scholarly journals Seizure control status and associated factors among pediatric epileptic patients at a neurologic outpatient clinic in Ethiopia

PLoS ONE ◽  
2021 ◽  
Vol 16 (11) ◽  
pp. e0259079
Author(s):  
Habtamu Digis Adal ◽  
Kassahun Alemu ◽  
Esileman Abdela Muche

Background Childhood epilepsy is a major public health problem worldwide. Even though anti-seizure medications (ASM) have been demonstrated to control seizures, children with epilepsy continue to have frequent seizures. There is a scarcity of data on seizure control status among pediatric epileptic patients in Ethiopia. The aim of this study was to assess seizure control status and associated factors among pediatric epileptic patients. Methods A hospital based cross-sectional study was done on 261 pediatric epileptic patients being followed up at the University of Gondar Comprehensive and Specialized Hospital, Northwest Ethiopia, from May 11 to August 11, 2019. The data were collected through caregiver interviews and patients’ medical records. All independent variables with p value of ≤ 0.2 in univariate analysis were taken to multivariable analysis. Adjusted odds ratio (AOR) with a 95% confidence interval was computed to see the predictors of seizure control status. Level of statistical significance was declared if p-value < 0.05. Result From a total of 261 patients, 159 (60.9%) were males and had a mean age was 10.16 ± 4.62 years. More than half (57.1%) of participants were urban dwellers. Almost all (98.5%) were diagnosed with generalized tonic-clonic seizures. Majority (75.1%) of the patients were on mono-therapy. Forty-six (17.6%) of the patients reported adverse effects related to ASMs. Two hundred-three (77.8%) of the patients were adherent to their medications. Nearly half (49.0%) of the patients had controlled seizures. Urban residency (AOR: 2.12; 95% CI: 1.15–3.89; P = 0.016), adherence to medication (AOR: 3.92; 95% CI: 1.84–8.36; P < 0.001), use of combined ASM(AOR: 0.29; 95% CI: 0.14–0.59; P = 0. 001), durations of ASM use [2–5 years (AOR: 5.81; 95% CI: 2.89–11.70; P <0.001) and >5years (AOR: 4.80; 95% CI: 1.91–12.09; P = 0.001)]were significantly associated with seizure control status. Conclusion Inadequate numbers of pediatric epileptic patients’ at the Ethiopian neurologic clinic achieved seizure control. Coming from a rural area, non-adherence to ASMs, use of multiple ASMs, and the use of ASMs for <2years were found to have a significant association with poorer seizure control, needing special attention to get control of seizure. Caregivers should closely monitor and address any barriers that contribute to ASM non-adherence and adverse drug events.

PLoS ONE ◽  
2021 ◽  
Vol 16 (3) ◽  
pp. e0249024
Author(s):  
Misganaw Gebrie Worku ◽  
Getayeneh Antehunegn Tesema ◽  
Achamyeleh Birhanu Teshale

Background Though the consequences of teenage pregnancy and early motherhood has been studied very well, little is known about the magnitude as well as the determinants of adolescent fatherhood. Unlike adolescent motherhood, limited public health programs are working on adolescent fatherhood. Currently, in developed countries, there is an increased work to acknowledge teen fathers in clinical practice and in the research forum, but still, there are more issues that need to be addressed in developing countries including Ethiopia. Therefore, this study aimed to investigate the prevalence and associated factors of adolescent fatherhood in Ethiopia based on the nationally representative survey. Methods This study used the 2016 Ethiopian Demographic and Health Survey (EDHS) data. A total weighted sample of 4455 adolescent men was included for the final analysis. For the associated factors, multilevel logistic regression analysis was conducted to consider the hierarchical nature of the EDHS data. Intra-class Correlation Coefficient (ICC), and deviance (-2LLR) were used for model comparison and for assessing model fitness. The model with the largest adjusted R2, lowest Bayesian Information Criteria (BIC) and the smallest cross-validation prediction error were considered as the best-fitted model. In the multivariable analysis, the Adjusted Odds Ratio (AOR) with 95% Confidence Interval (CI) were reported to declare the presence of statistically significant factors associated with adolescent fatherhood, and variables with p-value <0.05 were considered as a significant variable. Results The prevalence of adolescent fatherhood in Ethiopia was 6.79% [95%CI; 6.08%, 7.56%]. Adolescent men with contraceptive knowledge [AOR = 4.25; 95%CI = 1.23, 14.69], age in 20 to 24 years [AOR = 7.93; 95%CI = 3.66, 17.27] and being Muslim [AOR = 1.84; 95%CI = 1.02, 3.39] were significantly associated with Higher odds of adolescent fatherhood. Individuals who initiate sex lately [AOR = 0.35; 95%CI = 0.22, 0.54], being in female-headed family [AOR = 0.46; 95%CI; 0.26, 0.82] and being from Amhara region [AOR = 0.35; 95%CI = 0.14, 0.84] were significantly associated with lower odds of adolescent fatherhood. Conclusion In this study, adolescent fatherhood was a common public health problem in Ethiopia as it is closely linked with poor quality of life and premature death (year of potential life lost). Age of respondent, knowledge of respondent about contraceptive methods, early initiation of sex, religion, sex of household head, and region were significantly associated with adolescent fatherhood. Therefore, program planners and decision-makers should give special attention to adolescent men through enhancing reproductive health services utilization and their knowledge towards it to decrease the incidence of adolescent fatherhood.


2019 ◽  
Author(s):  
Muktar Abadiga

Abstract BACK GROUND Antiretroviral therapy has a remarkable clinical effect in decreasing the viral replication, reducing the progress of AIDS and deaths related to AIDS. The clinical outcome of ART depends on the strict adherence to antiretroviral medication. However; only a few studies have been done on the adherence status of ART and its determinant factors in Ethiopia and this study could provide an opportunity to identify obstacles to taking medication. Therefore, the purpose of this study was to assess adherence status and associated factors among HIV infected patients on ART attending Nekemte referral hospital, West Ethiopia. METHODS Institutional based cross-sectional study was conducted on 311 HIV/AIDS patients, from March 01 to March 30, 2019. The study participants were selected by simple random sampling method and were interviewed using structured questionnaires. The data were coded, checked, cleaned and entered into Epi data version 3.1 and then exported to SPSS window version 20.0 for analysis. Multivariable logistic regression was used to find the independent variables which best predict adherence. Association and statistical significance were measured using odds ratio at 95% confidence interval and p-value less than 0.05. RESULTS A total of 305 HIV/AIDS patients were included in this study. Out of this,73.1% were adhered to their medication. Respondent’s knowledge about HIV and its treatment (AOR=8.13, 95% CI: 3.06, 21.61), family/social support (AOR=7.36, 95% CI: 2.07, 26.10), adverse effects of ARV medications (AOR=5.62, 95% CI: 2.11, 14.93), co-morbidity of other chronic illness (AOR=5.46, 95% CI: 1.86, 16.02), and family disclosure status (AOR= 5.27, 95% CI: 2.20, 12.62) were significantly associated with adherence to medication among HIV/AIDS patients. CONCLUSION In this study, the level of adherence to antiretroviral therapy was found low compared to the WHO standard. The clinician should emphasize adverse drug reaction, early detect and treat co-morbidities, improve knowledge through health education, and encourage HIV/AIDS patient to disclose their HIV status.


2020 ◽  
Author(s):  
Berhanu Bifato ◽  
Amanuel Ayele ◽  
Muse Rike ◽  
Dalecha Dangura

Abstract Background: Community based health insurance is accepted as a capable tool of health system improvement and improves the health status of enrollees. Its mechanisms look for to protect low-income households from health related risks through mutual risk sharing at the community level. Even though Government’s efforts, the Community based health insurance enrolment rate remained low. Objective: To assess the community based health insurance enrollment and associated factors in Sidama Region, Ethiopia.Methods: A community based cross-sectional study was conducted in Sidama Region, 2020 using a pretested structured questionnaire. The study was conducted in randomly selected 770 households. The data entry was made by using Epi-info 2007 software. The data was analyzed by using SPSS version 20. Logistic regression statistical model was used to compute odds ratio with its 95% confidence interval to test the associations between dependent and independent variables. Then variables found to have P<0.25 in the bi-variable analysis taken as candidate for multivariable analysis. A P-value of 0.05 with a confidence interval of 95% was used to declare level of statistical significance. Result: Among 770 sampled households, 762 were interviewed and the response rate was 98.9%. About 20.2% of the respondents were enrolled in the scheme. Covariates such as፡ ages 31-59 years(AOR :2.62, 95% CI :1.48-4.66)and >=60 years(AOR : 2.87, 95% CI :1.23-6.74), households who had no formal education(AOR:1.66, 95% CI:1.02-2.72),affordability of premium (AOR:0.28, 95% CI: 0.15-0.54), knowledge on CBHI(AOR: 3.53; 95% CI: 1.21, 10.27) and perceived quality(AOR: 0.52, 95% CI: 0.25-0.87) had statistically significant association with community based health insurance enrollment.Conclusion: The prevalence of community based health insurance enrollment was low. This study identified the need to create knowledge and bring behavioral change in the community on the scheme in general. This study also revealed that regular contribution issue needs improvement based on affordability of households and building their trust on the program and efforts should be devoted to enhance quality of healthcare services to increase the enrollment.


2019 ◽  
Author(s):  
Merhawit Gebremeskel Hagos ◽  
Teferi Gebru Gebremeskel ◽  
Selam Shushay Kassahun ◽  
Birhane Hailu Gebrezgi ◽  
Manay Kifle Woldegebriel

Abstract Background Delay in receiving immunization is a major public health problem that has been associated with vaccine preventable disease epidemics. In Ethiopia, many children have not received the benefits of age appropriate immunization; thus more than 90% of child deaths are largely due to preventable communicable diseases. Therefore, assessment of magnitude and associated factors of delayed child immunization is essential to prevent morbidity and mortality among children. Objective To assess magnitude and factors associated with delayed immunization among 11 -23 months old children in Edagahamus Town, Tigray, Ethiopia, 2018 G.C. Method and materials A community based Cross-Sectional study was carried out on July1-30, 2018. Simple random sampling method was used to select study participants. Information was collected using structured, pre-tested questionnaire. Vaccination dates were obtained from children immunization cards and timeliness assessed based on the recommended age ranges. Data were entered and analyzed using SPSS version 20.0. Variable with P-value < 0.2 in bivariatewere exported to multivariate. The strength of association was identified using odds ratio with 95% confidence interval (CI) and P-value of <0.05 in multivariate was taken statistically significant. Results In this study the overall magnitude of delayed immunization was29.5%(95%CI 26.7-45). Private firm work of mothers(AOR=0.205 95% CI 0.068-0.617), sickness of the child(AOR= 11.8, 95% CI 6.16-22.65), Mothers who attend tertiary education (AOR 0.169, 95% CI 0.032-0.882) and secondary education (AOR 0.269, 95% CI 0.114-0.636) were significantly associated with delayed immunization. Conclusion From the study it is concluded that the magnitude of delayed immunization for children aged 12-23 months is high (29.5%) in Edagahamus. Delayed immunizations of children were predicted by Mother’s occupation, education and experience of illness of the child.


2020 ◽  
Author(s):  
Sisay Eshete Tadesse ◽  
Tefera Chane Mekonnen ◽  
Yitbarek Wasihun Feleke ◽  
Metadel Adane Mesfine ◽  
Nigus Cherie Bekele ◽  
...  

Abstract Background Worldwide there are up to 300,000 known plant species. But, only 2% are consumed by human. Under nutrition among under five children is still a public health problem. There is an information gap on the importance of agricultural biodiversity in relation to dietary intake and nutritional status. Objective to assess the correlation between agricultural bio-diversity, dietary diversity, household food insecurity and associated factors of wasting among 6-59 months old children. Method A community based cross-sectional study was employed among 367 systematically selected children aged 6-59 months from January to April 2018. The sample size was determined by Epi Info 7.2.5.1. Data were collected by open data kit. Height and weight were measured using height measuring board and SECA Germany. Data entry and analysis was done using Epi Data version 3.1 and STATA version 14. Descriptive statistics was computed and reported using frequency and percentage. Anthropometric measurements were analyzed using WHO Anthro 2005 software. Linear regression and correlation were done. A p-value of < 0.05 and 95% confidence intervals were used to see the statistical significance. Result The prevalence of wasting was 7.3%(95% C.I; 4.6, 10.0). Dietary diversity score is found to be correlated with height for weight Z score (r=-0.11, p-value=0.04) of children. Mother who are unable to read and write (B=-.126, 95% CI: -1.02, -.034) and dietary diversity score (B=.143, 95% CI: .14, 1.86) were factors associated with wasting. Conclusion and Recommendation Wasting is higher than the national target of Ethiopia. Educational status of mother and DDS were factors associated with wasting among children aged 6-59 months. Prevention of nutritional problem should include reducing illiteracy rate among mother/care-givers and promote diversified intake of diet among 6-59 months old.


2020 ◽  
Author(s):  
Temesgen Anteye Adamu ◽  
Adino Tesfahun Tsegaye

Abstract Background Scabies is an infestation of the skin by the human itch mite ( Sarcoptes scabiei var. hominis ). The parasite is found worldwide and affects people of all races and social classes. Studies shows that the prevalence of scabies is far different as 0.2% in developed countries up to 24% in developing countries. Ethiopia also reports scabies outbreak frequently since 2017. Recent studies show that the attack rate was 25% in Gondar city in Yekolo-temaries and 11% at Badewacho District, Southern Ethiopia. Methods A community based unmatched case-control (1:2 ratios) study was conducted in guna-begemidir district, using collected scabies line listed data and face to face interview to assess risk factors from January to February 2018 with sample size of 156 cases and 312 control. The data were collected using structured questionnaire, and analyzed using SPSS version 22 statistical software. Odds Ratios (OR), P value and 95% Confidence interval (CI) was computed to determine associated factors. Result A total of 4269 scabies case were reported from the district, attack rate of 7.9%. Of those cases 2254 (52.8%) were males. 10 (52.6%) kebeles were affected by the outbreak. The attack rate varies by kebeles which ranges from 0.88% to 25.5%. The highest attack rate was in mena-medihanealem kebele which is 25.5%. Sleeping with Scabies Patients, washing with scabies patients in the past 6 months, putting of cloths with diseased patient cloths and Household daily water consumption were significantly associated with scabies diseases on multivariable analysis. Conclusion and recommendation Scabies is public health problem in the district. Due to delayed detection and response, the disease was highly disseminated mainly because of drug shortage throughout the region. We recommend enhancing, strong ongoing active case surveillance of scabies; health education & availing drugs to all health facilities and do more on the above significant variables.


BMC Nutrition ◽  
2019 ◽  
Vol 5 (1) ◽  
Author(s):  
Melkamu Aderajew Zemene ◽  
Melaku Tadege Engidaw ◽  
Alemayehu Digssie Gebremariam ◽  
Desalegn Tesfa Asnakew ◽  
Sofonyas Abebaw Tiruneh

Abstract Background Adolescents are among the nutritionally vulnerable group due to their nutritional demand for pubertal spurt. At this age, adequate nutrition, nutritional education, and counseling are very important to halt the consequence and its impact on this segment of the population. So, the aim of this study was to assess the prevalence and its associated factors of nutritional status among high school adolescents aged 10–19 years in Debre Tabor Town, South Gondar Zone, and North central Ethiopia. Methods A cross-sectional study was conducted from September to October 2017. A total of 349 high school adolescents were selected by using simple random sampling. Data were collected through face to face interview and physical measurement. The data were entered into Epi info version 7 software and then exported into SPSS version 20 software for further analysis. A p-value < 0.2 was used to select independent variables for multivariable logistic regression. A p-value ≤0.05 was used to declare the statistical significance. Also, odd ratios were calculated with a 95% of the confidence interval to check the existence of the association. Result A total of 327 adolescents participated in this study with the overall response rate of 93.69%. The magnitude of stunting and thinness was 15% (95% CI: 11, 19) and 4.9% (95% CI: 2.4, 7.4) respectively. Sex (AOR: 2.24, 95% CI: 1.15, 4.36), residency (AOR: 2.48, 95% CI: 1.28, 4.82), and family size (AOR: 3.41, 95% CI: 1.65, 7.05) were the associated factors for stunting. Residence (AOR: 3.67, 95% CI: 1.16, 11.56), and living away from the family (AOR: 4.37, 95% CI: 1.20, 15.95) were the associated factors for the development of thinness. Conclusion Stunting is a mild public health problem but not thinness. Sociodemographic variables were the determinant factors for the development of stunting and thinness. To halt this, integrated adolescent related school and nutrition services is very important with adequate and quality food access to adolescents. In addition to this the government shall have to increase the access of education.


2020 ◽  
Vol 9 ◽  
pp. 216495612092362
Author(s):  
Gebremedhin Gebremichael ◽  
Melake Demena ◽  
Gudina Egata ◽  
Berhe Gebremichael

Background Although goiter is a major public health problem in Ethiopia and affects a large number of people, there was little evidence among adolescents particularly in Northern Ethiopia. This study was, therefore, aimed at investigating the prevalence of goiter and associated factors among adolescents in Gazgibla District, Northeast Ethiopia. Methods A community-based cross-sectional study was conducted among 596 adolescents from August 5–30, 2019. Data were collected using a structured questionnaire. Adolescents were assessed for goiter based on World Health Organization criteria. The level of iodine in household salt samples was tested using rapid test kit. Data were entered into EpiData version 3.1 and exported into Statistical Package for the Social Sciences version 22.0 for statistical analysis. Multivariable logistic regression analysis was done to control for all possible confounders and to identify predictors of goiter. Odds ratio along with 95% confidence interval (CI) was estimated to measure the strength of the association. Level of statistical significance was declared at P ≤ .05. Results The prevalence of goiter among adolescents was 42.5% (95% CI: 38.4%, 46.7%). Being a female (adjusted odds ratio [AOR] = 1.83, 95% CI: 1.18, 2.85), family history of goiter (AOR = 3.63, 95% CI: 2.31, 5.69), cabbage consumption at least once per week (AOR = 4.6, 95% CI: 2.42, 8.74), not consuming meat at all (AOR = 2.5, 95% CI: 1.17, 5.32), not consuming milk at all (AOR = 2.19, 95% CI: 1.19, 4.03), and inadequate iodine level of household salt (AOR = 7.05, 95% CI: 3.83, 12.97) were significantly associated with the development of goiter among adolescents. Conclusions The prevalence of goiter was very high in the study area. Therefore, the health sector of the district should invest efforts on improving the community’s awareness through disseminating key messages about iodized salt and iodine-rich foods.


2020 ◽  
Author(s):  
Nalinda Wellappuli ◽  
Nalika Sepali Gunawardena ◽  
PK Buddhika Mahesh ◽  
Shanthi Gunawardena ◽  
Champika Wickramasinghe ◽  
...  

Abstract Background Adolescence period is associated with psycho-social issues which affect their day to day activities and go beyond their adolescent age group. It has been recorded that prevalence of psycho-social issues are rising globally. The aim of this study was to estimate the prevalence and factors associated with the selected attributes of psycho-social well-being among 13 to 17-year in-school adolescents of Sri Lanka using the Global School Health Survey (GSHS), conducted in Sri Lanka. Methods GSHS, was a cross-sectional study conducted among 3,650 adolescents of aged 13–17, attending government schools. Data was collected using a self-administered questionnaire. Psychosocial well-being included questions of four selected outcomes (i.e. bullying, felling alone, sleep disturbances due to a worry, suicidal ideation and practices) and 10 potential associated factors of these. The sample was selected through a two-staged cluster sampling technique. In determining the independent associated factors, multivariable analysis was done with multiple logistic regression. Results Most of the students who responded belonged to the 13–15 age group (66.5%) and with 51.1% were females. More than one third of the participants (37.7%, 95%CI 36.1–39.5) had experienced bullying 30 days prior to the study. ‘Feeling loneliness’ and ‘experiencing anxiety’ had been experienced by 9.0% (95%CI 8.0–10.0) and 4.7% (95%CI 3.9–5.4), respectively. The prevalence of planning an attempt of suicide was 6.3%, while 6.6% had at least once attempted suicide. Multivariable analysis revealed that lacked parental support and being engaged in a fight were independently associated with being bullied, feeling lonely and considering attempting suicide. Mutual association of the four outcomes with each other indicate that being bullied was significantly associated with experiencing loneliness and feeling anxiety. In addition, experiencing loneliness was independently associated “considering an attempt of suicide” (OR = 2.9, 95%CI = 2.0 to 4.3). Feeling anxiety was also associated with considering attempting suicide (OR = 3.4, 95%CI = 2.1 to 5.4). Conclusion This study demonstrated that the prevalence of psycho-social wellbeing is among school going adolescents is a major public health problem in Sri Lanka. School-based interventions to address these issues should be designed with the goal of increasing adolescents’ awareness of possible preventive measures of unintentional injuries.


2020 ◽  
Vol 11 (2) ◽  
Author(s):  
Etsehiwot Debe Worku ◽  
Mulusew Andualem Asemahagn ◽  
Melese Linger Endalifer

Background: Human scabies is a highly contagious human dermatitis disease. As indicated by the national and regional reports, the epidemic of scabies became a major public health problem in Ethiopia since 2015. Objective: To identify the determinant factors of scabies outbreak in Takusa district, Northwest Ethiopia, 2017.Methods: A community based unmatched case-control study among 188 participants (63 cases and 125 controls) was conducted in Takusa district from September to October 2017. Data were collected using a pretested structured questionnaire. Multivariable logistic regression analysis was computed using SPSS version 22 to identify factors associated with scabies. Odds ratio at 95% CI and p-value less than 0.05 were used to describe the strength of the association and statistical significance. Results: The median age of cases was 20 years (ranges1-61). Presence of person with itching in the family (AOR=7.7, 95% CI:1.9-30.5), sleeping with scabies patient (AOR=3.99, 95% CI:1.37-11.7), travel to scabies epidemic area in the last six weeks (AOR=3.79, 95%CI:1.28-11.1) and infrequent use of detergent for showering (AOR=4.85; 95% CI: 1.3-17.9)) were found to be determinant factors of scabies outbreak. Conclusion: Frequent contact with people who develop scabies at home, not using detergents for washing, and mobility of people from non-epidemic to the epidemic areas were determinant factors. Giving special emphasis on regular awareness creation to the rural community is important to prevent scabies outbreak.


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