scholarly journals Haematological & Inflammatory Markers in Septicaemia and Its Prognostic Implications in Okhla Industrial Area

2021 ◽  
Vol 10 (8) ◽  
pp. 469-473
Author(s):  
Juhi Aggarwal ◽  
Swati Singh ◽  
Walia Murshida Huda ◽  
Mayur Kumar ◽  
Jagmohan Dhakad ◽  
...  
Keyword(s):  
Platelet Count ◽  
Neutrophil Count ◽  
Inflammatory Markers ◽  
Industrial Area ◽  
Critically Ill Patient ◽  
Healthy Controls ◽  
Cross Sectional ◽  
Distribution Width ◽  
Mortality And Morbidity ◽  
Study Results

BACKGROUND Sepsis remains an important cause of hospitalisation and mortality worldwide among patients admitted in intensive care units (ICU). Due to increasing mortality and morbidity of sepsis early diagnosis and treatment are essential. This can be achieved with the help of biomarkers–haematological and inflammatory i.e., C-reactive protein (CRP) and pro calcitonin (PCT). They are found to be highly sensitive and useful markers for early detection and management of sepsis. METHODS This is a cross-sectional study conducted from May 2019 to March 2020 in the Department of Biochemistry, ESI Hospital, Okhla. A total of 104 subjects were recruited for the study. Of them, 52 subjects were healthy controls, and 52 cases were ICU patients. Samples were taken to evaluate differential leucocyte count (DLC), red cell distribution width standard deviation (RDW SD), platelet count (PLT), absolute neutrophil count (ANC) and platelet crit as haematological markers whereas Creactive protein, fibrinogen and pro calcitonin indices were chosen as inflammatory. markers. RESULTS There was significant increase in the TLC (21583.51 ± 2240.36), total neutrophil count (7889.48 ± 1482.83), immature neutrophil (2.97 ± 1.67), fibrinogen levels (518.07 ± 66.74), CRP (0.048 ± 0.01) and pro calcitonin levels (0.062 ± 0.22) of the cases as compared to the healthy controls. The platelet count was observed to be higher in healthy subjects as compared to the patients in ICU. CONCLUSIONS The study results showed that clinical examination along with laboratory testing which include hematologic and inflammatory biomarkers is the most effective combination of parameters for rapidly and accurately predicting or diagnosing sepsis in a critically ill patient. KEY WORDS Sepsis, Haematological, Inflammatory, CRP, PCT, Fibrinogen

scholarly journals Comparison of Inflammatory Markers Between Adult and Pediatric Brucellosis Patients

2017 ◽  
Vol 4 (suppl_1) ◽  
pp. S350-S351 ◽  
Author(s):  
Recep Tekin ◽  
Fesih Aktar ◽  
Celal Ayaz
Keyword(s):  
Platelet Count ◽  
Neutrophil Count ◽  
Inflammatory Markers ◽  
Pediatric Patients ◽  
Adult Patients ◽  
Healthy Controls ◽  
Age And Gender ◽  
Distribution Width ◽  
The Mean ◽  
And Gender

Abstract Background Brucellosis is still endemic in many developing countries and frequently leads to misdiagnosis and treatment delays. Indirect inflammatory markers such as mean platelet volume (MPV), platelet distribution width (PDW), red cell distribution width (RDW), neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) have been identified as markers of inflammation. The present study aimed to evaluate and compare the levels of these markers for prognostic purposes, and to assess the correlation of C-reactive protein (CRP) with brucellosis in adults and children. Methods The study included 137 adults and 141 age- and gender-matched healthy controls, as well 71 children and 81 age- and gender-matched healthy controls. Hematological parameters and CRP were retrospectively recorded and compared between the adult and pediatric patients. Results The mean age of the adult patients (54% female) was 43.1 ± 15.4 years, whereas the mean age of the pediatric patients (50.7% male) was 9.5 ± 3.6 years. Significantly higher lymphocyte count, and lower neutrophil count, platelet count, RDW, MPV, NLR and PLR values were found in adult brucellosis patients compared with their healthy subjects, whereas higher lymphocyte count, PDW and lower neutrophil count, platelet count, MPV, NLR and PLR values were observed in pediatric brucellosis patients compared with the control subjects. Significantly higher neutrophil count (p=0.019) and NLR (p<0.001) were found in adult patients compared with the pediatric patients. Positive correlation was found between CRP and NLR (R2 = 0.052, P = 0.011), PLR (R2 = 0.061, P = 0.006) in adult patients. Conclusion Based on our findings, we consider that the use of complementary indirect markers such as MPV, NLR, PLR and RDW together with the CRP test – which is used concomitantly with serological diagnostic tests in situations where brucellosis is suspected – might be helpful in the diagnosis and follow-up of brucellosis, as well as in the evaluation of complications and response to therapy, in both adult and pediatric brucellosis patients. Disclosures All authors: No reported disclosures.

scholarly journals Evaluation of Cancer Patients with Older Adult for Awareness and Hospital Arrival Process of COVID-19 Pandemic During: A Cross-Sectional Study

2021 ◽  
Vol 7 ◽  
pp. 233372142199766
Author(s):  
Zeynep Sipahi Karslı ◽  
Berna Kurt ◽  
İbrahim Karadağ ◽  
Berna Çakmak Öksüzoğlu
Keyword(s):  
Cancer Patients ◽  
Older Adult ◽  
Cross Sectional Study ◽  
Arrival Process ◽  
Cross Sectional ◽  
Protective Measures ◽  
Hospital Arrival ◽  
Mortality And Morbidity ◽  
Correlational Design ◽  
Study Results

The study aimed to evaluate the Coronavirus pandemic awareness of cancer patients ≥65 years of age, considered a vulnerable group, and their hospital arrival process, follow-ups and treatments during the pandemic. COVID-19 pandemic was found to increases the mortality and morbidity rates of individuals who aged 65 years and older. The research was conducted with a cross-sectional descriptive correlational design. The sample consist of 77 cancer patients aged 65 years and older adult. Participants were recruited through convenience sampling. In total, 77 patients from the Oncology Hospital located in Ankara from April 29, 2020 to May 20, 2020. Data were collected using a two-part form and a questionnaire. The study was undertaken in accordance with the STROBE checklist for observational studies. Of the participants, 59.7% were female, the mean age was 70 years, 79.2% resided in Ankara and 98.7% traveled to the hospital by car. Looking at the gender and the protective measures taken at home, female participants were found to perform a statistically significant higher level of protective measures. In conclusion, the study results suggest that the restrictions for older adult oncology patients during the pandemic did not negatively affect the delivery of health care.

scholarly journals Analysis of complete blood counts in rotaviral gastroenteritis with special emphasis on platelet indices

2019 ◽  
Vol 6 (4) ◽  
pp. 1567
Author(s):  
Mahesh B. Maralihalli ◽  
Kavan R. Deshpande ◽  
Pallavi K Deshpande
Keyword(s):  
Platelet Count ◽  
Acute Phase ◽  
Acute Phase Reactant ◽  
Healthy Controls ◽  
Distribution Width ◽  
Platelet Counts ◽  
Rotavirus Gastroenteritis ◽  
Phase Reactant ◽  
Significant Difference ◽  
Complete Blood Counts

Background: The objectives of this study was to analyze complete blood counts in rotaviral gastroenteritis with special emphasis on platelet indices.Methods: Children diagnosed as rotavirus gastroenteritis and healthy controls were enrolled in this study. Severity of acute gastroenteritis was classified into mild, moderate and severe grades using Vesikari score. Rotavirus was determined in fresh stool samples using rapid diagnostic rotavirus antigen test. Hemoglobin, leukocyte, neutrophil to lymphocyte percentage ratio, platelet counts, mean platelet volume (MPV), platelet distribution width (PDW) and platelet crit (PCT) levels were assessed for all children. It’s a case control study conducted at Pediatric Speciality Hospital.Results: There were 30 cases with mean age 1.58 years. Healthy controls were 30 with mean age 2.10 years. Mean Hb was lower in cases. Mean of platelet counts was higher in cases. Mean MPV levels was lower in cases. Mean PCT value was higher in cases. Mean MPV to platelet ratio value was lower in cases. All parameters values showed no significant difference among mild, moderate and severe groups of rotaviral gastroenteritis cases. Platelet count was negatively correlated with Hb, MPVP and positively correlated with TLC and PCT. MPV was positively correlated with MPVP and PDW. PCT was negatively correlated with Hb, MPVP and positively correlated with TLC and platelet count.Conclusions: MPV can be used as negative acute phase reactant in rotavirus gastroenteritis and so is the MPV to platelet ratio. Platelet count is acute phase reactant in rotavirus gastroenteritis and so is the platelet crit value.

scholarly journals Study of platelet parameters in sick children

2021 ◽  
Vol 8 (3) ◽  
pp. 522
Author(s):  
Varada Vidya Rani ◽  
Ravichandrer Balasundaram
Keyword(s):  
Platelet Count ◽  
Chi Square ◽  
Distribution Width ◽  
Mortality And Morbidity ◽  
Predictors Of Mortality ◽  
Prediction Of Mortality ◽  
Significant Difference ◽  
Test Of Significance ◽  
And Gender ◽  
Sick Children

Background: Prediction of outcome of a patient plays a key role in the management of PICU. Studies have predicted that platelet parameters are novel predictors of mortality. Hence, present study was designed to assess the accuracy of platelet parameters (platelet count, MPV (mean platelet volume), PDW (platelet distribution width), PCT (Plateletcrit), MPV/PCT, PDW/Platelet count, MPV/platelet count in prediction of mortality and morbidity.  Methods: Total 66 children requiring admission to PICU, were divided as sick (with sick score≥3) and non-sick (with sick score<3). Their platelet parameters were compared. Platelet parameters were further studied with respect to morbidity and mortality. Statistical analysis was done using SPSS 22 version software. Chi-square test was used as test of significance for qualitative data. Continuous data was represented as mean and standard deviation. Independent t test was used as test of significance to identify the mean difference between two quantitative variables.  Results: Both groups were comparable in terms of age and gender. Significant difference in all platelet parameters were noted in between groups (p<0.001). Platelet parameters and their ratios were significant predictors of mortality and morbidity, with negative correlation to platelet count and plateletcrit (PCT), and positive correlation to the rest.Conclusions: Simple analysis of platelet indices at admission by haematology counter analysers could give us a great idea in predicting the mortality and morbidity of the children.  

scholarly journals Evaluation of Erythroid Disturbance and Thiol-Disulphide Homeostasis in Patients with Psoriasis

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Suzan Demir Pektas ◽  
Gokhan Pektas ◽  
Kursad Tosun ◽  
Gursoy Dogan ◽  
Salim Neselioglu ◽  
...  
Keyword(s):  
Disease Duration ◽  
Severity Index ◽  
Healthy Controls ◽  
C Reactive Protein ◽  
Psoriasis Area Severity Index ◽  
Cross Sectional ◽  
Distribution Width ◽  
Reactive Protein ◽  
Total Thiol ◽  
Blood Pressures

This study aims to assess how mean corpuscular volume (MCV), red cell distribution width (RDW), and thiol-disulphide homeostasis are altered in psoriasis patients. This is a cross-sectional review of 76 healthy volunteers and 87 psoriasis patients who were consecutively admitted to the department of dermatology. Psoriasis patients and healthy controls were statistically similar with respect to age, sex, body mass index, blood pressures, and disease duration (p>0.05for all). When compared to healthy controls, psoriasis patients had significantly higher MCV, RDW, C-reactive protein (CRP), disulphide, disulphide/native thiol, and disulphide/total thiol (p<0.001for all). However, psoriasis patients had significantly lower native thiol and native thiol/total thiol (p=0.009andp<0.001, respectively). When compared to healthy controls, the patients with Psoriasis Area Severity Index (PASI) ≤ 10 and patients with PASI > 10 had significantly higher MCV, disulphide, disulphide/native thiol, and disulphide/total thiol (p<0.001for all). The patients with PASI ≤ 10 and patients with PASI > 10 had significantly lower native thiol/native thiol than healthy controls (p<0.001for all). The psoriasis patients with PASI > 10 had significantly higher RDW and CRP than healthy controls and patients with PASI ≤ 10 (p<0.001for all). Disulphide, disulphide/native thiol, disulphide/total thiol, and native thiol/total thiol correlate significantly with both PASI scores and disease duration. Thiol-disulphide homeostasis is enhanced in psoriasis patients. Ongoing inflammation and increased oxidative stress in psoriasis patients also trigger the formation of prooxidants which are neutralized by antioxidants such as thiols. That is why plasma thiol levels are decreased in psoriasis patients.

scholarly journals “The incidence of ICU-associated pneumonia in patients admitted to ICU of major tertiary care hospitals”

2019 ◽  
Vol 26 (09) ◽  
pp. 1546-1550
Author(s):  
Muhammad Khuram Nouman ◽  
Syed Arsalan Akhter Zaidi ◽  
Bushra Zaidi ◽  
Kainat Saleem ◽  
Muhammad Khan Malik
Keyword(s):  
Mechanical Ventilation ◽  
Negative Impact ◽  
Tertiary Care ◽  
Cross Sectional Study ◽  
Primary Objective ◽  
Cross Sectional ◽  
Mortality And Morbidity ◽  
Mechanical Ventilation Duration ◽  
Study Results ◽  
Tertiary Care Hospitals

Background: Despite in techniques advancement to patient care for respiratory tracts are instrumented may complicate the IAP course up to 50% in patients with mechanical ventilation. It requires rapid diagnoses and treatment that is appropriate as per patient condition. Many studies revealed negative impact with delayed administration and antibiotic treatment in IAP patients may increase the hospital mortality and morbidity. The primary objective of the study was to estimate the incidence of IAP in the patient admitted in ICU of tertiary care hospitals in Rawalpindi Pakistan. Study Design: Observational cross sectional study. Setting: ICU units of various tertiary care hospitals in Rawalpindi, Pakistan. Period: One year from Dec 2016-Dec 2017. Materials and Methods: A total 450 subjects were enlisted for the study; these patients were selected randomly. The exclusion criteria include all patients with Acute Respiratory Distress Syndrome (ARDS) or those on long-term antibiotic or steroid therapy and all the pregnant women whereas all the patients of both sexes, kept on ventilator for more than 48 h and above the age of 18 years were included in this study. Results: We enrolled a total of 450 patients for this study. The average age of all the participants was   61.51 + 12.8 with range 36-91. 230(51.1%) of the patients were male whereas 220(48.9%) were females. The Trauma-Pulm contusion was absent in all patients. In ICU 150 (33.3%) were diagnosed with COPD, 150(33.3%) with Asthma, 220(48.9%) with ARDS, 10 (2.2%) with head trauma and 310 (68.8%) with diabetes.200 (44.4%) smokers, 40(8.8%) were having lung cancer, 310(68.8%) were hypertensive and 20 (4.4%) were with Pneumothorax - requiring Chest Tube. Conclusion: We may conclude from our study that ICU associated Pneumonia is a serious issue, that developed with longer hospital stay, duration of mechanical ventilation and re-intubation. By reducing the mechanical ventilation duration, pneumonia can be controlled.

scholarly journals Karakteristik Remaja Pengguna Narkoba Suntik dan Perilaku Berisiko HIV/AIDS di Kecamatan Ciledug Kota Tangerang

2008 ◽  
Vol 3 (2) ◽  
pp. 70
Author(s):  
Fauzi Syarif ◽  
Zarfiel Tafal
Keyword(s):  
Risk Behavior ◽  
Economic Status ◽  
Industrial Area ◽  
Living Environment ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Study Results ◽  
Aids Risk ◽  
Aids Risk Behavior ◽  
Hiv Aids

Prevalensi penderita HIV/AIDS di Kota Tangerang yang merupakan daerah industri dari tahun ke tahun meningkat tajam. Kecenderungan peningkatan kemungkinan disebabkan oleh letak strategis Kota Tangerang yang berbatasan langsung dengan Jakarta serta dengan geografi dan demografi yang hampir sama dengan Jakarta. Bersamaan dengan itu kasus peredaran dan pemakaian narkotika di wilayah Tangerang dari tahun ke tahun meningkat tajam. Penelitian bertujuan untuk mengetahui hubungan antara karakteristik remaja pengguna narkoba suntik (penasun) dengan perilaku berisiko tertular HIV/AIDS di Kecamatan Ciledug Kota Tangerang Tahun 2007. Data yang dikumpulkan secara cross sectional dilakukan pada 206 sampel responden remaja berusia 15–24 tahun yang menggunakan narkoba suntik melalui wawancara langsung dengan berpedoman pada kuesioner. Karakterisitk remaja tersebut meliputi karakteristik: pribadi (pengetahuan tentang HIV/AIDS, jenis kelamin, umur, tingkat pendidikan, status ekonomi, posisi urutan dalam keluarga, status orang tua, dengan siapa tinggal), lingkungan sosial (keterpaparan pergaulan dengan pengguna narkoba, pola asuh orang tua, lingkungan tempat tinggal) dan karakteristik budaya (masyarakat fanatisme agama, daerah pendatang/campur, kegiatan di luar rumah). Penelitian menunjukkan gambaran perilaku remaja penasun yang berisiko tertular HIV/AIDS mencapai angka 55,3%. Terdapat 8 (delapan) variabel yang berhubungan erat (p < 0,05) dengan perilaku penasun berisiko yaitu tingkat pengetahuan, umur, tingkat pendidikan, status ekonomi, status orang tua, pola asuh orang tua, lingkungan tempat tinggal dan kegiatan di luar rumah. Variabel yang paling dominan adalah tingkat pengetahuan dimana remaja penasun yang mempunyai tingkat pengetahuan kurang, mempunyai risiko tertular HIV/AIDS 6,9 kali dibandingkan yang mempunyai tingkat pengetahuan baik.Kata kunci : Pengguna narkoba suntik, remaja, HIV/AIDS.AbstractPrevalence of HIV-AIDS in Tangerang City—an industrial area, continues to increase. The increase may be caused by location of Tangerang which is directly bordered to Jakarta and having similar geographical and demographical characteristics to Jakarta. At the same time, there is a significant increase of drugs distribution and abuse. This study aims at investigating the relationship between injection-drug-user (IDU) teenager’s characteristics and HIV-AIDS high risk behavior in Ciledug Sub-district, Tangerang City in 2007. Data were collected through a cross-sectional survey conducted among 206 samples of IDU teenagers age 15-24 years old using questionnare administered in face-to-face interview. The study results show that HIV-AIDS risk behavior prevalence reached 55,3% among respondents and there were 8 variables with significant relationship (p < 0,05). Those 8 variables were knowledge, age, education level, economic status, parent status, parental care pattern, living environment, and outside home activity. The most dominant variable was knowledge where teenagers with low level of knowledge has 6,9 times higher risk of having HIV-AIDS risk behavior compared to those with higher level of knowledge.Keywords : IDU, teenagers, HIV-AIDS.

scholarly journals Risiko Hiperkolesterolemia pada Pekerja di Kawasan Industri

2012 ◽  
Vol 6 (5) ◽  
pp. 219
Author(s):  
Krisnawaty Bantas ◽  
Farida Mutiarawaty Tri Agustina ◽  
Dinie Zakiyah
Keyword(s):  
High Risk ◽  
Industrial Area ◽  
Smoking Behaviour ◽  
Mean Value ◽  
Blood Cholesterol ◽  
P Value ◽  
Cross Sectional ◽  
Mortality And Morbidity ◽  
Research Population ◽  
Cross Sectional Design

Hiperkolesterolemia adalah faktor risiko penting penyakit kardiovaskuler yang menjadi penyebab utama kematian dan kesakitan di seluruh dunia. Penyakit kardiovaskuler yang berdampak kerugian ekonomi dan penurunan produktivitas kerja dapat dicegah dengan mengendalikan faktor risiko terse- but. Penelitian ini bertujuan untuk mengetahui prevalensi dan faktor risiko hiperkolesterolemia di kalangan pekerja di kawasan industri Pulo Gadung tahun 2006. Penelitian yang menggunakan desain studi cross sectional ini mengamati variabel independen kebiasaan merokok, konsumsi alkohol, ke- biasaan olahraga, dan obesitas. Populasi penelitian adalah pekerja di 7 jenis perusahaan di kawasan industri Pulo Gadung yang berusia 20 tahun ke atas. Penelitian menemukan prevalensi hiperlipidemia 21,1%; nilai mean kadar kolesterol darah adalah 166,75 mg/dl dengan kadar terendah 77 mg/dl dan tertinggi (332 mg/dl). Ada hubungan yang bermakna antara vari- abel tempat bekerja dengan hiperkolesterolemia. Pekerja di perusahaan makanan, percetakan, garmen, dan kimia berisiko tinggi hiperkoles- terolemia (10,11; 6,08; 3,45; 3,55) dengan nilai p = 0,000; 0,004; 0,047; 0,045. Pekerja dengan indeks massa tubuh ≥ 25 berisiko tinggi hiperkoles- terolemia (odds ratio, OR = 1,67; nilai p = 0,004).Kata kunci: Hiperkolesterolemia, pekerja, kawasan industri, indeks massa tubuhAbstractGlobaly, coronary hard desease is a main cause of mortality and morbidity that can caused economic loses. Hypercholesterolemia is one of important risk faktor of cardiovasculer diseases that important to be controlled. The objective of this study is to know the prevalence and risk faktor of hiperko- lesterolemia among wokers in Pulo Gadung industrial area in 2006. The de- sain study used in this study is cross sectional design observes independent variables smoking behaviour, alcohol consumption, physical exercise, and obesity. The research population is the twenty year old or above workers who work in sevent types company in the industrial area of Pulo Gadung. The study paint out the prevalence of hyperlipidemia 21,1%, mean value on blood cholesterol level is 166,75 mg/dl, the lowest is 77 mg/dl and the highest is (332 mg/dl). Workers in food companies, printing, garment, and chemical, has high risk on hypercholesterolemia (10,11; 6,08; 3,45; 3,55) with p value = 0,000; 0,004; 0,047; 0,045). Workers with IMT ≥ 25 have high risk in hypercholesterolemia (OR = 1,67; p value = 0,004).Key words: Hipercholesterolemia, workers, industrial estate, body mass index

scholarly journals Platelet Markers Correlate with Glycemic Indices in Diabetic, but Not Diabetic-Myelodysplastic Patients with Normal Platelet Count

2010 ◽  
Vol 29 (1) ◽  
pp. 55-61 ◽  
Author(s):  
Maria Dalamaga ◽  
Konstantinos Karmaniolas ◽  
Antigoni Lekka ◽  
George Antonakos ◽  
Apollon Thrasyvoulides ◽  
...  
Keyword(s):  
Platelet Count ◽  
Disease Risk ◽  
Diabetic Patients ◽  
Cross Sectional ◽  
Distribution Width ◽  
Normal Platelet Count ◽  
Normal Platelet ◽  
Platelet Morphology ◽  
Glycemic Indices ◽  
Insulin Dependent

Background: Altered thrombocyte morphology and function have been reported in patients with diabetes mellitus (DM) type 2. The aim of the present study was to determine the associations between platelet morphology markers and hemoglobin A1C (HbA1c), fasting glucose (FG), hypertension and coronary heart disease (CHD) in patients with myelodysplastic syndromes (MDS) and DM, in patients with DM and in controls.Methods: This cross-sectional study included 30 cases with primary MDS with normal platelet count and non-insulin dependent diabetes, 30 non-insulin dependent diabetic patients and 30 non-diabetic, non-MDS controls matched on age and gender. Results: After adjusting for body mass index, platelet number, CHD and hypertension, HbA1cand FG were significant predictors of mean platelet volume (MPV) and platelet distribution width (PDW) in diabetic patients. There was no correlation between platelet parameters and HbA1cor FG in diabetic MDS patients. In controls, FG and hypertension predicted significant differences in platelet morphology. Platelet count correlated with platelet morphology in diabetic MDS and control groups, but not in diabetics.Conclusions: MPV and PDW are associated with glycemic indices in diabetic patients but not in diabetic MDS patients with normal platelet counts. Non-diabetic controls also exhibit FG related changes in platelet morphology. This suggests other factors inherent to bone marrow dysplasia, platelet turnover and biochemistry, or vascular environment affect platelet morphology in diabetic MDS patients even with normal platelet count. Platelet morphology in this population may be an early marker for myelodysplasia. These findings also support platelet morphology change as a marker for elevated macrovascular disease risk.

scholarly journals 320. Differentiating Dengue from COVID-19: A Diagnostic Challenge in the Tropical Regions of the Americas

2021 ◽  
Vol 8 (Supplement_1) ◽  
pp. S265-S266
Author(s):  
Fernando Rosso ◽  
Olga Lucia agudelo Rojas
Keyword(s):  
Platelet Count ◽  
Neutrophil Count ◽  
Cross Sectional Study ◽  
P Value ◽  
Diagnostic Challenge ◽  
Cross Sectional ◽  
Tropical Regions ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Initial Symptoms

Abstract Background The differentiation between dengue and coronavirus disease 2019 (COVID-19) diagnoses is a challenge in tropical regions due to the similarity of symptoms and limited access to specific diagnostic tests for each disease. The objective of this study was to describe the initial symptoms and laboratory test values of patients who presented to the emergency department with dengue or COVID-19. A cross-sectional study was performed in a single center in Cali, Colombia Methods The inclusion criteria were patients with a diagnosis of dengue or COVID-19 who were older than 14 years of age. All patients experienced fever or other symptoms for fewer than ten days. Linear regression was performed to evaluate the differences in the neutrophil-lymphocyte ratio (NLR) between patients diagnosed with COVID-19 and dengue and was adjusted for sex and age group (≤31 and &gt;31 years). The sample size was calculated to test the hypothesis that the median NLR in COVID-19 patients is higher than that in dengue patients. A p-value &lt; 0.05 was considered statistically significant for all analyses Results A total of 93 patients were included: 70 with dengue and 23 with COVID-19. Dengue patients were younger than COVID-19 patients. There were significant differences between dengue and COVID-19 patients regarding platelet count (p&lt; 0.01), neutrophil count (p&lt; 0.01), neutrophil-lymphocyte ratio (NLR) (p&lt; 0.01), and abnormal alanine transaminase (ALT) (p=0.03). The NLR was significantly higher in COVID-19 patients than in dengue patients (p&lt; 0.01). Table 1. Demographics, clinical and laboratory characteristics in COVID-19 and dengue patients. Conclusion In conclusion, during the first week of symptoms, absolute neutrophil count, NLR, and platelet count could help guide the initial differential approach between dengue and COVID-19. These findings could be useful in geographical areas with a lack of resources. Disclosures All Authors: No reported disclosures

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