Preoperative bisphosphonate treatment may adversely affect the outcome after shoulder arthroplasty

Aims The aim of this study was to investigate the effects of preoperative bisphosphonate treatment on the intra- and postoperative outcomes of arthroplasty of the shoulder. The hypothesis was that previous bisphosphonate treatment would adversely affect both intra- and postoperative outcomes. Patients and Methods A retrospective cohort study was conducted involving patients undergoing arthroplasty of the shoulder, at a single institution. Two patients with no previous bisphosphonate treatment were matched to each patient who had received this treatment preoperatively by gender, age, race, ethnicity, body mass index (BMI), and type of arthroplasty. Previous bisphosphonate treatment was defined as treatment occurring during the three-year period before the arthroplasty. The primary outcome measure was the incidence of intraoperative complications and those occurring at one and two years postoperatively. A total of 87 patients were included: 29 in the bisphosphonates-exposed (BP+) group and 58 in the non-exposed (BP-) group. In the BP+ group, there were 26 female and three male patients, with a mean age of 71.4 years (51 to 87). In the BP- group, there were 52 female and six male patients, with a mean age of 72.1 years (53 to 88). Results Previous treatment with bisphosphonates was positively associated with intraoperative complications (fracture; odds ratio (OR) 39.40, 95% confidence interval (CI) 2.42 to 6305.70) and one-year postoperative complications (OR 7.83, 95% CI 1.11 to 128.82), but did not achieve statistical significance for complications two years postoperatively (OR 3.45, 95% CI 0.65 to 25.28). The power was 63% for complications at one year. Conclusion Patients who are treated with bisphosphonates during the three-year period before shoulder arthroplasty have a greater risk of intraoperative and one-year postoperative complications compared with those without this previous treatment.

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Gender Influences on Shoulder Arthroplasty

Current Reviews in Musculoskeletal Medicine ◽

10.1007/s12178-021-09737-0 ◽

2022 ◽

Author(s):

Nicole J. Hung ◽

Stephanie E. Wong

Keyword(s):

Shoulder Arthroplasty ◽

Perioperative Complications ◽

Postoperative Outcomes ◽

Female Patients ◽

Increased Risk ◽

Functional Scores ◽

Hip And Knee Arthroplasty ◽

Male Patients ◽

Gender Based ◽

Preoperative Expectations

Abstract Purpose of Review As the incidence of shoulder arthroplasty continues to increase, there is growing interest in patient-based factors that may predict outcomes. Based on existing literature demonstrating gender-based disparities following total hip and knee arthroplasty, gender may also influence shoulder arthroplasty. The purpose of this review is to discuss the recent literature on the influence of gender on shoulder arthroplasty, focusing on differences in preoperative parameters, perioperative complications, and postoperative outcomes. Recent Findings While both female and male patients generally benefit from shoulder arthroplasty, several differences may exist in preoperative factors, acute perioperative complications, and postoperative outcomes. Preoperatively, female patients undergo shoulder arthroplasty at an older age compared to their male counterparts. They may also have greater levels of preoperative disability and different preoperative expectations. Perioperatively, female patients may be at increased risk of extended length of stay, postoperative thromboembolic events, and blood transfusion. Postoperatively, female patients may achieve lower postoperative functional scores and decreased range of motion compared to male patients. Differences in postoperative functional scores may be influenced by gender-based differences in activities of daily living. Finally, female patients may be at greater risk for periprosthetic fracture and aseptic loosening while male patients appear to be at greater risk for periprosthetic infection and revision surgery. Summary Current literature on the influence of gender on shoulder arthroplasty is limited and conflicting. Further research is necessary to delineate how gender affects patients at the pre- and postoperative levels to better inform decision-making and outcomes.

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Frailty in Elderly Gastric Cancer Patients Undergoing Gastrectomy

Digestive Surgery ◽

10.1159/000511895 ◽

2020 ◽

pp. 1-7

Author(s):

Guowei Kim ◽

Sa-Hong Min ◽

Yongjoon Won ◽

Kanghaeng Lee ◽

Sang Il Youn ◽

...

Keyword(s):

Gastric Cancer ◽

Postoperative Complications ◽

Cancer Patients ◽

Univariate Analysis ◽

Postoperative Outcomes ◽

Inhospital Mortality ◽

Early Postoperative Complications ◽

Frail Patients ◽

One Year ◽

Gastric Cancer Patients

Introduction: There is a dearth of literature on frailty specifically in elderly (aged ≥65 years) gastric cancer patients undergoing gastrectomy. We aim to assess the effects of frailty on postoperative outcomes. Methods: A review of a prospective database was performed from November 2011 to April 2019. Frailty was assessed by multidimensional frailty score (MFS). Outcomes assessed were early postoperative complications and mortality, and length of stay. Results: 289 patients were included. The mean age was 77.3 (range 66–94) years. 183 (63.3%) were males and 172 (59.5%) had early cancer. 275 (95.2%) underwent minimally invasive gastrectomy. 79 (27.3%) patients suffered early postoperative complications, with 47 (16.3%) suffering from Clavien-Dindo grade ≥2 complications. One-year, 90-day, 30-day, and inhospital mortality were 6.6, 1.4, 0.7, and 0%, respectively. 111 (38.4%) of patients were classified as “frail” based on MFS > 5. “Frail” patients were associated with higher 1-year mortality (odds ratio (OR) 4.51, 95% CI 1.57–12.98, p = 0.005) on univariate analysis. On multivariate analysis, “frail” patients did not have significantly increased 1-year mortality. However, when definition of “frail” was changed from MFS > 5 to MFS > 6, frailty was significantly associated with increased 1-year mortality (OR 3.73, 95% CI 1.11–12.53, p = 0.033). Conclusions: Elderly gastric cancer patients undergoing gastrectomy with MFS > 5 do not have increased mortality risk. The influence of frailty on postoperative outcomes may vary based on the risk of the surgical procedure.

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DOES LESION SITE AFFECTS OUTCOMES OF ENDOSCOPIC SUBMUCOSAL DISSECTION FOR COLON NEOPLASIA?

Koloproktologia ◽

10.33878/2073-7556-2019-18-2-33-41 ◽

2019 ◽

Vol 18 (2) ◽

pp. 33-48 ◽

Cited By ~ 2

Author(s):

D. A. Mtvralashvili ◽

A. A. Likutov ◽

V. V. Veselov ◽

O. A. Maynovskaya ◽

V. N. Kashnikov ◽

...

Keyword(s):

Postoperative Complications ◽

Endoscopic Submucosal Dissection ◽

Intraoperative Complications ◽

Lesion Size ◽

Lesion Site ◽

En Bloc ◽

Colon Neoplasms ◽

Submucosal Dissection ◽

One Year ◽

Complications Rate

AIM: to assess results of endoscopic submucosal dissection (ESD) for colon neoplasms due to lesion site.PATIENTS AND METHODS: One-hundred thirteen patients (66 females, aged 65,7±11,0 years) with colon neoplasms which underwent ESD for one year (January 2017 – January 2018) were included in the study. All patients were divided in two groups depending on lesion site. The first group included patients with lesions in caecum, ascending colon and proximal third of tranverse colon, the second group – other colon parts and intraperitoneal part of the rectum. All patients underwent preoperative tests including colonoscopy, gastroscopy and transabdominal ultrasound. ESD included lesion marking, injection, circular incision and dissection. The results obtained were analyzed statistically using Graph Pad 7 for Mac. RESULTS: the 1st group included 61 (54.0%) patients and the 2nd – 52 (46.0%). Laterally spreading tumors (LST) were detected more often in the 1st group (56 patients of the 1st group vs 38 – in the 2nd, p=0.03). The lesion size in the 1st group was 31±13 (7-80) mm and 29±11 (8-76) in the 2nd one (p=0.3). Conversion from ESD to resection occurred in 9 (8.0%) patients, in 5 patients of the 1st group and in 4 – the 2nd one (p=1.0). The only reason for conversion was unfavorable lesion lifting (≤2 mm).Most of the lesions were removed en bloc, specimen fragmentation after ESD occurred in 10 (9.6%) patients: in 5 (9.0%) in the 1st group and in 5 (10.4%) in the 2nd (р=1.0). Intraoperative complications during ESD in the 1st group occurred in 2 (3.5%) cases and in 2 (4.1%) – in the 2nd (р=1.0). Postoperative complications were detected in 2 (1.9%) patients. Histopathology showed adenocarcinoma in 9 (8.0%) patients. Two (1.7%) patients produced local recurrence. CONCLUSION: ESD is a safe method removal of colon ademonas. The intra- and postoperative complications rate is 3.5% and 1.9% for the 1st and the 2nd group. Local recurrences occurred in 2,04%. Unfavorable lesion lifting (≤2 mm) in right colon is a risk factor for specimen fragmentation or conversion.

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Evaluation of Hyponatremia among Psychiatric Inpatients: A Preliminary Local Appraisal

Neurodegeneration and Neurorehabilitation ◽

10.31579/2692-9422/004 ◽

2019 ◽

Vol 2 (1) ◽

pp. 01-04

Author(s):

Saeed Shafti

Keyword(s):

Clinical Symptoms ◽

Statistical Significance ◽

Psychiatric Inpatients ◽

Annual Incidence ◽

P Value ◽

Diagnostic And Statistical Manual ◽

Duration Of Illness ◽

Schizophrenic Patients ◽

Male Patients ◽

One Year

Introduction: Hyponatremia is one of the most frequent ion and water disorders and severe hyponatremia is associated with well-known clinical symptoms and manifestations. In the present assessment the incidence and clinical profile of hyponatremia have been probed among a great sample of non-western psychiatric inpatients and compared with the available data in literature regarding prevalence and other associated clinical characteristics. Methods: All inpatients with idiopathic hyponatremia during the last sixty-four months had been included in the present study. Clinical diagnosis, as well, was in essence based on ‘Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM-5)’. Statistical significance had been defined as a p value ≤0.05. Results: While the annual incidence of hyponatremia in current evaluation was around 0.01%, the annual incidence of mortality due to hyponatremia was around 0.001%. It was significantly more prevalent among male psychiatric inpatients (p<0.04) and patients with duration of illness in excess of one year (p<0.04). Furthermore it was meaningfully more evident among schizophrenic patients (p<0.007), in comparison with remaining primary psychiatric disorders. There was no significant relationship between hyponatremia and symptomatic profile, or serum level of sodium and occurrence of seizure. Conclusion: Hyponatremia was significantly more prevalent among male patients and cases with duration of illness in excess of one year. Furthermore it was meaningfully more evident among schizophrenic patients.

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PS02.236: THE IMPACT OF PREOPERATIVE SKELETAL MUSCLE MASS ON POSTOPERATIVE OUTCOMES AFTER ESOPHAGECTOMY FOR ESOPHAGEAL CANCER

Diseases of the Esophagus ◽

10.1093/dote/doy089.ps02.236 ◽

2018 ◽

Vol 31 (Supplement_1) ◽

pp. 189-189

Author(s):

Shion Uemura ◽

Toshiaki Shichinohe ◽

Yuma Ebihara ◽

Yo Kurashima ◽

Soichi Murakami ◽

...

Keyword(s):

Skeletal Muscle ◽

Esophageal Cancer ◽

Postoperative Complications ◽

Muscle Mass ◽

Skeletal Muscle Mass ◽

Postoperative Outcomes ◽

High Morbidity ◽

Significant Difference ◽

Male Patients ◽

The Impact

Abstract Background It is said that preoperative muscle volume is likely associated with postoperative short- and long-term outcomes in several kinds of cancer by many reports. Esophagectomy for esophageal cancer (EC) is associated with high morbidity and EC has one of the worst prognoses in several kinds of cancer. We investigated the association of preoperative skeletal muscle mass with postoperative outcomes to improve them. Methods We analyzed 150 patients who underwent esophagectomy from February 2002 to March 2016. The cross-sectional area of the psoas muscle index (PMI) was measured at the third lumbar vertebral level using computed tomography. Clavien-Dindo classifications were used to analyze postoperative complications. Since skeletal muscle mass is significantly different according to gender, all analyses were completed by gender (male: 124, female: 26). The Mann-Whitney U test and the chi-square test were used to compare two groups for the analysis of postoperative complications. Multivariate analysis of postoperative complications was performed using a logistic regression model. Survival analyses were performed using a Cox proportional hazard model. Differences were considered to be significant if the P value was less than 0.05. Results In male patients, PMI value was significantly higher in CD≦ II groups than CD≧ III groups. It was also a independent factor for predicting postoperative complications (odds ratio: 0.995, 95% confidence interval: 0.991–0.999, P = 0.02). On the other hand, there was not a significant difference between PMI and overall survival. In female patients, PMI was not associated with postoperative complications and survival. Only pulmonary function (vital capacity percentage) was associated with postoperative complications and survival. Conclusion Preoperative muscle mass was associated with postoperative complications in male patients with EC. In male patients, PMI can be a useful tool to predict postoperative outcomes and select patients who require preoperative nutritional intervention and rehabilitation. Disclosure All authors have declared no conflicts of interest.

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OPERATIONS FOR ANEURISM OF THE ABDOMINAL AORTIC DEPARTMENT - RESECTION WITH THE FOLLOWING PROSTHETICS AND ENDOPROSTHETICS: A COMPARATIVE ANALYSIS OF COMPLICATIONS

СИСТЕМНЫЙ АНАЛИЗ И УПРАВЛЕНИЕ В БИОМЕДИЦИНСКИХ СИСТЕМАХ ◽

10.36622/vstu.2020.19.2.007 ◽

2020 ◽

pp. 43-49

Author(s):

Андрей Анатольевич Иванов ◽

Александр Иванович Жданов ◽

Максим Сергеевич Шевелин ◽

Александр Сергеевич Брежнев

Keyword(s):

Comparative Analysis ◽

Postoperative Complications ◽

Statistical Significance ◽

Aortic Aneurysms ◽

Surgical Interventions ◽

Vein Thrombosis ◽

Scientific Hypothesis ◽

Abdominal Aortic ◽

Life Threatening ◽

High Level

В статье представлены данные оригинального исследования по улучшению хирургического лечения аневризм брюшного отдела аорты. С этой целью произведен сравнительный анализ двух альтернативных друг другу операций: 1) резекции аневризмы с последующим протезированием аорты; 2) эндопротезирования аорты. Сформулировано научное предположение о том, что замена «классических» операций резекции аневризмы на «альтернативные» операции эндопротезирования приведет к принципиальному снижению уровня послеоперационных осложнений. В независимых группах пациентов с использованием сравниваемых хирургических вмешательств произведена точная качественная и количественная оценка послеоперационных осложнений: нетромботических - кардиальных, пульмональных, ренальных и тромботических - тромбозов глубоких вен и тромбозов браншей протеза. После реализации исследования было установлено, что замена «классических» операций на «альтернативные» достоверно приводит к принципиальному снижению уровня наиболее жизнеопасных осложнений - кардиальных (острых форм ишемической болезни сердца, нарушений сердечного ритма), пульмональных (пневмоний, тромбоэмболии легочной артерии, респираторного дистресс-синдрома взрослых) и ренальных (острой почечной недостаточности). Некоторое исключение составили менее жизнеопасные тромботические осложнения. Полученные результаты имеют высокий уровень статистической значимости, что позволяет рекомендовать их к рассмотрению к использованию в практике сосудистой хирургии The article presents data from an original study to improve the surgical treatment of abdominal aortic aneurysms. For this purpose, a comparative analysis of two alternate operations was performed: 1) aneurysm resection followed by aortic prosthetics; 2) aortic endoprosthetics. The scientific hypothesis is formulated that the replacement of the «classical» operations of resection of the aneurysm with «alternative» operations of endoprosthetics will lead to a fundamental decrease in the level of postoperative complications. In independent groups of patients using the compared surgical interventions, an accurate qualitative and quantitative assessment of postoperative complications was made: non-thrombotic - cardiac, pulmonary, renal and thrombotic - deep vein thrombosis and prosthetic jaw thrombosis. After the study was completed, it was found that the fundamental replacement of «classical» operations with «alternative» reliably leads to a fundamental decrease in the level of the most life-threatening complications - cardiac (acute forms of coronary heart disease, cardiac arrhythmias), pulmonary (pneumonia, pulmonary thromboembolism, respiratory distress syndrome of adults) and renal (acute renal failure). Some exceptions were less life-threatening thrombotic complications. The results obtained have a high level of statistical significance, which allows us to recommend them for consideration in the practice of vascular surgery

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Gene mutation and drug resistance of M. tuberculosis in the patients followed up in the city of Moscow

Tuberculosis and lung diseases ◽

10.21292/2075-1230-2019-97-12-34-44 ◽

2020 ◽

Vol 97 (12) ◽

pp. 34-44

Author(s):

M. A. Krasnova ◽

E. M. Belilovsky ◽

S. E. Borisov ◽

A. A. Khakhalina ◽

Yu. D. Mikhaylova ◽

...

Keyword(s):

Drug Resistance ◽

Statistical Significance ◽

Molecular Genetic ◽

Previous Treatment ◽

Repeated Treatment ◽

Phenotypic Resistance ◽

Therapy Regimen ◽

Treatment History ◽

History Of ◽

Relationship Of

The article describes a retrospective study of the results of microbiological and molecular genetic tests of 685 M. tuberculosis cultures isolated from 685 adult tuberculosis patients registered for dispensary follow-up in Moscow in 2014.The following was identified during the study: phenotypic drug resistance (FDR) of MTB to rifampicin, isoniazid, fluoroquinolones, kanamycin, amikacin, and capreomycin in groups of patients with different treatment history; the frequency of FDR to the above anti-tuberculosis drugs in strains with mutations being drug resistance markers; the frequency of various mutations in case of FDR of mycobacteria in the patients from different groups; the relationship of FDR or the presence of a particular mutation with various characteristics of the patients and their treatment history.The history of previous treatment was determined as statistical significance to provide the greatest influence on the spread of drug resistant MTB: patients undergoing repeated treatment had FDR more often and also a much more pronounced variety of mutations being markers of FDR to certain anti-tuberculosis drugs.The results of the study showed that the detection of genetic mutations in MBT associated with FDR was a reliable tool for predicting phenotypic resistance and should be used as the main method for selecting anti-tuberculosis drugs when compiling the etiotropic therapy regimen.

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Changes In Prothrombin And Activated Partial Thromboplastin Time During Replacement Therapy With Human Recombinant Growth Hormone In Growth Hormone Deficient Adults

American Journal of Clinical Pathology ◽

10.1093/ajcp/aqaa161.224 ◽

2020 ◽

Vol 154 (Supplement_1) ◽

pp. S102-S103

Author(s):

Y S Kamel

Keyword(s):

Growth Hormone ◽

Replacement Therapy ◽

Healthy Subjects ◽

Recombinant Growth Hormone ◽

Gh Replacement ◽

Coagulation Tests ◽

Before And After ◽

Human Recombinant Growth Hormone ◽

Male Patients ◽

One Year

Abstract Introduction/Objective The aim of this study was to investigate the effects of GH administration on basic coagulation parameters: PT, aPTT and fibrinogen concentrations in adult GHD patients before and during one year of GH replacement. Methods Twenty-one adult patients with severe GHD (mean age +/- SE: 38.6 +/- 2.8 years) were included in this hospital based, prospective, interventional study. All patients were treated with rhGH for 12 months (GH dose: 0.4 mg/day for male and 0.6 mg/day for female patients). IGF-1 concentrations were determined using RIA-INEP kits. Basic coagulation tests, i.e. aPTT and fibrinogen concentrations, were measured before and after 3, 6 and 12 months of treatment with rhGH. Control values were obtained from fourteen “healthy” subjects matched by age, sex and body mass index (BMI). Results At baseline, we observed no significant differences in PT, aPTT and fibrinogen values between GHD and healthy subjects. IGF-1 concentrations increased significantly within 3 months of GH therapy (8.2 +/- 1.5 vs. 24.2 +/- 2.9 nmol/l, p <0.05) and remained stable thereafter. A significant increase in PT values, which was more pronounced in female subjects, was noted after 6 and 12 months of treatment with GH. aPTT values increased significantly after 12 months of treatment only in male patients (28.8 +/- 4.6 vs. 39.7 +/- 2.1 s.; p <0.05). No significant changes in fibrinogen concentrations were found during the study. Conclusion Twelve months of GH replacement therapy led to a significant increase in PT and aPTT values in adult GHD patients, while fibrinogen concentrations did not change. Changes in PT were more pronounced in female GHD patients, while an increase in aPTT values was observed only in male patients with GHD. The clinical significance of these changes needs further evaluation.

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The Role of Visceral Obesity, Sarcopenia and Sarcopenic Obesity on Surgical Outcomes After Liver Resections for Colorectal Metastases

World Journal of Surgery ◽

10.1007/s00268-021-06073-9 ◽

2021 ◽

Author(s):

M. Runkel ◽

T. D. Diallo ◽

S. A. Lang ◽

F. Bamberg ◽

M. Benndorf ◽

...

Keyword(s):

Risk Factors ◽

Postoperative Complications ◽

Visceral Obesity ◽

The Body ◽

Postoperative Outcomes ◽

Sarcopenic Obesity ◽

Colorectal Metastases ◽

Complication Rates ◽

The Impact ◽

Body Compositions

Abstract Background The impact of body compositions on surgical results is controversially discussed. This study examined whether visceral obesity, sarcopenia or sarcopenic obesity influence the outcome after hepatic resections of synchronous colorectal liver metastases. Methods Ninety-four consecutive patients with primary hepatic resections of synchronous colorectal metastases were identified from a single center database between January 2013 and August 2018. Patient characteristics and 30-day morbidity were retrospectively analyzed. Body fat and skeletal muscle were calculated by planimetry from single-slice CT images at the level of L3. Results Fifty-nine patients (62.8%) underwent minor hepatectomies, and 35 patients underwent major resections (37.2%). Postoperative complications occurred in 60 patients (62.8%) including 35 patients with major complications (Clavien–Dindo grade III–V). The mortality was nil at 30 days and 2.1% at 90 days. The body mass index showed no influence on postoperative outcomes (p = 1.0). Visceral obesity was found in 66 patients (70.2%) and was significantly associated with overall and major complication rates (p = .002, p = .012, respectively). Sarcopenia was observed in 34 patients (36.2%) without a significant impact on morbidity (p = .461), however, with longer hospital stay. Sarcopenic obesity was found in 18 patients (19.1%) and was significantly associated with postoperative complications (p = .014). Visceral obesity, sarcopenia and sarcopenic obesity were all identified as significant risk factors for overall postoperative complications. Conclusion Visceral obesity, sarcopenic obesity and sarcopenia are independent risk factors for overall complications after resections of CRLM. Early recognition of extremes in body compositions could prompt to perioperative interventions and thus improve postoperative outcomes.

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Photorefractive keratectomy for correction of myopia: Our one-year experience

Vojnosanitetski pregled ◽

10.2298/vsp1210852r ◽

2012 ◽

Vol 69 (10) ◽

pp. 852-857

Author(s):

Mirko Resan ◽

Miroslav Vukosavljevic ◽

Milorad Milivojevic

Keyword(s):

Visual Acuity ◽

Postoperative Complications ◽

Intraoperative Complications ◽

Mean Value ◽

Ablation Depth ◽

Laser In Situ Keratomileusis ◽

Photorefractive Keratectomy ◽

Corneal Tissue ◽

Surgical Method ◽

A Prospective Study

Background/Aim. Photorefractive keratectomy (PRK), after laser in situ keratomileusis (LASIK), is commonly performed refractive surgical method worldwide. The aim of this study was to examine the effectiveness and safety of PRK in correction of various strengths of myopia and to assess how much corneal tissue is being removed with one diopter sphere (Dsph) correction by using different optical zones (OZ). Methods. A prospective study with a follow-up period of 6 months included 55 patients of which 100 myopic eyes were treated by PRK method (one eye was included in 10 patients). Myopic eyes with a preoperative best corrected visual acuity (BCVA) = 1.0 (20/20) were analysed. In order to assess the effectiveness of PRK operated myopic eyes were divided into four groups according to the dioptric power: 1)? -1.75 Dsph (n = 26); 2) from -2 to -3.75 Dsph (n = 44); 3) from -4 to -6.75 Dsph (n = 23), and 4) ? -7 Dsph (n = 7). Myopic eyes with preoperative BCVA ? 0.9 (amblyopic eyes) were excluded from the study, as well as eyes with astigmatism > -1.5 Dcyl. To assess the effectiveness of PRK we examined the percentage of eyes in the mentioned groups, which derived uncorrected visual acuity (UCVA) 6 months after the intervention to the following: a) UCVA = 1.0 (20/20) and b) UCVA ? 0.5 (20/40). To assess the safety of PRK we examined the frequency of intraoperative and postoperative complications. To estimate how much corneal tissue was removed with one Dsph correction by using different OZ, we used preoperative and postoperative (after 6 months) central pachymetry values expressed in ?m and volume of cornea (central 7 mm) expressed in mm?. In that sense, we used only the myopic eyes with clear preoperative spherical refraction. The total number of these eyes was 27, of which 16 eyes were treated using a 6.5 mm OZ and 11 eyes using a 7 mm OZ. Results. Refractive spherical equivalent (RSE) for all eyes was in the range from -0.75 to -8.75 Dsph, and preoperative mean value of RSE with standard deviation (mean RSE ? SD) was -3.32 ? 1.83 Dsph. Six months after PRK, 91% of eyes had UCVA = 20/20, and 99% of eyes had UCVA ? 20/40. In the first group (? -1.75 Dsph) preoperative mean RSE ? SD was -1.34 ? 0.32 Dsph, six months after PRK, 96% of eyes had UCVA = 20/20, and 100% of eyes had UCVA ? 20/40. In the second group (from -2 to -3.75 Dsph) preoperative mean RSE ? SD was - 2.95 ? 0.57 Dsph, six months after PRK, 89% of eyes had UCVA = 20/20, and 100% of eyes had UCVA ? 20/40. In the third group (from -4 to -6.75 Dsph) preoperative mean RSE ? SD was - 4.93 ? 0.70 Dsph, six months after PRK, 100% of eyes had UCVA = 20/20. In the fourth group (? - 7 Dsph) preoperative mean RSE ? SD was -7.71 ? 0.67 Dsph, six months after PRK, 57% of eyes had UCVA = 20/20, and 86% of eyes had UCVA ? 20/40. There were no intraoperative complications while postoperative complications occurred in 2 patients - in both cases in one eye (2%). In that cases, epithelial defects were detected. In the group of eyes that were treated by 6.5 mm OZ mean RSE ? SD was -2.45 ? 0.99 Dsph, the ablation depth per 1 Dsph was 17.54 ? 5.58 ?m and ablated volume of central 7 mm cornea by 1 Dsph was 0.43 ? 0.18 mm?. In the group of eyes that were treated by 7 mm OZ mean RSE ? SD was -3.32 ? 2.26 Dsph, the ablation depth per 1 Dsph was 23.73 ? 6.91 ?m and ablated volume of central 7 mm cornea by 1 Dsph was 0.61 ? 0.31 mm?. Conclusion. PRK is effective and safe refractive surgical method for correcting myopia up to -8 .75 Dsph. OZ size is the main factor determining the depth of the excimer laser ablation of the corneal tissue volume consumed by 1 Dsph. Higher OZ value determines higher consumption of cornea tissue.

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