scholarly journals Twins Eye Study in Tasmania (TEST): Rationale and Methodology to Recruit and Examine Twins

2009 ◽  
Vol 12 (5) ◽  
pp. 441-454 ◽  
Author(s):  
David A. Mackey ◽  
Jane R. MacKinnon ◽  
Shayne A. Brown ◽  
Lisa S. Kearns ◽  
Jonathan B. Ruddle ◽  
...  
Keyword(s):  
Poor Quality ◽  
Participation Rates ◽  
Research Groups ◽  
Ocular Biometry ◽  
Quantitative Trait Analysis ◽  
Twin Registry ◽  
Genome Wide ◽  
Local Media ◽  
Insight Into

AbstractVisual impairment is a leading cause of morbidity and poor quality of life in our community. Unravelling the mechanisms underpinning important blinding diseases could allow preventative or curative steps to be implemented. Twin siblings provide a unique opportunity in biology to discover genes associated with numerous eye diseases and ocular biometry. Twins are particularly useful for quantitative trait analysis through genome-wide association and linkage studies. Although many studies involving twins rely on twin registries, we present our approach to the Twins Eye Study in Tasmania to provide insight into possible recruitment strategies, expected participation rates and potential examination strategies that can be considered by other researchers for similar studies. Five separate avenues for cohort recruitment were adopted: (1) piggy-backing existing studies where twins had been recruited, (2) utilizing the national twin registry, (3) word-of-mouth and local media publicity, (4) directly approaching schools, and finally (5) collaborating with other research groups studying twins.

Tylosaurus ivoensis: a giant mosasaur from the early Campanian of Sweden

2002 ◽  
Vol 93 (1) ◽  
pp. 73-93 ◽  
Author(s):  
Johan Lindgren ◽  
Mikael Siverson
Keyword(s):  
Poor Quality ◽  
Nominal Species ◽  
Southern Sweden ◽  
Niobrara Formation ◽  
Type Specimens ◽  
Good Insight ◽  
Size And Morphology ◽  
Insight Into ◽  
Stratigraphic Interval

ABSTRACTThe nominal species Mosasaurus ivoensis from the latest early Campanian of the Kristianstad Basin in southern Sweden, is redescribed and assigned to the tylosaurine genus Tylosaurus on the basis of its dental and vertebral morphology. A partial skeleton (KUVP 1024) from the late Coniacian to earliest Campanian Smoky Hill Chalk Member of the Niobrara Formation in western Kansas, USA, was previously referred to “M”. ivoensis. Nevertheless, its marginal teeth are markedly different, both in size and morphology, from those of topotypic T. ivoensis.Examination of type specimens and topotypic material of the nominal tylosaurines Hainosaurus pembinensis from the late early Campanian of Manitoba, Canada, H. gaudryi from the late Santonian or early Campanian of northwestern France, and H. lonzeensis from the Coniacian or Santonian of Belgium, indicates that all three may be Tylosaurus.The utility of isolated tooth-crowns in mosasaur taxonomy has been hampered by the often poor quality of the published illustrations of these fossils in combination with poor stratigraphic control. All Swedish remains of T. ivoensis, including 172 marginal teeth, 6 pterygoid teeth, several jawbone fragments and 12 vertebrae, were collected from a narrow stratigraphic interval corresponding to the highest biozone in the German eight-fold division of the early Campanian, providing the first good insight into the intraspecific dental variation in a tylosaurine mosasaur.

Combining Supervised and Unsupervised Machine Learning Methods for Phenotypic Functional Genomics Screening

2020 ◽  
Vol 25 (6) ◽  
pp. 655-664
Author(s):  
Wienand A. Omta ◽  
Roy G. van Heesbeen ◽  
Ian Shen ◽  
Jacob de Nobel ◽  
Desmond Robers ◽  
...  
Keyword(s):  
Machine Learning ◽  
Training Set ◽  
Data Set ◽  
Genome Wide ◽  
Machine Learning Model ◽  
Exploratory Data ◽  
Interfering Rna ◽  
Insight Into ◽  
Training Sets

There has been an increase in the use of machine learning and artificial intelligence (AI) for the analysis of image-based cellular screens. The accuracy of these analyses, however, is greatly dependent on the quality of the training sets used for building the machine learning models. We propose that unsupervised exploratory methods should first be applied to the data set to gain a better insight into the quality of the data. This improves the selection and labeling of data for creating training sets before the application of machine learning. We demonstrate this using a high-content genome-wide small interfering RNA screen. We perform an unsupervised exploratory data analysis to facilitate the identification of four robust phenotypes, which we subsequently use as a training set for building a high-quality random forest machine learning model to differentiate four phenotypes with an accuracy of 91.1% and a kappa of 0.85. Our approach enhanced our ability to extract new knowledge from the screen when compared with the use of unsupervised methods alone.

Australian Adult Consumers’ Beliefs About Plant Foods: A Qualitative Study

2005 ◽  
Vol 32 (6) ◽  
pp. 795-808 ◽  
Author(s):  
Emma Lea ◽  
Anthony Worsley ◽  
David Crawford
Keyword(s):  
Qualitative Study ◽  
Poor Quality ◽  
Environmental Benefits ◽  
Perceived Barriers ◽  
Community Group ◽  
Plant Foods ◽  
Health Related ◽  
Group Members ◽  
Insight Into

This exploratory qualitative study examined consumers’ perceived barriers and benefits of plant food (fruits, vegetables, grains, legumes, nuts, seeds) consumption and views on the promotion of these foods. Ten focus groups were conducted in Melbourne, Australia. Groups consisted of employees of various workplaces, community group members, university students, and inner-city residents. Health-related benefits predominated, particularly relating to the properties of plant foods (e.g., vitamins). Taste, variety, versatility, and environmental benefits were also considered important. The main barriers to eating plant foods were lack of knowledge and skills and length of preparation time. The poor quality of plant foods was also an issue for consumers. Awareness of the promotion of plant foods was generally high. Participants noted that promotions require a stronger practical emphasis with a focus on quick, easy-to-prepare foods and meals. These findings provide insight into effective ways to promote a higher consumption of plant foods.

Theoretical insight into the disordered structure of (Z)-2-[(E)-(4-methoxybenzylidene)hydrazinylidene]-1,2-diphenylethanone: the role of noncovalent interactions

2018 ◽  
Vol 74 (9) ◽  
pp. 1058-1067
Author(s):  
Xue-Jie Tan ◽  
Di Wang ◽  
Xu-Gang Lei ◽  
Jun-Peng Chen
Keyword(s):  
Room Temperature ◽  
Noncovalent Interactions ◽  
Poor Quality ◽  
X Ray ◽  
Disordered Structure ◽  
Theoretical Insight ◽  
Insight Into ◽  
Shed Light

A global glide disorder has been discovered during an X-ray investigation of the crystal structure of (Z)-2-[(E)-(4-methoxybenzylidene)hydrazinylidene]-1,2-diphenylethanone (MHDE, C22H18N2O2) at room temperature. In another crystal, however, such disorder disappears (still at room temperature). Even though the disorder may be partly due to the poor quality of the harvested crystal, the structure can shed light on the nature of disorder. With the help of quantum chemical calculations, it is found that the global disorder seems to be connected with the need for stabilization of the somewhat rigid but mobile and unstable molecular structure. The most relevant feature driving the packing of the disordered structure concerns the slight perturbations (such as glide) of two or more disorder components (fractional occupancies) distributed throughout the crystal.

scholarly journals Impact of Stress on Epilepsy: Focus on Neuroinflammation—A Mini Review

2021 ◽  
Vol 22 (8) ◽  
pp. 4061
Author(s):  
Claudia Espinosa-Garcia ◽  
Helena Zeleke ◽  
Asheebo Rojas
Keyword(s):  
Chronic Stress ◽  
Acute Stress ◽  
Poor Quality ◽  
Preclinical Research ◽  
Acute And Chronic Stress ◽  
Outcome Severity ◽  
State Depression ◽  
The Impact ◽  
Insight Into

Epilepsy, one of the most common neurological disorders worldwide, is characterized by recurrent seizures and subsequent brain damage. Despite strong evidence supporting a deleterious impact on seizure occurrence and outcome severity, stress is an overlooked component in people with epilepsy. With regard to stressor duration and timing, acute stress can be protective in epileptogenesis, while chronic stress often promotes seizure occurrence in epilepsy patients. Preclinical research suggests that chronic stress promotes neuroinflammation and leads to a depressive state. Depression is the most common psychiatric comorbidity in people with epilepsy, resulting in a poor quality of life. Here, we summarize studies investigating acute and chronic stress as a seizure trigger and an important factor that worsens epilepsy outcomes and psychiatric comorbidities. Mechanistic insight into the impact of stress on epilepsy may create a window of opportunity for future interventions targeting neuroinflammation-related disorders.

A Brief Overview of the Effect of War Injuries on Sexual Health and Intimacy

2016 ◽  
Author(s):  
Kathryn Ellis
Keyword(s):  
Sexual Health ◽  
Spinal Cord Injuries ◽  
Poor Quality ◽  
Post Traumatic Stress ◽  
War Injuries ◽  
Post Traumatic ◽  
Sexual Avoidance ◽  
Orthopedic Injuries ◽  
Insight Into

This chapter establishes definitions of sexual health and intimacy, provides insight into how they interact and affect successful relationships, and communicates the importance of addressing the sexual and intimacy needs of injured service members and their partners. Common deployment-related diagnoses, including post-traumatic stress disorder, traumatic brain injury, orthopedic injuries, spinal cord injuries, genital injuries, burns, and facial injuries, and their possible corresponding limitations are reviewed, along with how such limitations can result in sexual avoidance and intimacy avoidance, thus leading to more relationship issues and poor quality of life. The experience of partners, including perceptions about the dependence of the injured service member, is discussed as well.

An experience of performing spirometry by trained general practitioners

2020 ◽  
pp. 34-36
Author(s):  
M. A. Pokhaznikova ◽  
E. A. Andreeva ◽  
O. Yu. Kuznetsova
Keyword(s):  
General Practitioners ◽  
Quality Criteria ◽  
Poor Quality ◽  
Male Gender ◽  
Study Research ◽  
The Poor ◽  
Quality Of Research ◽  
Forced Expiratory Maneuver ◽  
Maximal Effort

The article discusses the experience of teaching and conducting spirometry of general practitioners as part of the RESPECT study (RESearch on the PrEvalence and the diagnosis of COPD and its Tobacco-related aetiology). A total of 33 trained in spirometry general practitioners performed a study of 3119 patients. Quality criteria met 84.1% of spirometric studies. The analysis of the most common mistakes made by doctors during the forced expiratory maneuver is included. The most frequent errors were expiration exhalation of less than 6s (54%), non-maximal effort throughout the test and lack of reproducibility (11.3%). Independent predictors of poor spirogram quality were male gender, obstruction (FEV1 /FVC<0.7), and the center where the study was performed. The number of good-quality spirograms ranged from 96.1% (95% CI 83.2–110.4) to 59.8% (95% CI 49.6–71.4) depending on the center. Subsequently, an analysis of the reasons behind the poor quality of research in individual centers was conducted and the identified shortcomings were eliminated. The poor quality of the spirograms was associated either with the errors of the doctors who undertook the study or with the technical malfunctions of the spirometer.

KUALITAS HIDUP PASIEN STROKE DI POLIKLINIK RAWAT JALAN RUMAH SAKIT SWASTA YOGYAKARTA

2019 ◽  
Vol 7 (3) ◽  
pp. 232-237
Author(s):  
Hana Larasati ◽  
Theresia Titin Marlina
Keyword(s):  
Quality Of Life ◽  
Social Relations ◽  
Hemorrhagic Stroke ◽  
Poor Quality ◽  
Social Dimension ◽  
Stroke Patients ◽  
Sampling System ◽  
Post Stroke ◽  
Psychological Dimension

Background: stroke is a disorder of nervous system function that occurs suddenly and is caused by brain bleeding disorders that can affect the quality of life physical dimensions, social dimensions, psychological dimensions, environmental dimensions. Based on the result of Lumbu study (2015) the number of samples were 71 people collected data using the (WHOQOL-BREF). There were 56 people (78,9%) had the poor quality of life of post stroke. The mean of post-stroke quality of life domain was physical domain (45,27%), psychological domain (49,87%), social relations domain (48,15%) and environmental domain (50.01%). Objective: the purpose of the study was know the quality of life of the stroke patients in Outpatient Polyclinic of Private Hospital in Yogyakarta. Methods: used descriptive quantitative by using questionnaire test of purposive sampling system based on patients who have been affected of ischemic or hemorrhagic stroke before, number 30 respondents. Result: quality of life of stroke patient of medium physical dimension (67%), psychological dimension (71%), social dimension (67%), dimension good environment (63%). Conclusion: the quality of life of stroke patients of physical dimension, psychological dimension, and moderate social dimension, while the quality of life of stroke patients were good environmental dimension.   Keywords: Hemorrhagic stroke, ischemic stroke, quality of life

YEAR 2020: ON THE REMAINING REPRODUCTIVE THREATS AND THEIR NEUTRALIZATION ON THE WAYS TO IMPROVE STRATEGIC PLANNING AND INDUSTRIAL POLICY, THE DEPLOYMENT OF THE NATIONAL INNOVATION SYSTEM AND ITS SECTORAL AND REGIONAL SUBSYSTEMS

2020 ◽  
pp. 3-53
Author(s):  
Yu.B. Vinslav
Keyword(s):  
Strategic Planning ◽  
Industrial Policy ◽  
Innovation System ◽  
Poor Quality ◽  
National Innovation System ◽  
State Regulation ◽  
Industrial Complex ◽  
The Past ◽  
Technological Modernization

The article analyzes the main indicators of the evolution of the domestic economy and its industrial complex in the past year (in January — November 2019). It Identifies trends in this evolution, including negative trends that determine the preservation of reproductive threats in 2020: sluggishness, instability and low quality of economic growth. The main reasons for the fact that the objective resource capabilities of the macro level were clearly not used enough to effectively solve the urgent problems of technological modernization of the economy and increase people’s welfare are established. The main reason is the poor quality of public administration, including imperfect strategic planning and industrial policy; there is still no modern national innovation system in the country. Accordingly, recommendations for improving the quality of state regulation in its specified components are justified. The recommended measures, according to the author, will help the economy to move to a trajectory of rapid, sustainable and high-quality growth.

Gender and Regional Differences in the Life Expectancy in Russia

2020 ◽  
Vol 27 (1) ◽  
pp. 106-120 ◽  
Author(s):  
L. A. Rodionova ◽  
E. D. Kopnova
Keyword(s):  
Drinking Water ◽  
Alcohol Consumption ◽  
Life Expectancy ◽  
Gender Gap ◽  
Poor Quality ◽  
Living Conditions ◽  
Regional Differentiation ◽  
Russian Regions ◽  
Poor Nutrition

The relevance of the chosen topic is closely related to the development of a system for monitoring the implementation of the May Presidential Decree (2018) to increase life expectancy and improve the quality of life of the population. It has been stated that despite the positive dynamics of life expectancy over the past decade, Russia still has a huge regional differentiation (16,6 years for women, 18,2 years for men in 2016) and an average gender gap - 10,6 years. The choice of factors affecting the gender gap in life expectancy in Russian regions is supported by a conclusion most common in foreign studies that climatic conditions, living conditions, the quality of food and drinking water, alcohol consumption are essential components of public health and life expectancy.The article provides an overview of studies on assessment factors of life expectancy, presents the authors’ approach to identifying gender gaps in life expectancy, living conditions, and lifestyle affecting the indicator of life expectancy. The paper presents the results of a comparative analysis of gender gap in life expectancy in Russia and foreign countries. The paper studies the correlation between living conditions and lifestyle, and life expectancy.Classification of the regions by the life expectancy at birth for men and women is an important component of this study. The authors used Rosstat data for 2016 and the k-means method to select three clusters of Russian regions taking into account gender, living conditions and lifestyle. The paper identifies similar health problems of the regions that are associated with alcohol consumption, poor nutrition and poor quality of drinking water, poor housing and living conditions. The lowest life expectancy rates for men and women are recorded in regions of the 1st cluster (Jewish Autonomous Region, Republic of Tuva, Chukotka Autonomous Area). High mortality rates are a result of external causes. There is a poor quality of drinking water and poor nutrition, excessive alcohol consumption, and inadequate housing conditions.Based on the obtained results were determined possible reserves for reducing the gender and regional differentiation of life expectancy.

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