Ongoing research protocols for the pharmacological treatment of neuropsychiatric symptoms in dementia

2020 ◽  
pp. 1-9
Author(s):  
M. Canevelli ◽  
G. Remoli ◽  
M. Toccaceli Blasi ◽  
L. Tariciotti ◽  
G. Sarli ◽  
...  
Keyword(s):  
Research Effort ◽  
Neuropsychiatric Symptoms ◽  
Phase 1 ◽  
Research Priorities ◽  
Eligibility Criteria ◽  
Ongoing Research ◽  
Research Activities ◽  
Effective Interventions ◽  
Dementia Research ◽  
Ongoing Phase

The implementation of effective interventions for neuropsychiatric symptoms (NPS) is perceived as one of the most pressing research priorities in the field of dementia and one of the main unmet needs from the perspective of affected individuals and their caregivers and relatives. Nevertheless, to date, only a relatively marginal part of dementia research has focused on NPS. This study aimed to describe and discuss the state of the art concerning the identification and development of new pharmacological treatments for NPS in dementia. A review of 320 ongoing phase 1, 2, 3, and 4 protocols registered in the clinicaltrials.gov database was performed. All the trials enrolling patients with dementia were selected. Only studies adopting clinical measures of NPS frequency and/or severity as primary outcome were retained and analyzed. Overall, only a minority of ongoing phase 1, 2, 3 and 4 protocols on dementia (i.e., 9.0%) is primarily targeting NPS. Most of these studies are adopting a placebo-controlled parallel assignment design, testing oral compounds, and targeting specific NPS (mostly agitation and/or aggression). A total of 3,445 subjects with dementia will tentatively be recruited in these trials. The methodologies adopted in these studies, the characteristics of the tested interventions, the eligibility criteria, and the operational definitions of NPS are presented and discussed. The relevance of NPS is not yet matched by an adequate research effort. The current tendency at privileging disease-modifying approaches and other symptoms of dementia and the methodological complexity of studying NPS are still substantially contributing to the gap between research activities and clinical needs.

scholarly journals Use of Biomarkers in Ongoing Research Protocols on Alzheimer’s Disease

2020 ◽  
Vol 10 (3) ◽  
pp. 68 ◽  
Author(s):  
Marco Canevelli ◽  
Giulia Remoli ◽  
Ilaria Bacigalupo ◽  
Martina Valletta ◽  
Marco Toccaceli Blasi ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Phase 1 ◽  
Amyloid Deposition ◽  
Tau Pathology ◽  
Eligibility Criteria ◽  
Ongoing Research ◽  
Research Protocols ◽  
Ongoing Phase ◽  
Selection Of

The present study aimed to describe and discuss the state of the art of biomarker use in ongoing Alzheimer’s disease (AD) research. A review of 222 ongoing phase 1, 2, 3, and 4 protocols registered in the clinicaltrials.gov database was performed. All the trials (i) enrolling subjects with clinical disturbances and/or preclinical diagnoses falling within the AD continuum; and (ii) testing the efficacy and/or safety/tolerability of a therapeutic intervention, were analyzed. The use of biomarkers of amyloid deposition, tau pathology, and neurodegeneration among the eligibility criteria and/or study outcomes was assessed. Overall, 58.2% of ongoing interventional studies on AD adopt candidate biomarkers. They are mostly adopted by studies at the preliminary stages of the drug development process to explore the safety profile of novel therapies, and to provide evidence of target engagement and disease-modifying properties. The biologically supported selection of participants is mostly based on biomarkers of amyloid deposition, whereas the use of biomarkers as study outcomes mostly relies on markers of neurodegeneration. Biomarkers play an important role in the design and conduction of research protocols targeting AD. Nevertheless, their clinical validity, utility, and cost-effectiveness in the “real world” remain to be clarified.

scholarly journals Increasing Polychaete diversity as a consequence of increasing research effort in Greek waters: new records and exotic species

2005 ◽  
Vol 6 (1) ◽  
pp. 74 ◽  
Author(s):  
N. SIMBOURA ◽  
A. ZENETOS
Keyword(s):  
New Species ◽  
Exotic Species ◽  
New Records ◽  
Research Effort ◽  
Aegean Sea ◽  
Ongoing Research ◽  
Research Activities ◽  
Increasing Trend ◽  
Lessepsian Migrants ◽  
First Time

The increasing diversity of the Greek Polychaete fauna over the last seven decades, as illustrated graphically, shows an increasing trend which is proportionately related to the research effort exerted. Ongoing research activities mainly in the depths of the N. Aegean Sea, as a result of which 13 new records have been added to the Greek Polychaete fauna, confirming the above statement. The new species records are presented along with their geographical distribution and habitat. According to the latest checklist of the Greek Polychaeta, 753 species of Polychaetes have been recorded in Greek waters. Finally, it should be noted that 6 Lessepsian migrants and 16 species have been recorded in the Mediterranean for the first time. Their distribution within Greece and worldwide is given and their presence in Greek waters is discussed.

scholarly journals The first research agenda for the chiropractic profession in Europe

2014 ◽  
Vol 22 (1) ◽  
Author(s):  
Sidney M Rubinstein ◽  
Jenni Bolton ◽  
Alexandra L Webb ◽  
Jan Hartvigsen
Keyword(s):  
Research Agenda ◽  
Phase 1 ◽  
Academic Research ◽  
Research Priorities ◽  
Chiropractic Profession ◽  
Future Research ◽  
Economic Evaluations ◽  
Phase 2 ◽  
Research Activities ◽  
The Uk

Abstract Background Research involving chiropractors is evolving and expanding in Europe while resources are limited. Therefore, we considered it timely to initiate a research agenda for the chiropractic profession in Europe. The aim was to identify and suggest priorities for future research in order to best channel the available resources and facilitate advancement of the profession. Methods In total, 60 academics and clinicians working in a chiropractic setting, and who had attended any of the annual European Chiropractors’ Union/European Academy of Chiropractic (ECU/EAC) Researchers’ Day meetings since their inception in 2008, were invited to participate. Data collection consisted of the following phases: phase 1 identification of themes; phase 2 consensus, which employed a Delphi process and allowed us to distill the list of research priorities; and phase 3 presentation of the results during both the Researchers’ Day and a plenary session of the annual ECU Convention in May 2013. In addition, results were distributed to all ECU member countries. Results The response rate was 42% from phase 1 and 68% from phase 2. In general, participants were middle-aged, male and had been awarded a Doctor of Philosophy (PhD) as well as chiropractic degree. Approximately equal numbers of participants had obtained their chiropractic degree from the UK/Europe and North America. The majority of participants worked primarily in an academic/research environment and approximately half worked in an independent institution. In total, 58% of the participants were from the UK and Denmark, collectively representing 44% of the chiropractors working in Europe. In total, 70 research priorities were identified, of which 19 reached consensus as priorities for future research. The following three items were thought to be most important: 1) cost-effectiveness/economic evaluations, 2) identification of subgroups likely to respond to treatment, and 3) initiation and promotion of collaborative research activities. Conclusions This is the first formal and systematic attempt to develop a research agenda for the chiropractic profession in Europe. Future discussion and study is necessary to determine whether the themes identified in this survey should be broadly implemented.

scholarly journals Conducting Research in Persons With Dementia During the COVID-19 Pandemic: Challenges and Strategies

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. 310-310
Author(s):  
Ying-Ling Jao ◽  
Diane Berish ◽  
Ann Kolanowski
Keyword(s):  
Older Adults ◽  
Nursing Homes ◽  
Assisted Living ◽  
Ongoing Research ◽  
Health Crisis ◽  
Emergency Situations ◽  
Research Activities ◽  
People With Dementia ◽  
Dementia Research ◽  
Challenges And Strategies

Abstract The COVID-19 pandemic has caused a health crisis for vulnerable older adults, physically and psychologically. Despite the urgent demand for clinical research for people with dementia, research activities are restricted due to the pandemic. This symposium will share the experiences of researchers conducting studies with older persons with dementia during the COVID-19 pandemic. The presenters share their strategies to overcome challenges at different stages of the study process during the pandemic. The research projects include work conducted in acute care, assisted living, nursing homes, and the community. The presentations include perspectives from different geographic areas and across countries in North America. The first presenter reports the challenges in continuing an ongoing research project, and shares strategies to engage stakeholders and plan a new protocol for recruitment and in-person data collection with residents with dementia in nursing homes. The second presenter reports on the barriers and facilitators of conducting an ongoing clinical trial with older adults with dementia across hospital and community settings and discusses strategies to meet project goals which include modifications to the protocol and analytic plan. The third presenter describes adaptations made to a study intervention designed to promote quality resident-staff interactions in assisted living and alterations to stakeholder engagement. The fourth presenter describes challenges and strategies to engage older adults with dementia via technology. The discussant will synthesize the findings across studies and highlight policy and research implications for the COVID-19 pandemic as well as other emergency situations.

scholarly journals A human antibody selective for transthyretin amyloid removes cardiac amyloid through phagocytic immune cells

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Aubin Michalon ◽  
Andreas Hagenbuch ◽  
Christian Huy ◽  
Evita Varela ◽  
Benoit Combaluzier ◽  
...  
Keyword(s):  
Immune Cells ◽  
Ex Vivo ◽  
Phase 1 ◽  
Hereditary Disease ◽  
Elderly Subjects ◽  
Human Antibody ◽  
Cardiac Amyloid ◽  
Healthy Elderly ◽  
Ongoing Phase

AbstractTransthyretin amyloid (ATTR) cardiomyopathy is a debilitating disease leading to heart failure and death. It is characterized by the deposition of extracellular ATTR fibrils in the myocardium. Reducing myocardial ATTR load is a therapeutic goal anticipated to translate into restored cardiac function and improved patient survival. For this purpose, we developed the selective anti-ATTR antibody NI301A, a recombinant human monoclonal immunoglobulin G1. NI301A was cloned following comprehensive analyses of memory B cell repertoires derived from healthy elderly subjects. NI301A binds selectively with high affinity to the disease-associated ATTR aggregates of either wild-type or variant ATTR related to sporadic or hereditary disease, respectively. It does not bind physiological transthyretin. NI301A removes ATTR deposits ex vivo from patient-derived myocardium by macrophages, as well as in vivo from mice grafted with patient-derived ATTR fibrils in a dose- and time-dependent fashion. The biological activity of ATTR removal involves antibody-mediated activation of phagocytic immune cells including macrophages. These data support the evaluation of safety and tolerability of NI301A in an ongoing phase 1 clinical trial in patients with ATTR cardiomyopathy.

scholarly journals Novel Treatments and Technologies Applied to the Cure of Neuroblastoma

Children ◽  
2021 ◽  
Vol 8 (6) ◽  
pp. 482
Author(s):  
Irene Paraboschi ◽  
Laura Privitera ◽  
Gabriela Kramer-Marek ◽  
John Anderson ◽  
Stefano Giuliani
Keyword(s):  
Research Effort ◽  
Treatment Strategies ◽  
Adverse Outcomes ◽  
Treatment Protocols ◽  
Ongoing Research ◽  
Hematopoietic Stem ◽  
Novel Treatments ◽  
Therapeutic Modalities ◽  
High Risk Disease ◽  
Novel Treatment Strategies

Neuroblastoma (NB) is the most common extracranial solid tumour in childhood, accounting for approximately 15% of all cancer-related deaths in the paediatric population1. It is characterised by heterogeneous clinical behaviour in neonates and often adverse outcomes in toddlers. The overall survival of children with high-risk disease is around 40–50% despite the aggressive treatment protocols consisting of intensive chemotherapy, surgery, radiation therapy and hematopoietic stem cell transplantation2,3. There is an ongoing research effort to increase NB’s cellular and molecular biology knowledge to translate essential findings into novel treatment strategies. This review aims to address new therapeutic modalities emerging from preclinical studies offering a unique translational opportunity for NB treatment.

scholarly journals Resolution of Serious Vaso-Occlusive Pain Crises: Results from the Ongoing Phase 1/2 HGB-206 Group C Study of LentiGlobin for Sickle Cell Disease (SCD; bb1111) Gene Therapy

2021 ◽  
Vol 27 (3) ◽  
pp. S12-S13
Author(s):  
Mark C. Walters ◽  
Alexis A. Thompson ◽  
Markus Y. Mapara ◽  
Janet L. Kwiatkowski ◽  
Lakshmanan Krishnamurti ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Phase 1 ◽  
Cell Disease ◽  
Ongoing Phase

scholarly journals Recent trends in batteries and lubricants for electric vehicles

2021 ◽  
Vol 13 (5) ◽  
pp. 168781402110217
Author(s):  
Raj Shah ◽  
Blerim Gashi ◽  
Sergio González-Poggini ◽  
Melanie Colet-Lagrille ◽  
Andreas Rosenkranz
Keyword(s):  
Surface Engineering ◽  
Combustion Engine ◽  
Steering System ◽  
Energy Output ◽  
Ongoing Research ◽  
Effective Utilization ◽  
Research Activities ◽  
Recent Trends ◽  
Li Ion ◽  
Driving Range

Future progress in hybrid and battery vehicles heavily relies on the optimization of involved battery components and lubricants. Attention must specifically be given to the material composition and surface coatings of the electrodes as well as the electrolyte used to maximize energy output, while also ensuring safety. Additionally, prioritizing the effective utilization of specific lubricants for electric motors and various tribological contacts, such as wheel bearings and the steering system, is the prospective goal of lubrication research. The energy output of the most promising battery, the Li-ion battery (LIB), must result in driving ranges, which can compete with the 600 km driving range of combustion engine (ICE) vehicles. Consequently, ongoing research activities in cell chemistry, electrode surface engineering, electrolyte engineering, and engine lubrication offer the greatest opportunity in achieving these goals.

scholarly journals Effects of sport-related repetitive subconcussive head impacts on biofluid markers: a scoping review protocol

BMJ Open ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. e046452
Author(s):  
Liivia-Mari Lember ◽  
Michail Ntikas ◽  
Stefania Mondello ◽  
Lindsay Wilson ◽  
Angus Hunter ◽  
...  
Keyword(s):  
Scoping Review ◽  
Unmet Need ◽  
Research Priorities ◽  
Medical Decision ◽  
Cochrane Library ◽  
Eligibility Criteria ◽  
Head Impacts ◽  
Review Protocol ◽  
Ebsco Host ◽  
Clinical Trials Registry

IntroductionSport-related repetitive subconcussive head impacts (RSHIs) are increasingly thought to be associated with adverse long-term outcomes. However, owing to potentially subtle effects, accurate assessment of harm to the brain as a consequence of RSHI is a major challenge and an unmet need. Several studies suggest that biofluid markers can be valuable objective tools to aid the diagnosis and injury characterisation and help in medical decision-making. Still, by and large, the results have been limited, heterogeneous and inconsistent. The main aims of this scoping review are therefore (1) to systematically examine the extent, nature and quality of available evidence from studies investigating effects of RSHI on fluid biomarkers and (2) to formulate guidelines and identify gaps with the aim to inform future clinical studies and the development of research priorities.Methods and analysesWe will use a comprehensive search strategy to retrieve all available and relevant articles in the literature. The following electronic databases will be systematically searched: MEDLINE (EBSCO host; from 1809 to 2020); Scopus (from 1788 to 2020); SPORTDiscus (from 1892 to 2020); CINAHL Complete (from 1937 to 2020); PsycINFO (from 1887 to 2020); Cochrane Library (to 2020); OpenGrey (to 2020); ClinicalTrials.gov (to 2020) and WHO International Clinical Trials Registry Platform (to 2020). We will consider primarily biomedical studies evaluating the biofluid markers following RSHI. Two independent reviewers will screen articles for inclusion using predefined eligibility criteria and extract data of retained articles. Disagreements will be resolved through consensus or arbitrated by a third reviewer if necessary. Data will be reported qualitatively given the heterogeneity of the included studies. In synthesising the evidence, we will structure results by markers, sample types, outcomes, sport and timepoints.Ethics and disseminationEthics approval is not required. We will submit results for peer-review publication, and present at relevant conferences.

scholarly journals Alzheimer's Disease–Related Dementias Summit 2016: National research priorities

Neurology ◽  
2017 ◽  
Vol 89 (23) ◽  
pp. 2381-2391 ◽  
Author(s):  
Roderick A. Corriveau ◽  
Walter J. Koroshetz ◽  
Jordan T. Gladman ◽  
Sophia Jeon ◽  
Debra Babcock ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Alzheimer Disease ◽  
Scientific Progress ◽  
Research Priorities ◽  
Lewy Body Dementia ◽  
National Plan ◽  
Relevant Research ◽  
Challenges And Opportunities ◽  
Dementia Research

Goal 1 of the National Plan to Address Alzheimer’s Disease is to prevent and effectively treat Alzheimer disease and Alzheimer disease–related dementias by 2025. To help inform the research agenda toward achieving this goal, the NIH hosts periodic summits that set and refine relevant research priorities for the subsequent 5 to 10 years. This proceedings article summarizes the 2016 Alzheimer's Disease–Related Dementias Summit, including discussion of scientific progress, challenges, and opportunities in major areas of dementia research, including mixed-etiology dementias, Lewy body dementia, frontotemporal degeneration, vascular contributions to cognitive impairment and dementia, dementia disparities, and dementia nomenclature.

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