scholarly journals Phytotherapy for seizure: An overview of the most important indigenous Iranian medicinal plants with anticonvulsant properties

2019 ◽  
Vol 6 (4) ◽  
pp. 367-372
Author(s):  
Behrooz Farzan ◽  
Somayeh Shahsavari ◽  
Saber Abbaszadeh ◽  
Hassan Teimouri
Keyword(s):  
Medicinal Plants ◽  
Scientific Information ◽  
Epileptic Seizures ◽  
Review Article ◽  
Anticonvulsant Effect ◽  
Protective Effects ◽  
Congenital Diseases ◽  
Search Terms ◽  
Heracleum Persicum ◽  
Lavandula Officinalis

The statistics show that more than fifty million people worldwide suffer from seizure and epilepsy, and most of them are resistant to antiepileptic drugs. The causes of seizure attacks are different, including various diseases of the nervous system, infections, tumors, brain trauma, congenital diseases, fever, toxicity and metabolic factors. Currently, drugs such as phenytoin, phenobarbital, carbamazepine, valproic acid and diazepam are used to treat epileptic seizures, which in turn lead to side effects. Studies have shown that the use of natural and herbal antiseptic agents has beneficial and protective effects. In this review article, the most important indigenous Iranian medicinal plants used to treat seizures are reported. Information to conduct this review article has been obtained using the search terms seizure, neurological lesion, phytotherapy, Iran, medicinal plants, extracts and essential oils to retrieve articles indexed in databases such as Scopus, Scientific Information Database, Magiran, Google Scholar and other Persian databases. The relevant articles were further reviewed for medicinal plants with anticonvulsant properties. Based on the results, medicinal plants such as Peganum harmala, Lavandula officinalis, Matricaria chamomilla, Tanacetum sonbolii, Launaea acanthodes, Ocimum basilicum, Salvia sahendica, Ruta graveolens, Elaeagnus angustifolia, Ziziphora tenuior, Heracleum persicum and Scrophularia striata are among the most important medicinal plants in Iran with anticonvulsant effect.

Campylobacter: A Review of New Promising Remedies with Medicinal Plants and Natural Antioxidants

2020 ◽  
Vol 20 (15) ◽  
pp. 1462-1474
Author(s):  
Iraj Salimikia ◽  
Mahmoud Bahmani ◽  
Saber Abbaszadeh ◽  
Mahmoud Rafieian-Kopaei ◽  
Mohammad Reza Nazer
Keyword(s):  
Medicinal Plants ◽  
Web Of Science ◽  
Scientific Information ◽  
Natural Antioxidants ◽  
Review Article ◽  
Antibacterial Resistance ◽  
Search Terms ◽  
Oil Extract ◽  
Zoonotic Bacteria ◽  
Antibiotic Agents

Campylobacter (curved bacteria) is considered one of the most important and common zoonotic bacteria and the three leading bacterial causes of gastroenteritis and diarrhea. Antibacterial resistance is growing and expanding. The aim of this review article is to report anti-Campylobacter medicinal plants. For this purpose, the search terms consisting of Campylobacter, medicinal plants, essential oil, extract, and traditional medicine were used to retrieve the relevant articles published in the journals indexed in Information Sciences Institute, Web of Science, PubMed, Scopus, Google Scholar, and Scientific Information Databases. Then, the findings of eligible articles were analyzed. According to the analysis, 71 medicinal plants were found to exert anti-Campylobacter effect. The active compounds of these plants are possibly nature-based antibiotic agents that are effective on Campylobacter. If these compounds are isolated, purified, and studied in pharmaceutical investigations, they can be used to produce nature-based, anti-Campylobacter antibiotics.

Neuroprotective Effects of Medicinal Plants in Cerebral Hypoxia and Anoxia: A Systematic Review

2020 ◽  
Vol 10 (5) ◽  
pp. 550-565
Author(s):  
Nasibeh Amirzargar ◽  
Saeid Heidari-Soureshjani ◽  
Qian Yang ◽  
Saber Abbaszadeh ◽  
Mojtaba Khaksarian
Keyword(s):  
Medicinal Plants ◽  
Protein Tyrosine Kinase ◽  
Scientific Information ◽  
Hypoxia Inducible Factor ◽  
Cerebral Hypoxia ◽  
Protective Effects ◽  
Neuroprotective Effects ◽  
Necrosis Factor Alpha ◽  
Expression Of Genes ◽  
Inhibit Lipid Peroxidation

Background: Hypoxia and anoxia are dangerous and sometimes irreversible complications in the central nervous system (CNS), which in some cases lead to death. Objective: The aim of this review was to investigate the neuroprotective effects of medicinal plants in cerebral hypoxia and anoxia. Methods: The word hypox*, in combination with some herbal terms such as medicinal plant, phyto* and herb*, was used to search for relevant publications indexed in the Institute for Scientific Information (ISI) and PubMed from 2000-2019. Results: Certain medicinal plants and herbal derivatives can exert their protective effects in several ways. The most important mechanisms are the inhibition of inducible nitric oxide synthase (iNOS), production of NO, inhibition of both hypoxia-inducible factor 1α and tumor necrosis factor-alpha activation, and reduction of extracellular glutamate, N-Methyl-D-aspartic and intracellular Ca (2+). In addition, they have an antioxidant activity and can adjust the expression of genes related to oxidant generation or antioxidant capacity. These plants can also inhibit lipid peroxidation, up-regulate superoxide dismutase activity and inhibit the content of malondialdehyde and lactate dehydrogenase. Moreover, they also have protective effects against cytotoxicity through down-regulation of the proteins that causes apoptosis, anti-excitatory activity, inhibition of apoptosis signaling pathway, reduction of pro-apoptotic proteins, and endoplasmic reticulum stress that causes apoptosis during hypoxia, increasing anti-apoptotic protein, inhibition of protein tyrosine kinase activation, decreasing proteases activity and DNA fragmentation, and upregulation of mitochondrial cytochrome oxidase. Conclusion: The results indicated that medicinal plants and their compounds mainly exert their neuroprotective effects in hypoxia via regulating proteins that are related to antioxidant, anti-apoptosis and anti-inflammatory activities.

scholarly journals Ethnobotanical treatments for earache and sore throat

2019 ◽  
Vol 10 (2) ◽  
pp. 1354-1360
Author(s):  
Behrooz Farzan ◽  
Saber Abbaszadeh ◽  
Hassan Teimouri
Keyword(s):  
Medicinal Plants ◽  
Traditional Medicine ◽  
Sore Throat ◽  
Scientific Information ◽  
Review Article ◽  
The Body ◽  
Mentha Pulegium ◽  
Throat Pain ◽  
Iranian Traditional Medicine ◽  
Information Database

Different organs of the body may develop complications for various reasons and cause pain. The pain may also occur in the ear and throat, and cause discomfort in the patient. In traditional medicine, medicinal plants are used to treat these complications. Therefore, in this review, the medicinal plants used for the treatment of ear pain and sore throat in the Iranian ethnobotanical studies will be reported. The information obtained in this review article was obtained by searching for relevant materials using keywords such as ear pain, sore throat, pain, ethnobotany, phytotherapy, medicinal plants and Iran in articles indexed in databases such as Megiran, Scientific Information Database, PubMed, ScienceDirect, and ISI. Artemisia, pumpkin, Quarcus brantii, sheng, barangan, Solanum nigru, Mentha pulegium, hashshir, sage, eucalyptus, currant, bullfish, cannabis and cumin are among the most important medicinal plants used to treat sore throat and ear pain in Iranian traditional medicine.

Ethnopharmacological Survey of Medicinal Plants Used in the Traditional Treatment of Female Infertility in Fez Region, Morocco

2019 ◽  
Vol 18 (5) ◽  
pp. 321-339 ◽  
Author(s):  
M. Slighoua ◽  
I. Mahdi ◽  
F. Ez-zahra Amrati ◽  
S. Boukhira ◽  
A. EL Hamsas EL Youbi ◽  
...  
Keyword(s):  
Reproductive Health ◽  
Medicinal Plants ◽  
Plant Species ◽  
Rosmarinus Officinalis ◽  
Female Infertility ◽  
Mentha Pulegium ◽  
Traditional Treatment ◽  
Lavandula Officinalis

An ethnopharmacological survey was carried out among 224 informants to collect the information on medicinal plants used for the traditional treatment of female infertility in the Fes, Meknes and Boulemane region. In total, 63 plant species belonging to 29 families were used against female infertility. The most frequently cited plants were Lavandula officinalis (26.33%), Mentha pulegium (13.83%), Mentha suaveolens (11.16%), Rosmarinus officinalis (10.71%) and Petroselinum sativum (8.03%). Furthermore, the present study represents a useful documentation for the preservation of this knowledge about medicinal plants and for the amelioration of women reproductive health.

Quercetin: A Potential Candidate For The Treatment Of Arthritis

2021 ◽  
Vol 21 ◽  
Author(s):  
Ahsas Goyal ◽  
Neetu Agrawal
Keyword(s):  
Rheumatoid Arthritis ◽  
Medicinal Plants ◽  
Therapeutic Potential ◽  
Gouty Arthritis ◽  
Potential Candidate ◽  
Protective Effects ◽  
Preclinical Models ◽  
Healthy Life ◽  
Health Promoting ◽  
Dietary Component

: Diet plays a significant role in ensuring healthy life and the bioactive compounds present in food and medicinal plants may be developed as drugs that combat various illnesses. A bioactive flavanoid, quercetin which is a dietary component possesses numerous health-promoting effects. In preclinical models of rheumatoid arthritis, gouty arthritis and osteoarthritis, quercetin has shown significant joint protective effects. Taking into account the significance of this compound, the present review discusses its anti-arthritic properties, demonstrating its mechanism of action for the treatment of arthritis with its therapeutic potential.

scholarly journals Positive Allosteric Modulator of mGluR4 PHCCC Exhibits Proconvulsant Action in Three Models of Epileptic Seizures in Immature Rats

2012 ◽  
pp. 619-628 ◽  
Author(s):  
E. SZCZUROWSKA ◽  
P. MAREŠ
Keyword(s):  
Metabotropic Glutamate Receptors ◽  
Rhythmic Activity ◽  
Epileptic Seizures ◽  
Allosteric Modulator ◽  
Anticonvulsant Effect ◽  
Positive Allosteric Modulator ◽  
Adult Rats ◽  
Absence Seizures ◽  
Implanted Electrodes ◽  
Immature Rats

The activation of metabotropic glutamate receptors subtype 4 (mGluR4) potentiates models of absence seizures in adult rats. These seizures are age-dependent, but data concerning the role of mGluR4 in immature brain is insufficient. N-phenyl-7-(hydroxyimino)cyclopropa[b]chromen-1acarboxamide (PHCCC), which is a positive allosteric modulator of these receptors, was used in three different models of seizures in immature rats: 1) convulsions induced by high doses of pentetrazol (PTZ; a model of generalised tonic-clonic seizures); 2) rhythmic electro-encephalographic (EEG) activity induced by low doses of PTZ (a model of absence seizures); and 3) electrically elicited cortical afterdischarges (ADs, a model of myoclonic seizures). We administered four doses of PHCCC (1, 3, 10 and 20 mg/kg) in PTZ-induced convulsions and two doses (3 and 10 mg/kg) in the two electrophysiological models of freely moving rats with implanted electrodes. Every dose and age group consisted from 8 to 10 rats. PTZ-elicited convulsions were not significantly influenced by PHCCC. In contrast, PHCCC potentiated the effect of a subconvulsant dose (60 mg/kg) of PTZ. The 10-mg/kg dose of PHCCC significantly prolonged the duration of PTZ-induced rhythmic activity episodes and shortened the intervals between individual episodes in 25-day-old rats (P25). In contrast, this potentiation was not seen in P18 rats. Cortical ADs were significantly prolonged with repeated stimulations by both doses of PHCCC in P12 and P18 animals. P25 rats exhibited only slightly longer AD durations. In conclusion, we did not find any anticonvulsant effect of PHCCC. On the contrary, proconvulsant action was demonstrated in all three models in immature rats.

scholarly journals Medicinal Plants with Anti-Trichomonas vaginalis Activity in Iran: A Systematic Review

2019 ◽  
Author(s):  
Hajar ZIAEI HEZARJARIBI ◽  
Najmeh NADEALI ◽  
Mahdi FAKHAR ◽  
Masoud SOOSARAEI
Keyword(s):  
Systematic Review ◽  
Medicinal Plants ◽  
Trichomonas Vaginalis ◽  
Scientific Information ◽  
Medicinal Herbs ◽  
In Vivo Studies ◽  
Eligibility Criteria ◽  
Sexually Transmitted

Background: Trichomoniasis, due to Trichomonas vaginalis, is one of the most common sexually transmitted parasitic diseases in the world such as Iran. This systematic review aimed to explore the studies evaluating the medicinal herbs with anti- T. vaginalis activity which used in Iran. Methods: Articles published in 4 Persian and 4 English databases were obtained between 2000 and 2015 including Google Scholar, PubMed, Science Direct, Scopus, Magiran, Barakatkns (formerly IranMedex), Elm net, and SID (Scientific Information Database). Studies out of Iran, studies on animal models and articles on other parasite species than T. vaginalis were excluded from this review. Results: Twenty-one articles including in vitro experiments, met our eligibility criteria. Thoroughly, 26 types of plants were examined against T. vaginalis. Medicinal herbs such as Artemisia, Zataria multiflora, and Lavandula angustifolia are remarkably effective on T. vaginalis. As such, use of other parts of these plants in different concentrations and timelines is recommended for future in vivo studies. Conclusion: The present systematic review provides comprehensive and useful information about Iranian medicinal plants with anti-T. vaginalis activity, which would be examined in the future experimental and clinical trials and herbal combination therapy.

scholarly journals Protective Effects of Vitamin D –A Review Article

2018 ◽  
Vol 10 (4) ◽  
pp. 388-391
Author(s):  
Athira Sreelatha ◽  
Nidhin Varghese Sam ◽  
Roshni Pushpa Raghavan
Keyword(s):  
Vitamin D ◽  
Review Article ◽  
Protective Effects

scholarly journals Calotropis procera (Arka): A Tribal Herb of Utmost Significance

2021 ◽  
Vol 8 (3) ◽  
Author(s):  
Isha Kumari ◽  
Gitika Chaudhary
Keyword(s):  
Medicinal Plants ◽  
Review Article ◽  
Calotropis Procera ◽  
Pharmacological Properties ◽  
The Family ◽  
Anti Oxidant ◽  
Phytochemical Constituents ◽  
The Rich ◽  
The Tropics ◽  
Important Medicinal Plant

Nature has gifted humans a vast variety of medicinal plants, which are the rich source of bioactive compounds. Calotropis procera is an important medicinal plant that belongs to the family asclepiadaceae. It is commonly known as madar and milkweed plant in english and arka in hindi. It is mostly found in the tropics of asia and africa. Calotropis procera is a highly valued plant in the folk medication system. Each part of the plant is richly endowed with diverse nature of phytochemical constituents like alkaloids, proteins, vitamins, carbohydrates, saponins, terpenes, and flavonoids, etc. These phytochemicals are significantly associated with various therapeutic and pharmacological properties such as anti-microbial, anti-oxidant, anti-inflammatory, anti-ulcer, antifertility, anti-diarrheal, and spasmolytic. In this review article, the therapeutic and pharmacological value of this important plant has been summarized along with its utilization in the folklore and ayurvedic medicinal system.

scholarly journals Overview and Insights into Carbapenem Allergy

Pharmacy ◽  
2019 ◽  
Vol 7 (3) ◽  
pp. 110 ◽  
Author(s):  
Yuman Lee ◽  
Nicole Bradley
Keyword(s):  
Case Reports ◽  
Review Article ◽  
Limited Data ◽  
Substantial Impact ◽  
Cross Sensitivity ◽  
Search Terms ◽  
Incidence Risk ◽  
Pubmed Search ◽  
The Individual ◽  
Insight Into

Understanding antibiotic allergies and the risk of cross-sensitivity between and within antibiotic classes can have a substantial impact on patient care. The purpose of this review article is to provide insight into carbapenem allergies, describing the overall incidence, risk factors, and in-class cross-sensitivity. A PubMed search was conducted using the following search terms: carbapenem, allergy, cross-sensitivity, incidence, imipenem/cilastatin, meropenem, ertapenem, and doripenem. Article bibliographies and relevant drug monographs were also reviewed. The overall reported incidence of carbapenem allergy is 0.3%–3.7%. Risk of cross-sensitivity between penicillins and carbapenems is less than 1% in patients with a positive penicillin skin test. Data on cross-sensitivity between cephalosporins and carbapenems are limited; however, the risk appears to also be low. No clinical studies have described cross-sensitivity between the carbapenem agents thus far. The limited data available from case reports demonstrates a lack of cross-sensitivity between the individual carbapenems, suggesting that an alternative carbapenem may cautiously be used in patients with a reported carbapenem allergy.

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