scholarly journals Cardiovascular Disease and Frailty: What Are the Mechanistic Links?

2019 ◽  
Vol 65 (1) ◽  
pp. 80-86 ◽  
Author(s):  
Ralph Stewart
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Daily Living ◽  
Clinical Syndrome ◽  
Adverse Outcomes ◽  
Contributing Factors ◽  
Aging Populations ◽  
Physiological Reserve ◽  
Common Risk Factors ◽  
Poor Nutrition

Abstract BACKGROUND In aging populations, cardiovascular disease (CVD) and frailty are common and often coexist. It is possible that common risk factors and pathophysiological pathways increase the risk of both CVD and frailty. CONTENT Frailty is a complex clinical syndrome with multiple causes and contributing factors. It is characterized by multisystem impairment that decreases physiological reserve and increases vulnerability to stress. Diverse methods have been used to evaluate frailty. Most include 1 or several measures related to reduced exercise, physical function, cognition, activities of daily living, comorbidities, deficits and/or markers of physiological dysfunction. CVD and frailty may be linked by several mechanisms. CVD can accelerate frailty, and frailty increases the risk of adverse outcomes in patients with CVD. Common pathophysiological pathways are also important. Low physical activity, poor nutrition, diabetes, hypertension, and smoking may increase the risk of both CVD and frailty. Further research is needed to evaluate whether biomarkers of dysfunction across multiple body systems, which are known to be associated with aging, and with CV and non-CV morbidity and mortality, are also associated with frailty. SUMMARY Multiple pathophysiological pathways are associated with both CVD and frailty, which interact to further increase the risk of adverse outcomes.

Hyperlipidemia in Patients with Periodontitis

2005 ◽  
Vol 6 (3) ◽  
pp. 78-85 ◽  
Author(s):  
Amir Moeintaghavi ◽  
A. Haerian-Ardakani ◽  
Mohammadreza Talebi-Ardakani ◽  
I. Tabatabaie
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Risk Factor ◽  
Serum Lipids ◽  
Plasma Lipids ◽  
Male Gender ◽  
Case Group ◽  
Pocket Depth ◽  
Common Risk Factors ◽  
Age And Sex

Abstract Background Periodontitis is a bacterial infection, which has been classified as a local chronic inflammation. This, as well as cardiovascular disease, may share common risk factors such as smoking, diabetes, behavioral factors, aging, and male gender. The aim of this study was to evaluate the association between hyperlipidemia and periodontitis. Materials & Methods The levels of plasma lipids in 40 subjects with periodontitis (CPITN score III or IV, pocket depth 4 mm) with mean age 32.3 ±1.2 years were measured and compared with those obtained from 40 age and sex matched controls. Both groups were systemically healthy according to their medical history. Results Total cholesterol (CHL) and triglycerides (TG) were significantly higher in the case group (P=0.045 and P=0.016, respectively). HDL and LDL cholesterols were higher in patients but did not have any significant differences with controls. The frequency of persons with pathologic values of TG and CHL were significantly higher in cases compared with controls. Conclusions These results showed hyperlipidemia may be associated with periodontitis in healthy people. However, it is unclear whether periodontitis causes an increase in levels of serum lipids or hyperlipidemia is a risk factor for both periodontitis and cardiovascular disease. Citation Moeintaghavi A, Haerian-Ardakani A, Talebi-Ardakani M, Tabatabaie I. Hyperlipidemia in Patients with Periodontitis. J Contemp Dent Pract 2005 August;(6)3:078-085.

Glucocorticoids and insulin resistance: old hormones, new targets

1999 ◽  
Vol 96 (5) ◽  
pp. 513-523 ◽  
Author(s):  
Robert C. ANDREWS ◽  
Brian R. WALKER
Keyword(s):  
Risk Factors ◽  
Insulin Resistance ◽  
Cardiovascular Disease ◽  
Cardiovascular Risk ◽  
Insulin Sensitivity ◽  
Cardiovascular Risk Factors ◽  
Therapeutic Strategy ◽  
Clinical Syndrome ◽  
Glucocorticoid Action ◽  
Novel Therapeutic

Insulin resistance has been proposed as a mediator of the association between risk factors for cardiovascular disease in the population. The clinical syndrome of glucocorticoid excess (Cushing's syndrome) is associated with glucose intolerance, obesity and hypertension. By opposing the actions of insulin, glucocorticoids could contribute to insulin resistance and its association with other cardiovascular risk factors. In this review, we describe briefly the known mechanisms of insulin resistance and highlight the potential mechanisms for the effect of glucocorticoids. We then discuss factors which modulate the influence of glucocorticoids on insulin sensitivity; this highlights a novel therapeutic strategy to manipulate glucocorticoid action which may prove to be a useful tool in treating subjects with insulin resistance. Finally, we describe evidence from human studies that glucocorticoids make an important contribution to the pathophysiology of insulin resistance in the population.

scholarly journals Public knowledge of cardiovascular disease and its risk factors in Tangail, Bangladesh: a cross-sectional survey

2019 ◽  
Vol 6 (5) ◽  
pp. 1838
Author(s):  
Masuder Rahman ◽  
Sakila Akter ◽  
Fatama Tous Zohora ◽  
Abu Zaffar Shibly
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Heart Attack ◽  
Physical Inactivity ◽  
Public Health Problem ◽  
Major Public Health Problem ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Unhealthy Diet ◽  
Common Risk Factors

Background: Cardiovascular Disease (CVD) is a major public health problem throughout the world. In Bangladesh, the reliable data concerning various aspects of CVD is inadequate at present due to lack of national population-based surveys or central administrative health data. Given the rising incidence of CVDs in Bangladesh, an improved understanding of the CVD, symptoms and risk factors is needed. Hence, this study was performed to assess the level of knowledge towards CVD types, warning symptoms of heart attack or stroke, and CVD risk factors.Methods: A descriptive cross-sectional survey was conducted from May 2018 to June 2018 using standard questionnaire on a sample of 350 randomly selected Bangladeshi individuals. All the data of the study were input in SPSS (Statistical Package for the Social Sciences) version 20.0 software from IBM for windows and the gathered data thus analyzed using SPSS & Microsoft Excel.Results: The respondents’ knowledge about types of CVD, symptom heart attack, symptom of stroke and the risk factors of CVD are 38.9%, 67.7%, 35.7%, and 92.9% respectively. The most common risk factors of CVD found to be known by around than two-third of respondents were unhealthy diet (66.9%), physical inactivity (64.3), obesity (61.4%), and smoking (58.6%).Conclusions: The respondents’ knowledge about types of CVD, symptom heart attack, symptom of stroke and the risk factors of CVD are 38.9%, 67.7%, 35.7%, and 92.9% respectively. The most common risk factors of CVD found to be known by around than two-third of respondents were unhealthy diet (66.9%), physical inactivity (64.3), obesity (61.4%), and smoking (58.6%).

scholarly journals The Bi-Directional Relationship between Periodontal Disease and Hyperlipidemia

2008 ◽  
Vol 02 (02) ◽  
pp. 142-149 ◽  
Author(s):  
Ozlem Fentoglu ◽  
F. Yesim Bozkurt
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Periodontal Disease ◽  
Serum Lipids ◽  
Plasma Lipids ◽  
Periodontal Infection ◽  
Increased Risk ◽  
Potential Link ◽  
Common Risk Factors ◽  
Accumulation Of Lipids

ABSTRACTIt has been proposed for several decades that infections may be responsible for the accelerated development of atherosclerosis. The initiation of the atherosclerotic plaque is ascribed to focal accumulation of lipids. This explains the importance of plasma lipids in the development of atherosclerosis. Recent reports point towards a possible association between periodontal disease and increased risk for cardiovascular disease. Thus, periodontitis and cardiovascular disease may share common risk factors, and association between periodontitis and coronary heart disease may be due to the elevated levels of plasma lipids. Epidemiological and clinical studies have also suggested that there is a relationship between periodontal disease and impaired lipid metabolism. In this review, we summarized the potential link mechanisms in the association between periodontal infection and serum lipids. (Eur J Dent 2008;2:142-149)

Epidemiology of Peripheral Artery Disease and Polyvascular Disease

2021 ◽  
Vol 128 (12) ◽  
pp. 1818-1832
Author(s):  
Aaron W. Aday ◽  
Kunihiro Matsushita
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Coronary Artery Disease ◽  
Peripheral Artery Disease ◽  
Microvascular Disease ◽  
Adverse Outcomes ◽  
Peripheral Artery ◽  
Cardiovascular Morbidity And Mortality ◽  
Increase Risk ◽  
Artery Disease

Atherosclerotic lower extremity peripheral artery disease (PAD) is increasingly recognized as an important cause of cardiovascular morbidity and mortality that affects >230 million people worldwide. Traditional cardiovascular risk factors, including advanced age, smoking, and diabetes, are strongly linked to an increase risk of PAD. Although PAD has been historically underappreciated compared with coronary artery disease and stroke, greater attention on PAD in recent years has led to important new epidemiological insights in the areas of thrombosis, inflammation, dyslipidemia, and microvascular disease. In addition, the concept of polyvascular disease, or clinically evident atherosclerosis in multiple arterial beds, is increasingly identified as a particularly malignant cardiovascular disease worthy of special clinical attention and further study. It is noteworthy that PAD may increase the risk of adverse outcomes in similar or even greater magnitude than coronary disease or stroke. In this review, we highlight important new advances in the epidemiology of PAD with a particular focus on polyvascular disease, emerging biomarkers, and differential risk pathways for PAD compared with other atherosclerotic diseases.

Longitudinal association between adolescent negative emotions and adulthood cardiovascular disease risk: an opportunity for healthcare quality improvement

2020 ◽  
Vol 27 (8) ◽  
pp. 2323-2339
Author(s):  
Sharan Srinivas ◽  
Kavin Anand ◽  
Anand Chockalingam
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Quality Improvement ◽  
Negative Emotion ◽  
Negative Emotions ◽  
Biological Data ◽  
Risk Category ◽  
Cvd Risk ◽  
Content Type ◽  
Common Risk Factors

PurposeWhile cardiovascular disease (CVD) is the leading cause of death globally, over 80% of the cases could be prevented through early lifestyle changes. From the perspective of quality management in healthcare, this may offer an effective prevention window if modifiable CVD risk factors are identified and treated in adolescence. The purpose of this research is to examine the negative emotions in adolescents and determine if it independently increases CVD risk later in life.Design/methodology/approachLongitudinal data from 12,350 participants of the Add Health study, which conducted a multi-wave survey for 14 years from adolescence (Wave 1) through adulthood (Wave 4), were used to test the research hypothesis. Four items (perception of life, self-reported depression, perceived loneliness and fearfulness) reflective of adolescent negative emotion were identified from the Wave 1 questionnaire, and factor analysis was conducted to confirm the hypothesized structure. The outcome variable, 30-year adulthood CVD risk category (high or low risk), was estimated using biomarkers, biological data and other factors collected during the 14-year follow-up in Wave 4. A logistic regression analysis was employed to assess the impact of adolescent negative emotions on adulthood CVD risk after adjusting for common risk factors such as sociodemographic characteristics, socioeconomic status and medical conditions in adolescence.FindingsThe results indicated adolescent negative emotion to be significantly associated with CVD risk category (p-value < 0.0001), even after controlling for common risk factors. A unit increase in the level of adolescent negative emotion increased the chance of being in the high CVD risk group in adulthood by 8% (odds ratio = 1.08 ± 0.03).Practical implicationsHealthcare providers and organizations could capitalize on the research findings by screening for negative emotions early in life through individual and societal interventions. The findings also provide an opportunity for implementing quality improvement initiatives to deliver robust preventive care, which, in turn, could improve the overall population health, reduce healthcare costs and improve care quality.Originality/valueAlthough previous studies showed a strong link between adolescent physiological factors (e.g. obesity) and adulthood cardiovascular disease (CVD), the association between adolescent outlook/attitude (negative emotion) and CVD risk has not been examined.

scholarly journals Impairments in Activities of Daily Living in Older Japanese Men in Hawaii and Japan

2011 ◽  
Vol 2011 ◽  
pp. 1-8 ◽  
Author(s):  
Robert D. Abbott ◽  
Aya Kadota ◽  
Katsuyuki Miura ◽  
Takehito Hayakawa ◽  
Takashi Kadowaki ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Risk Factor ◽  
Alcohol Use ◽  
Cigarette Smoking ◽  
Activities Of Daily Living ◽  
Daily Living ◽  
Japanese Men ◽  
Similar Association

Introduction. Hypertension and cigarette smoking are dominant risk factors for cardiovascular disease in Japan while in westernized countries, broader effects encompass obesity, diabetes, and hypercholesterolemia. This paper examines whether different associations also appear important in the manifestation of activities of daily living (ADL) in older Japanese men in Hawaii and Japan.Methods. Measures of ADL (feeding, toileting, dressing, bathing, and walking around the house) were assessed from 1995 to 1999 in 1,893 men in Hawaii and 543 men in Japan. Concomitant risk factors were measured from 1990 to 1993.Results. In Hawaii, diabetes increased the odds of ≥1 ADL impairment nearly 1.5-fold (P=.020). A similar association was absent in Japan. In contrast, the odds of an ADL impairment in Japan was increased more than 5-fold in the presence of stroke (P<.001). The association in Hawaii was significantly weaker (P=.007). In both cohorts, past alcohol use was associated with a greater likelihood of ADL impairment.Conclusion. In this comparison of genetically similar samples, findings suggest that different strengths in risk factor associations with cardiovascular disease in Japan and westernized countries may also include different strengths in associations with impaired ADL.

scholarly journals Phenotypes and subphenotypes of delirium: a review of current categorisations and suggestions for progression

Critical Care ◽  
2021 ◽  
Vol 25 (1) ◽  
Author(s):  
Emily M. L. Bowman ◽  
Emma L. Cunningham ◽  
Valerie J. Page ◽  
Daniel F. McAuley
Keyword(s):  
Risk Factors ◽  
Clinical Symptoms ◽  
Clinical Syndrome ◽  
Adverse Outcomes ◽  
Biological Mechanism ◽  
Family Counselling ◽  
Targeted Treatments ◽  
Potential Methods ◽  
The Relationship ◽  
Level 2

AbstractDelirium is a clinical syndrome occurring in heterogeneous patient populations. It affects 45–87% of critical care patients and is often associated with adverse outcomes including acquired dementia, institutionalisation, and death. Despite an exponential increase in delirium research in recent years, the pathophysiological mechanisms resulting in the clinical presentation of delirium are still hypotheses. Efforts have been made to categorise the delirium spectrum into clinically meaningful subgroups (subphenotypes), using psychomotor subtypes such as hypoactive, hyperactive, and mixed, for example, and also inflammatory and non-inflammatory delirium. Delirium remains, however, a constellation of symptoms resulting from a variety of risk factors and precipitants with currently no successful targeted pharmacological treatment. Identifying specific clinical and biological subphenotypes will greatly improve understanding of the relationship between the clinical symptoms and the putative pathways and thus risk factors, precipitants, natural history, and biological mechanism. This will facilitate risk factor mitigation, identification of potential methods for interventional studies, and informed patient and family counselling. Here, we review evidence to date and propose a framework to identify subphenotypes. Endotype identification may be done by clustering symptoms with their biological mechanism, which will facilitate research of targeted treatments. In order to achieve identification of delirium subphenotypes, the following steps must be taken: (1) robust records of symptoms must be kept at a clinical level. (2) Global collaboration must facilitate large, heterogeneous research cohorts. (3) Patients must be clustered for identification, validation, and mapping of subphenotype stability.

scholarly journals The The Circulating Visfatin Level Relation to the Severity of Chronic Kidney Disease

2020 ◽  
Vol 8 (B) ◽  
pp. 969-972
Author(s):  
Oleksii Korzh ◽  
Anna Titkova ◽  
Yana Fylenko
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Filtration Rate ◽  
Estimated Glomerular Filtration Rate ◽  
Urine Albumin ◽  
Common Risk Factors ◽  
Visfatin Level ◽  
Study Participants

BACKGROUND: Adipokines have been associated with atherosclerotic heart disease, which has plenty of common risk factors with chronic kidney disease (CKD), but their association with CKD has not been well characterized. AIM: We investigated the association between the serum visfatin level and CKD. METHODS: The serum visfatin levels in 101 CKD patients and 101 controls were compared. CKD was defined as estimated glomerular filtration rate (eGFR) <60 ml/min/1.73 m2 or presence of albuminuria (≥30 mg/24 h). RESULTS: After adjustment for established CKD risk factors, the median (interquartile range) of the serum visfatin was 3.65 ng/ml (2.31–4.59) in patients with CKD and 1.66 ng/ml (0.90–2.45) in controls without CKD (p < 0.0001 for group difference). Serum visfatin was significantly and inversely correlated with eGFR (r = –0.79, p < 0.0001) and positively correlated with urine albumin (r = 0.71, p < 0.0001) in the study participants. There was a strong dose-response and the significant relationship between serum visfatin level and CKD severity, assessed by GFR and albuminuria, regardless of established risk factors for CKD, including hypertension, diabetes, and cardiovascular disease. CONCLUSION: Our results show that circulating visfatin is associated with the risk and severity of CKD. These results suggest that longitudinal studies and clinical trials should be conducted to investigate if adipocytokines play a role in the development and progression of CKD independent of body mass index or waist circumference. These important findings may advance our further understanding of CKD risk factors.

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