scholarly journals Prevalence of hyperuricemia in professional athletes and its role in the genesis of various pathological conditions and metabolic disturbances

2018 ◽  
Vol 12 (3) ◽  
pp. 82-88 ◽  
Author(s):  
M. S. Eliseev ◽  
I. Т. Vykhodets ◽  
I. V. Kruglova ◽  
M. N. Chikina ◽  
O. V. Zhelyabina ◽  
...  
Keyword(s):  
Healthy Volunteers ◽  
Sports Medicine ◽  
Statistical Processing ◽  
Serum Levels ◽  
Professional Athletes ◽  
Control Group ◽  
Healthy Population ◽  
Metabolic Disturbances ◽  
Pathological Conditions ◽  
Clinical Center

In recent decades, the prevalence of hyperuricemia (HU) is increasing worldwide; the role of uric acid (UA) in the genesis of various metabolic disorders, cardiovascular diseases, and kidney disease is being discussed. There are very few investigations of the rate of HU and its role in the development of diseases in certain social groups, including in professional athletes.Objective:to estimate the prevalence of HU and its role in the genesis of various pathological conditions and metabolic disturbances in professional athletes.Patients and methods.A retrospective comparative one-stage study was conducted, for which 2148 athletes who met inclusion criteria were selected and examined in the Federal Research and Clinical Center for Sports Medicine and Rehabilitation, Federal Biomedical Agency, in 2015. A control group consisted of 99 ageand sex-matched healthy volunteers examined at the V.A. Nasonova Research Institute of Rheumatology in 2017. The analysis included a comparison of the rate of HU and other examined parameters in professional athletes and healthy volunteers. The examined parameters were separately compared in athletes with/without HU, followed by statistical processing of results.Results.HU was detected in 306 (14.2%) of the 2148 athletes, more often in men (n=253 (20%) than in women (n=53 (6%); (p<0.001). The rate of HU in the athletes was comparable with that in the healthy population (12.1%). The athletes with HU (n=306) compared with the other athletes (n=1842) had the following statistically higher indicators: the mean serum levels of creatinine, triglycerides, aspartate aminotransferase, alanine aminotransferase, gamma-glutamyltranspeptidase, creatinine phosphokinase, and myoglobin, glomerular filtration rate, and body mass index (BMI) (p<0.00001 for all cases).Conclusion.HU is detected quite often in professional athletes (14.2%), which is comparable with the indicators seen in healthy volunteers (12.1%). The high prevalence of HU and its association with indicators reflecting kidney function, lipid metabolic disturbances, and BMI necessitate further investigations aimed at searching the causes of HU and methods of its prevention and treatment in professional athletes.

scholarly journals Role of vitamin D serum levels in prevention of primary and recurrent melanoma

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
M. Lombardo ◽  
A. Vigezzi ◽  
G. Ietto ◽  
C. Franchi ◽  
V. Iori ◽  
...  
Keyword(s):  
Vitamin D ◽  
Serum Levels ◽  
Mitotic Rate ◽  
Control Group ◽  
Healthy Population ◽  
Histological Subtype ◽  
Melanoma Diagnosis ◽  
Significant Difference ◽  
Tumour Location

AbstractPatients afflicted with melanoma show lower vitamin D serum levels (VDSL) than the healthy population. This hypothesis agrees with its well-known antiproliferative features. An observational study was carried out to collect VDSL in patients suffering from melanoma. Our aim was to identify a potential connection between low VDSL and the risk to incur melanoma. Furthermore, we studied the association between VDSL at the diagnosis of melanoma and other germane prognostic factors. The population held in regard was composed of 154 patients with a diagnosis of melanoma between 2016 and 2019. These patients were retrospectively collected from our follow-up storage. We compared VDSL to clinical and pathological parameters (age, sex, tumour location, Breslow’s depth, Clark’s level, histological subtype, ulceration, et aliqua). Moreover, we recruited a control group with negative melanoma history. Mean and median of VDSL were significantly lower in the melanoma group. Instead, we found a negative association between melanoma and VDSL > 30 ng/L (OR 0.11; p < 0.0001). No correlation between VDSL and both Breslow’s depth and Clark’s level was discovered, but the VDSL comparison between thin (depth ≤ 1 mm) and thick tumours (depth > 1 mm) revealed a statistically significant difference (21.1 ± 8.2 ng/L vs 17.8 ± 8.1; p = 0.01). Moreover, VDSL were significantly lower in melanomas with mitotic rate ≥ 1/mm2 (22.1 ± 8.3 ng/L; p < 0007). Nevertheless, no connection was found between VDSL and both ulceration and positive sentinel nodes (p = 0.76; p = 0.74). Besides, our study revealed no association between VDSL and histological subtype (p = 0.161). Lower VDSL correlate with thick and high mitotic rate tumours. Future prospective studies would investigate if appropriate upkeep of suitable VDSL can decrease the risk of primary and recurrent melanoma diagnosis.

scholarly journals Policosanol Attenuates Statin-Induced Increases in Serum Proprotein Convertase Subtilisin/Kexin Type 9 When Combined with Atorvastatin

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Yuan-Lin Guo ◽  
Rui-Xia Xu ◽  
Cheng-Gang Zhu ◽  
Na-Qiong Wu ◽  
Zhi-Ping Cui ◽  
...  
Keyword(s):  
Healthy Volunteers ◽  
Statistical Significance ◽  
Serum Levels ◽  
Statin Treatment ◽  
Control Group ◽  
Proprotein Convertase ◽  
To Receive ◽  
Modest Effect

Objective. Statin treatment alone has been demonstrated to significantly increase plasma proprotein convertase subtilisin/kexin type 9 (PCSK9) levels. The effect of policosanol combined with statin on PCSK9 is unknown.Methods. Protocol I: 26 patients with atherosclerosis were randomly assigned to receive either atorvastatin 20 mg/d or policosanol 20 mg/d + atorvastatin 20 mg/d for 8 weeks. Protocol II: 15 healthy volunteers were randomly assigned to either policosanol 20 mg/d or a control group for 12 weeks. Serum levels of PCSK9 were determined at day 0 and the end of each protocol.Results. Protocol I: atorvastatin 20 mg/d significantly increased serum PCSK9 level by 39.4% (256 ± 84 ng/mL versus 357 ± 101 ng/mL,P=0.002). However, policosanol 20 mg/d + atorvastatin 20 mg/d increased serum PCSK9 level by only 17.4% without statistical significance (264 ± 60 ng/mL versus 310 ± 86 ng/mL,P=0.184). Protocol II: there was a trend toward decreasing serum PCSK9 levels in the policosanol group (289 ± 71 ng/mL versus 235 ± 46 ng/mL,P=0.069).Conclusion. Policosanol combined with statin attenuated the statin-induced increase in serum PCSK9 levels. This finding indicates that policosanol might have a modest effect of lowering serum PCSK9 levels.

scholarly journals The Effects of Exercise on Appetite in Older Adults: A Systematic Review and Meta-Analysis

2021 ◽  
Vol 8 ◽  
Author(s):  
Sarah Hubner ◽  
Julie Blaskewicz Boron ◽  
Karsten Koehler
Keyword(s):  
Physical Activity ◽  
Systematic Review ◽  
Older Adults ◽  
Sports Medicine ◽  
Physical Activity Intervention ◽  
Later Life ◽  
Future Research ◽  
Control Group ◽  
Healthy Population ◽  
Appetite Control

Background: The effect of physical activity and exercise on hunger and satiety has been well-studied in younger adults, but the influence of aging is less understood. While some evidence suggests that acute bouts of exercise induce a compensatory eating drive, long-term activity may improve satiety sensitivity. The objective of this study was to investigate the effects of exercise on appetite in older adults.Methods: We systematically reviewed available literature investigating the effect of exercise on appetite in older adults adults (CRD42020208953). PubMed, PsycINFO, Academic Search Complete, the Sports Medicine &amp; Education Index, and Web of Science, were searched for peer-reviewed articles published in English with no date restriction. Included studies implemented a primary exercise or physical activity intervention with a control group, on a generally healthy population ≥60 years of age. Selected studies included at least one appetite outcome. Risk of bias was assessed using the 11-point Physiotherapy Evidence Database (PEDro) tool. Standardized mean difference summary statistics (Hedge's g effect sizes) and 95% confidence intervals were reported.Results: We identified 15 reports (13 studies) which met all inclusion criteria (5 resistance training, 3 aerobic, 6 mixed modalities). Studies included 443 participants (Age = 68.9 ± 5.2, 82.3% female) and had generally “good” bias scores (PEDro = 6.4 ± 0.88). Random effects meta-analyses revealed that the exercising group showed statistically significant reductions in glucose [SMD = −0.34 (95% CI: −0.67, −0.02), p &lt; 0.05, PEDro =6.4 ± 0.45] and leptin [SMD = −0.92 (95% CI: −1.28, −0.57), p &lt; 0.00001, PEDro = 6.2 ± 0.75].Discussion: This systematic review revealed that exercise and physical activity may modulate resting hunger and satiety in older adults. Decreases in fasting leptin and glucose hormones suggest that exercise promotes satiety sensitivity in adults aged 60+. This review highlights that engaging in exercise and activity programs may provide a meaningful avenue for improving chronic and functional disease burden in later life by promoting appetite control and balanced energy intake. Recommendations for future research include investigations of appetite in response to varied exercise modalities within more diverse and representative samples of older adults.

scholarly journals Features of immune response in children with varying severity of atopic dermatitis

2021 ◽  
Vol 16 (1) ◽  
pp. 20-26
Author(s):  
S.M. Nedelska ◽  
D.O. Vakula
Keyword(s):  
Immune Response ◽  
Atopic Dermatitis ◽  
Age Groups ◽  
Statistical Processing ◽  
Serum Levels ◽  
Young Age ◽  
Control Group ◽  
Healthy Children ◽  
Th2 Immune Response ◽  
Low Levels

Background. Atopic dermatitis (AD) is the most common allergic disease among children of young age. Severe forms of AD with skin bacterial and fungal overgrowth may be associated with features of the immune response in different age groups. Plenty of studies demonstrated not only polarization of the Th2 immune response in AD patients, but also the Th1 immune dysregulation. The purpose of this study was to investigate the features of the immune response in children with varying severity of atopic dermatitis. Materials and methods. The study included 85 children aged 3 months to 3 years with a verified diagnosis of AD, living in the Zaporozhzhia region. Twenty healthy children without atopy formed a control group. The patients were divided into groups depending on the severity of AD based on the SCORAD scale. The serum levels C3, C4–2, CD3+, CD19–, CD4+, CD8–, CD4–, CD8+, CD3–, CD56+, CD19+, CD14, CD45, IgA, IgM, IgG, IgE, С3, С4–2, phagocytic acti­vity of neutrophils, and proliferative activity of lymphocytes were measured by flow cyto­metry (Synevo). ELISA method was used to detect serum levels of IL-13 (ELISA Kit, Thermo Fisher Scientific, Austria). Statistical processing of the results was performed using the official software package Statistica 13.0. Results. The study revealed eosinophilia in 60 % of the children with a mild and moderate course of AD (Me 5.62 [3.64; 7.81]) and in 56 % of the children with a severe course (Me 6.18 [3.13; 9.42]). The children with a severe course of AD and low levels of IL-13, C3 had transient hypogammaglobulinemia and significantly lower le­vels of the C3 complement, increased levels of CD4+, CD8– with simultaneously decreased levels of CD4–, CD8+ compared with groups of the children with high levels of ­IL-13 (р < 0.05). Conclusion. The results suggest that severe forms of AD in children of the young age were associated with changes in the complement system and low levels of cytotoxic cells, transient hypogammaglobulinemia. It requires deeper research of the cascades of the immune response in children with AD.

scholarly journals Changes in the biochemical composition of saliva in diabetic patients

2006 ◽  
Vol 53 (4) ◽  
pp. 209-216 ◽  
Author(s):  
Biljana Andjelski-Radicevic ◽  
Silvija Mirkovic ◽  
Tatjana Todorovic ◽  
Obrad Zelic
Keyword(s):  
Biochemical Composition ◽  
Diabetes Mellitus Type 1 ◽  
Control Group ◽  
Diabetic Patients ◽  
Healthy Population ◽  
Total Proteins ◽  
Clinical Center ◽  
School Of Dentistry ◽  
Dm Type 2

Introduction: Diabetic patients, beside numerous acute and chronic complications, often have oral manifestations of the disease. Aim: The aim of the study was to establish changes in saliva of diabetic patients in relation to healthy population in order to use saliva in the disease monitoring, as well as the changes depending on the type of diabetes. Materials and methods: The study comprised 52 adult patients of both sexes and at the age between 18 and 79 with Diabetes mellitus type 1 and 2 who were treated at the Institute for endocrinology, diabetes and metabolic disorders of the Clinical center of Serbia. The control group consisted of 67 volunteers from Belgrade, students at the School of Dentistry, aged between 19 and 24. The whole of unstimulated and stimulated saliva was collected and biochemical parameters (glucose, total proteins, albumin, sodium and potassium) were determined by methods commonly used for serum. Results: The results showed that salivary potassium level was increased in saliva of diabetic patients, that of sodium and total proteins was decreased, and glucose and albumin did not show changes compared to the control group. Concentrations of total proteins and potassium were higher in patients with DM type 2, and sodium was higher in DM type 1 (p = 0.05). Conclusion: Diabetic patients often have changes in biochemical composition of saliva.

scholarly journals IL-17A, IL-22, IL-6, and IL-21 Serum Levels in Plaque-Type Psoriasis in Brazilian Patients

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
Priscilla Stela Santana de Oliveira ◽  
Pablo Ramon Gualberto Cardoso ◽  
Emerson Vasconcelos de Andrade Lima ◽  
Michelly Cristiny Pereira ◽  
Angela Luzia Branco Pinto Duarte ◽  
...  
Keyword(s):  
Healthy Volunteers ◽  
Severity Index ◽  
Serum Levels ◽  
Statistical Correlation ◽  
Control Group ◽  
Inflammatory Skin Disease ◽  
Serum Samples ◽  
Cytokine Detection ◽  
Plaque Type ◽  
Pasi Score

Psoriasis is a chronic inflammatory skin disease characterized by alterations in cytokines produced by both Th1 and Th17 pathways. The aim of this study was to evaluate serum levels of pivotal cytokines and correlate them with clinical parameters. Serum samples from 53 psoriasis patients and 35 healthy volunteers, matched by the proportion of sex and age ratios, were collected for ELISA cytokine detection. Psoriasis Area and Severity Index (PASI) was assessed at the time of sampling in psoriasis patients. Our findings demonstrate that IL-17A, IL-22, and IL-6 serum concentrations were significantly higher in psoriasis patients than in the control group. No statistical correlation could be found between cytokines concentrations, PASI score, and age in this study. Although our results do not show any correlation between serum levels of IL-17A, IL-22, and IL-6 and disease activity, the present study confirms that they were increased in Brazilian psoriasis patients in comparison to healthy volunteers.

scholarly journals Smell training increases cognitive smell skills of wine tasters compared to the general healthy population. The WINECAT Study

2010 ◽  
Vol 48 (3) ◽  
pp. 273-276
Author(s):  
F.S. Marino-Sanchez ◽  
I. Alobid ◽  
S. Cantellas ◽  
C. Alberca ◽  
J.M. Guilemany ◽  
...  
Keyword(s):  
Healthy Volunteers ◽  
Forced Choice ◽  
Control Group ◽  
Healthy Population ◽  
Healthy Controls ◽  
Smell Test ◽  
Wine Experts

Background: Wine experts show higher accuracy than novices in selecting a wine that matches a sample. Only one study has compared wine experts with non-trained healthy controls on smell. The aim of this study was to compare the smell characteristics, both sensorial and cognitive, of wine tasters with Spanish healthy population using the Barcelona Smell Test-24. Methods: Wine tasters were tested for smell and compared with a control group of healthy volunteers, by tasting 20 odours and scoring smell detection, identification, intensity, irritability, freshness, pleasure and forced choice. Results: Wine tasters performed significantly better on identification and forced choice than healthy controls. In addition, wine tasters perceived more odours as intense, but fewer as irritating than controls. Conclusions: Probably linked to smell education, wine tasters show better cognitive but not sensorial smell skills than a non-trained healthy population.

scholarly journals CORRELATION ANALYSIS OF GSTP1 GENE POLYMORPHISM WITH MORBIDITY OF PRIMARY METASTATIC COLORECTAL CANCER

2020 ◽  
Vol 2 ◽  
pp. 25-31
Author(s):  
Yuri Bazhora ◽  
Sergii Chetverikov ◽  
Viacheslav Onyshchenko ◽  
Mykhailo Chetverikov ◽  
Valeriia Chetverikova-Ovchynnyk
Keyword(s):  
Colorectal Cancer ◽  
Correlation Analysis ◽  
Gene Polymorphism ◽  
Metastatic Colorectal Cancer ◽  
Glutathione Transferase ◽  
Control Group ◽  
Healthy Population ◽  
Glutathione S Transferase ◽  
Pathological Conditions ◽  
Gstp1 Gene

Colorectal cancer (CRC) is one of the most common malignancies. Susceptibility to malignant processes is mediated by genetically driven differences in the effectiveness of detoxification of potential carcinogens. One of the factors that may influence the risk of CRC is the glutathione-S-transferase (GST) gene family that encodes glutathione transferase enzymes. The GSTP1 gene is expressed both in normal and pathological conditions. Determining its specific alleles may be a marker of CRC. The aim of the research – to study GSTP1 gene polymorphism, which is likely to be more common among patients with primary metastatic colorectal cancer compared with healthy population. Materials and methods. The study involved 12 patients with primary metastatic colorectal cancer aged 43 to 72 years, the control group was represented by a sample of 31 people without cancer. Results. The incidence of advanced CRC in the presence of GSPT1 Val / Val (aa) polymorphism is statistically significantly higher than in the presence of Ile / Ile (AA) and Ile / Val (Aa) GSPT1 polymorphism. Conclusions. Among people with GSTP1 Val / Val (aa) polymorphism, primary CRC is 4.4 times more likely than among people with GSPT1 Ile / Ile (AA) and Ile / Val (Aa) polymorphisms, which are statistically significant (P < 0.05). The obtained results indicate the possibility of conducting a genetic study of GSTP1 polymorphism to form groups of potential risk of CRC.

scholarly journals Evaluation of Sex Hormone Levels in Patients with Pemphigus Vulgaris in Comparison to the Healthy Population

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Fatemeh Lavaee ◽  
Fahimeh Rezazadeh ◽  
Nasrin Saki ◽  
Zahra Tavazo ◽  
Saman Baghaei
Keyword(s):  
Sex Hormones ◽  
Pemphigus Vulgaris ◽  
Serum Levels ◽  
Cross Sectional Study ◽  
Control Group ◽  
Case Group ◽  
Healthy Population ◽  
Healthy Controls ◽  
Cross Sectional ◽  
The Mean

Background and Aim. The onset of autoimmune diseases is associated with the levels of sex hormones. Pemphigus vulgaris is an autoimmune disease with a higher prevalence in postmenopausal women. The present study is aimed at evaluating the sex hormones’ levels in patients with pemphigus vulgaris in comparison to healthy controls. Materials and Methods. This cross-sectional study was performed on patients with pemphigus vulgaris referred to Faghihi Hospital and Shiraz Dental Faculty in 2017-2018. The participants included 26 women with histopathologically confirmed pemphigus vulgaris and 26 healthy age-matched controls. The serum levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), estrogen, progesterone, testosterone, prolactin, dehydroepiandrosterone (DHEA), and dihydrotestosterone (DHT) were evaluated in both groups. Independent t -test and two-way ANOVA were used for data analysis. Results. The mean age of the patients was 49.88 ± 10.46 years and that of the control group was 49.92 ± 11.30 years. Unlike the case group, the DHEA serum level was significantly higher among nonmenopausal participants in the control group. Moreover, the levels of testosterone and DHEA were significantly lower in the case group in comparison to the control group ( p = 0.015 and p = 0.026 , respectively). Conclusion. Considering the effects of age and menopause, the serum levels of testosterone and DHEA were significantly lower in the patients with pemphigus vulgaris than in the healthy controls. Hence, these hormones might have a role in the pathogenesis of pemphigus vulgaris.

scholarly journals Vasopressin serum levels in patients with severe brain lesions and in brain-dead patients

2004 ◽  
Vol 62 (2a) ◽  
pp. 226-232 ◽  
Author(s):  
Eliane de Araújo Cintra ◽  
Jayme Antunes Maciel Jr ◽  
Sebastião Araújo ◽  
Margaret de Castro ◽  
Edna Freitas Martins ◽  
...  
Keyword(s):  
Healthy Volunteers ◽  
Venous Blood ◽  
Serum Levels ◽  
Brain Lesions ◽  
Control Group ◽  
Open Label ◽  
Significant Statistical Difference ◽  
Significant Difference ◽  
Brain Dead ◽  
Trial Setting

INTRODUCTION: Patients with severe brain lesions (SBL) and brain-dead patients (BD) frequently present with vasopressin (AVP) secretion disorders. OBJECTIVE: To evaluate AVP serum levels in SBL and BD patients. DESIGN: Prospective, open label, observational trial. SETTING: A general teaching hospital. METHOD: Three groups of adult subjects (age> 18y) of both sexes were included in this study: control group: 29 healthy volunteers; SBL group: 17 patients with Glasgow Coma Scale (GCS)< 8; and BD group: 11 brain-dead patients. Samples of venous blood were collected in the morning at rest from healthy volunteers and at 8 hourly intervals over a period of 24h from SBL and BD patients for AVP determinations. Concomitantly, some clinical and laboratorial variables were also recorded. RESULTS: AVP serum levels (pg/ml) were [mean (SD); median]: control [2.2(1.1); 2.0]; SBL [5.7(6.3); 2.9]; and BD [2.6(1.0); 2.8]. AVP serum levels varied greatly in SBL patients, but without statistically significant difference in relation to the other groups (p=0.06). Hypotension (p=0.02), hypernatremia (p=0.0001), serum hyperosmolarity (p=0.0001) and urinary hypoosmolarity (p=0.003) were outstanding in BD patients when compared with SBL. CONCLUSIONS: The AVP serum levels did not demonstrate significant statistical difference between the groups, only showing a greater variability in SBL patients (manifested as serum spike levels). Hypernatremia and hyperosmolarity were present in BD patients, indicating a failure of the hypothalamic-pituitary system in AVP production and release.

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