scholarly journals Therapeutic Potential of Polymer-Coated Mesoporous Silica Nanoparticles

2019 ◽  
Vol 10 (1) ◽  
pp. 289 ◽  
Author(s):  
Kuldeep K. Bansal ◽  
Deepak K. Mishra ◽  
Ari Rosling ◽  
Jessica M. Rosenholm
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Therapeutic Potential ◽  
Mesoporous Silica Nanoparticles ◽  
Drug Loading ◽  
Polymer Coatings ◽  
Drug Delivery Carrier ◽  
Great Solution ◽  
Selection Of

Mesoporous silica nanoparticles (MSNs) find tremendous applications in drug delivery due to several advantages such as their easy fabrication process, high drug loading, biodegradability, biocompatibility, and so forth. Nevertheless, despite several advantages, the use of this striking drug delivery carrier is restricted due to premature drug release owing to the porous structure. Coating of the pores using polymers has emerged as a great solution to this problem. Polymer coatings, which act as gatekeepers, avoid the premature release of loaded content from MSNs and offers the opportunity for controlled and targeted drug delivery. Therefore, in this review, we have compiled the polymer-based coating approaches used in recent years for improving the drug delivery capability of MSNs. This manuscript provides an insight into the research about the potential of polymer-coated MSNs, allowing the selection of right polymer for coating purposes according to the desired application.

scholarly journals Polymeric Mesoporous Silica Nanoparticles for Enhanced Delivery of 5-Fluorouracil In Vitro

Pharmaceutics ◽  
2019 ◽  
Vol 11 (6) ◽  
pp. 288 ◽  
Author(s):  
Thashini Moodley ◽  
Moganavelli Singh
Keyword(s):  
Side Effects ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Therapeutic Potential ◽  
Mesoporous Silica Nanoparticles ◽  
Drug Loading ◽  
Hek293 Cells ◽  
Cancer Drug ◽  
Delivery Vehicles

There is a need for the improvement of conventional cancer treatment strategies by incorporation of targeted and non-invasive procedures aimed to reduce side-effects, drug resistance, and recurrent metastases. The anti-cancer drug, 5-fluorouracil (5-FU), is linked to a variety of induced-systemic toxicities due to its lack of specificity and potent administration regimens, necessitating the development of delivery vehicles that can enhance its therapeutic potential, while minimizing associated side-effects. Polymeric mesoporous silica nanoparticles (MSNs) have gained popularity as delivery vehicles due to their high loading capacities, biocompatibility, and good pharmacokinetics. MSNs produced in this study were functionalized with the biocompatible polymers, chitosan, and poly(ethylene)glycol to produce monodisperse NPs of 36–65 nm, with a large surface area of 710.36 m2/g, large pore volume, diameter spanning 9.8 nm, and a favorable zeta potential allowing for stability and enhanced uptake of 5-FU. Significant drug loading (0.15–0.18 mg5FU/mgmsn), controlled release profiles (15–65%) over 72 hours, and cell specific cytotoxicity in cancer cells (Caco-2, MCF-7, and HeLa) with reduced cell viability (≥50%) over the non-cancer (HEK293) cells were established. Overall, these 5FU-MSN formulations have been shown to be safe and effective delivery systems in vitro, with potential for in vivo applications.

scholarly journals Synthesis and compatibility evaluation of versatile mesoporous silica nanoparticles with red blood cells: an overview

RSC Advances ◽  
2019 ◽  
Vol 9 (61) ◽  
pp. 35566-35578 ◽  
Author(s):  
Subhankar Mukhopadhyay ◽  
Hanitrarimalala Veroniaina ◽  
Tadious Chimombe ◽  
Lidong Han ◽  
Wu Zhenghong ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Blood Cells ◽  
Drug Delivery Systems ◽  
Mesoporous Silica Nanoparticles ◽  
Drug Loading ◽  
Loading Capacity ◽  
High Drug ◽  
High Drug Loading

Protean mesoporous silica nanoparticles are propitious candidates over decades for nanoscale drug delivery systems due to their unique characteristics, including changeable pore size, mesoporosity, high drug loading capacity and biodegradability.

Mesoporous Silica Nanoparticles as a Prospective and Promising Approach for Drug Delivery and Biomedical Applications

2019 ◽  
Vol 19 (4) ◽  
pp. 285-295 ◽  
Author(s):  
Xiaohui Pu ◽  
Jia Li ◽  
Peng Qiao ◽  
Mengmeng Li ◽  
Haiyan Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Biomedical Applications ◽  
Mesoporous Silica Nanoparticles ◽  
Release Kinetics ◽  
Drug Loading ◽  
Synthetic Methods ◽  
Pubmed Database ◽  
Modified Surface

Background: With the development of nanotechnology, nanocarrier has widely been applied in such fields as drug delivery, diagnostic and medical imaging and engineering in recent years. Among all of the available nanocarriers, mesoporous silica nanoparticles (MSNs) have become a hot issue because of their unique properties, such as large surface area and voidage, tunable drug loading capacity and release kinetics, good biosafety and easily modified surface. Objective: We described the most recent progress in silica-assisted drug delivery and biomedical applications according to different types of Cargo in order to allow researchers to quickly learn about the advance in this field. Methods: Information has been collected from the recently published literature available mainly through Title or Abstract search in SpringerLink and PubMed database. Special emphasis is on the literature available during 2008-2017. Results: In this review, the major research advances of MSNs on the drug delivery and biomedical applications were summarized. The significant advantages of MSNs have also been listed. It was found that the several significant challenges need to be addressed and investigated to further advance the applications of these structurally defined nanomaterials. Conclusion: Through approaching this review, the researchers can be aware of many new synthetic methods, smart designs proposed in the recent year and remaining questions of MSNs at present.

scholarly journals Live-Cell Imaging of Colloidal Mesoporous Silica Nanoparticles for Drug Delivery: Drug Loading, Pore Sealing and Controlled Release

2011 ◽  
Vol 100 (3) ◽  
pp. 600a
Author(s):  
Anna M. Sauer ◽  
Axel Schlossbauer ◽  
Valentina Cauda ◽  
Hanna Engelke ◽  
Christian Argyo ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Live Cell Imaging ◽  
Cell Imaging ◽  
Mesoporous Silica Nanoparticles ◽  
Drug Loading ◽  
Live Cell ◽  
Pore Sealing

Synthesis of Mesoporous Silica Nanoparticles for Drug Delivery

2014 ◽  
Vol 602-603 ◽  
pp. 67-70
Author(s):  
Ya Zhen Wu ◽  
Xiao Yun Jia ◽  
Yuan Hua Lin ◽  
De Ping Liu
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Surface Area ◽  
Mesoporous Silica Nanoparticles ◽  
Close Correlation ◽  
Release Kinetic ◽  
Incipient Wetness Impregnation ◽  
Drug Delivery Carrier

Mesoporous silica nanoparticles (MSNs) is an attractive candidate as a drug delivery carrier due to their large surface area, high pore volume and t intrinsic biocompatibility. Here, MSNs were synthesized by the hydrolysis and condensation of tetraethyl orthosilicate (TEOS) with cetyltrimethylammonium bromide (CTAB) acting as structural directing agent. A large mesopore with diameter of 3.8 to 5.5 nm of MCM-41style can be obtained via the addition of 1,3,5-trimethylbenzene. Metoprolol tartrate as a selective β1 receptor blocker was embedded on MSNs by the incipient wetness impregnation. The delivery profiles were collected in vitro in SBF at pH 7.4. A close correlation can be observed between the drug release kinetic and the mesopore size and specific surface area of MSNs.

scholarly journals Galactosylated Chitosan-Functionalized Mesoporous Silica Nanoparticle Loading by Calcium Leucovorin for Colon Cancer Cell-Targeted Drug Delivery

Molecules ◽  
2018 ◽  
Vol 23 (12) ◽  
pp. 3082 ◽  
Author(s):  
Wei Liu ◽  
Fan Wang ◽  
Yongchao Zhu ◽  
Xue Li ◽  
Xiaojing Liu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Colon Cancer ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Tumor Cells ◽  
Targeted Drug Delivery ◽  
Mesoporous Silica Nanoparticles ◽  
Drug Loading ◽  
Targeted Drug ◽  
Galactosylated Chitosan

Targeted drug delivery to colon cancer cells can significantly improve the efficiency of treatment. We firstly synthesized carboxyl-modified mesoporous silica nanoparticles (MSN–COOH) via two-step synthesis, and then developed calcium leucovorin (LV)-loaded carboxyl-modified mesoporous silica nanoparticles based on galactosylated chitosan (GC), which are galectin receptor-mediated materials for colon-specific drug delivery systems. Both unmodified and functionalized nanoparticles were characterized by scanning electron microscopy (SEM), transmission electron microscope (TEM), X-ray diffraction (XRD), Fourier transform infrared (FT-IR), nitrogen sorption, and dynamic light scattering (DLS). Drug release properties and drug loading capacity were determined by ultraviolet spectrophotometry (UV). LV@MSN–COOH/GC had a high LV loading and a drug loading of 18.07%. In vitro, its release, mainly by diffusion, was sustained release. Cell experiments showed that in SW620 cells with the galectin receptor, the LV@MSN–COOH/GC metabolized into methyl tetrahydrofolic acid (MTHF) and 5-fluorouracil (5-FU)@MSN–NH2/GC metabolized into FdUMP in vivo. MTHF and 5-fluoro-2′-deoxyuridine 5′-monophosphate (FdUMP) had combined inhibition and significantly downregulated the expression of thymidylate synthase (TS). Fluorescence microscopy and flow cytometry experiments show that MSN–COOH/GC has tumor cell targeting, which specifically recognizes and binds to the galectin receptor in tumor cells. The results show that the nano-dosing system based on GC can increase the concentrations of LV and 5-FU tumor cells and enhance their combined effect against colon cancer.

scholarly journals A pH-responsive mesoporous silica nanoparticles-based drug delivery system with controlled release of andrographolide for OA treatment

2021 ◽  
Vol 8 (4) ◽  
Author(s):  
Mingwei He ◽  
Zainen Qin ◽  
Xiaonan Liang ◽  
Xixi He ◽  
Bikang Zhu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Drug Delivery System ◽  
Delivery System ◽  
Mesoporous Silica Nanoparticles ◽  
Cruciate Ligament ◽  
Drug Loading ◽  
Inflammatory Factors ◽  
Ph Responsive

Abstract Andrographolide (AG) has favorable anti-inflammatory and antioxidative capacity. However, it has low bioavailability due to high lipophilicity and can be easily cleared by the synovial fluid after intra-articular injection, leading to low therapeutic efficiency in osteoarthritis (OA). Herein, we designed a nano-sized pH-responsive drug delivery system (DDS) for OA treatment by using modified mesoporous silica nanoparticles (MSNs) with pH-responsive polyacrylic acid (PAA) for loading of AG to form AG@MSNs-PAA nanoplatform. The nanoparticles have uniform size (∼120 nm), high drug loading efficiency (22.38 ± 0.71%) and pH-responsive properties, beneficial to sustained release in OA environment. Compared with AG, AG@MSNs-PAA showed enhanced antiarthritic efficacy and chondro-protective capacity based on IL-1β-stimulated chondrocytes and anterior cruciate ligament transection-induced rat OA model, as demonstrated by lower expression of inflammatory factors and better prevention of proteoglycan loss. Therefore, the AG@MSNs-PAA nanoplatform may be developed as a promising OA-specific and on-demand DDS.

scholarly journals HOLLOW MESOPOROUS SILICA NANOPARTICLES FABRICATION FOR ANTICANCER DRUG DELIVERY

2020 ◽  
Vol 58 (1) ◽  
pp. 39 ◽  
Author(s):  
Ngoc Tram Nguyen Thi ◽  
Dai Hai Nguyen
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Anticancer Agents ◽  
Pore Volume ◽  
Mesoporous Silica Nanoparticles ◽  
Drug Loading ◽  
High Surface ◽  
Loading Capacity ◽  
Hollow Mesoporous Silica

Mesoporous silica nanoparticles (MSNs) have attracted significant attention from researchers thanks to their high surface area and pore volume, which can increase drug loading capacity. Moreover, MSNs, with their biocompatibility and ease of surface functionalization, are seen as potential drug delivery system. However, the loading of drug into MSNs system still needs further improvement. In this study, hollow mesoporous silica nanoparticles (HMSNs) were fabricated in order to increase the drug loading capacity of nanosilica materials. The synthesized HMSNs possessed inner hollow cores that could remarkably raise the total pore volume and thus improve the capacity for cargo loading. HMSNs were synthesized according to the hard-template method with three main steps: (1) forming of solid SiO2 nanoparticles as templates, (2) forming of core-shell structure by coating MSN layers onto the templates, and (3) forming of hollow core structure by etching away the solid template. The HMSNs product was characterized by TEM, XRD, TGA and FTIR. In addition, drug loading capacity of the material was evaluated with doxorubicin as model drug. The results indicated remarkable improvement in drug loading capacity, compared to MSN sample. Cell assays on cancer lines showed high biocompatibility. These results demonstrated the potential of HMSNs in the delivery of anticancer agents.

scholarly journals Application of mesoporous silica nanoparticles for drug delivery to cancer cells

2020 ◽  
pp. 5-15
Keyword(s):  
Drug Delivery ◽  
Drug Resistance ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Cancer Cells ◽  
Efflux Pump ◽  
Mesoporous Silica Nanoparticles ◽  
Drug Loading ◽  
Controlled Drug Release ◽  
Multi Drug Resistance

Cancer is one of the main causes of death worldwide. Chemotherapy is the most common method for cancer therapy which represent non-specific side effects on normal cells and tissues and drug resistance in cancer cells. There are two main mechanisms for Multi Drug Resistance (MDR) in cancer cells including: drug efflux pump and activation of anti-apoptotic pathways. Cancer chemotherapy disadvantages can be overcome by using nanoparticulate drug delivery systems like Mesoporous Silica Nanoparticles (MSNs) that have been used as drug delivery system since 2001. The present review included synthesis, targeted (active or passive) drug delivery to cancer cells, co-delivery of anticancer drugs and siRNA by MSNs and its toxicity. This review revealed that MSNs are good candidate for drug delivery to cancer cells due to its unique properties including: controllable pore and particle sizes, thermal and chemical stability, modifications of outer and inner surfaces of nanoparticles for drug and siRNA loading, attachment of ligand for targeted drug delivery, high drug loading capacity and controlled drug release, biocompatibility and biodegradation in aqueous medium.

Preparation of Mesoporous Silica Nanoparticles for Insulin Drug Delivery

2013 ◽  
Vol 829 ◽  
pp. 251-257 ◽  
Author(s):  
Abdollah Zakeri Siavashani ◽  
Masoume Haghbin Nazarpak ◽  
Fateme Fayyaz Bakhsh ◽  
Tayebeh Toliyat ◽  
Mehran Solati-Hashjin
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Size Distribution ◽  
Mesoporous Silica Nanoparticles ◽  
Drug Carrier ◽  
Drug Loading ◽  
Hydrothermal Process ◽  
Analytical Techniques

This study has focused on mesoporous silica nanoparticles as a drug delivery system of insulin, which was synthesized via a hydrothermal process. The morphology and composition of the silica nanoparticles were characterized by different analytical techniques such as Scanning Electron Microscope (SEM), X-Ray Diffraction Analysis (XRD), Fourier Transform Infrared spectroscopy (FTIR) and BrunauerEmmettTeller (BET). The percentage of drug loading and the in vitro drug release properties of the mesoporous silica nanoparticles in gastrointestinal tract were investigated in simulated gastrointestinal conditions by ultraviolet-visible spectroscopy. The results showed the amorphous structure of SBA-15 in mesoporous silica particles has a narrow pore size distribution. Also, particles shape was nearly wheat-like with almost homogeneous size distribution. Furthermore, it was revealed that the mesoporous silica nanoparticles have a high insulin loading and release capacity. These prominent behaviors make mesoporous silica nanoparticles promising material as a drug carrier for insulin delivery.

Sign in / Sign up

Export Citation Format

Share Document