scholarly journals Investigation of 2 Models to Set and Evaluate Quality Targets for Hb A1c: Biological Variation and Sigma-Metrics

2015 ◽  
Vol 61 (5) ◽  
pp. 752-759 ◽  
Author(s):  
Cas Weykamp ◽  
Garry John ◽  
Philippe Gillery ◽  
Emma English ◽  
Linong Ji ◽  
...  

Abstract BACKGROUND A major objective of the IFCC Task Force on Implementation of HbA1c Standardization is to develop a model to define quality targets for glycated hemoglobin (Hb A1c). METHODS Two generic models, biological variation and sigma-metrics, are investigated. We selected variables in the models for Hb A1c and used data of external quality assurance/proficiency testing programs to evaluate the suitability of the models to set and evaluate quality targets within and between laboratories. RESULTS In the biological variation model, 48% of individual laboratories and none of the 26 instrument groups met the minimum performance criterion. In the sigma-metrics model, with a total allowable error (TAE) set at 5 mmol/mol (0.46% NGSP), 77% of the individual laboratories and 12 of 26 instrument groups met the 2σ criterion. CONCLUSIONS The biological variation and sigma-metrics models were demonstrated to be suitable for setting and evaluating quality targets within and between laboratories. The sigma-metrics model is more flexible, as both the TAE and the risk of failure can be adjusted to the situation—for example, requirements related to diagnosis/monitoring or international authorities. With the aim of reaching (inter)national consensus on advice regarding quality targets for Hb A1c, the Task Force suggests the sigma-metrics model as the model of choice, with default values of 5 mmol/mol (0.46%) for TAE and risk levels of 2σ and 4σ for routine laboratories and laboratories performing clinical trials, respectively. These goals should serve as a starting point for discussion with international stakeholders in the field of diabetes.

2005 ◽  
Vol 36 (3) ◽  
pp. 103-115 ◽  
Author(s):  
Robert A. Wicklund

Abstract: Solidarity in the classic sense pertains to a cohesion among humans that entails physical contact, shared emotions, and common goals or projects. Characteristic cases are to be found among families, close friends, or co-workers. The present paper, in contrast, treats a phenomenon of the solidarity of distance, a solidarity based in fear of certain others and in incompetence to interact with them. The starting point for this analysis is the person who is motivated to interact with others who are unfamiliar or fear-provoking. Given that the fear and momentary social incompetence do not allow a full interaction to ensue, the individual will move toward solidarity with those others on a symbolic level. In this manner the motivation to approach the others is acted upon while physical and emotional distance is retained.


Author(s):  
Andrew van der Vlies

Two recent debut novels, Songeziwe Mahlangu’s Penumbra (2013) and Masande Ntshanga’s The Reactive (2014), reflect the experience of impasse, stasis, and arrested development experienced by many in South Africa. This chapter uses these novels as the starting point for a discussion of writing by young black writers in general, and as representative examples of the treatment of ‘waithood’ in contemporary writing. It considers (spatial and temporal) theorisations of anxiety, discerns recursive investments in past experiences of hope (invoking Jennifer Wenzel’s work to consider the afterlives of anti-colonial prophecy), assesses the usefulness of Giorgio Agamben’s elaboration of the ancient Greek understanding of stasis as civil war, and asks how these works’ elaboration of stasis might be understood in relation to Wendy Brown’s discussion of the eclipsing of the individual subject of political rights by the neoliberal subject whose very life is framed by its potential to be understood as capital.


2015 ◽  
Vol 44 (4) ◽  
pp. 687-705 ◽  
Author(s):  
RACHAEL DOBSON

AbstractThis article argues that constructions of social phenomena in social policy and welfare scholarship think about the subjects and objects of welfare practice in essentialising ways, with negativistic effects for practitioners working in ‘regulatory’ contexts such as housing and homelessness practice. It builds into debates about power, agency, social policy and welfare by bringing psychosocial and feminist theorisations of relationality to practice research. It claims that relational approaches provide a starting point for the analysis of empirical practice data, by working through the relationship between the individual and the social via an ontological unpicking and revisioning of practitioners' social worlds.


Hypatia ◽  
2005 ◽  
Vol 20 (2) ◽  
pp. 69-87 ◽  
Author(s):  
Bettina Schmitz ◽  
Julia Jansen

How much violence can a society expect its members to accept? A comparison between the language theories of Julia Kristeva and Jacques Lacan is the starting point for answering this question. A look at the early stages of language acquisition exposes the sacrificial logic of patriarchal society. Are those forces that restrict the individual to be conceived in a martial imagery of castration or is it possible that an existing society critically questions those points of socialization that leave their members in a state of homelessness? The following considerations should help to distinguish between unavoidable and avoidable forms of violence.


1985 ◽  
Vol 50 (3) ◽  
pp. 604-610
Author(s):  
Francoise Point

The starting point of this work was Saracino and Wood's description of the finitely generic abelian ordered groups [S-W].We generalize the result of Saracino and Wood to a class ∑UH of subdirect products of substructures of elements of a class ∑, which has some relationships with the discriminator variety V(∑t) generated by ∑. More precisely, let ∑ be an elementary class of L-algebras with theory T. Burris and Werner have shown that if ∑ has a model companion then the existentially closed models in the discriminator variety V(∑t) form an elementary class which they have axiomatized. In general it is not the case that the existentially closed elements of ∑UH form an elementary class. For instance, take for ∑ the class ∑0 of linearly ordered abelian groups (see [G-P]).We determine the finitely generic elements of ∑UH via the three following conditions on T:(1) There is an open L-formula which says in any element of ∑UH that the complement of equalizers do not overlap.(2) There is an existentially closed element of ∑UH which is an L-reduct of an element of V(∑t) and whose L-extensions respect the relationships between the complements of the equalizers.(3) For any models A, B of T, there exists a model C of TUH such that A and B embed in C.(Condition (3) is weaker then “T has the joint embedding property”. It is satisfied for example if every model of T has a one-element substructure. Condition (3) implies that ∑UH has the joint embedding property and therefore that the class of finitely generic elements of ∑UH is complete.)


2017 ◽  
Vol 23 (3) ◽  
pp. 721-734 ◽  
Author(s):  
Matthias Murawski ◽  
Markus Bick

Purpose Considering working in the digital age, questions on the consequences for the individual workers are, so far, often neglected. The purpose of this paper is to deal with the question of whether the digital competences of the workforce is a research topic. The authors argue for the thesis that it is indeed a research topic. Design/methodology/approach In addition to a literature analysis of the top IS, HR, and learning publications, non-scientific sources, as well as the opinions of the authors, are included. The authors’ thesis is challenged through a debate of corresponding pros and cons. Findings The definition of digital competences lacks scientific depth. Focussing on the workforce is valid, as a “lifelong” perspective is not mandatory for research. Digital competence research is a multidisciplinary task to which the IS field can make a valuable contribution. Research limitations/implications Although relevant references are included, some aspects are mainly driven by the opinions of the authors. The theoretical implications encompass a call for a scientific definition of digital competences. Furthermore, scholars should focus on the competences of the workforce, including occupations, roles, or industries. The authors conclude by providing a first proposal of a research agenda. Practical implications The practical implications include the alignment of multiple stakeholders for the design of “digital” curricula and the integration by HR departments of the construct of digital competences, e.g. for compensation matters and job requirements. Originality/value This paper is one of very few contributions in the area of the digital competences of the workforce, and it presents a starting point for future research activities.


2005 ◽  
Vol 14 (1) ◽  
pp. 141-162
Author(s):  
Clare Spencer

This essay presents a comparative study of the sociological assumptions implicit, and to some extent explicit, in the work of two famous architects, Charles Rennie Mackintosh and Le Corbusier. The inhabitant implied through the architectural practice of Le Corbusier resembles Elias's homo clausus (closed person), the mode of self experience viewed by Elias as the dominant one in Western society and one which sees the individual person as a ‘thinking subject’ and the starting point of knowledge. Mackintosh's designs, in contrast, imply individual people closer to Elias‘s homines aperti, social beings who are shaped through social interaction and interdependence. This paper demonstrates how, as well as fulfilling social, cultural and political needs, architecture carries, within in its designs, certain assumptions about how people and how they do, and should, live. The adoption of an Eliasian perspective provides an interesting insight into how these assumptions can shape self-experience and social interaction in the buildings of each architect.


2020 ◽  
Author(s):  
Shelly Lazar ◽  
Manas Ranjan Prusty ◽  
Khaled Bishara ◽  
Amir Sherman ◽  
Eyal Fridman

AbstractGenetic loci underlying variation in traits with agronomic importance or genetic risk factors in human diseases have been identified by linkage analysis and genome-wide association studies. However, narrowing down the mapping to the individual causal genes and variations within these is much more challenging, and so is the ability to break linkage drag between beneficial and unfavourable loci in crop breeding. We developed RECAS9 as a transgene-free approach for precisely targeting recombination events by delivering CRISPR/Cas9 ribonucleotide protein (RNP) complex into heterozygous mitotic cells for the barley (Hordeum vulgare) Heat3.1 locus. A wild species (H. spontaneum) introgression in this region carries the agronomical unfavourable tough rachis phenotype (non-brittle) allele linked with a circadian clock accelerating QTL near GIGANTEA gene. We delivered RNP, which was targeted between two single nucleotide polymorphism (SNPs), to mitotic calli cells by particle bombardment. We estimated recombination events by next generation sequencing (NGS) and droplet digital PCR (ddPCR). While NGS analysis grieved from confounding effects of PCR recombination, ddPCR analysis allowed us to associate RNP treatment on heterozygous individuals with significant increase of homologous directed repair (HDR) between cultivated and wild alleles, with recombination rate ranging between zero to 57%. These results show for the first time in plants a directed and transgene free mitotic recombination driven by Cas9 RNP, and provide a starting point for precise breeding and fine scale mapping of beneficial alleles from crop wild relatives.


2018 ◽  
pp. 53-63
Author(s):  
Leonid Kondratyk

Kondratyk L. "Ideas of Civil Religion in the Creative Work of Cyril Methodians". The author is based on the fact that the civil religion is such a sociocultural phenomenon in which, through the prism of a peculiar religious language and specific practices, the necessity of acquiring and establishing a national state is substantiated, which originates in the need of the community to find the sacral in the activity that is inherent in the transcendent, eternally -linear character and which is rooted in the history of the territory. It is proved that the soil on which the ideas of the Cyril and Methodius civil religion originated is Western European romanticism, religiosity, the starting point of which was the idea of religion as the focus of the spiritual world of the individual and community, the idea of the Higher Reason that sets the directions for historical development, Christianity a decisive role in the spiritual and moral and social renewal of mankind, the view of Ukraine as an independent cultural and historical and social force, the influence of creativity T. Shevche gt; The main ideas of the civil religion of the Cyril Methodians are as follows: the messianism of the Ukrainian spirit manifests itself in the ability to unite the Slavs in the best way, because Ukraine is inspired by self-sacrifice with the Christian spirit and has apostolic intercession; Kiev - the capital of the resurrected from the oppression of the Slavs, the city - in which the courts prevail, truth, equality; concepts "temple", "truth", "righteous judgment", "freedom", "brotherhood", "equality", "love", "Kiev", "Kiev mountains" - the basic concepts-symbols of the Ukrainian civil religion; in the Ukrainian community with the need to coincide Christian values and moral standards, which dominate it.


2011 ◽  
Vol 1 (2) ◽  
pp. 35-44
Author(s):  
Hanne Nørreklit

The purpose of this article is to establish the symbolic forms that are presently used in selected mainstream management models and to assess whether the connection between leadership and individual human reality would be improved if the management models were fundamentally inspired by those used by a successful manager and artist.The theoretical starting point of this article is Cassirer’s (Cassirer 1999) philosophy of symbolic forms. A symbolic form is “a way of having a life world” (own translation) (Cassirer 1999). In a symbolic form, a person discovers and unfolds an ability to build his own universe as an ideal universe which enables the person to “understand and interpret, to articulate and organize, synthesize and universalize his human experience” (Cassirer 1962: 221). Symbolic forms such as art, science, myth and religion thus have common features and structures in their basic function of creating common human existence. When the symbolic form is science, ideals of objectivity and precision in the description of phenomena and their relations dominate man’s formation of his universe. In art, man unfolds an ability to be subjective and create empathetic insight into matters and their diversity (Cassirer 1962). Where science as symbolic form conceptualizes objects, art teaches us empathetic insight. The symbolic forms of art and science perceive a phenomenon differently. For example, science will perhaps see a constellation as a trigonometric function, whereas it may be considered by art as a “Hogarthian shape of beauty” (own translation) (Cassirer 1999: 62). Like the symbolic form of art, the symbolic form of myth builds on emotional sympathy, but differs by believing in the existence of the constellation. It is used to create a natural or magical unity of life. Monotheistic religions also include ideas of striving for a sense of unity, but here the idea is to achieve a universal, ethical sense of unity in an individualized society. Thus the symbolic form of religion helps the individual to choose between right and wrong.With this in mind, we examine the use of symbolic forms embedded in selected mainstream management models. Subsequently, we study the symbolic forms embedded in the management discourse as the concept is unfolded by the successful Artistic Director of the Royal Danish Opera, Kasper Holten, when he talks about management, with a view to determining the extent to which this practice differs from the symbolic forms embedded in the mainstream management models. The analysis shows that mainstream management models are primarily rooted in the symbolic form of science, although they tend to gradually include the symbolic form of religion or the symbolic form of myth. Generally speaking, the mainstream management models tend to exercise power over the individual’s emphatic insight and autonomous reflection and thereby constrain the scope for human creativity and individuality. Distinctively, Kasper Holten’s management discourse integrates the symbolic forms of art and science. With art as the dominant symbolic form, Kasper rejects new public management’s perception about opera and the management of art while at the same time – through discourses that bind to the individuality of the network of players – forming personal and social identities which come together to realize a world of existential ideas about operas in general as well as opera in particular.The article is relevant because it provides insight into the ways in which management models, through the use of myth and science as symbolic forms, exercise influence on human existence and interaction and thereby influence the scope for human freedom and exercise of power and also because it provides insight into the features and structures concerning human existence and co-existence from which mainstream management models cut themselves off by not using art as a form of consciousness. The constructive aspect is a parallel outline of features and structures in a new management discourse which are better suited for postmodern society.


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