scholarly journals Type 2 diabetes mellitus: time to change the concept

2013 ◽  
Vol 16 (1) ◽  
pp. 91-102 ◽  
Author(s):  
Shmuel Levit ◽  
Yury Ivanovich Filippov ◽  
A S Gorelyshev
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Heterogeneous Group ◽  
Therapy Goals ◽  
Current Review ◽  
The Common ◽  
Contemporary Approach

Diabetes mellitus is a heterogeneous group of diseases that, although unified by a number of characteristics, require a differential thera- peutic approach. Current review discusses key pathogenic features of type 2 diabetes mellitus that determine therapy goals and options in management. We further enunciate and pathogenetically substantiate a new "gravicentric" concept for treatment of type 2 diabetes mellitus that differs in many ways from the common contemporary approach.

scholarly journals Polymorphism Study on SLC30A8 and Its Association with Type 2 Diabetes

2016 ◽  
Vol 02 ◽  
pp. 118
Author(s):  
M Vignesh ◽  
T Sangeetha ◽  
T Varsha ◽  
◽  
◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Tryptophan Residue ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide ◽  
The World ◽  
Hereditary Factors ◽  
The Common

Type 2 diabetes mellitus (T2DM) is one of the threatening disorders in the world. It affects people of all ages. Type 2 diabetes mellitus is a condition in which the glucose level in the blood is elevated due to improper function of the secretion of insulin from beta cells of the pancreas. It is a multifactorial disease because it is caused by both environmental and hereditary factors. One of the genes which play an important role in type 2 diabetes mellitus is SLC30A8 which encodes for zinc transporter ZnT8. The common polymorphic site for SLC30A8 is rs13266634. This single-nucleotide polymorphism leads to type 2 diabetes mellitus by replacing the arginine residue with tryptophan residue. This review mainly focuses on the polymorphic studies in the gene SLC30A8 and its association with type 2 diabetes mellitus.

scholarly journals The Cross-talk Relationship between Metformin and Gut Microbiota

2020 ◽  
Author(s):  
Hyder O. Mirghani
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Gut Microbiota ◽  
Plasma Glucose ◽  
Controlled Trials ◽  
Randomized Controlled ◽  
Current Review

Background: Metformin is the first-line oral therapy for type 2 diabetes mellitus. However, its mode of action is poorly defined. There is an increasing awareness regarding the cross talk of gut microbiota and metformin. The current review aimed to assess the bidirectional relationship between metformin and gut microbiota. Methods: Electronic search was conducted in Pub Med and the first 100 articles in Google Scholar published until November 2019. However, only randomized controlled trials on humans published in the English language were included.  The terms “gut microbiota,” “gut flora "and “ metformin” were as keywords to perform the search. Although 124 articles were retrieved, only six met the inclusion criteria of the study. Results: Of the six full texts of randomized controlled trials included in the study, two-thirds were published in Europe, one in the USA, and one in China. Six hundred-thirty five patients were included and the duration of the studies ranged from seven days to six months. The studies concluded that microbiota modulates some metformin actions on plasma glucose; while metformin enhances the abundance of microbiota that positively affect insulin resistance and plasma glucose. Conclusion: The current review showed that microbiota dysbiosis may mediate metformin antidiabetic effects. Whereas metformin shifted the gut microbiota toward the beneficial species ameliorating insulin resistance. The present study might provide insights into a novel therapeutic approach to treat type 2 diabetes mellitus. Key words: gut microbiota, metformin, type 2 diabetes

scholarly journals Diabetes mellitus type 2: a new indication for hypercortisolism screening?

2012 ◽  
Vol 15 (4) ◽  
pp. 95-102
Author(s):  
Natalya Ivanovna Volkova ◽  
Maria Igorevna Antonenko ◽  
Liliya Alexandrovna Ganenko
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Detailed Analysis ◽  
Diabetes Mellitus Type 2 ◽  
Cushing Syndrome ◽  
Clinical Signs ◽  
Diabetes Mellitus Type ◽  
Current Review

Current review discusses novel data concerning prevalence of Cushing syndrome without characteristic clinical signs among patients with type 2 diabetes mellitus. We also provide detailed analysis of difficulties in diagnostics and management of this condition

scholarly journals Cancer Risk in Type 2 Diabetes Mellitus: Metabolic Links and Therapeutic Considerations

2011 ◽  
Vol 2011 ◽  
pp. 1-11 ◽  
Author(s):  
Grace Sun ◽  
Sangeeta R. Kashyap
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Cancer Risk ◽  
Metabolic Pathways ◽  
The Common ◽  
Potential Impact ◽  
The Relationship ◽  
Therapeutic Considerations

Type 2 diabetes mellitus (DM2) is increasing in incidence, creating worldwide public health concerns and impacting morbidity and mortality rates. An increasing number of studies have demonstrated shared associations between DM2 and malignancy, including key clinical, biochemical, and metabolic commonalities. This paper will attempt to explore the relationship between the various types of cancer and diabetes, the common metabolic pathways underlying cancer development, and the potential impact of various antidiabetes therapies on cancer risk.

scholarly journals Common co-morbid conditions associated with type 2 diabetes mellitus

2020 ◽  
Vol 19 (2) ◽  
pp. 237-239
Author(s):  
Kartick Chanda Shaha ◽  
Md Shamsur Rahman ◽  
Tasmin Shahnaz ◽  
Habibunnahar
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Medical College Hospital ◽  
Outpatient Department ◽  
College Hospital ◽  
Medical College ◽  
The Common ◽  
Morbid Conditions

Objective: The aim of the present study was to find out the common co-morbid conditions associated with type 2 diabetes mellitus. Methods: A descriptive, cross sectional study was conducted from January 2016 to June 2016 among 300 patients attending at Medicine outpatient department of the Community Based Medical College Hospital and Endocrine outpatient department of the Mymensingh Medical College Hospital after obtaining requisite consent from the patients. Data were collected through the interviewing of the patients. The collected data were entered into the computer and analyzed by using SPSS (version 20.1) to know the common co-morbid conditions associated with type 2 diabetes mellitus. The study was approved by the institutional ethical committee. Results: In a pool of 300 type 2 diabetics, Most of the patients (57.3%) belonged to the middle age group 41-60 years. More than half of the respondents were female (n=223, 74.3%). Among 300 cases, 188 patients had shown association with different co-morbid conditions. Female patients (77%) suffered from more co-morbid conditions than male patients (23%). Hypertension was the most commonly associated disease (65.42%) with DM. Conclusion: Most of the diabetic patients have co-morbid conditions. Hypertension was the most commonly associated disease with DM. Bangladesh Journal of Medical Science Vol.19(2) 2020 p.237-239

scholarly journals Association between Subclinical Hypothyroidism and Albuminuria in Patients with Type 2 Diabetes Mellitus: A Cross Sectional Study in Iran

2020 ◽  
pp. 67-75
Author(s):  
Atousa Najmaldin ◽  
Solmaz Askari ◽  
Majid Foroutan
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Subclinical Hypothyroidism ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
The Common ◽  
Tsh Levels

Introduction: Studies have shown the association between subclinical hypothyroidism and type 2 diabetes. However, the common complications of type 2 diabetes, such as diabetic nephropathy and albuminuria with subclinical hypothyroidism, are not fully clear yet. This study thus aimed to determine the association between subclinical hypothyroidism and albuminuria in patients with type 2 diabetes mellitus. Methods: This was a cross-sectional study, of 140 individuals diagnosed with type 2 diabetes mellitus (DM) admitted to the internal clinics of Kosar Hospital in Semnan, Iran in 2017-2018. The participants were selected, and were compared based on having 2 TSH levels above normal (>4.2 mIU/L) 3 months apart, as well as patients were divided to two groups including, subclinical hypothyroidism group (n=40) and euthyroid group (n=100) based on demographic information, laboratory information and indicators such as albuminuria, and urinary albumin-to-creatinine ratio (UACR). Findings: The mean and standard deviation of UACR in patients with subclinical hypothyroidism were significantly higher than those of euthyroid patients (46.09 ± 27 9.27 vs. 3.94 ± 0.24 and P = 0.015, respectively). In patients with subclinical hypothyroidism, there was a statistically significant and direct relationship between UACR values with primary TSH level (r = 0.555, P< 0.001) and UACR values with secondary TSH level (r = 0.563, P< 0.001). Conclusion: Among type 2 DM patients, the rate of albuminuria in subclinical hypothyroidism group was significantly higher than that of euthyroid patients and with increasing initial and recurrent TSH levels, UACR values and consequently albuminuria increased.

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