scholarly journals Neonatal screening for congenital hypothyroidism: results and perspectives. Hormone research

2000 ◽  
Vol 46 (1) ◽  
pp. 37-46
Author(s):  
F. Delange
Keyword(s):  
Mental Retardation ◽  
Thyroid Hormones ◽  
Congenital Hypothyroidism ◽  
Neonatal Screening ◽  
Hepatitis A ◽  
Postnatal Period ◽  
Pediatric Endocrinology ◽  
Industrial Countries ◽  
Hormone Research ◽  
The Brain

Congenital hypothyroidism (HB) is detected in 1 out of 4,000 newborns [1, 2]. G is one of the most common diseases in pediatric endocrinology [3 |, as well as one of the most common cases of reversible brain damage and mental retardation in industrial countries. The delay in mental development in hepatitis A is associated with the fact that thyroid hormones take an active part in the development of the brain | 4], the formation of which occurs in utero and in the early postnatal period until the 2nd or 3rd year of life [5].

scholarly journals CONGENITAL HYPOTHYROIDISM

2016 ◽  
pp. 95-98
Author(s):  
N. V. Nikolayenko
Keyword(s):  
Mental Retardation ◽  
Congenital Hypothyroidism ◽  
Neonatal Screening ◽  
Early Stage ◽  
Hormone Deficiency ◽  
Endocrine Disorder ◽  
Screening Programs ◽  
Adequate Therapy

Congenital hypothyroidism (CH) is the most common congenital endocrine disorder whose incidence in newborns is 1:2,000 to 1:4,000. It is the leading cause of mental retardation. Neonatal Screening Programs make it possible to identify the disease at an early stage and to start the adequate therapy of the children, thanks to which it is possible to avoid complications related to the hormone deficiency.

scholarly journals Incidence of Congenital Hypothyroidism in the Newborn of A Tertiary Hospital in Southern Bangladesh

1970 ◽  
Vol 29 (3) ◽  
pp. 82-87
Author(s):  
CH Rasul ◽  
SN Lucky ◽  
SR Miah ◽  
F Moslem
Keyword(s):  
Mental Retardation ◽  
Birth Weight ◽  
Blood Sample ◽  
Congenital Hypothyroidism ◽  
Neonatal Screening ◽  
Medical College Hospital ◽  
Cord Blood Sample ◽  
College Hospital ◽  
Female Ratio ◽  
Medical College

Background: Congenital hypothyroidism is the commonest preventable cause of mental retardation. It is more prevalent in endemic goiter regions like Bangladesh. But magnitude of the problem has not been studied at national level.Objective: To detect the incidence of congenital hypothyroidism among the newborn delivered in Khulna Medical College Hospital in southern part of Bangladesh and to rationalize the development of neonatal screening program.Methodology: All the living newborns delivered between Oct '01 to June ‘05 in Khulna Medical College Hospital were included in the study. After taking the relevant information from mother, cord blood sample were collected from the newborn within 24 hours of birth and kept in freezer. At the end of collection of each two month, the lot of blood sample was sent to the laboratory of Institute of Nuclear Medicine, Dhaka for radioimmunoassay of TSH. Potential cases with TSH value above 10 MIU/L were recalled for thyroid function test for confirmation of diagnosis.Results: After discarding unsatisfactory samples, 1353 samples were assayed for TSH. Among the study population 88.2% hailed from Khulna district and the rest of the cases came from neighboring districts. Male to female ratio was 1.2:1. Regarding the birth weight 33.4% babies were of low birth weight. TSH above 10 MIU/L were found in 35 babies among whom one baby was hypothyroid and the other member of the twin was also hypothyroid although the TSH level was below 10 MIU/L. Thus incidence of congenital hypothyroidism was 1.5 per thousand living newborn among the studied cases.Conclusion: The incidence of congenital hypothyroidism in southern part of the country is quite high in relation to global incidence. Although this is not the national picture but the high figure is alarming. So, neonatal screening program should be implemented as soon as possible to find out the real case burden in the community and thereby to take care of them and reduce the number of mentally retarded children in our country. Key words: Congenital hypothyroidism; neonatal screening; mental retardation. DOI: 10.3329/bjch.v29i3.6186 Bangladesh J Child Health 2005; Vol 29 (3): 88-92

scholarly journals Consensus guidelines of congenital hypothyroidism by the European Society for pediatric endocrinology and the European Society for Endocrinology: key points and comments

2021 ◽  
Vol 17 (2) ◽  
pp. 4-12
Author(s):  
E. V. Shreder ◽  
T. Y. Shiryaeva ◽  
E. V. Nagaeva ◽  
O. B. Bezlepkina
Keyword(s):  
Congenital Hypothyroidism ◽  
European Society ◽  
Neonatal Screening ◽  
Clinical Problem ◽  
Consensus Guidelines ◽  
Pediatric Endocrinology ◽  
Pediatric Practice ◽  
Key Points ◽  
Screening Diagnostics

Congenital hypothyroidism is an actual clinical problem in pediatric practice. Previous clinical guidelines were published in 2014. The presented clinical recommendations are based on articles published from January 2013 to early 2020. The consensus guidelines include such sections as results of neonatal screening, diagnostics and criteria for treatment, lifelong follow-up, genetics of congenital hypothyroidism, family genetic counselling. The key points of new congenital hypothyroidism guidelines were commented by pediatric endocrinologists of Russians.

Pubertal development and adult height in patients with congenital hypothyroidism detected by neonatal screening in southern Brazil

2020 ◽  
Vol 33 (11) ◽  
pp. 1449-1455
Author(s):  
Suzana Nesi-França ◽  
Rodrigo B. Silveira ◽  
Juliana Cristina R. Rojas Ramos ◽  
Adriane A. Cardoso-Demartini ◽  
Monica N. Lima Cat ◽  
...  
Keyword(s):  
Congenital Hypothyroidism ◽  
Neonatal Screening ◽  
Adult Height ◽  
Screening Program ◽  
Pubertal Development ◽  
Z Score ◽  
Normal Range ◽  
Adequate Treatment ◽  
Increased Risk ◽  
Puberty Onset

AbstractObjectivesAdequate treatment of congenital hypothyroidism (CH) is required for normal growth and sexual development. To evaluate pubertal development in patients with permanent CH detected by a statewide Neonatal Screening Program of Paraná and, secondly, to evaluate adult height (AH) in a subgroup of patients.MethodsClinical, laboratory, and auxological data obtained from medical records of 174 patients (123 girls).ResultsMedian chronological age (CA) at treatment initiation was 24 days, and mean initial levothyroxine dose was 11.7 ± 1.9 μg/kg/day; mean CA at puberty onset was 11.5 ± 1.3 years (boys) and 9.7 ± 1.2 years (girls); mean CA in girls who underwent menarche (n=81) was 12.1 ± 1.1 years. Thyroid-stimulating hormone (TSH) values above the normal range were observed in 36.4% of the boys and 32.7% of the girls on puberty onset, and in 44.6% around menarche. Among 15 boys and 66 girls who had reached the AH, the median height z-score value was significantly greater than the target height (TH) z-score value in boys (p=0.01) and in girls (p<0.001). Boys with normal TSH values at puberty onset had greater mean AH z-score compared with boys with TSH values above the normal range (p=0.04).ConclusionsIn this group, pubertal development in girls with CH was not different from that reported in healthy girls in the general Brazilian population. Boys with higher TSH at puberty onset may have an increased risk of not reaching their potential height compared with those with normal TSH during this period. In a subgroup who attained AH, the median AH z-score was greater than the median TH z-score.

scholarly journals Thyroid hormones and seasonal reproductive neuroendocrine interactions

Reproduction ◽  
2008 ◽  
Vol 136 (1) ◽  
pp. 1-8 ◽  
Author(s):  
Nobuhiro Nakao ◽  
Hiroko Ono ◽  
Takashi Yoshimura
Keyword(s):  
Thyroid Hormone ◽  
Thyroid Hormones ◽  
Biological Process ◽  
Critical Role ◽  
Day Length ◽  
Seasonal Reproduction ◽  
Seasonal Breeding ◽  
Length Changes ◽  
Neuroendocrine Axis ◽  
The Brain

Many animals that breed seasonally measure the day length (photoperiod) and use these measurements as predictive information to prepare themselves for annual breeding. For several decades, thyroid hormones have been known to be involved in this biological process; however, their precise roles remain unknown. Recent molecular analyses have revealed that local thyroid hormone activation in the hypothalamus plays a critical role in the regulation of the neuroendocrine axis involved in seasonal reproduction in both birds and mammals. Furthermore, functional genomics analyses have revealed a novel function of the hormone thyrotropin. This hormone plays a key role in signaling day-length changes to the brain and thus triggers seasonal breeding. This review aims to summarize the currently available knowledge on the interactions between elements of the thyroid hormone axis and the neuroendocrine system involved in seasonal reproduction.

scholarly journals MR and CT imaging in the Dyke-Davidoff-Masson syndrome: report of three cases and contribution to pathogenesis and differential diagnosis

1998 ◽  
Vol 56 (4) ◽  
pp. 803-807 ◽  
Author(s):  
PAULO HENRIQUE AGUIAR ◽  
WEI LIU CHING ◽  
HELIO LEITÃO ◽  
F. ISSA ◽  
GUILHERME LEPSKI ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Mental Retardation ◽  
Brain Injury ◽  
Paranasal Sinuses ◽  
Facial Asymmetry ◽  
Cerebral Injury ◽  
Radiological Features ◽  
Cerebral Hemiatrophy ◽  
The Brain ◽  
Syndrome Report

Cerebral hemiatrophy or Dyke-Davidoff-Masson syndrome is a condition characterized by seizures, facial asymmetry, contralateral hemiplegia or hemiparesis, and mental retardation. These findings are due to cerebral injury that may occur early in life or in utero. The radiological features are unilateral loss of cerebral volume and associated compensatory bone alterations in the calvarium, like thickening, hyperpneumatization of the paranasal sinuses and mastoid cells and elevation of the petrous ridge. The authors describe three cases. Classical findings of the syndrome are present in variable degrees according to the extent of the brain injury. Pathogenesis is commented.

Sign in / Sign up

Export Citation Format

Share Document