scholarly journals Effects of cyproheptadine on body weight gain in children with nonorganic failure to thrive in Taiwan: A hospital-based retrospective study

PLoS ONE ◽  
2021 ◽  
Vol 16 (10) ◽  
pp. e0258731
Author(s):  
Yi-Chun Lin ◽  
Hung-Rong Yen ◽  
Fuu-Jen Tsai ◽  
Chung-Hsing Wang ◽  
Lung-Chang Chien ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Weight Gain ◽  
Body Mass ◽  
Body Weight Gain ◽  
Failure To Thrive ◽  
University Hospital ◽  
Physical Growth ◽  
Prepubertal Children ◽  
Significant Difference ◽  
Cyproheptadine Hydrochloride

Failure to thrive (FTT) impairs the expected normal physical growth of children. This study aimed to evaluate the effects of cyproheptadine hydrochloride on growth parameters in prepubertal children with FTT. The medical records of prepubertal children who were newly diagnosed with FTT at China Medical University Hospital between 2007 and 2016 were retrospectively examined. The patients were divided into two groups depending on whether they had (T-group) or had not (NT-group) received cyproheptadine hydrochloride (0.3 mg/kg daily) for at least 14 days. The mean length of the treatment period was 97.22 days (range: 14–532 days). Weight, height, and body mass index were adjusted for age using the median values in the growth charts for Taiwanese boys and girls as the reference. A total of 788 patients aged 3–11 years were enrolled, 50 in the T-group and 738 in the NT-group. No statistically significant difference in the median age-adjusted weight value was noted between the T-group and NT-group during the follow up period. In the T-group, age-adjusted weight and body mass index were inversely associated with age (P <0.001, P <0.001) and positively associated with medication duration (P = 0.026, P = 0.04). Our findings underscore the positive association between cyproheptadine hydrochloride treatment and weight gain among prepubertal children. Further prospective clinical studies with a. longer and consistent treatment course is warranted.

scholarly journals Annual body mass index gain and risk of hypertensive disorders of pregnancy in a subsequent pregnancy

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Sho Tano ◽  
Tomomi Kotani ◽  
Takafumi Ushida ◽  
Masato Yoshihara ◽  
Kenji Imai ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Weight Gain ◽  
Body Mass ◽  
Body Weight Gain ◽  
Subsequent Pregnancy ◽  
The Body ◽  
Hypertensive Disorders Of Pregnancy ◽  
Hypertensive Disorders ◽  
Age Related ◽  
History Of

AbstractWeight gain during interpregnancy period is related to hypertensive disorders of pregnancy (HDP). However, in interpregnancy care/counseling, the unpredictability of the timing of the next conception and the difficulties in preventing age-related body weight gain must be considered while setting weight management goals. Therefore, we suggest considering the annual change in the body mass index (BMI). This study aimed to clarify the association between annual BMI changes during the interpregnancy period and HDP risk in subsequent pregnancies. A multicenter retrospective study of data from 2009 to 2019 examined the adjusted odds ratio (aOR) of HDP in subsequent pregnancies. The aORs in several annual BMI change categories were also calculated in the subgroups classified by HDP occurrence in the index pregnancy. This study included 1,746 pregnant women. A history of HDP (aOR, 16.76; 95% confidence interval [CI], 9.62 − 29.22), and annual BMI gain (aOR, 2.30; 95% CI, 1.76 − 3.01) were independent risk factors for HDP in subsequent pregnancies. An annual BMI increase of ≥ 1.0 kg/m2/year was related to HDP development in subsequent pregnancies for women without a history of HDP. This study provides data as a basis for interpregnancy care/counseling, but further research is necessary to validate our findings and confirm this relationship.

Evaluation of Vitamin D Deficiency and Its Relationship with Body Mass Index in Children 1 To 16 Years

2021 ◽  
Author(s):  
Elham Nozari Mirarkolaei ◽  
Mahdi Gholami ◽  
Elham Rostami ◽  
Azita Aliakbarniya ◽  
Massoumeh Hotelchi ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Vitamin D ◽  
Children And Adolescents ◽  
Vitamin D Deficiency ◽  
Body Mass ◽  
Body Weight Gain ◽  
Thyroid Stimulating Hormone ◽  
Overweight And Obesity ◽  
Mazandaran Province ◽  
Significant Difference

Introduction: Body weight gain in children and teenagers is one of the major challenges that cause undesirable health outcomes. Simultaneously with the prevalence of overweight and obesity, children and adolescents are diagnosed with 25-hydroxyvitamin D (25(OH)D) deficiency in different sides of the world. The present study aimed to assess 25(OH)D status among Iranian volunteers aged 1-16 years and find the correlation between 25(OH)D status and body mass index (BMI) subjects.    Material and Methods: The total volunteers included 807 Iranian children aged 1 to 16 referred to the general and endocrinology clinics in Babol city, Mazandaran Province. A trained physician determined anthropometric characteristics. Serum levels of calcium (Ca), phosphate (P), creatinine (Cr), urea, thyroxine (T4), thyroid-stimulating hormone (TSH), and 25(OH)D were assessed in all children.      Results: 25.27% of the children were 25(OH)D deficient, and 59.1% were insufficient. There was no significant difference in serum 25(OH)D level between girls and boys (P=0.13). A significant negative correlation was found in serum 25(OH)D level with weight (P=0.000, r=-0.12), BMI (P=0.000, r=-0.13), and age (P=0.000, r=-0.13). Conclusion: These data displayed that 25(OH)D insufficiency is highly prevalent among children in the north of Iran. Serum 25(OH)D levels are affected by age and BMI value. Improving vitamin D deficiency helps to maintain the health of children and adolescents during this critical period.

scholarly journals Utility of modified mid-pregnancy body mass index in predicting obstetric outcomes in Middle Eastern population

2021 ◽  
Vol 7 (1) ◽  
pp. 19-22
Author(s):  
Muzibunnisa A Begam ◽  
Sultan M Salahudheen
Keyword(s):  
Body Mass Index ◽  
Weight Gain ◽  
Body Mass ◽  
Middle Eastern ◽  
Obstetric Outcomes ◽  
Maternal Body Mass Index ◽  
Institute Of Medicine ◽  
Eastern Population ◽  
Significant Difference ◽  
Middle Eastern Population

Objective: To test the value of mid-pregnancy maternal body mass index (BMI) and weight gain in the second half of pregnancy in predicting pregnancy outcomes among Middle Eastern population where pre-gravid BMI was not available. Methods: Retrospective analysis of the obstetric outcomes of 290 women with singleton pregnancies who were categorized into underweight (UW), normal weight (NW), overweight (OW) and obese (OB) according to the BMI at 24-28 weeks of gestation and compared with recommended pre-gravid values by Institute of Medicine (2009). Results: The results showed that the gestational diabetes rate was significantly lower among the UW (2.4%) compared with the NW (8.8%, p<0.05), the OW (14.3%, p=0.006), and OB (20.5%, 0.001). The risk of having macrosomia was eight times higher among OW compared with NW women. The C-section rate was lowest among the UW group but there was no significant difference in terms C-section and low birth weight between groups. The obstetric outcomes among women whose weight gain was above the 90th and below the tenth centiles were not different. Conclusion: The prediction of obstetric outcomes by mid-pregnancy BMI is comparable to pre-gravid BMI. The results are encouraging, and further larger studies are needed to confirm the applicability

scholarly journals Changes in Body Weight and Blood Pressure among Women Using Depo-Provera injection in Northwest Ethiopia

2019 ◽  
Author(s):  
Muluken Fekadie Zerihun ◽  
Tabarak Malik ◽  
Yohannes Mulu Ferede ◽  
Tesfahun Bekele ◽  
Yigizie Yeshaw
Keyword(s):  
Blood Pressure ◽  
Body Mass Index ◽  
Body Weight ◽  
Weight Gain ◽  
Body Mass ◽  
T Test ◽  
P Value ◽  
Arterial Blood ◽  
Significant Difference ◽  
Depo Provera

Abstract Objectives: Depo-Provera is an injectable contraceptive method containing medroxyprogesterone acetate. It has some adverse effects like changes in menstrual pattern, loss in bone mineral density and risk of weight gain. Therefore, this study is aimed at to investigate the effects of Depo-Provera on body weight and blood pressure among Ethiopian women. Institution based cross-sectional study design was conducted from January 2017 to April 2017. Data were analyzed using SPSS version 21 software. Paired t-test, independent t-test and ANOVA were used to evaluate the presence of mean difference and relationship between changes in variables and duration of use of Depo-Provera. P-value ≤ 0.05 were considered as statistically significant. Results: The mean weight and body mass index (BMI) of Depo-Provera users were increased significantly (p=0.02 for mean body weight and p=0.019, for body mass index). There was no significant difference in mean arterial blood pressure (MAP) of Depo-Provera users compared to controls or their respective pretreatment value (p-value=0.85 for Depo-Provera users and 0.67 for non-users). The finding of this study revealed that there is an increased weight gain and BMI among Depo-Provera users compared to non-users, which really requires attention of health professionals and other stake holders.

scholarly journals Changes in Height, Weight, and Body Mass Index in Children with Craniopharyngioma after Three Years of Growth Hormone Therapy: Analysis of KIGS (Pfizer International Growth Database)

2004 ◽  
Vol 89 (11) ◽  
pp. 5435-5440 ◽  
Author(s):  
Mitchell Geffner ◽  
Michael Lundberg ◽  
Maria Koltowska-Häggström ◽  
Roger Abs ◽  
Johan Verhelst ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Weight Gain ◽  
Body Mass ◽  
Growth Patterns ◽  
The Other ◽  
Gh Therapy ◽  
Gh Treatment ◽  
Prepubertal Children ◽  
International Growth ◽  
The Mean

Abstract Extreme degrees of obesity may occur in association with hypothalamic tumors, usually after surgical intervention. This phenomenon has been reported to occur in as many as 25–75% of children undergoing extensive surgical extirpation of craniopharyngiomas (Cranio). Because less is known about the auxology of children with Cranio with milder alterations in growth, we undertook a 3-yr longitudinal analysis, using the KIGS database (Pfizer International Growth Database), to study their growth patterns and evolution of weight. We compared the effect of GH therapy on height, weight, and body mass index (BMI) in 199 prepubertal children with diagnosed Cranio treated by surgery and/or radiotherapy to two other groups of children with other causes of organic GH deficiency (OGHD): one with postsurgical and/or postirradiated OGHD (OGHD + S/I; n = 92) and the other with OGHD not due to Cranio and not having undergone either surgery or irradiation (OGHD − S/I; n = 85). At the start of GH therapy, 1) mean chronological (P &lt; 0.0001) and bone (P = 0.0002) ages were youngest in OGHD − S/I and oldest in OGHD + S/I; 2) the mean height sd score (SDS) was lowest in OGHD − S/I and comparably higher in the other two groups (P &lt; 0.0001); 3) mean weight and BMI SDS were greatest in Cranio and least in OGHD − S/I (both P &lt; 0.0001); and 4) the mean initial GH dose prescribed was highest in OGHD − S/I and comparable in the other two groups (P &lt; 0.0001). After 3 yr of GH therapy, 1) mean bone age remained youngest in OGHD − S/I and oldest in OGHD + S/I (P &lt; 0.0001); 2) mean height SDS was highest in Cranio and comparably lower in the other two groups (P = 0.0159); 3) mean weight and BMI SDS remained greatest in Cranio and least in OGHD − S/I (P &lt; 0.0001 and P = 0.0003, respectively); and 4) the mean GH dose remained highest in the OGHD − S/I group and least in the Cranio group (P = 0.0082). There were statistically significant increases within each group between the start of treatment and after 3 yr of GH therapy in height and weight, but not in BMI SDS. Lastly, after 3 yr of GH treatment, children in the Cranio group continued to have disproportionately heavier weight and higher BMI (with the greatest values in those with lower stimulated peak GH concentrations) compared with members of the other two groups, with no salutary effect of GH treatment on weight SDS and a mild improvement in BMI SDS. After S/I treatment, children with Cranio are disproportionately prone to varying degrees of weight gain compared with children with other forms of OGHD. In the present cohort of prepubertal children with Cranio, GH therapy induced excellent linear growth, but failed to have an ameliorative effect on weight gain and had only a slight beneficial effect on BMI gain. Because affected children may have resultant significant long-term medical morbidity and diminished quality of life, it is critical that the mechanism of this phenomenon be determined to devise helpful preventive or therapeutic interventions.

scholarly journals Association between variability in body mass index and development of type 2 diabetes: Panasonic cohort study

2021 ◽  
Vol 9 (1) ◽  
pp. e002123
Author(s):  
Hiroshi Okada ◽  
Masahide Hamaguchi ◽  
Momoko Habu ◽  
Kazushiro Kurogi ◽  
Hiroaki Murata ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Body Mass Index ◽  
Body Weight ◽  
Weight Gain ◽  
Body Mass ◽  
Cox Regression ◽  
Body Weight Gain ◽  
Design And Methods ◽  
Fourth Quartile

IntroductionContrasting results have been reported for the association between the variability in body weight and development of diabetes. In the present study, we evaluated the association between the variability in body mass index (BMI) and development of type 2 diabetes in 19 412 Japanese participants without obesity and without body weight gain or loss during the study period.Research design and methodsWe recorded body weight of the participants consecutively each year in Panasonic Corporation, Osaka, Japan from 2008 to 2014 to evaluate the variability of BMI. The participants with obesity (BMI ≥25 kg/m2) at baseline and body weight gain or loss from 2008 to 2014 (delta BMI ≥±1 kg/m2) were excluded from the study. In total, 416 participants developed type 2 diabetes from 2015 to 2018. We used coefficient of variation (CV) to represent the variability in BMI during 6 years of the study period.ResultsCox regression analyses revealed that the risk of developing type 2 diabetes was higher in the fourth quartile (HR 1.33; 95% CI 1.01 to 1.75) of CV of BMI than that in the first quartile (lowest quartile) of CV of BMI after adjusting for multiple confounding factors. The risk for developing diabetes increased by 11.1% per 1% increase in CV of BMI.ConclusionsIn conclusion, the variability in BMI is a risk factor for the development of diabetes in the Japanese population without obesity and without body weight gain or loss.

scholarly journals Relationship between changes in body mass index during pregnancy and pregnancy rhinitis

2021 ◽  
Vol 20 (1) ◽  
pp. 23-26
Author(s):  
L. V. Georgieva ◽  
◽  
V. A. Stepanova ◽  
Keyword(s):  
Body Mass Index ◽  
Weight Gain ◽  
Pregnant Women ◽  
Body Mass ◽  
Body Weight Gain ◽  
Total Weight ◽  
Control Group ◽  
Total Weight Gain ◽  
Pregnancy Rhinitis ◽  
Weight Gain During Pregnancy

Objective of the study: to determine the relationship between the total weight gain during pregnancy and the development of rhinitis during pregnancy. The study involved 49 pregnant women with symptoms of rhinitis during pregnancy, aged 24 to 41 years (30,4 ± 0,6 years), and 33 pregnant women without symptoms of rhinitis aged 20 to 38 years (mean age 29,7 ± 0,7 years). The study included the assessment of complaints, history taking, otorhinolaryngological examination, calculation of body mass index before pregnancy and by the time of delivery and estimation of total body weight gain during pregnancy, and follow-up study. Based on the study, statistically significant differences between body mass indexes by the time of delivery in study group and in healthy pregnant group were not revealed. However, in the group of women with pregnant rhinitis, the dynamics of body mass index (total weight gain) significantly exceeded this indicator in the control group (13,3 ± 0,9 kg and 10,5 ± 1,3 kg, respectively). Pathological weight gain during pregnancy was observed more often in women with pregnancy rhinitis who were overweight before pregnancy.

scholarly journals Changes in Body Weight and Blood Pressure among Women Using Depo-Provera injection in Northwest Ethiopia

2019 ◽  
Author(s):  
Muluken Fekadie Zerihun ◽  
Tabarak Malik ◽  
Yohannes Mulu Ferede ◽  
Tesfahun Bekele ◽  
Yigizie Yeshaw
Keyword(s):  
Blood Pressure ◽  
Body Mass Index ◽  
Body Weight ◽  
Weight Gain ◽  
Body Mass ◽  
T Test ◽  
P Value ◽  
Arterial Blood ◽  
Significant Difference ◽  
Depo Provera

Abstract Objectives: Depo-Provera is an injectable contraceptive method containing medroxyprogesterone acetate. It has some adverse effects like changes in menstrual pattern, loss in bone mineral density and risk of weight gain. Therefore, this study is aimed at to investigate the effects of Depo-Provera on body weight and blood pressure among Ethiopian women. Institution based cross-sectional study design was conducted from January 2017 to April 2017. Data were analyzed using SPSS version 21 software. Paired t-test, independent t-test and ANOVA were used to evaluate the presence of mean difference and relationship between changes in variables and duration of use of Depo-Provera. P-value ≤ 0.05 were considered as statistically significant. Results: The mean weight and body mass index (BMI) of Depo-Provera users were increased significantly (p=0.02 for mean body weight and p=0.019, for body mass index). There was no significant difference in mean arterial blood pressure (MAP) of Depo-Provera users compared to controls or their respective pretreatment value (p-value=0.85 for Depo-Provera users and 0.67 for non-users). The finding of this study revealed that there is an increased weight gain and BMI among Depo-Provera users compared to non-users, which really requires attention of health professionals and other stake holders.

scholarly journals Body Image Perceptions and Eating Patterns Among Preadolescent Children

2007 ◽  
Vol 5 (1) ◽  
pp. 14-22 ◽  
Author(s):  
Karen M. Skemp-Arlt ◽  
Richard P. Mikat
Keyword(s):  
Body Mass Index ◽  
Body Image ◽  
Weight Gain ◽  
Body Mass ◽  
Eating Attitude ◽  
Eating Patterns ◽  
Body Type ◽  
Disturbed Eating ◽  
Preadolescent Children ◽  
Significant Difference

Preadolescent children are showing patterns of body distortion and unhealthy dieting practices to attempt weight manipulation. The present study examined body image perceptions and interest in weight manipulation among 215 preadolescent children (girls, n =101) (mean age = 10) in third, fourth, and fifth grades. To measure body image perceptions, children were asked to answer two multiple choice questions: I think I am: fat, skinny, in-between; and I would like to: lose weight, gain weight, stay the same. Interest in weight manipulation was measured using the Children’s Eating Attitude Test (ChEAT). Results indicated that children show a fairly accurate perception of their body shape and size and this remained consistent for both genders and across all age groups. ANOVA results showed children who felt they were “fat” had a significantly higher level of disturbed eating patterns (ChEAT mean = 14.00) compared to the children who felt they were “in-between” (ChEAT mean = 6.95) (p = .009). Children who indicated they would like to “lose weight” had significantly higher ChEAT scores (mean = 9.19) than those who wanted to “stay the same” (mean = 6.56) (p = .033). ChEAT scores for girls showed a significant difference between the “fat” group (mean = 29.00) and the “in-between” group (mean = 6.81) (p < .001) and between the “fat” group and the “skinny” group (mean = 10.78) (p = .002). Twenty-five percent of this sample of children indicated a desire to “lose weight” (mean body mass index = 21.35) and 67% desired to “stay the same” (mean body mass index = 17.45). Preadolescent children are showing a desire for a thinner body type and are already developing a motivation to avoid weight gain or obesity through dietary manipulation. Early identification of body distortion and disturbed eating patterns could help with education and prevention strategies.

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