Modifying effects of TNF-α, IL-6 and VDR genes on the development risk and the course of COVID-19. Pilot study

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Liliia Fishchuk ◽  
Zoia Rossokha ◽  
Valeriy Pokhylko ◽  
Yuliia Cherniavska ◽  
Svitlana Tsvirenko ◽  
...  
Keyword(s):  
Genetic Factors ◽  
Study Group ◽  
Intensive Care Patients ◽  
Tnf Α ◽  
Pcr Rflp ◽  
The World ◽  
Laboratory Examinations ◽  
Development Risk

Abstract Objectives COVID-19 continues to range around the world and set morbidity and mortality antirecords. Determining the role of genetic factors in the development of COVID-19 may contribute to the understanding of the pathogenetic mechanisms that lead to the development of complications and fatalities in this disease. The aim of our study was to analyze the effect of TNF-α (rs1800629), IL-6 (rs1800795) and VDR (rs731236 and rs1544410) genes variants on the development risk and the course of COVID-19 in intensive care patients. Methods The study group included 31 patients with diagnosis “viral COVID-19 pneumonia”. All patients underwent standard daily repeated clinical, instrumental and laboratory examinations. Determination of IL-6, TNF-α, and VDR genes variants was performed using the PCR-RFLP method. Results It was found a significant increase in the rate of the CC genotype and C allele (38.7 vs. 12.0% and 0.6 vs. 0.4%, respectively) of the IL-6 gene in all patients of the study in comparison with population frequencies. There was a significantly higher rate of heterozygous genotypes TC and GA of the VDR gene in group of died patients. The rs1800629 variant of the TNF-α gene is associated with the need for respiratory support and its longer duration in patients with COVID-19. Conclusions The obtained results support a hypothesis about the influence of variants of IL-6, TNF-α and VDR genes on severity of COVID-19. However, in order to draw definite conclusions, further multifaceted research in this area are need.

scholarly journals SPECIAL ASPECTS OF MISCARRIAGE IN WOMEN WITH RECCURENT MISCARRIAGE

2018 ◽  
Vol 25 (1) ◽  
Author(s):  
Olga Muntyan ◽  
Olga Bulavenko
Keyword(s):  
Early Diagnosis ◽  
Genetic Factors ◽  
Recurrent Miscarriage ◽  
Etiologic Factor ◽  
Histopathological Study ◽  
Endocrine Disorders ◽  
Study Group ◽  
Sequential Action ◽  
Female Genital

Missing pregnancy is a consequence of the simultaneous or sequential action of several factors. The main causes of miscarriage and spontaneous interruption of pregnancy include: genetic factors, endocrine disorders, immune and infectious factors, congenital and acquired diseases of female genital organs. In almost 50% of women, it is not impossible to determine the reason of miscarriage, so the question of early diagnosis and prevention of this condition is quite acute.Materials and methods. In this study, we performed a pathohistological study of the deciduum in order to determine the etiological factor of the pathology of implantation of the embryo and placentation. The study included 88 women with a diagnosis of "recurrent miscarriage" that met the criteria for inclusion and exclusion.Results of research. In the study group, the age of women was from 19 to 35 years old (mean age was 27.6±4.1 years old). The abortion was observed at differentst ages of pregnancy, more often during the period of 4-9 weeks of gestation (67 cases – 76.14%). According to the results of the histopathological study of decidouum lymphohistiocytic infiltration was revealed in the stroma of villi in 62 cases (70.45%), other changes were less common.Conclusions and perspectives of further research. The obtained data indicate that the determination of the etiologic factor of miscarriage of the pregnancy, especially in women with a diagnosis "Reccurent miscarriage of obscure etiology", will allow to predict the development of the pathology of implantation and placentation in subsequent pregnancies.Prospects for further research are to develop adequate preparation before pregnancy and prevention of the pathology of implantation and placentation.

scholarly journals Host genetic factors associated with hepatitis B virus infection and progression to chronic disease: A systematic review and Meta analysis

2019 ◽  
Author(s):  
Hussein Mukasa Kafeero ◽  
Dorothy Ndagire Ndagire ◽  
Hasifah Nanyingi Nanyingi ◽  
Hakim Sendagire Sendagire
Keyword(s):  
Hepatitis B ◽  
Odds Ratio ◽  
Genetic Factors ◽  
Random Effects Model ◽  
Hepatitis B Virus Infection ◽  
Hepatitis B Infection ◽  
Tnf Α ◽  
B Virus ◽  
Reduced Risk

Abstract Abstract Back ground Contradicting results from many laboratories on the role of genetic factors in the susceptibility/resistance to hepatitis B infection have been reported. In this review we examined 27 published full research articles and assessed the role of Th1/Th2 cytokine promoter and vitamin D receptor gene polymorphisms. We summarized the available data on the relationship between the gene polymorphisms and susceptibility/resistance to hepatitis B virus infection together with likely disease evolution to come up with candidate single nucleotide polymorphisms implicated in the disease state with the population. Method The study was done in tandem with the PRISMA standards and the Cochran’s Q test, I2 statistics for heterogeneity and the Odds ratio were calculated using a commercially available soft ware called MedCalcs (http://www.medcalc.org). A random effects model was used to pool the odds ratio for heterogeneities ≥50% or else a fixed effects model was used. All analyses were done at 95% Confidence Interval and a P<0.05 was considered statistically significant. Results We found that IL-10-592C/A genotype AA (P=0.017, OR=0.752, 95%CI=0.595 to 0.950) and TNF-α-238G/A genotype AA+ AG (P<0.001, OR=0.407, 95%CI=0.005 to 30.1) were significantly associated with reduced risk of hepatitis B infection by the random effects model. TNF-α-238G/A genotype GG had the risk of chronic infection (OR=3.587, 95% CI= 0.127 to 101.176) under the random effect model. Most of the other SNPs had borderline risk of HBV infection (OR 0.6 to 1.12) with a few cases of high risk, IL-10-1082A/G genotype AA (OR=1.608, 95%CI=0.861 to 3.003) and reduced risk, IL-10-1082A/G genotype AG (OR=0.485, 95% CI=0.232 to 1.014) Conclusion We found that IL-10-592C/A genotype AA and TNF-α-238G/A genotype AA+ AG were significantly associated with reduced risk of hepatitis B infection.

Familial trichotillomania: role of genetic factors in the determination of subtypes

2013 ◽  
Vol 25 (3) ◽  
pp. 187-190
Author(s):  
Ghaffari Nejad Alireza ◽  
Fariborz Estilaee ◽  
Mohammad M. Sadeghi
Keyword(s):  
Psychiatric Disorders ◽  
Serotonin Receptors ◽  
Genetic Factors ◽  
Genetic Disorder ◽  
Family Members ◽  
Hair Pulling ◽  
Psychiatric Syndrome ◽  
The Family

ObjectivesTrichotillomania (TTM) is a psychiatric syndrome characterised by the inability to control repetitive hair pulling. Psychiatric data reveal that TTM is not usually prevalent among all family members of patients, and so far only one case of familial TTM has been reported.MethodsIn this study, we report a case of familial TTM that afflicted four sisters and discuss the importance of genetic factors in this disorder.ResultsThis report suggests that, similar to many other psychiatric disorders, TTM can be detected in other family members and that genetic factors not only have a significant role in the development of such disorders but also in determination of the disorder subtype. This report also shows that the comorbidities in one member of the family might predict the existence of comorbidities in other members. On the basis of response to medication.Conclusionthe authors suggest that a genetic disorder like polymorphism in serotonin receptors or dopamine can cause such a disorder.

scholarly journals Prophetic Sira and the Construction of Indonesian Islam

2021 ◽  
Vol 4 (1) ◽  
pp. 88-105
Author(s):  
Muhammad Abdul Karim
Keyword(s):  
The Other ◽  
Cultural Complexity ◽  
Modes Of Transmission ◽  
Indonesian Archipelago ◽  
The World ◽  
The Face

Indonesian Islam has gone through a long journey in its history since the first advent up to the present day. In this course, one should note that the process of Islamization was formed under a set of historical and cultural complexity. Among those, the role of Islamic preaching is the most important. Under this canopy, the process of transmission and transformation took the first place as the main force. As the Qur’an and Sunna are the major sources for all Muslims around the world. Both had also become the main streams in Islamicization. Seerat-e-nabi, beside the Qur’an, in this case has a place of honor. It became one of the major sources of all Islamic heritages in Indonesia. The prophet Muhammad PBUH (peace be upon him) was immersed within the Indonesian Islamic traditions in various fields and spheres. It is fair to say that the story of the islamicization of the Indonesian archipelago and the face of Indonesian Islam today is culturally formed by the determination of seerat-e-nabi, besides the Qur’anic scripture. In the other words, the birth and the face of Islam really depend on how its adherents interpret and take a cultural reception on the seerat-e-nabi. This paper tries to capture the prophetic heritage in Indonesian Islam in twofold analysis; transmission and transformation. The former tries to explore how the heritage of seerat-e-nabi flowed into the scene of Indonesian moslem life through various modes of transmission up to the present day. The latter aims at how the seerat-e-nabi became the force and inspiration for the various receptions of institutional matters.    

scholarly journals TEACHER'S READINESS FOR FORMATION OF CIVIL IDENTITY OF SCHOOL STUDENTS AND PATRIOTIC EDUCATION

2018 ◽  
Vol 2 ◽  
pp. 5
Author(s):  
Tatyana Bugachuk ◽  
Olga Koryakovtseva
Keyword(s):  
Social Order ◽  
Civic Identity ◽  
Educational Organizations ◽  
School Students ◽  
World Community ◽  
The World ◽  
Patriotic Education ◽  
Role Of Teachers

The article deals with the actual question of the role of teachers in the patriotic education and the formation of students' civic identity. The authors of the article presented the results of a study on the determination of teachers' readiness for the formation of civic identity and patriotic education of schoolchildren, which was carried out using the author’s questionnaire and as a result of which the authors came to a contradiction about the need to educate patriots at a higher, qualitatively new level in accordance with social order and lack the readiness of teachers of general educational organizations to patriotic education in new conditions. Emphasis is placed on the organization of systematic work on the training of teachers of general educational organizations for patriotic education and the formation of the civic identity of schoolchildren in the new conditions for the development of the world community.

scholarly journals Functional Role of Dietary Intervention to Improve the Outcome of COVID-19: A Hypothesis of Work

2020 ◽  
Vol 21 (9) ◽  
pp. 3104 ◽  
Author(s):  
Giovanni Messina ◽  
Rita Polito ◽  
Vincenzo Monda ◽  
Luigi Cipolloni ◽  
Nunzio Di Nunno ◽  
...  
Keyword(s):  
Dietary Intervention ◽  
Unknown Origin ◽  
World Health ◽  
Dietary Regimen ◽  
Tnf Α ◽  
The World ◽  
Regimen Modification ◽  
Health Organization ◽  
Pro Inflammatory Cytokines

Background: On the 31 December 2019, the World Health Organization (WHO) was informed of a cluster of cases of pneumonia of unknown origin detected in Wuhan City, Hubei Province, China. The infection spread first in China and then in the rest of the world, and on the 11th of March, the WHO declared that COVID-19 was a pandemic. Taking into consideration the mortality rate of COVID-19, about 5–7%, and the percentage of positive patients admitted to intensive care units being 9–11%, it should be mandatory to consider and take all necessary measures to contain the COVID-19 infection. Moreover, given the recent evidence in different hospitals suggesting IL-6 and TNF-α inhibitor drugs as a possible therapy for COVID-19, we aimed to highlight that a dietary intervention could be useful to prevent the infection and/or to ameliorate the outcomes during therapy. Considering that the COVID-19 infection can generate a mild or highly acute respiratory syndrome with a consequent release of pro-inflammatory cytokines, including IL-6 and TNF-α, a dietary regimen modification in order to improve the levels of adiponectin could be very useful both to prevent the infection and to take care of patients, improving their outcomes.

Role of Plasma miRNA-501 Expression Profile as a Marker of Hepatocellular Carcinoma (HCC) Progression With Hepatitis C Virus Infection

2019 ◽  
Vol 152 (Supplement_1) ◽  
pp. S134-S134
Author(s):  
Mohamed Shedid ◽  
Mohamed Abdelmonem ◽  
Ayman Boraik ◽  
Alaa Elmetwalli ◽  
Ahmed Esmael
Keyword(s):  
Rna Extraction ◽  
Control Group ◽  
Hepatitis C Virus Infection ◽  
Rt Pcr ◽  
The World ◽  
Noninvasive Biomarker ◽  
Biological Aspects ◽  
Plasma Mirna

Abstract Introduction HCV is a health problem that confronts many countries in the world. Those patients will develop complications like cirrhosis and HCC, which is one of the most common cancers in the world, especially in Egypt, and considered the third leading cause of death worldwide. The prognosis of HCC is still dismal due to the late diagnosis. miRNAs are small, short noncoding RNAs, which have roles in the diagnosis of HCC. In our study, we focus on biological aspects of miRNAs. We report that miR-501 is strongly expressed and observed in the process of HCC development. miR-501 regulation is important as an oncofetal relevant to the diagnosis of HCC. Method This study was conducted on 100 adult patients; 25 patients were positive for anti-HCV and 25 patients were negative for HCV and enrolled as a control group. Patients were categorized into three groups: fibrosis (n = 25), CHC (n = 25), and HCC (n = 25) related to HCV evident by CT abdomen. All patients and controls were subjected to full clinical assessment and laboratory investigation. Blood (8 mL) was withdrawn from subjects, and 3 mL was collected in EDTA tubes for processing total RNA extraction and miRNA. The remaining 5 mL was left for determination of biochemical parameters. miRN-501 expression levels were determined by RT-PCR. Results The data revealed a significant increase in levels of AST, ALT, ALP, and CBC in both HCC and CHC groups compared to controls. The results of miRNA expression showed that miR-501 was higher in the HCC group than non-HCC group at P1.1. Conclusion miR-501 can be used as a noninvasive biomarker for early diagnosis of HCC among patients with HCV on account of its affectability for HCC.

The role of the main ingredients of chocolate in the formation of its beneficial properties for the consumer

2021 ◽  
pp. 582-587
Author(s):  
I.V. Goloviznin ◽  
A.V. Ryzhakova
Keyword(s):  
Human Health ◽  
Complete Information ◽  
The Body ◽  
Specific Product ◽  
Regular Process ◽  
The World ◽  
The Impact ◽  
Confectionery Product

Chocolate is the most staple and consumed confectionery product in Russia and the world. The determination of the beneficial properties of such a product as chocolate is an important and regular process of food institutions in every country, since new lines of already well-known manufacturers and new manufacturers with an innovative assortment are added to the retail assortment. Today, it is very relevant and important to understand the impact of new products on human health. In this regard, in order to provide complete information on a specific product, it is necessary to know its composition, ingredients and their effect on the body separately and within the framework of a specific product. Along with its beneficial properties, chocolate can also affect health negatively. It is necessary to understand the mechanism of the effect of chocolate on human health when consumed and to assess the risks that may arise subsequently after its active consumption.

scholarly journals Les Allemagnes et la division Est-Ouest : Une ambivalence politique

2005 ◽  
Vol 16 (3) ◽  
pp. 547-559
Author(s):  
Paul Létourneau
Keyword(s):  
International Organizations ◽  
Special Functions ◽  
States Of Affairs ◽  
Concrete Case ◽  
Long Run ◽  
Official Policy ◽  
The World ◽  
Definition Of

This article is about the role of international bureaucracies in the determination of the general policies of international organizations. In this paper it is argued that in general international organizations' Secretariats generally do wield, considerable power over the definition of the institutions' strategies, i.e. those activities, priorities and projects which taken together make up the program of the institution for a given period. Indeed, the international bureaucrats exercise tremendous control over the content of the program. This is so because international organizations have special functions in the world System. They must see to it that, certain states of affairs prevail in the world over the long run. It is, therefore, no surprise that the programs' content be more or less shielded from conjonctural fluctuations. The article then proceeds to test these hypotheses on a concrete case: the analysis of the processus through which Unesco's program goes before becoming the official policy of the organization.

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