Potential prognostic value of miRNAs as biomarker for progression and recurrence after nephrectomy in renal cell carcinoma: a literature review

Diagnosis ◽  
2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Daniela Fasanella ◽  
Alessio Antonaci ◽  
Francesco Esperto ◽  
Roberto M. Scarpa ◽  
Matteo Ferro ◽  
...  
Keyword(s):  
Literature Review ◽  
Prognostic Markers ◽  
Methylation Status ◽  
Area Under The Curve ◽  
Strong Relationship ◽  
Routine Clinical Practice ◽  
Free Survival ◽  
Hazard Ratios ◽  
To Come ◽  
The Relationship

Abstract Objectives We provide a systematic literature review on tissue miRNAs in patients with RCC to evaluate and summarize their usefulness as prognostic markers. We undertook a systematic search for articles in English using the PubMed-Medline database from January 2010 to December 2020. Studies were identified and selected according to the PRISMA criteria and the PICO methodology. The population consisted of RCC patients undergoing nephrectomy and the main outcome of interest was recurrence-free survival (RFS). Only studies providing hazard ratios (HRs) from multivariate or univariate analyzes with corresponding 95% confidence intervals (CI) and/or area under the curve (AUC) were considered. Content All nine included studies (1,541 patients) analyzed the relationship between tissue miRNA expression levels (up or downregulated) and RFS. Some of these found that the methylation status of miR-9-1, miR-9-3 and miR-124 was associated with a high risk of relapse. Moreover, miR-200b overexpression was associated with OS. MiR-210 overexpression indicated a shorter OS than those who were miR-210 negative. Finally, patients with high miR-125b expression had shorter CSS than those with low expression; similarly, patients with low miR-126 expression also had shorter CSS time. Summary and Outlook Several studies tested the usefulness of specific miRNAs to predict RCC recurrence. Some of them showed a fair accuracy and strong relationship between specific miRNA over or under-expression and survival outcomes. However, results from these studies are preliminary and miRNAs use in routine clinical practice is still far to come.

Sequential monitoring of PD-L1 on circulating stromal cells in blood predicts PFS in NSCLC patients undergoing immunotherapy after definitive chemoradiation.

2021 ◽  
Vol 39 (15_suppl) ◽  
pp. 8534-8534
Author(s):  
Daniel L Adams ◽  
Alexander Augustyn ◽  
Jianzhong He ◽  
Yawei Qiao ◽  
Ting Xu ◽  
...  
Keyword(s):  
Stromal Cells ◽  
Progression Free Survival ◽  
Free Survival ◽  
Hazard Ratios ◽  
Fda Approval ◽  
Inflammatory State ◽  
Nsclc Patients ◽  
Tumor Biopsies ◽  
Relationship Of ◽  
The Relationship

8534 Background: Cancer Associated Macrophage-Like cells (CAMLs) are circulating stromal cells in the blood of patients (pts) with solid tumors that are phagocytic macrophages that may represent the inflammatory state of the tumor microenvironment. Previously, we demonstrated CAMLs ≥50µm after chemo-radiation therapy (CRT) in NSCLC is associated with worse progression free survival (PFS) and overall survival (OS). We also showed that PDL1 expression in CAMLs is dynamic & can change with CRT, difficult to assess with repeat biopsies, but possible with liquid biopsy. For this study we evaluated whether CAML properties can predict response to CRT with/without immunotherapy (IMT) agents in unresectable NSCLC. Methods: A single blind multi-year prospective study was undertaken to test the relationship of PDL1 expression and ≥50µm CAML size to PFS/OS in NSCLC, pre and post CRT with (n = 96) and without (n = 72) anti-PDL1/PD1 IMT. This included atezolizumab (prospective single arm NCT02525757) n = 39, durvalumab n = 52 or pembrolizumab n = 5 both after 2018 FDA approval. We recruited 168 pts with pathologically confirmed unresectable NSCLC prior to CRT. Blood samples 15 mL were taken at baseline (BL), CRT completion (T1), and ̃1 month after CRT (T2) (with n = 96 or without n = 72 IMT). Blood was filtered by CellSieve filtration and CAMLs quantified for size ( < 49 µm or ≥50 µm) and PDL1 expression to evaluate PFS and OS hazard ratios (HRs) by censored univariate and multivariate analysis at 24 months. Results: CAMLs were found in 90% of all samples, average 5.8 CAMLs/15mL. At BL, ≥50µm CAMLs did not predict PFS in CRT/IMT pts (HR 1.6, p = 0.220) nor CRT alone (HR 1.3, p = 0.593). However, after completion of CRT (T1) ≥50µm CAMLs predicted PFS in CRT/IMT pts (HR 2.7, p = 0.003) and CRT alone (HR 2.5, p = 0.015). In primary tumor biopsies, PDL1 expression > 1% did not predict CRT/IMT response (PFS HR 1.8, p = 0.262 & OS HR 2.3, p = 0.158). At BL, high CAML PDL1 did not predict PFS in CRT/IMT pts (HR 1.4, p = 0.427) nor CRT alone (HR 1.1, p = 0.982). Further, at CRT completion (T1), high CAML PDL1 only trended for better PFS in CRT/IMT pts (HR 1.7, p = 0.137), but not CRT alone (HR 1.1, p = 0.972). At T2, however, pts with continuously high CAML PDL1 had significantly better PFS with IMT (HR 3.2, p = 0.002) vs CRT alone (HR 1.4, p = 0.616). While ≥50µm CAMLs at BL did not predict 24 month progression, ≥50 µm CAMLs after CRT (with or without 1 cycle of anti-PDL1 IMT) was 84% accurate at predicting progression. Further subtyping and analysis is ongoing to evaluate OS and PDL1 in the CAML populations. Conclusions: Our data suggests that in unresectable NSCLC, ≥50 µm CAMLs after completion of CRT is prognostic regardless of IMT use. PDL1 expression in CAMLs also appears to predict for response to consolidated IMT after CRT. Additional studies are needed to validate these findings.

Identification of a lncRNA prognostic signature-related to stem cell index and its significance in colorectal cancer

2021 ◽  
Author(s):  
Xiao-Cheng Wang ◽  
Ya Liu ◽  
Fei-Wu Long ◽  
Liang-Ren Liu ◽  
Chuan-Wen Fan
Keyword(s):  
Colorectal Cancer ◽  
Overall Survival ◽  
Prognostic Markers ◽  
The Cancer Genome Atlas ◽  
Prognostic Signature ◽  
Free Survival ◽  
Cancer Genome Atlas ◽  
Bioinformatic Approaches ◽  
Cell Phenotypes ◽  
The Relationship

Background: The relationship between long noncoding RNAs (lncRNAs) and the mRNA stemness index (mRNAsi) in colorectal cancer (CRC) is still unclear. Materials & methods: The mRNAsi, mRNAsi-related lncRNAs and their clinical significance were analyzed by bioinformatic approaches in The Cancer Genome Atlas (TCGA)-COREAD dataset. Results: mRNAsi was negatively related to pathological features but positively related to overall survival and recurrence-free survival in CRC. A five mRNAsi-related lncRNAs prognostic signature was further developed and showed independent prognostic factors related to overall survival in CRC patients, due to the five mRNAsi-related lncRNAs involved in several pathways of the cancer stem cells and malignant cancer cell phenotypes. Conclusion: The present study highlights the potential roles of mRNAsi-related lncRNAs as alternative prognostic markers.

scholarly journals Prognostic Role of microRNA-155 in Various Carcinomas: Results from a Meta-Analysis

2013 ◽  
Vol 34 (6) ◽  
pp. 379-386 ◽  
Author(s):  
Jing He ◽  
Fengmei Zhang ◽  
Ying Wu ◽  
Wei Zhang ◽  
Xiaoli Zhu ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Patients ◽  
Prognostic Value ◽  
Meta Analysis ◽  
Statistical Significance ◽  
Prognostic Role ◽  
Free Survival ◽  
Hazard Ratios ◽  
The Relationship

BACKGROUND: Recent studies have shown that microRNAs (miRNA) have prognostic values in cancers. This meta-analysis seeks to summarize the global predicting role of miR-155 for survival in patients with a variety of carcinomas.METHODS: Eligible studies were identified through multiple search strategies. Data were extracted from studies investigating the relationship between miR-155 expression and survival in cancer patients. Combined hazard ratios (HRs) of miR-155 for outcome were analyzed.RESULTS: A total of 16 studies dealing with various carcinomas were included for this meta-analysis. For overall survival, higher miR-155 expression could significantly predict worse outcome with the pooled HR of 2.057 (95% CI: 1.392–3.039). For relapse or progress-free survival, elevated miR-155 was also a significant predictor, with a combined HR of 1.918 (95% CI: 1.311–2.806,). In addition, subgroup analysis showed that higher expression of miR-155 had the trends to predict worse outcome in lung cancer. However, the HRs did not reach the statistical significance.CONCLUSION: Our findings suggest that miR-155 detection has a prognostic value in cancer patients. Regularly measuring miR-155 expression may be useful in clinical practice.

scholarly journals ANALISIS SEGMENTASI POST-HOC PELUMAS 4T DAN HUBUNGAN ATRIBUT-ATRIBUT PELUMAS 4T DENGAN KARAKTERISTIK DEMOGRAFI PELANGGAN DI SURABAYA

2006 ◽  
Vol 5 (1) ◽  
Author(s):  
Jenu Widjaja Tandjung ◽  
Armanu Toyib ◽  
Multifiah .
Keyword(s):  
Secondary Data ◽  
Strong Relationship ◽  
Growing Up ◽  
Chi Square ◽  
Interaction Detection ◽  
Respondent Characteristic ◽  
To Come ◽  
Post Hoc ◽  
Relationship Of ◽  
The Relationship

A competition of 4T oil business is growing up. It can be seen from the increasing of a number of producers that have NPT (registered oil number). Customers will have more choices selecting many trademarks of 4T oil. To come out on top of this competition, the oil producers need to know oil attributes that influence customer choosing trademarks of 4T oil.This study wants to know the relationship between customer demography based on age, income, education level, sex and occupation with the choosing of 4T oil attributes. Besides, it is also to know the oil attributes that have strong relationship with characteristics of customer demography. The researcher also wants to know the relationship of customer demography of 4T oil with 4T oil post-hoc segmentation.This study focuses on 4T oil with motorcycle owners who change 4T oil in the garages in city area of Surabaya as samples. In taking sample, rescuer used accidental sampling with 168 people as respondents. Respondent characteristic is limited on demographically characteristic. Besides using primer data, it also used secondary data which taken from tabloid of Marketing, Jawa Pos, Badan Pusat Statistik, Indommercial and Bulletin Dirjen Migas. Scale and measurement that are used in this study is Likert Scale. Whereas, researcher used correlation of Rank Spearman and CHAID (Chi-Square Automatic Interaction Detection) as method of data analysis.The interesting result of this study is the choosing of 4T oil attributes in relation with characteristic of demography that is age, income, education, and occupation. Whereas, sex is not in relation with the choosing of 4T oil attributes. Besides, the customers of 4T oil tend to be rational that is taking more consideration on quality, acceleration of machine and oil endurance comparing with appearance and price.

scholarly journals Doğrudan Yabancı Sermaye Yatırımları ileGelir Eşitsizliği İlişkisi: Literatür İncelemesi

2021 ◽  
Vol 3 (1) ◽  
pp. 46-64
Author(s):  
Yeter Kaplan ◽  
Munise Tuba Aktaş
Keyword(s):  
Foreign Direct Investment ◽  
Income Inequality ◽  
Literature Review ◽  
Empirical Study ◽  
Wage Inequality ◽  
Direct Investment ◽  
The Other ◽  
Theoretical Approaches ◽  
To Come ◽  
The Relationship

In the literature, it is possible to come across studies examining the effect of foreign direct investment (FDI) on income inequality. In this study, a literature review has been conducted in order to better consideration the effect of FDI on income inequality. In this context, the main purpose of the study is to reveal the effect of FDI on income inequality within the framework of theoretical approaches based on empirical study findings. In addition, the study aims to contribute to the debates on the effects of foreign direct investment on income inequality. The findings of the studies on the relationship between FDI and income inequality shows differences. In some of the studies examined, there are findings supporting that FDI increases income and wage inequality. On the other hand, some other studies have found evidences that FDI reduces income inequality. Otherwise, there are also studies showing that FDI does not have a significant effect on income inequality.

Individual patient data (IPD) analysis of progression-free survival (PFS) versus overall survival (OS) as an endpoint for metastatic colorectal cancer (mCRC) in modern trials: Findings from the 16,700 patients (pts) ARCAD database.

2013 ◽  
Vol 31 (15_suppl) ◽  
pp. 3533-3533 ◽  
Author(s):  
Qian Shi ◽  
Aimery De Gramont ◽  
Marc E. Buyse ◽  
Axel Grothey ◽  
Hans-Joachim Schmoll ◽  
...  
Keyword(s):  
Survival Rates ◽  
Progression Free Survival ◽  
Least Square ◽  
Free Survival ◽  
Hazard Ratios ◽  
Examination Methods ◽  
Line Of Therapy ◽  
Ecog Ps ◽  
Superiority Trials ◽  
The Relationship

3533 Background: PFS has previously been established as a surrogate for OS based on IPD from first-line mCRC trials conducted before 1999. As mCRC treatment (trt) has advanced in the last decade and OS has increased from 1 to 2 years, this surrogacy required re-examination. Methods: IPD from 16,762 pts, median age 62, 62% male, 53% ECOG PS 0 were available from 22 1st line mCRC studies conducted from 1997-2006; 12 tested targeted (anti-angiogenic and/or anti-EGFR) regimens. The relationship between PFS (first event of progression or death) and OS was evaluated at patient-, trt-arm-, and trial-levels using correlation (corr.) coefficients and R2 (closer to 1 the better) from weighted least square (WLS) regression of arm-specific survival rates and trial-specific hazard ratios (HRs), estimated using Cox and Copula bivariate models. The concordance of significance (CoS) of the treatment effects (TEs) on both endpoints was calculated. Results: 44% pts received a targeted regimen. Median PFS was 8 and OS was18 months. The corr. between PFS and OS was modest at all three levels with low CoS in TE comparisons (see Table). Analyses limited to trials testing targeted trts, non-strategy trials, or superiority trials did not improve surrogacy. Conclusions: In modern mCRC trials, where survival post-first progression exceeds time to first progression, PFS TEs do not reliably predict TEs on OS. Nonetheless, until alternative endpoints of clinical benefit can be validated, PFS remains a relevant primary endpoint for 1st line mCRC trials, as our data demonstrate that the ability for any agent to produce an OS benefit from a single line of therapy is challenging. [Table: see text]

scholarly journals Blockchain from the Perspective of Privacy and Anonymisation: A Systematic Literature Review

Sensors ◽  
2020 ◽  
Vol 20 (24) ◽  
pp. 7171
Author(s):  
Francisco José de Haro-Olmo ◽  
Ángel Jesús Varela-Vaca ◽  
José Antonio Álvarez-Bermejo
Keyword(s):  
Literature Review ◽  
Systematic Literature Review ◽  
Homomorphic Encryption ◽  
Data Extraction ◽  
Strong Relationship ◽  
Ring Signature ◽  
Blockchain Technology ◽  
Data Obfuscation ◽  
The Relationship

The research presented aims to investigate the relationship between privacy and anonymisation in blockchain technologies on different fields of application. The study is carried out through a systematic literature review in different databases, obtaining in a first phase of selection 199 publications, of which 28 were selected for data extraction. The results obtained provide a strong relationship between privacy and anonymisation in most of the fields of application of blockchain, as well as a description of the techniques used for this purpose, such as Ring Signature, homomorphic encryption, k-anonymity or data obfuscation. Among the literature researched, some limitations and future lines of research on issues close to blockchain technology in the different fields of application can be detected. As conclusion, we extract the different degrees of application of privacy according to the mechanisms used and different techniques for the implementation of anonymisation, being one of the risks for privacy the traceability of the operations.

scholarly journals Array-Based Epigenetic Aging Indices May Be Racially Biased

Genes ◽  
2020 ◽  
Vol 11 (6) ◽  
pp. 685 ◽  
Author(s):  
Robert Philibert ◽  
Steven R.H. Beach ◽  
Man-Kit Lei ◽  
Frederick X. Gibbons ◽  
Meg Gerrard ◽  
...  
Keyword(s):  
Methylation Status ◽  
Area Under The Curve ◽  
European Ancestry ◽  
Bonferroni Correction ◽  
Aging Index ◽  
Epigenetic Aging ◽  
Important Health ◽  
Characteristic Area ◽  
Relationship Of ◽  
The Relationship

Epigenetic aging (EA) indices are frequently used as predictors of mortality and other important health outcomes. However, each of the commonly used array-based indices has significant heritable components which could tag ethnicity and potentially confound comparisons across racial and ethnic groups. To determine if this was possible, we examined the relationship of DNA methylation in cord blood from 203 newborns (112 African American (AA) and 91 White) at the 513 probes from the Levine PhenoAge Epigenetic Aging index to ethnicity. Then, we examined all sites significantly associated with race in the newborn sample to determine if they were also associated with an index of ethnic genetic heritage in a cohort of 505 AA adults. After Bonferroni correction, methylation at 50 CpG sites was significantly associated with ethnicity in the newborn cohort. The five most significant sites predicted ancestry with a receiver operator characteristic area under the curve of 0.97. Examination of the top 50 sites in the AA adult cohort showed that methylation status at 11 of those sites was also associated with percentage European ancestry. We conclude that the Levine PhenoAge Index is influenced by cryptic ethnic-specific genetic influences. This influence may extend to similarly constructed EA indices and bias cross-race comparisons.

scholarly journals Peranan Faktor Lingkungan dan Kontributor Selama Kehamilan terhadap Hipospadia

e-CliniC ◽  
2021 ◽  
Vol 9 (1) ◽  
Author(s):  
Ester J. Tuju ◽  
Harsali F. Lampus ◽  
Stephanus J. Ch. Tangel
Keyword(s):  
Risk Factors ◽  
Environmental Factors ◽  
Literature Review ◽  
Maternal Age ◽  
Strong Relationship ◽  
First Trimester ◽  
Google Scholar ◽  
Increased Risk ◽  
Review Study ◽  
The Relationship

Abstract: The etiology of hypospadias is not certainly known and is still controversial. Environmental factors and their influence during pregnancy can be risk factors for increased incidence of hypospadias. This study was aimed to obtain the risk factors of hypospadias. This was a literature review study using three databases, as follows: ClinicalKey, PubMed, and Google Scholar. There were 47 literatures in this study. The results showed that from the 47 literatures containing risk factors of hypospadias, 8 literatures reported the relationship between pesticides and hypospadias; 3 literatures reported the relationship between smoking and increased risk of hypospadias; 6 literatures revealed that there was a strong relationship between maternal age and increased risk of hypospadias; 8 literatures showed that low births weight babies were associated with hypospadias and placental insufficiency as its cause; 5 literatures stated that several drugs consumed by pregnant women during the first trimester were related to the increased risk of hypospadias. In conclusion, environmental factors and contributors during pregnancy are the risk factors of hypospadias.Keywords: hypospadias, risk factors, environmental factors, contributors during pregnancy Abstrtrak: Etiologi hipospadia belum diketahui dengan pasti dan masih bersifat kontroversial. Faktor lingkungan serta hal yang berpengaruh selama kehamilan dapat menjadi faktor risiko peningkatan kejadian hipospadia. Penelitian ini bertujuan untuk mengetahui faktor risiko hipospadia. Jenis penelitian ialah literature review dengan menggunakan database ClinicalKey, PubMed, dan Google Scholar. Hasil penelitian mendapatkan bahwa dari 47 literatur yang memuat tentang faktor risiko hipospadia, 8 literatur memuat adanya hubungan antara pestisida dengan hipospadia, 3 literatur memuat bahwa merokok berkaitan dengan peningkatan risiko hipospadia, 6 literatur memuat bahwa usia ibu memiliki hubungan kuat dengan peningkatan risiko hipospadia, 8 literatur memuat bahwa bayi berat lahir rendah berkaitan dengan hipospadia dan insufisiensi plasenta menjadi penyebab terjadinya hal tersebut, 5 literatur memuat bahwa beberapa obat obatan yang dikonsumsi ibu hamil selama trimester pertama berkaitan dengan peningkatan risiko hipospadia. Simpulan penelitian ini ialah faktor lingkungan dan kontributor selama kehamilan merupakan faktor risiko hipospadia.Kata kunci: hipospadia, faktor risiko, factor lingkungan, Kontributor selama kehamilan

B-Cell Count and Survival: Differentiating Chronic Lymphocytic Leukemia (CLL) from and Monoclonal B-Cell Lymphocytosis (MBL) Based on Clinical Outcome.

Blood ◽  
2008 ◽  
Vol 112 (11) ◽  
pp. 2062-2062
Author(s):  
Tait Shanafelt ◽  
Neil E. Kay ◽  
Gregory Jenkins ◽  
Timothy G. Call ◽  
Clive S. Zent ◽  
...  
Keyword(s):  
Clinical Outcome ◽  
B Cell ◽  
Cell Count ◽  
Prognostic Value ◽  
Prognostic Markers ◽  
Continuous Variables ◽  
Mutation Status ◽  
Free Survival ◽  
Relationship Of ◽  
The Relationship

Abstract BACKGROUND: The diagnosis of CLL among asymptomatic patients without lymphadenopathy or cytopenias has historically been based on documenting a characteristic lymphocyte clone and the presence of lymphocytosis. Currently, there are no data regarding what lymphocyte type (absolute lymphocyte count [ALC] or B-cell count) or threshold should be used for this diagnosis. We analyzed the relationship of these lymphocyte counts to clinical outcome in a cohort of 459 patients to determine whether the CLL diagnosis: should be based on ALC or B-cell count what lymphocyte threshold should be used for diagnosis whether any lymphocyte counts has independent prognostic value after accounting for molecular prognostic markers. METHODS: We used the Mayo Clinic CLL database to identify all Rai stage 0 patients diagnosed with CLL between 1/1/00 and 12/31/07 who were evaluated and had flow cytometry at Mayo within 12 months of diagnosis. All patients had lymphocytosis (ALC ≥5 x 109/L) and fulfilled the 1996 criteria for CLL. Raw data from the peripheral blood flow analysis was used in conjunction with blood counts to determine ALC and absolute B-cell count at diagnosis. Estimates of survival were calculated using the Kaplan-Meier method. RESULTS: To assess whether B-cell count or ALC more strongly related to clinical outcome, we evaluated the relationship of these variables with treatment free survival (TFS) and overall survival (OS; n=459). When treated as continuous variables (i.e. measuring risk of each 1.0 x 109/L increase in cell count), both ALC and B-cell count were related to TFS (hazard ratio [HR] ALC=1.02; p&lt;0.0001; HR B-cell count=1.02; p&lt;0.0001) and OS (HR ALC=1.02; p=0.04; HR B-cell count=1.02; p=0.02). Because B-cell count and ALC related to TFS and OS as a continuous variables, we next evaluated what threshold (nearest 1.0 x109/L) at diagnosis best related to an individual’s risk of requiring chemotherapeutic treatment and/or dying of CLL using the HR (log rank statistic) and c-statistic [c=1 indicates perfect discrimination between poor survivors and good survivors; c=0.5 equivalent to chance]. The B-cell threshold that best predicted OS was 11 x 109/L (HR=2.36, p=0.01; c=0.60). This threshold also predicted TFS (HR=3.02; p&lt;0.0001; c=0.64). With respect to ALC, a threshold of 12 x 109/L was able to predict TFS (HR=2.28, p=0.003; c=0.62) but not OS (HR=1.62, p=0.12; c=0.56). The B-cell threshold used in the current diagnostic criteria (5 x 109/L) was able to predict TFS (HR=3.24, p&lt;0.0001; c=0.63), but not OS (HR=1.64, p=0.13; c=0.55) Finally, we evaluated the ability of B-cell count to predict TFS independent of IGHV mutation status, ZAP-70 status, CD38 status, and FISH. Since not all patients had all prognostic tests performed, the predictive value of B-cell count (&lt; or ≥11 x 109) independent of the other prognostic variable was assessed for each variable independently. B-cell count retained prognostic value independent of IGHV mutation status, ZAP-70 status, CD38 status, and FISH (all p≤0.001) [Table]. CONCLUSIONS: Although B-cell count and ALC have similar ability to predict TFS and OS as continuous variables, B-cell count may be a better predictor of TFS and OS when a defined lymphocyte threshold is used. These findings provide evidence to justify the recent proposal by Hallek et al (Blood 111:5446) to base the diagnosis of CLL on B-cell count rather than ALC. The results also provide justification for retaining the size of the B-cell count as part of the diagnostic criteria even in the era of molecular/biologic prognostic markers, but imply a threshold of 11 x 109 is the B-cell count that best predicts patient’s TFS and risk of death. Differentiating between CLL and MBL based on a patient’s likelihood of developing clinical symptoms and dying of disease could minimize unnecessary psychologic distress caused by labeling asymptomatic individuals at low risk for adverse clinical consequences as having leukemia. TABLE: TREATMENT FREE SURVIVAL HR p-value CD38 + 3.20 0.0002 B-cell ≥11 3.10 0.0001 ZAP + 8.33 &lt; 0.0001 B-cell ≥11 6.86 &lt; 0.0001 Unmutated 5.26 &lt; 0.0001 B-cell ≥11 3.06 0.001 FISH (17p- or 11q-) 3.97 0.01 B-cell ≥11 3.67 &lt; 0.0001

Sign in / Sign up

Export Citation Format

Share Document