparative Analysis of Double and Trifocal IOL Implantation in Femtosecond Laser-Assisted Cataract Surgery

2019 ◽  
Vol 16 (1S) ◽  
pp. 68-73 ◽  
Author(s):  
O. I. Orenburkina
Keyword(s):  
Visual Acuity ◽  
Femtosecond Laser ◽  
Cataract Surgery ◽  
Average Distance ◽  
Clinical Results ◽  
Main Group ◽  
Intraocular Lenses ◽  
Control Group ◽  
Lighting Conditions ◽  
Near Visual Acuity

Purpose: to compare the clinical results of implantations of bi-and trifocal intraocular lenses (IOL) in femtosecond laser-assisted cataract surgery. Patients and methods. The article presents the results of the Acrysof IQ Panoptix trifocal lens implantations in 84 patients (112 eyes) — the main group and Acrysof IQ Restor bifocal IOL implantations in 52 patients (98 eyes) — the control group. All patients underwent femtosecond laser-assisted cataract surgery (FLACS). The following data were evaluated: uncorrected distance visual acuity (UCDVA) , uncorrected near visual acuity (30–45 cm) and at an average distance (50–70 cm) at discharge, after 14 days, 1 and 3 months after the surgery under photopic and mesopic lighting conditions. Postoperative refractometry data; the defocusing curve was performed in patients with a high UCDVA (0.9–1.0) monocularly under photopic conditions using standard optotypes 14 days after surgery; aberrometry indicators. Results. It was shown that both lenses provided high uncorrected distance and near visual acuity in photopic lighting conditions. At the same time, the Acrysof IQ Panoptix lens provided significantly better visual acuity at an intermediate distance and was more resistant to defocusing conditions. Refraction data: after 1 month, emmetropia was observed in 87 % of patients in the main group and in 85 % of control group, after 6 months — 92 and 89 % respectively. There were no significant differences in high order aberrations and total aberrations between patients of the compared groups. Conclusion. The use of the PanOptix trifocal lens made it possible to obtain maximum visual acuity at different distances, regardless of the level of illumination.

scholarly journals Blood antioxidant capacity change in patients with the «dry» form of age-related macular degeneration treated with polarized polychromatic non-coherent light and dynamic electromyostimulation

2012 ◽  
Vol 93 (6) ◽  
pp. 994-996
Author(s):  
F R Saifullina ◽  
R Z Sharafieva ◽  
V I Pogorel’tsev ◽  
F M Fayzrahmanova ◽  
E A Abdulaeva
Keyword(s):  
Visual Acuity ◽  
Antioxidant Capacity ◽  
Macular Degeneration ◽  
Combined Treatment ◽  
Mean Value ◽  
Main Group ◽  
Age Related Macular Degeneration ◽  
Control Group ◽  
Coherent Light ◽  
Age Related

Aim. To assess the antioxidant capacity in patients with the «dry» form of age-related macular degeneration before and after combined treatment with polarized polychromatic non-coherent light and dynamic electromyostimulation. Methods. Two groups of patients with the «dry» form of age-related macular degeneration were examined. 40 patients (80 eyes) from the main group were treated using combined treatment and 39 patients (78 eyes) in the group of control who were treated conventionally. The integral blood antioxidant capacity was measured by galvanometry. Results. Blood antioxidant capacity in healthy subjects is 26.0 kC/l. In patients of the main group blood antioxidant capacity before the treatment was equal to 22.81±0.27 kC/l, compared to 22.17±0.20 kC/l in control group (total mean value 22.49±0.27 kC/l). There was a relevant elevation of the blood antioxidant capacity at the late stages after the treatment - up to 12 months, compared to only 2 months in the control group. Visual acuity in patients of the main group before the treatment was 0.87±0.02, after the treatment was finished - 0.96±0,01 (p 0.001), 2 months after the treatment - 0.95±0.01 (p 0.001), 6 months after the treatment - 0.96±0.01 (p 0.001), 12 months after the treatment - 0.95±0.01 (p 0.001). Visual acuity in patients of the control group before the treatment was 0.91±0.02, after the treatment was finished - 0.95±0.02 (p 0.05), 2 months after the treatment - 0.94±0.02 (p 0.05), 6 months after the treatment - 0.92±0.02 (p 0.05). 12 months after the treatment the visual acuity deteriorated compared to the treatment start and was measured as 0.89±0.02. Conclusion. There is a decrease of blood antioxidant capacity (22.49±0.27 kC/l) in patients with the «dry» form of age-related macular degeneration; a relevant increase of blood antioxidant capacity and visual acuity can be observed up to 12 months after the treatment with polarized polychromatic non-coherent light and dynamic electromyostimulation.

scholarly journals EFFICACY OF USING VIRTUAL REALITY IN POST-STROKE UPPER LIMB PARESIS

2018 ◽  
Vol 35 (1) ◽  
pp. 60-67 ◽  
Author(s):  
M V Dolganov ◽  
M I Karpova
Keyword(s):  
Virtual Reality ◽  
Upper Limb ◽  
Standard Therapy ◽  
Main Group ◽  
Control Group ◽  
Limb Function ◽  
Acute Period ◽  
Training Course ◽  
Assessment Scores ◽  
Upper Limb Function

Aim. To estimate the efficacy of using training by means of virtual reality in restoration of the upper limb function in patients during the acute period of stroke. Materials and methods. 48 patients in the acute period of stroke (average time from the onset of stroke 4.5 ± 1.3 days, mean age 67 (45; 72.1) years were randomized into 2 groups: the main group (standard therapy + virtual reality) and the control (standard therapy alone). Patients of the main group underwent a course of virtual reality training, lasting for 15 minutes, twice a day for 10 days. The functional status before the onset of training course and after it was evaluated using Fugl-Meyer Assessment Scores (FMA), Motor Assessment Scale (MAS), Ashworth Scale, Modified Barthel Index Score (MBI), Action Research Arm Test (ARAT), 9-Hole Peg Test, Rankin Scale, Function Independence Measure (FIM) and dynamometry. Results. When assessing FMA of “upper limb” ( p = 0.029), “wrist” ( p = 0.04), “hand speed” ( p = 0.02); MAS ( p = 0.042), 9-Hole Peg Test ( p = 0.028), paretic hand dynamometry ( p = 0.03) and FIM ( p = 0.045), patients of the main group demonstrated statistically significant improvement versus the control group. Conclusions. The results detected that inclusion of a short training course, using virtual reality, improves the upper limb function in patients during the acute period of stroke.

scholarly journals Effects of Selenium and Melatonin on Ocular Ischemic Syndrome

2019 ◽  
Vol 2019 ◽  
pp. 1-6
Author(s):  
Hande Hüsniye Telek
Keyword(s):  
Lipid Peroxidation ◽  
Anterior Segment ◽  
Study Groups ◽  
Control Group ◽  
Ocular Ischemic Syndrome ◽  
Group 4 ◽  
Ischemia Group ◽  
Group 3 ◽  
Group 2 ◽  
Ischemic Syndrome

Purpose. To determine the effects of selenium, melatonin, and selenium + melatonin administered for one month on anterior chamber (AC) malondialdehyde (MDA) and AC glutathione (GSH) levels in patients with ocular ischemic syndrome. Materials and Methods. Thirty-five patients were included in the study. Study groups were formed as follows: (1) control group, (2) ischemia group, (3) selenium + ischemia group, (4) melatonin + ischemia group, and (5) selenium + melatonin + ischemia group. AC samples were obtained. MDA and GSH levels in AC samples were evaluated. Results. MDA levels were significantly increased in ischemia groups. Selenium and melatonin supplementation resulted in reduction of MDA levels and significant increase in GSH values. Discussion. Increased lipid peroxidation associated with ischemia of the anterior segment has been prevented by selenium and melatonin supplementation. This trial is registered with ClinicalTrials.gov NCT04005222.

scholarly journals ULTRASOUND EXAMINATION POSSIBILITIES IN ADENOMYOSIS DIAGNOSTICS IN PATIENTS WITH REPRODUCTIVE LOSS

2018 ◽  
Vol 25 (6) ◽  
pp. 142-148
Author(s):  
A. V. Pomortsev ◽  
T. B. Makuhina ◽  
Y. V. Grushevskaya
Keyword(s):  
Ultrasound Examination ◽  
Color Doppler ◽  
Color Doppler Imaging ◽  
Main Group ◽  
High Risk Group ◽  
Doppler Imaging ◽  
Control Group ◽  
Junctional Zone ◽  
Early Stages ◽  
Reproductive Losses

Aim.The research was designed to study the possibilities of ultrasound examination with Color Doppler imaging (CDI) and three-dimensional volumetric reconstruction (3D) in the diagnostics of adenomyosis of minimal prevalence in patients with unspecified infertility and reproductive losses at the early stages of gestation.Materials and methods.40 patients with unspecified infertility and early pregnancy loss (the main group) and 35 healthy patients (the control group) were examined in the course of the study. All patients underwent small pelvic ultrasound in В / CDI / 3D-modes with an assessment of the junctional zone (JZ) on days 5-7 and 18-22 of the menstrual cycle (MC).Results.In the main group, there was a discrepancy between the structure of the endometrium and the phase of the cycle at 5-7 days of the MC, a decrease in vascularization of the JZ at 18-22 days of the MC, a local increase in blood flow in the endometrium in phases 1 and 2 of the MC; the fuzziness of the junctional zone, an increase in min and max thickness of the junctional zone, the difference between them, as well as the ratio of max thickness of the junctional zone to the thickness of the uterus wall regardless of the phase of the MC (p = 0.005; 0.0001; 0.005; 0.03; 0.0004; 0, 0001; 0.0001; 0.0001; 0.0001 respectively).Conclusion.Ultrasonography with the CDI and 3D reconstruction allows us to identify a high-risk group by the presence of a minimal prevalence of adenomyosis in the patients with unspecified infertility and reproductive losses at the early stages of gestation.

scholarly journals The role and place of glucocorticosteroids in treatment of COVID-19 pneumonia without hypoxemia

2021 ◽  
pp. 162-172
Author(s):  
V. V. Salukhov ◽  
E. V. Kryukov ◽  
A. A. Chugunov ◽  
M. A. Kharitonov ◽  
Yu. V. Rudakov ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Clinical Symptoms ◽  
Severe Form ◽  
Main Group ◽  
Control Group ◽  
Low Doses ◽  
Comprehensive Therapy ◽  
Early Use ◽  
Small Doses

Introduction. The article presents the problems of the use of glucocorticosteroids in the treatment of patients with coronavirus– associated pneumonia (COVID-19) without hypoxemia. The experience of the preemptive use of low doses of glucocorticosteroids in the treatment of such patients in a hospital is described. Simplification of a unified scheme of pathogenetic therapy with glucocorticosteroids in the above patients is urgent. The article highlights the effectiveness of the early use of low doses of glucocorticosteroids in the treatment of a specific cohort of patients with COVID-19.Objective. To assess the clinical efficacy and safety of early use of small doses of methylprednisolone in the comprehensive therapy of patients with moderate to severe COVID-19 pneumonia to prevent the development of complications and improve the outcomes of the disease.Materials and methods. The study included 40 hospitalized patients from 37 to 68 years (average age 52. years) with a diagnosis of moderate to severe COVID-19 pneumonia. Patients were randomized into two groups: the main group (n = 20) and the control group (n = 20). The main group additionally received methylprednisolone: 4 mg tablets, 7 tablets per day, divided into 2 doses (4 tablets in the morning and 3 tablets at lunchtime). The effectiveness of the therapy was evaluated based on the primary combined endpoint of the study, which included progression of the disease to an extremely severe form or the occurrence of pulmonary and extrapulmonary complications that required transfer to the intensive care unit, or death of the patient during the followup period. The secondary combined endpoint of the study was resolution of clinical symptoms of the disease or achievement of reference values of laboratory and instrumental indicators.Results. No lethal outcomes were observed in the compared groups, there were no cases of development of an extremely severe course, complications requiring transfer to the intensive care unit in the main group.Conclusion. Early use of small doses methylprednisolone of in comprehensive therapy of patients with moderate and severe COVID-19 pneumonia reduces the incidence of life-threatening complications and improves the outcomes of the disease. 

scholarly journals Influence of L-tryptophan use on the dynamics of cognitive functions in the complex therapy of delayed psycho-speech development in children

2018 ◽  
Vol 17 (2) ◽  
pp. 71-79 ◽  
Author(s):  
V. M. Polyakov ◽  
L. V. Rychkova ◽  
T. A. Belogorova ◽  
V. I. Mikhnovich ◽  
O. V. Bugun ◽  
...  
Keyword(s):  
Cognitive Performance ◽  
Cognitive Functions ◽  
Standard Therapy ◽  
Visual Memory ◽  
Cognitive Activity ◽  
Group Versus ◽  
Main Group ◽  
Speech Development ◽  
Control Group ◽  
Complex Therapy

The purpose of this studyis to evaluate the ability of L-tryptophan used in complex therapy of delayed psycho-speech development in children to influence the dynamics of cognitive performance.Materials and methods. The study included 80 children aged 3–7 years with delayed psycho-speech development (DPSD). The main group consisted of 37 children (25 male and 12 female), a control group – 43 patients (30 male and 13 female). Both groups of children were comparable in age, sex, degree of speech and cognitive impairment, and IQ level. Patients in the main group have taken standard therapy with L-tryptophan (25–50 mg per day depending on the age) supplement for 14 days. Control patients have taken standard therapy only. Psychodiagnostic tests at the entrance and exit of patients from this study was carried out for evaluation the dynamics of cognitive functions. All differences were considered significant at p < 0.05.Results. The study suggests that oral L-tryptophan intake selectively affects the dynamics of cognitive performance in children with DPSD. So, we studied pre- and post-treatment cognitive performance in both group patients and noted a significant improvement in the visual memory (p < 0.001) and an increase in thinking productivity (p < 0.001) in the tryptophan group versus similar indicators in the control group. Intergroup differences (p < 0.001 and p = 0.026, respectively, for the main and control groups) also found.Conclusion. Two-week L-tryptophan intake in complex therapy of DPSD in children can significantly improve the cognitive activity, and greatly increase both the effectiveness and sustainability of treatment outcomes, which will significantly reduce the time and frequency of hospitalization and financial costs for the rehabilitation of this patients. 

Color Doppler Imaging of the Ocular Ischemic Syndrome

Ophthalmology ◽  
1992 ◽  
Vol 99 (9) ◽  
pp. 1453-1462 ◽  
Author(s):  
Allen C. Ho ◽  
Wolfgang E. Lieb ◽  
Patrick M. Flaharty ◽  
Robert C. Sergott ◽  
Gary C. Brown ◽  
...  
Keyword(s):  
Color Doppler ◽  
Color Doppler Imaging ◽  
Doppler Imaging ◽  
Ocular Ischemic Syndrome ◽  
Ischemic Syndrome
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