scholarly journals Reduced mortality in COVID-19 patients treated with colchicine: Results from a retrospective, observational study

PLoS ONE ◽  
2021 ◽  
Vol 16 (3) ◽  
pp. e0248276
Author(s):  
Lucio Manenti ◽  
Umberto Maggiore ◽  
Enrico Fiaccadori ◽  
Tiziana Meschi ◽  
Anna Degli Antoni ◽  
...  
Keyword(s):  
Clinical Improvement ◽  
Strong Association ◽  
Pulmonary Complications ◽  
Control Group ◽  
Improvement Rate ◽  
Protein Levels ◽  
Reactive Protein ◽  
Randomized Controlled ◽  
Daily Change ◽  
Efficacy Profile

Objectives Effective treatments for coronavirus disease 2019 (COVID-19) are urgently needed. We hypothesized that colchicine, by counteracting proinflammatory pathways implicated in the uncontrolled inflammatory response of COVID-19 patients, reduces pulmonary complications, and improves survival. Methods This retrospective study included 71 consecutive COVID-19 patients (hospitalized with pneumonia on CT scan or outpatients) who received colchicine and compared with 70 control patients who did not receive colchicine in two serial time periods at the same institution. We used inverse probability of treatment propensity-score weighting to examine differences in mortality, clinical improvement (using a 7-point ordinary scale), and inflammatory markers between the two groups. Results Amongst the 141 COVID-19 patients (118 [83.7%] hospitalized), 70 (50%) received colchicine. The 21-day crude cumulative mortality was 7.5% in the colchicine group and 28.5% in the control group (P = 0.006; adjusted hazard ratio: 0.24 [95%CI: 0.09 to 0.67]); 21-day clinical improvement occurred in 40.0% of the patients on colchicine and in 26.6% of control patients (adjusted relative improvement rate: 1.80 [95%CI: 1.00 to 3.22]). The strong association between the use of colchicine and reduced mortality was further supported by the diverging linear trends of percent daily change in lymphocyte count (P = 0.018), neutrophil-to-lymphocyte ratio (P = 0.003), and in C-reactive protein levels (P = 0.009). Colchicine was stopped because of transient side effects (diarrhea or skin rashes) in 7% of patients. Conclusion In this retrospective cohort study colchicine was associated with reduced mortality and accelerated recovery in COVID-19 patients. This support the rationale for current larger randomized controlled trials testing the safety/efficacy profile of colchicine in COVID-19 patients.

scholarly journals Clearing heat and resolving phlegm for acute exacerbation of chronic obstructive pulmonary disease with the syndrome of phlegm-heat obstruction of the lung

2020 ◽  
Vol 48 (8) ◽  
pp. 030006052094550
Author(s):  
Jia Yang ◽  
Junchao Yang
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Acute Exacerbation ◽  
Large Scale ◽  
Control Group ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Protein Levels ◽  
Reactive Protein

Objective This study aimed to evaluate the effect of clearing heat and resolving phlegm for acute exacerbation of chronic obstructive pulmonary disease with the syndrome of phlegm-heat obstruction of the lung. Methods This was a real-world retrospective cohort study of inpatients at our institution from 1 January 2015 to 31 December 2017. The patients were divided into two groups according to whether they received oral traditional Chinese medicine (TCM) for clearing heat and resolving phlegm or routine treatment (controls). Efficacy and safety indicators were analyzed. Propensity score matching was used to control for confounding factors. Results Among 488 patients, 164 (82 pairs) were successfully matched. The changes in neutrophils (%) and C-reactive protein levels were more significant in the TCM group than in the control group. The duration of fever was significantly shorter in the TCM group than in the control group. Conclusions The therapy of clearing heat and resolving phlegm might effectively control the inflammatory reaction of acute exacerbation of chronic obstructive pulmonary disease in patients with the syndrome of phlegm-heat obstruction of the lung, especially for those with fever. Nevertheless, large-scale and prospective studies are required to provide a higher quality of evidence.

C-reactive protein levels are related to suicidality in euthymic patients with bipolar disorder

2016 ◽  
Vol 33 (S1) ◽  
pp. S337-S337
Author(s):  
M. Pantovic Stefanovic ◽  
B. Dunjic-Kostic ◽  
M. Lackovic ◽  
A. Damjanovic ◽  
A. Jovanovic ◽  
...  
Keyword(s):  
Suicide Attempts ◽  
Previous History ◽  
Control Group ◽  
Healthy Controls ◽  
C Reactive Protein ◽  
Course Of Illness ◽  
Protein Levels ◽  
Reactive Protein ◽  
History Of ◽  
Competing Interest

IntroductionImmune alterations are believed to be an important part in etiopathogenesis of affective disorders. However, it is not clear if the altered immune mediators are related to distinct disorders or particular psychopathology.AimsThe aim of our study was to explore the differences in C-reactive protein levels (CRP) between euthymic BD patients and healthy controls, as well as to explore the relationship between CRP and lifetime presented psychopathology within BD.MethodsThe study group consisted of 83 patients diagnosed with BD, compared to the healthy control group (n = 73) and matched according to age, gender, and body mass index (BMI). Lifetime psychopathology has been assessed according to predominant polarity as well as previous history of suicide attempts and psychotic episodes.ResultsThe CRP levels were significantly higher in BD patients when compared to healthy controls. After covarying for confounders, we observed that CRP levels, in euthymic BD patients, were related to number of previous suicide attempts, but not other indicators of lifetime psychopathology.ConclusionsBD patients per se, and particularly those with more suicide attempts, are more likely to present with proinflammatory state, even when in remission. Previous history of suicide attempts could bear specifically vulnerable endophenotype within BD. Systemic, longitudinal monitoring of the course of illness, and potential inflammatory mediators that underlie its systemic nature is warranted.Disclosure of interestThe authors have not supplied their declaration of competing interest.

scholarly journals Effectiviness of Lime Peel Extract (Citrus aurantifolia Swingle) against C-Reactive Protein Levels in Alloxan-Induced Wistar Rats

2021 ◽  
Vol 9 (1) ◽  
Author(s):  
Rivan Virlando Suryadinata ◽  
Amelia Lorensia ◽  
Kezia Sefania
Keyword(s):  
Protein Level ◽  
Wistar Rats ◽  
Control Group ◽  
C Reactive Protein ◽  
Protein Levels ◽  
Reactive Protein ◽  
Post Test ◽  
Lime Peel ◽  
Peel Extract ◽  
Test Control

Hyperglycemia is a metabolic disease that is most often found and continuously increasing. Various complications due to hyperglycemia in the blood can cause tissue damage. It will increase free radicals that can trigger an inflammatory response characterized by an increased C-reactive protein in the blood. Prevention can be done by administering flavonoid antioxidant and lime peel containing high flavonoid. This study aims to analyze the efficacy of lime peel extract against C-reactive protein level with hyperglycemia through alloxan-induced Wistar rats (140 mg/kgBW). It is an experimental study using a post-test control group design that was carried out at the Pharmacology Laboratory of the Universitas Surabaya for the period July–August 2020. Experimental Wistar rats were divided into a negative control group, a positive control group, and three groups with different doses of lime peel extract (2.35 mg, 4.7 mg, and 9.4 mg). Treatment was carried out for 30 days before measuring the C-reactive protein levels in the blood using ELISA. The results showed a difference in C-reactive protein level between groups (Man-Whitney, p=0.004). The increase in the dose of lime peel extract (9.4 mg) showed the lowest C-reactive protein level. Therefore, it can be concluded that the administration of lime peel extract in hyperglycemia conditions can reduce the inflammatory process in the body. EFEK EKSTRAK KULIT JERUK NIPIS (CITRUS AURANTIFOLIA SWINGLE) TERHADAP KADAR C-REACTIVE PROTEIN PADA TIKUS WISTAR YANG DIINDUKSI ALOKSANHiperglikemia merupakan penyakit metabolik yang paling sering dijumpai dan terus mengalami peningkatan dari tahun ke tahun. Berbagai komplikasi akibat hiperglikemia dalam darah dapat menyebabkan kerusakan jaringan. Hal ini dikarenakan hiperglikemia akan meningkatkan radikal bebas sehingga memicu respons inflamasi yang ditandai dengan peningkatan C-reactive protein dalam darah. Pencegahan dapat dilakukan dengan pemberian asupan antioksidan flavonoid. Kulit jeruk nipis memiliki kandungan flavonoid yang tinggi. Penelitian ini bertujuan menganalisis efikasi ekstrak kulit jeruk nipis terhadap kadar C-reactive protein pada tikus Wistar dengan kondisi hiperglikemia melalui induksi aloksan (140 mg/kgBB). Metode pada penelitian ini adalah eksperimental dengan menggunakan post-test control group yang dilaksanakan di Laboratorium Farmakologi Universitas Surabaya periode Juli–Agustus 2020. Hewan coba tikus Wistar dibagi menjadi kelompok kontrol negatif, kelompok kontrol positif, dan tiga kelompok perlakuan dengan pemberian dosis ekstrak jeruk nipis yang berbeda (2,35 mg; 4,7 mg; dan 9,4 mg). Pemberian perlakuan dilakukan selama 30 hari, selanjutnya akan dilakukan pengukuran kadar C-reactive protein dalam darah dengan menggunakan ELISA. Hasil penelitian memperlihatkan perbedaan kadar C-reactive protein antarkelompok (Mann-Whitney, p=0,004). Peningkatan pemberian dosis ekstrak kulit jeruk nipis (9,4 mg) menunjukkan penurunan kadar C-reactive protein paling rendah. Oleh karena itu, dapat disimpulkan bahwa pemberian ekstrak kulit jeruk nipis pada kondisi hiperglikemia dapat menurunkan proses inflamasi dalam tubuh.

The effects of five days of intensive preoperative inspiratory muscle training on postoperative complications and outcome in patients having cardiac surgery: a randomized controlled trial

2019 ◽  
Vol 33 (5) ◽  
pp. 913-922 ◽  
Author(s):  
Xiaoyu Chen ◽  
Lin Hou ◽  
Yuanyuan Zhang ◽  
Xiangjing Liu ◽  
Bohan Shao ◽  
...  
Keyword(s):  
Cardiac Surgery ◽  
Intervention Group ◽  
Pulmonary Complications ◽  
Inspiratory Muscle ◽  
Inspiratory Muscle Training ◽  
Control Group ◽  
Postoperative Pulmonary Complications ◽  
Muscle Training ◽  
Randomized Controlled ◽  
Inspiratory Muscle Strength

Objective: To determine the prophylactic efficacy of short-term intensive preoperative inspiratory muscle training on the incidence of postoperative pulmonary complications in patients scheduled for cardiac surgery. Design: Single-blind, randomized controlled pilot study. Setting: TEDA International Cardiovascular Hospital, China. Subjects: In total, 197 subjects aged ⩾50 years scheduled for cardiac surgery were selected. Intervention: The intervention group ( n = 98) received five days of preoperative inspiratory muscle training on top of the usual care received by the patients in the control group ( n = 99). Main measures: The primary outcome variable was the occurrence of postoperative pulmonary complications. The secondary outcome variables were inspiratory muscle strength, lung function and length of hospitalization. Results: After cardiac surgery, a total of 10 (10.2%) of the 98 patients in the intervention group and 27 (27.3%) of 99 patients in the control group had postoperative pulmonary complications (risk ratio, 0.23; 95% confidence interval (CI), 0.09–0.58, P = 0.002). The study revealed that, compared with the control group, the intervention group had a significant increase in inspiratory muscle strength (by 10.48 cm H2O, P < 0.001), forced expiratory volume in the first second of expiration (FEV1) %predicted (by 3.75%, P = 0.030), forced vital capacity (FVC) %predicted (by 4.15%, P = 0.008) and maximal voluntary ventilation (MVV) %predicted (by 6.44%, P = 0.034). Length of hospital stay was 7.51 (2.83) days in the intervention group and 9.38 (3.10) days in the control group ( P = 0.039). Conclusion: A five-day intensive pattern of preoperative inspiratory muscle training reduced the incidence of postoperative pulmonary complications and duration of postoperative hospitalization in patients undergoing cardiac surgery.

scholarly journals Evaluation of the role of CRP as an early predictor of chorioamnionitis in PPROM

2018 ◽  
Vol 7 (4) ◽  
pp. 1351 ◽  
Author(s):  
Amika Aggarwal ◽  
Sangeeta Pahwa
Keyword(s):  
Predictive Value ◽  
Early Stage ◽  
Control Group ◽  
Total Leucocyte Count ◽  
C Reactive Protein ◽  
Protein Levels ◽  
Reactive Protein ◽  
A Prospective Study ◽  
Early Predictor

Background: Preterm birth is one of the most important cause of perinatal morbidity and mortality. PROM is defined as spontaneous rupture of membranes before the onset of uterine contraction. Objective of present study was to evaluate the role of CRP as an early predictor of Chorioamnionitis in PPROM.Methods: A prospective study was done on 50 cases with PPROM and 50cases of control group without PPROM. All mothers and babies were observed from the time of admission to the time of discharge.Results: C-reactive protein appears to be the most sensitive acute phase protein; rising of less than 24 hours makes it suitable to serve as a marker for diagnosing an infective process in early stage. On comparing C-reactive protein levels with other laboratory tests and indicators of infection (e.g. total leucocyte count DLC, maternal fever, maternal tachycardia, fetal tachycardia) we found CRP level to be more sensitive (100%) but less specific (69.56%) in identifying clinical Chorioamnionitis. The positive predictive value was 22.22% and negative predictive value was 100%.Conclusions: In cases of PPROM, raised CRP is an early predictor of clinical Chorioamnionitis as well as histological Chorioamnionitis.

Serum Endothelial Cell–Specific Molecule 1 (Endocan) Levels in Patients With Acute Myocardial Infarction and Its Clinical Significance

Angiology ◽  
2016 ◽  
Vol 68 (4) ◽  
pp. 354-359 ◽  
Author(s):  
Chong-Rong Qiu ◽  
Qiang Fu ◽  
Jian Sui ◽  
Qian Zhang ◽  
Peng Wei ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Endothelial Cell ◽  
Endothelial Dysfunction ◽  
High Sensitivity ◽  
Control Group ◽  
C Reactive Protein ◽  
Protein Levels ◽  
Reactive Protein ◽  
The Relationship

Endothelial dysfunction is involved in the process of acute myocardial infarction (AMI), that is, the endothelial cell–specific molecule 1 (ESM-1; endocan) is a novel endothelial dysfunction marker. However, the relationship between patients with AMI and serum ESM-1 levels is not very clear. Patients with AMI (n = 216) and a control group (n = 60) without AMI were included in the study. High-sensitivity C-reactive protein (hsCRP) was measured, and the severity of AMI was assessed by a modified Gensini stenosis scoring system. Serum ESM-1 levels were significantly higher in the AMI group ( P < .05). High-sensitivity C-reactive protein levels were also significantly higher in the AMI group ( P < .05). In patients with AMI, serum ESM-1 levels were not significantly correlated with hsCRP levels. There was no significant correlation between serum ESM-1 level and Gensini score. Our findings suggest that serum ESM-1 levels may be a novel biomarker of endothelial dysfunction in patients with AMI.

scholarly journals Welfare Benefits of Intradermal Vaccination of Piglets

Animals ◽  
2020 ◽  
Vol 10 (10) ◽  
pp. 1898 ◽  
Author(s):  
Déborah Temple ◽  
Marta Jiménez ◽  
Damián Escribano ◽  
Gerard Martín-Valls ◽  
Ivan Díaz ◽  
...  
Keyword(s):  
Porcine Circovirus Type ◽  
Growing Pigs ◽  
Porcine Circovirus ◽  
Control Group ◽  
Intradermal Vaccination ◽  
Post Vaccination ◽  
Treatment Groups ◽  
Welfare Benefits ◽  
Protein Levels ◽  
Reactive Protein

Vaccination is reported as a stressful and painful event for animals. This study investigated whether needle-free intradermal vaccination improves the welfare of weaned pigs through the reduction of stress and pain biomarkers and improvement of behavioural parameters compared to traditional intramuscular injection with a needle. A total of 339 weaned piglets were allocated to 3 treatment groups: Intradermal Application of Liquids (IDAL) pigs, vaccinated against Porcine Circovirus type 2 (PCV2) by means of intradermal vaccination using a needle-free device Porcilis® PCV ID; Intramuscular (IM) pigs vaccinated against PCV2 with Porcilis® PCV intramuscularly with a needle; CONTROL pigs were managed identically but did not receive any vaccine injection. At the time of the injection, the reaction of IDAL piglets was similar to control piglets, whereas a greater percentage of piglets vaccinated intramuscularly displayed high-pitch vocalizations (7% CONTROL, 7% IDAL, 32% IM) and retreat attempts (3% CONTROL, 7% IDAL, 39% IM). The day after vaccination, IDAL piglets did not differ from the control piglets for any of the behavioural variables studied through scan samplings. IM piglets showed a lower frequency of social negative interactions (p = 0.001) and rope manipulation (p = 0.04) compared to the CONTROL group. Resting postures did not differ between treatments. At 28 h post-vaccination, IDAL piglets presented lower blood C-reactive protein levels (CONTROL = 20 μg/mL; IDAL = 39 μg/mL; IM = 83 μg/mL, p < 0.0001) and blood Haptoglobin (CONTROL = 1.8 mg/mL; IDAL = 1.9 mg/mL vs. IM = 3.1 mg/mL, p < 0.0001) compared to IM piglets. Salivary chromogranin A and alpha-amylase did not differ between treatment groups when measured 25 min post-vaccination. The method of vaccination did not affect the growth of the piglets or their rectal temperature. These results support that needle-free intradermal vaccination reduces vaccination-related pain in growing pigs.

scholarly journals AGE AND GENDER PREDILECTION OF PLASMA C-REACTIVE PROTEIN LEVELS ON MORTALITY IN FIRST EVER ACUTE ISCHEMIC STROKE

2021 ◽  
pp. 1-4
Author(s):  
Bharat L. Konin ◽  
Shiney Aggarwal ◽  
Swaraj S. Waddankeri
Keyword(s):  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Control Group ◽  
C Reactive Protein ◽  
Stroke Patients ◽  
Age And Gender ◽  
Protein Levels ◽  
Reactive Protein ◽  
Markers Of Inflammation ◽  
And Gender

Background and Purpose: The measurement of markers of inflammation or thrombosis has been proposed as a method to improve the prediction of risk in patients with vascular disease. The role of C-reactive protein (CRP) as a novel plasma marker of atherothrombotic disease is currently under investigation. We related age and gender predilection of plasma CRP levels to first ever ischemic stroke and its role on mortality. Methods: Sixty patients with either hypertension or diabetes or both or none without thrombolysis with first ever acute ischemic stroke patients were examined. CT scan of brain was done after 24 hours of onset of symptoms to confirm the diagnosis. Plasma CRP level was determined after 12 - 72 hours range after the onset of symptoms in all CT confirmed ischemic stroke patients. This clinical study was done during June 2018 to January 2020. CRP was randomly measured in 60 age and sex matched individuals admitted in other wards of the hospital matched in all possible criteria expect the disease under study as a control group. Results: The CRP concentration in ischemic strokes is independent of infarction site, the value was more between 51-70 years of age group and almost equal in both gender. 54 of the 60 ischemic strokes studied had CRP value >6 mg/l and only 6 patients had <6 mg/l (p<0.001), chi square test value is ²=73.65 which is statistically significant. Only 7 of the 60 control group had CRP >6 mg/l. Conclusion: In this study mean C-Reactive protein levels were significantly higher in patients with ischemic stroke when compared to controls. C-reactive protein level increases as age advances. C-reactive protein is a better prognostic marker with no gender predilection and not a mortality predictor.

scholarly journals Compression therapy after posterior lumbar decompression and internal fixation: a prospective, randomized, clinical study

2019 ◽  
Author(s):  
Wu Sun ◽  
Jing-hua Gao ◽  
ZHU Li-guo ◽  
Wei Xiao ◽  
Zhen-zhong Wang ◽  
...  
Keyword(s):  
Blood Cell ◽  
Internal Fixation ◽  
Compression Therapy ◽  
Control Group ◽  
C Reactive Protein ◽  
Protein Levels ◽  
Reactive Protein ◽  
Lumbar Decompression ◽  
Suction Drain ◽  
Closed Suction Drain

Abstract Background: Wound-related complications have become an inevitable problem for spinal surgeons. Negative pressure drainage is the main method to prevent postoperative hematoma and related complications, which is still controversial. This prospective, randomized, controlled study was designed to evaluate the efficacy of compression therapy in the treatment of complications after posterior decompression and internal fixation of the lumbar spine, with emphasis on pain, anemia and inflammation. Methods: Sixty consecutive patients with an average age of 59 years (43–78 years) who were selected for posterior lumbar decompression and internal fixation were randomly assigned into two groups with an equal number of patients. The groups comprised patients on closed suction drain with compression therapy after surgery or those with closed suction drain alone. The drainage volume, visual analogue scale pain score for back pain, white blood cell and red blood cell counts, hemoglobin levels, erythrocyte sedimentation rate, and C-reactive protein levels on the 1st, 3rd, and 10th days after the operation were compared between the two groups. Results: The average follow-up was 6 months and ranged from 3 to 11 months. Drainage volume, the visual analogue scale score, and C-reactive protein levels on the 10th day after the operation were significantly lower in the treatment group than in the control group. The red blood cell count and hemoglobin levels on the 3rd and 10th days after the operation were significantly higher in the treatment group than in the control group (all P<0.05). At the time of discharge, wounds in the two groups showed grade A healing, and there were no signs of late infection in the groups. Conclusions: For postoperative posterior lumbar decompression and internal fixation, compression therapy relieves pain, alleviates anemia and the inflammatory response.

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