scholarly journals Health and environmental applications of gut microbiome: a review

2017 ◽  
Vol 24 (3) ◽  
pp. 467-482 ◽  
Author(s):  
Soumya Chatterjee ◽  
Sibnarayan Datta ◽  
Sonika Sharma ◽  
Sarika Tiwari ◽  
Dharmendra K. Gupta
Keyword(s):  
Microbial Communities ◽  
Gut Microbiome ◽  
Ecological Communities ◽  
Anatomy And Physiology ◽  
Physiological Processes ◽  
Health Related ◽  
History Of ◽  
Subsequent Elimination ◽  
Life On Earth

AbstractLife on Earth harbours an unimaginable diversity of microbial communities. Among these, gut microbiome, the ecological communities of commensal, symbionts (bacteria and bacteriophages) are a unique assemblage of microbes. This microbial population of animal gut helps in performing organism’s physiological processes to stay healthy and fit. The role of these microbial communities is immense. They continually maintain interrelation with the intestinal mucosa in a subtle equilibrium and help the gut for different functions ranging from metabolism to immunologic functions like upgradation of nutrient-poor diets, aid in digestion of recalcitrant food components, protection from pathogens, contribute to inter- and intra-specific communication, affecting the efficiency as disease vectors etc. The microbial diversity in the gut depends upon environmental competition between microbes, their sieving effects and subsequent elimination. Due to wide diversity of anatomy and physiology of the digestive tracts and food habits, the gut microbiome also differs broadly among animals. Stochastic factors through the history of colonization of the microbiome in a species andin situevolution are likely to establish interspecies diversity. Moreover, the microbes offer enormous opportunity to discover novel species for therapeutic and/or biotechnological applications. In this manuscript, we review the available knowledge on gut microbiome, emphasising their role in health and health related applications in human.

INTERPRETATION OF SPACE AND TIME IN ONTOLOGICAL PHILOSOPHY NAVOI

2021 ◽  
Vol 1 (2) ◽  
pp. 80-87
Author(s):  
Toji Omonovich Norov ◽  
Keyword(s):  
Human Life ◽  
History Of Philosophy ◽  
Human Intelligence ◽  
Time And Space ◽  
Space And Time ◽  
History Of ◽  
Life On Earth ◽  
The Universe ◽  
Holy Book

The universe, the space that make up their basis planets in it, their creation, the main essence of their creation, form, composition, meaning, movements, interactions, their influence on human life and activities, the role of man in the universe and in life on Earth, life, the criteria of activity and processes occurring in time and space have long been of interest to humanity. One of the main problems in the history of philosophy is the question of space and time. This problem was defined in different ways in the great schools of thought by thinkers of different periods. One of these great thinkers is Alisher Navoi. Navoi's works, along with other socio-philosophical themes, uniquely express and analyze the problems of the firmament and time. Its main feature is that it is based on the divine (pantheistic) religion, Islam, its holy book, the Koran and other theological sources, as well as on the secrets of nature and the Universe, the main miracle of Allah - human intelligence, the power of enlightenment, they are the key revealing all these secrets.

scholarly journals Plumage iridescence is associated with distinct feather microbiota in a tropical passerine

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Veronika Gvoždíková Javůrková ◽  
Erik D. Enbody ◽  
Jakub Kreisinger ◽  
Kryštof Chmel ◽  
Jakub Mrázek ◽  
...  
Keyword(s):  
Sexual Selection ◽  
Community Structure ◽  
Microbial Communities ◽  
Plumage Coloration ◽  
Microbial Load ◽  
Sexual Dichromatism ◽  
Physiological Processes ◽  
Fitness Consequences ◽  
Future Work

Abstract Birds present a stunning diversity of plumage colors that have long fascinated evolutionary ecologists. Although plumage coloration is often linked to sexual selection, it may impact a number of physiological processes, including microbial resistance. At present, the degree to which differences between pigment-based vs. structural plumage coloration may affect the feather microbiota remains unanswered. Using quantitative PCR and DGGE profiling, we investigated feather microbial load, diversity and community structure among two allopatric subspecies of White-shouldered Fairywren, Malurus alboscapulatus that vary in expression of melanin-based vs. structural plumage coloration. We found that microbial load tended to be lower and feather microbial diversity was significantly higher in the plumage of black iridescent males, compared to black matte females and brown individuals. Moreover, black iridescent males had distinct feather microbial communities compared to black matte females and brown individuals. We suggest that distinctive nanostructure properties of iridescent male feathers or different investment in preening influence feather microbiota community composition and load. This study is the first to point to structural plumage coloration as a factor that may significantly regulate feather microbiota. Future work might explore fitness consequences and the role of microorganisms in the evolution of avian sexual dichromatism, with particular reference to iridescence.

How Virtue Was Born

Gerontology ◽  
2017 ◽  
Vol 64 (2) ◽  
pp. 201-204 ◽  
Author(s):  
Martin A. Nowak ◽  
Karl Sigmund
Keyword(s):  
Social Contract ◽  
Evolutionary Biology ◽  
Evolution Of Cooperation ◽  
European Forum ◽  
The Social ◽  
History Of ◽  
Life On Earth

This paper summarizes the Opening Lecture of the European Forum Alpbach 2017 in Tyrol/Austria (https://www.alpbach.org/de/). It deals with the evolution of cooperation throughout the history of life on Earth, and in particular human cooperation based on partnership. It emphasizes the role of institutions providing incentives for cooperation, and the role of praise and blame in guiding our actions. This helps for a better understanding of the social contract, based on evolutionary biology and psychology.

scholarly journals A History of Neglect: Negotiating the Role of Safety in the Manhattan Project, 1939-1945

2008 ◽  
Vol 11 ◽  
Author(s):  
Katherine Zwicker
Keyword(s):  
World War Ii ◽  
Atomic Bomb ◽  
Manhattan Project ◽  
National Defense ◽  
Government Officials ◽  
Radiation Hazards ◽  
Health Related Research ◽  
Health Related ◽  
History Of

This paper examines the role of safety within the Manhattan Project, the Allied effort to build an atomic bomb during World War II. As an integral component of the American national defense strategy, the atomic bomb project was afforded tremendous resources and incorporated the expertise of the country's top scientists, engineers, government officials, and military personnel. As a result, considerable Scientific and technological achievement was realized The Manhattan Project marked an important point in the ascendancy of science and technology throughout the twentieth century. However, the largely political and military goals of the project had consequences. Insufficient knowledge was gained regarding radiation hazards as a result of a preoccupation with speedy and secretive nuclear weapons development and the difficulty scientists had conducting health-related research. This paper argues that safety concerns were secondary to speed and secrecy in the search for the world's first atomic bomb.

scholarly journals The role of public goods in planetary evolution

2017 ◽  
Vol 375 (2109) ◽  
pp. 20160359 ◽  
Author(s):  
James O. McInerney ◽  
Douglas H. Erwin
Keyword(s):  
Public Goods ◽  
Phylogenetic Signal ◽  
Eukaryotic Cell ◽  
Early History ◽  
Evolutionary Transition ◽  
Direct Graph ◽  
Planetary Evolution ◽  
History Of ◽  
Life On Earth

Biological public goods are broadly shared within an ecosystem and readily available. They appear to be widespread and may have played important roles in the history of life on Earth. Of particular importance to events in the early history of life are the roles of public goods in the merging of genomes, protein domains and even cells. We suggest that public goods facilitated the origin of the eukaryotic cell, a classic major evolutionary transition. The recognition of genomic public goods challenges advocates of a direct graph view of phylogeny, and those who deny that any useful phylogenetic signal persists in modern genomes. Ecological spillovers generate public goods that provide new ecological opportunities. This article is part of the themed issue ‘Reconceptualizing the origins of life’.

What is the role of prophylaxis in the improvement of health-related quality of life of patients with hemophilia?

Hematology ◽  
2013 ◽  
Vol 2013 (1) ◽  
pp. 52-55 ◽  
Author(s):  
David Buchbinder ◽  
Margaret V. Ragni
Keyword(s):  
Quality Of Life ◽  
Health Related Quality ◽  
The Past ◽  
Related Quality ◽  
Health Related ◽  
History Of ◽  
Lost Time ◽  
The Impact

Abstract A 32-year-old male with severe hemophilia presents for his annual evaluation. He has a history of multiple joint bleeds that he has always treated on-demand, that is, after they occur. You have recommended prophylaxis, that is, preventively, before they occur, to decrease his episodes of bleeding; however, he had been reluctant to comply in the past. He is having difficulty keeping up at work because of interruptions, pain, and lost time at work. He is willing to consider a trial of prophylaxis. You discuss the impact of hemophilia on his health-related quality of life (HRQOL) and consider measuring his HRQOL over time using a generic measure of HRQOL to determine whether prophylaxis will reduce interruptions, pain, and lost time from work and improve his HRQOL.

scholarly journals ADRB2 gene polymorphism and preterm labor

2022 ◽  
pp. 9-17
Author(s):  
R. E. Kazakov ◽  
R. A. Chilova ◽  
K. O. Akopov ◽  
E. A. Sokova
Keyword(s):  
Preterm Labor ◽  
Gene Polymorphisms ◽  
Gene Encoding ◽  
Physiological Processes ◽  
History Of ◽  
Β2 Adrenergic Receptor ◽  
Adrb2 Gene ◽  
Scientific Facts ◽  
Relationship Of

This article discusses issues related to the role of polymorphism of the ADRB2 gene encoding β2-adrenergic receptor in preterm labor and tocolysis. Information is provided on scientific studies related to the search for associations of the carriage of alleles and genotypes of ADRB2 with the preterm labor, as well as with the pharmacological response to tocolytic therapy using β2-adrenergic agonists. The history of the discovery of the relationship of ADRB2 gene polymorphisms with preterm labor is presented in chronological order. As scientific facts emerge, researchers are faced with the question: how can ADRB2 gene polymorphisms affect physiological processes? That is, whether they affect by changing the primary structure of the receptor or by changing the level of expression. Depending on the answer to this question, pharmacogenetics are faced with a further task: what to study - individual polymorphisms or haplotypes?

scholarly journals Falling through the cracks’ – the role of assertive alcohol outreach teams in treating comorbid mental health problems in people with addictions

BJPsych Open ◽  
2021 ◽  
Vol 7 (S1) ◽  
pp. S277-S277
Author(s):  
E. Naomi Smith ◽  
Emily Finch ◽  
Colin Drummond
Keyword(s):  
Mental Health ◽  
Mental Health Problems ◽  
Hospital Admissions ◽  
Health Problems ◽  
Mental Health Needs ◽  
Health Related ◽  
History Of ◽  
The Impact ◽  
Drug And Alcohol

AimsInput from Assertive Alcohol Outreach Teams (AAOTs) reduces the ‘burden’ on already overstretched community mental health teams (CMHTs).AAOTs are specialist addictions services. This project focuses on an AAOT based in the London, which engages with people with severe alcohol and illicit substance misuse problems.Previous research has shown that input from AAOTs reduces hospital admissions. This project examined the impact of AAOT input on reducing the ‘burden’ on CMHTs.MethodThe full caseload of the Southwark-based AAOT was reviewed, including mental health records, general practitioner notes, hospital notes and discharge summaries. We collected data on diagnoses and previous hospital admissions. Patients were assessed to determine whether they met criteria to be open to a CMHT (the presence of complex or serious mental health problems, in addition to addictions).ResultThe caseload was made up of 39 patients, 85% of patients were deemed to meet criteria for being under the care of a CMHT. Only 15% of patients are currently under the care of a CMHT. 87% of patients had at least one comorbid psychiatric diagnosis. 72% of patients had had at least one emergency department or medical hospital admission due to mental health-related problems. 39% had previous admissions to mental health wards. 21% of patients has been admitted under Section of Mental Health Act.ConclusionThe majority of AAOT patients have severe mental health problems in addition to addictions. The patients are complex and often have a history of disengagement from standard mental health services. Formal diagnosis and treatment of comorbid mental health problems is challenging in the presence of protracted drug and alcohol misuse. AAOT input appears to address a serious ‘gap’ in supporting patients with complex mental health needs who are often ineligible for CMHT input or disengage from CMHT support.

scholarly journals A gut check at the doctor

2017 ◽  
Vol 39 (2) ◽  
pp. 34-36
Author(s):  
Elisabeth M. Bik ◽  
Audrey D. Goddard ◽  
Daniel E. Almonacid ◽  
Zachary S. Apte
Keyword(s):  
Microbial Communities ◽  
Gut Microbiome ◽  
Intestinal Tract ◽  
Medical Professionals ◽  
Clinical Tool ◽  
Health Changes ◽  
Physiological Processes

Have you ever been curious to find out which microbes live inside your intestinal tract (otherwise known as your gut)? Our gut is full of microbes that are intricately connected to many physiological processes, and these communities vary between persons or as a result of changes in our diet, lifestyle or health. Changes in these microbial communities are associated with certain diseases, and the analysis of the composition of our gut microbiome can be used as a clinical tool by medical professionals.

scholarly journals The gut microbiome: Relationships with disease and opportunities for therapy

2018 ◽  
Vol 216 (1) ◽  
pp. 20-40 ◽  
Author(s):  
Juliana Durack ◽  
Susan V. Lynch
Keyword(s):  
Gut Microbiome ◽  
Immune Cell ◽  
Respiratory Illnesses ◽  
Inflammatory Conditions ◽  
Mucosal Surfaces ◽  
Primary And Secondary Metabolism ◽  
Metabolic Conditions ◽  
History Of ◽  
And Function

Over the past decade, our view of human-associated microbes has expanded beyond that of a few species toward an appreciation of the diverse and niche-specialized microbial communities that develop in the human host with chronological age. The largest reservoir of microbes exists in the distal gastrointestinal tract, both in the lumen, where microbes facilitate primary and secondary metabolism, and on mucosal surfaces, where they interact with host immune cell populations. While local microbial-driven immunomodulation in the gut is well described, more recent studies have demonstrated a role for the gut microbiome in influencing remote organs and mucosal and hematopoietic immune function. Unsurprisingly, therefore, perturbation to the composition and function of the gut microbiota has been associated with chronic diseases ranging from gastrointestinal inflammatory and metabolic conditions to neurological, cardiovascular, and respiratory illnesses. Considerable effort is currently focused on understanding the natural history of microbiome development in humans in the context of health outcomes, in parallel with improving our knowledge of microbiome–host molecular interactions. These efforts ultimately aim to develop effective approaches to rehabilitate perturbed human microbial ecosystems as a means to restore health or prevent disease. This review details the role of the gut microbiome in modulating host health with a focus on immunomodulation and discusses strategies for manipulating the gut microbiome for the management or prevention of chronic inflammatory conditions.

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