scholarly journals Pengaruh suplementasi β-carotene terhadap kadar glukosa darah dan kadar malondialdehida pada tikus sprague dawley yang diinduksi Streptozotocin

2014 ◽  
Vol 2 (2) ◽  
pp. 41-46
Author(s):  
Elida Soviana ◽  
Banundari Rachmawati ◽  
Nyoman Suci Widyastiti
Keyword(s):  
Free Radicals ◽  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Negative Control ◽  
Male Rats ◽  
Sprague Dawley ◽  
Significant Difference ◽  
Decrease Blood Glucose ◽  
Β Carotene

Background : Hyperglycemia on diabetes mellitus can cause increasing of free radicals production. Free radicals caused lipid peroxidation reaction by forming malondialdehyde (MDA). β-carotene has antioxidant activity may inhibit the formation of ROS.Objective : To prove the effect of multilevel doses β-carotene 1 mg/kg BW, 20 mg/kg BW and 20 mg/kg BW on alternate days within 30 days orally supplementation on blood glucose level and MDA level on Sprague Dawley male rats induced by streptozotocin (STZ). Methods : Thirty rats were randomly divided into 5 groups: X1=Negative control/diabetic, X2 (STZ 40 mg/kg BW + BC 1 mg/kg BW), X3 (STZ 40 mg/kg BW + BC 10mg/kg BW), X4 (STZ 40 mg/kg BW + BC 20 mg/kg BW), X5 (technic control/non diabetic). β-Carotene supplementation was given by nasogastric tube on alternate days within thirty days. Blood glucose level was measured by GOD-PAP and MDA level by ELISA with TBARS methods. Data was analized using paired t-test, wilcoxon, one way anova and post hoc bonferroni. Results : there was a significant difference of blood glucose level (p = 0,0001) and MDA level (p = 0,0001) after suplementation β-carotene on alternate days within 30 days orally. β-carotene 10 mg/kg BW was the most effective and efficient dose to lowering blood glucose, while 20 mg/kg BW to lowering MDA level. Conclusion : The multilevel doses β-carotene (1 mg/kg BW, 10 mg/kg BW and 20 mg/kg BW) on alternate days within 30 days orally supplementation can decrease blood glucose and MDA level. β-carotene 10 mg/kg BW is the most effecetive and efficient to decrease blood glucose and β-carotene 20 mg/kg BW to decrease MDA level.

scholarly journals PENGARUH SINBIOTIK KEFIR TEPUNG PISANG BATU (Musa balbisiana) TERHADAP KADAR GLUKOSA DARAH TIKUS SINDROM METABOLIK

2020 ◽  
Vol 7 (1) ◽  
pp. 18-27
Author(s):  
Dhea Marliana Salsabila ◽  
Taufik Maryusman ◽  
Iin Fatmawati
Keyword(s):  
Metabolic Syndrome ◽  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Negative Control ◽  
Standard Diet ◽  
Sprague Dawley ◽  
High Fat ◽  
Musa Balbisiana ◽  
Significant Difference

Metabolic syndrome begins with insulin resistance characterized by hyperglycemia. Synbiotic kefir banana (Musa balbisiana Colla) flour reduces blood glucose level. This study was conducted to analyze the effects of synbiotic kefir banana (M. balbisiana) flour on blood glucose level of metabolic syndrome rats. This study used 24 Sprague Dawley.rats which were divided into four groups, i.e. negative control was given standard diet, positive control was given high fat fructose diet (HFFD), treatment I (PI) and treatment II (PII) were given HFFD and synbiotic kefir banana (M. balbisiana) flour 1.8 mL 200 g־¹ rat BW per day (PI) and 3.6 mL 200 g־¹ rat BW per day (PII), respectively, for three weeks. The result showed a significant difference (p=0.000) in blood glucose after giving synbiotic kefir banana (M. balbisiana) flour. Synbiotic kefir banana (M. balbisiana) flour reduced blood glucose level in metabolic syndrome rats.Keywords: banana flour, blood glucose level, kefir, metabolic syndrome, synbiotic ABSTRAKSindrom metabolik diawali resistensi insulin yang ditandai hiperglikemia. Sinbiotik kefir tepung pisang batu (M. balbisiana) menurunkan kadar glukosa darah. Penelitian ini dilakukan untuk menganalisis pengaruh sinbiotik kefir tepung pisang batu (M. balbisiana) terhadap kadar glukosa darah tikus sindrom metabolik. Penelitian ini menggunakan 24 tikus Sprague Dawley yang dibagi menjadi empat kelompok, yaitu kontrol negatif yang diberi pakan standar, kontrol positif yang diberi high fat fructose diet (HFFD), dan perlakuan I (PI) serta perlakuan II (PII) yang masing-masing diberi HFFD dan sinbiotik kefir tepung pisang batu (M. balbisiana) 1,8 mL 200 g־¹ BB tikus per hari (PI) dan 3,6 mL 200 g־¹ BB tikus per hari (PII) selama tiga minggu. Hasil menunjukkan perbedaan kadar glukosa darah setelah pemberian sinbiotik kefir tepung pisang batu (M. balbisiana) secara signifikan (p=0,000). Sinbiotik kefir tepung pisang batu (M. balbisiana) menurunkan kadar glukosa darah tikus sindrom metabolik.

scholarly journals Effect of Long Bean (Vignaunguiculata) on Blood Glucose Level of Mice (Mus musculus) Induced by Alloxan

2015 ◽  
Vol 9 (2) ◽  
Author(s):  
Intan Fitri Aprila ◽  
M. Nur Salim ◽  
Razali Daud ◽  
T. Armansyah ◽  
Nuzul Asmilia ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Mus Musculus ◽  
Negative Control Group ◽  
Positive Control ◽  
Negative Control ◽  
Control Group ◽  
Distilled Water ◽  
Decrease Blood Glucose

The aim of this research was to find out the effect of long bean (Vigna unguiculata) on level of blood glucose on mice (Mus musculus) induced by alloxan. Twelve mice with the weigh of 25-40 grams and clinically healthy were used in this research. All mice were randomly divided into 4 treatment groups, 3 mice each. K0 was negative control group, only given aquadest. K1, K2, and K3 groups were induced by alloxan 0.5 ml. K1 group was positive control. K2 group was fed with 100 grams long bean mixed with 50 ml distilled water. K3 group was fed with 100 grams long bean mixed with 100 ml distilled water. Long bean was fed orally 0.5 ml every morning and evening for 7 consecutive days. On day eight the examination of blood glucose level was performed. The average level of blood glucose were K0 (142.00±23.39), K1 (167.00±10.54), K2 (122.67±12.50), dan K3 (154.67±16.26) mg/dL. In conclusion, the administration of long bean for seven consecutive days does not decrease blood glucose level on mice induced by alloxan.Key words: blood glucose, alloxan, long bean

scholarly journals Penurunan Kadar Glukosa Darah Sewaktu Melalui Terapi Reiki Pada Pasien Diabetes Melitus Tipe 2

2011 ◽  
Vol 14 (2) ◽  
pp. 113-120
Author(s):  
Ester Inung Sylvia ◽  
Krisna Yetti ◽  
Rr.Tutik Sri Hariyati
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Complementary Therapy ◽  
The Body ◽  
Purposive Sampling ◽  
Significant Difference ◽  
Decrease Blood Glucose ◽  
Diabetes Melitus

AbstrakReiki merupakan terapi komplementer untuk menurunkan kadar glukosa darah. Terapi ini menggunakan energi alami yangdisalurkan pada tubuh pasien dengan tujuan menyelaraskan energi yang tidak seimbang dalam tubuhnya. Penelitian untukmengetahui pengaruh Reiki terhadap penurunan glukosa darah dan mengidentifikasi apakah faktor stres dan berat badan(obesitas) berperan dalam penurunan KGD pasien Diabetes Melitus tipe 2 dilakukan di Klub Diabetes sebuah RS di Jakarta.Desain penelitian pre-eksperimental dengan pendekatan one-group pretest-posttest design. Sejumlah 18 sampel dipilih denganteknik purposive sampling. Terapi dilakukan selama tiga puluh hari dengan dua metode, secara langsung dan jarak jauh. Hasilpenelitian menunjukkan perbedaan bermakna antara glukosa darah sebelum dan setelah intervensi Reiki (p= 0,000; α= 0,05).Penelitian ini menyarankan penggunaan Reiki dalam asuhan keperawatan.Kata Kunci: diabetes melitus tipe 2, kadar glukosa darah, Reiki, terapi komplementerAbstractReiki is one of the complementary therapies that are used to decrease blood glucose level. The therapy transfers naturalenergy into the patient’s body to synchronize the energy imbalance in the body. The research to examine the effect of Reiki andthe role of the stress and weight factor to decrease blood glucose level of DM type 2 patients was held in a hospital-baseddiabetic club in Jakarta. The design of this study was pre-experimental with the one-group pretest-posttest design. Eighteenpatients were selected with the purposive sampling technique. Reiki therapy was performed in 30 days using two methods:direct and distant healing method. The result revealed that there was a significant difference in random blood glucose levelbefore and after the Reiki intervention (p= 0.000; α= 0.05). It is recommended to incorporate the Reiki therapy in nursingcare.Keywords: type 2 Diabetes Mellitus, blood glucose level, Reiki, complementary therapy

scholarly journals PENGARUH EKSTRAK ETANOLIK BUAH PARIJOTO (Medinilla speciosa Blume) TERHADAP KADAR GULA DARAH DAN FUNGSI SEKSUAL TIKUS JANTAN GALUR WISTAR MODEL DIABETES MELLITUS KRONIK

2018 ◽  
Vol 15 (2) ◽  
pp. 1
Author(s):  
Rina Wijayanti ◽  
Asih Puji Lestari
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Sexual Function ◽  
Glucose Level ◽  
Ethanolic Extract ◽  
Negative Control ◽  
Male Rats ◽  
Control Group ◽  
Negative Group ◽  
One Way Anova

ABSTRACTChronic diabetes mellitus is a disease of increased blood glucose levels in a long time so that it can affect sexual function such as damage spermatogenesis and aphrodisiac function. Parijoto has flavonoid content. This study aimed to determine the effect of ethanolic extract of parijoto (Medinilla speciosa Blume) fruit in blood glucose level and the sexual function in alloxan-induced diabetic male rats. The design of the study was post test only control group design, 25 male wistar rats aged 2 months with BB 100-200 gram divided into 5 groups. Group 1 (normal control), group 2 (negative control) induced alloxan 100mg / kgBB, groups 3, 4, and 5 were alloxan induced and administered EEBP at doses of 100 mg / kgBW, 250 mg / kgBW, and 500 mg / kgBW. Alloxan-induced rats were left for 4 weeks to achieve chronic DM. Data analysis of blood glucose level and spermatozoa quality using one way anova followed by LSD post hoc. While aphrodisiac of introducing and climbing using one way anova continued by LSD and coitus using kruskal wallis. The results showed that there were significant differences between negative control with normal group, III, IV, and V. The effect of ethanolic extract of parijoto fruit on blood glucose level and sexual function in alloxan-induced diabetic male rats showed no difference between treatment group of 100 mg / kgBW with negative group, and there were significant differences between treatment group of 250 mg / kgBW and 500 mg / kgBW with negative group. Ethanolic extract of parijoto fruit at dose 250 mg / kgBB and 500 mg / kgBB decrease blood glucose level, improve and increase sexual function in alloxan-induced diabetic male rats.

Effects of Blood Glucose Changes and Physostigmine on Anesthetic Requirements of Halothane in Rats 

1997 ◽  
Vol 87 (2) ◽  
pp. 354-360 ◽  
Author(s):  
Yumiko Ishizawa ◽  
Shuichiro Ohta ◽  
Hiroyuki Shimonaka ◽  
Shuji Dohi
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Minimum Alveolar Concentration ◽  
Severe Hypoglycemia ◽  
Dependent Manner ◽  
Sprague Dawley ◽  
Control Value ◽  
Sprague Dawley Rats ◽  
Brain Acetylcholine

Background Although hyper- and hypoglycemia induce neurophysiologic changes, there have been no reports on the effects of blood glucose changes on anesthetic requirements. This study examined the effects of hyper- and hypoglycemia on the minimum alveolar concentration (MAC) of halothane in rats. In addition, based on a previous finding that the level of brain acetylcholine was reduced during mild hypoglycemia, the authors examined the influence of physostigmine on MAC during hypoglycemia. Methods In Sprague-Dawley rats, anesthesia was induced and maintained with halothane in oxygen and air. The MAC was determined by observing the response to tail clamping and tested during mild hypoglycemia (blood glucose level, 60 mg/dl) and hyperglycemia (blood glucose level, 300 and 500 mg/dl) induced by insulin and glucose infusion, respectively (experiment 1). The effects of 0.3 and 1.0 mg/kg physostigmine given intraperitoneally on MAC were examined in rats with mild and severe hypoglycemia (blood glucose level, 60 and 30 mg/dl; experiment 2). Results In experiment 1, mild hypoglycemia significantly reduced the MAC of halothane (0.76 +/- 0.03%) compared with the control value (0.92 +/- 0.04%), but hyperglycemia did not change MAC. In experiment 2, mild and severe hypoglycemia reduced MAC of halothane in a degree-dependent manner. Physostigmine (1 mg/kg) had no effect on MAC regardless of blood glucose level, but 0.3 mg/kg reduced MAC. Conclusions Hypoglycemia reduced anesthetic requirements in a degree-dependent manner, whereas hyperglycemia had no effects. Although the mechanism of hypoglycemic MAC reduction needs further investigations, physostigmine studies suggest that this may not be related to inhibition of cholinergic transmission.

scholarly journals Comparison between the QRMA Measurement with the Anamnesis and the Capillary Blood Glucose Test

Jurnal NERS ◽  
2020 ◽  
Vol 14 (2) ◽  
pp. 224
Author(s):  
Muflih Muflih ◽  
Suwarsi Suwarsi ◽  
Fajarina Lathu Asmarani
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Blood Sugar ◽  
Glucose Level ◽  
Blood Sugar Level ◽  
Capillary Blood ◽  
Capillary Blood Glucose ◽  
Blood Glucose Test ◽  
Significant Difference ◽  
Glucose Test

ABSTRACTIntroduction: The examination of patients with diabetes mellitus (DM) can be done by reviewing their complaints and through a capillary blood glucose level test to determine the value of their Random Blood Glucose Level. QRMA (Quantum Resonance Magnetic Analyzer) is claimed to be able to check the patient’s bodily condition (including blood glucose) with an accuracy of 85%. The purpose of this study was to verify the validity of the QRMA tool and its accuracy by comparing the results of the anamnesis and the examination conducted using the capillary blood glucose test method.Methods: The research method used was a cross-sectional design. The total sample consisted of 44 respondents in the working area of the Community Health Centers in Yogyakarta with the risk factor being blood sugar level instability. The sampling technique used was purposive sampling. The main variable in this study was the value of the blood sugar level measured based on the coefficient value of the QRMA tool and the value of Random Blood Glucose obtained through the capillary blood glucose test.Results: The blood glucose value was not correlated significantly with the coefficient value of QRMA. The value of blood glucose when examined alongside the result of the respondent's anamnesis showed there to be a significant difference. The value of the QRMA coefficient when examined against the results from the history of the respondents showed no significant difference. Linear regression showed that the variables of height, body weight, and IMT had a correlation with the QRMA coefficient value.Conclusion: The QRMA tool was not able to provide a picture of the actual condition of the blood glucose level of the respondents when compared with the results of the anamnesis and the blood glucose value from the capillary blood glucose test. Non-invasive health measurement devices such as QRMA are not used by nurses as a standard for determining the health status of DM patients.

Impact of muscle mass on blood glucose level

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Murtada Taha ◽  
Yaser A. AlNaam ◽  
Thekra Al Maqati ◽  
Lenah Almusallam ◽  
Gharam Altalib ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Muscle Mass ◽  
Glucose Level ◽  
Glucose Utilization ◽  
Treatment Modalities ◽  
Healthy Population ◽  
Inverse Association ◽  
Significant Difference ◽  
The Mean

Abstract Objectives At present, diabetes is one of the leading causes of mortality across the world. It was hypothesized that muscle mass could have a significant influence on blood glucose level and this corelation if established successfully could pave way for novel treatment modalities for type 2 diabetes mellitus (T2DM). In the present study, the association between muscle mass and blood glucose level was examined in a healthy population who was not having T2DM at baseline and was undergoing a regular course of exercise. Methods The clinical study was performed involving 53 healthy male populations between 10 and 60 years of age. The participants were sampled in accordance with the quantitative experimental study design, using nonprobability sampling techniques. The independent variable measured among the subjects included muscle mass and blood glucose level, using bioelectrical impedance and a simple glucometer respectively. Subgroup analysis amongst different substantial parameters including body mass index (BMI), myostatin inhibitor usage, and age factor that could affect the muscle mass and glucose level correlation were also studied simultaneously. Results The study findings demonstrated a negative correlation between muscle mass and glucose utilization levels. There was a significant difference in the mean muscle mass of the participants which was 36.2453, and the mean glucose utilization level which was 15.1493%. Pearson correlation between the muscle mass and percentage of glucose utilization of the participants indicated a significant difference (since p-value <0.05) between these two studied parameters. Conclusions The study finding suggests an inverse association of the skeletal muscle mass with blood glucose level which encourages the implication of muscle-building exercises as the preventive measure for T2DM.

UJI PERBANDINGAN EFEKTIVITAS ANTIDIABETES EKSTRAK POLISAKARIDA DAN SENYAWA POLIFENOL ALGA COKLAT (Sargassum sp.) PADA MENCIT YANG DIINDUKSI ALOKSAN

2018 ◽  
Vol 4 (1) ◽  
pp. 48
Author(s):  
Agung Giri Samudra ◽  
Fathur Sani K ◽  
Moniq Chintama
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Brown Algae ◽  
Positive Control ◽  
Negative Control ◽  
The Body ◽  
Group Iii ◽  
Percentage Decrease ◽  
Polyphenolic Extract

Diabetes is one of the most common diseases in the world. So there is an effort to prevent or treat the disease. As brown algae (Sargassum sp.) Contains polysaccharides that regulate sugar intake in the body, and polyphenols act as antioxidants that can stimulate insulin secretion in pancreatic β cells. This study aims to determine the effectiveness of Antidiabetes Polysaccharide Extract and Brown Algae Polifenol Compounds (Sargassum sp) On Alloxaninduced Mice. The test animals were grouped into 4 groups I (CMC 1%), Group II (Glibenclamide 0.52mg / 20grBB), Group III (5mg / 20grBB polyphenol extract), Group IV (5mg / 20grBB polysaccharide extract). Blood glucose was measured using Easy touch glucometer on days 0, 3, 7, 14, 21, and 28. Analyze data using one-way ANOVA, followed by LSD test. The percentage decrease in blood glucose level in positive control, polyphenol extract and polysaccharide were 42,86%, 58,12%, and 54,20%. Statistically, the polyphenolic extract and the brown algae polysaccharide lower the blood glucose level significantly compared with the negative control (p≤0,05). Decreased blood glucose in polyphenol extracts and polysaccharides showed statistically significant differences

scholarly journals EFFECT OF AEROBIC EXERCISES AND RESISTANCE TRAINING ON GLUCOSE LEVELS IN TYPE 2 DIABETIC SUBJECTS.

2017 ◽  
Vol 10 (7) ◽  
pp. 360
Author(s):  
Aishwarya Pramod Benkar ◽  
Smita Bhimrao Kanase
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Resistance Training ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Postprandial Blood Glucose ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Significant Difference

Objective: Diabetes mellitus is a leading cause of death and disability in the world and its prevalence is predicted to rise to 10% by 2030. Hence, this study is conducted with objectives to find out the effect of aerobic exercises and resisted exercises on blood glucose levels in type 2 diabetes mellitus (T2DM) subjects and to compare the effect of both exercises on blood glucose level.Method: The comparative study was conducted at Krishna Institute of Medical Sciences Deemed University, Physiotherapy department, Karad. 30 participants with age group between 30 and 65 years were taken. Subjects were selected as per inclusion and exclusion criteria. Group A (15) participants were given aerobic exercise on static bicycle, and Group B (15) participants were given resistance training using dumbbells and weight cuffs for 5 days/week for 4 weeks. Diet recommendations were given to every participant.Results: Statistical analysis was performed using paired and unpaired t-test. Analysis showed statistically extremely significant difference in fasting blood glucose level and postprandial blood glucose level in both the groups (p≤0.0001).Conclusion: Thus, this study concludes that both aerobic exercises and resistance training prove to be beneficial in controlling blood glucose levels in T2DM subjects.

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