Greater effects of high- compared with moderate-intensity interval training on thyroid hormones in overweight/obese adolescent girls

2020 ◽  
Vol 41 (4) ◽  
Author(s):  
Wissal Abassi ◽  
Nejmeddine Ouerghi ◽  
Hatem Ghouili ◽  
Salma Haouami ◽  
Anissa Bouassida
Keyword(s):  
Insulin Resistance ◽  
Body Mass ◽  
Adolescent Girls ◽  
Aerobic Capacity ◽  
Interval Training ◽  
Moderate Intensity ◽  
Model Assessment ◽  
Active Recovery ◽  
Obese Adolescent ◽  
Training Groups

AbstractObjectivesTo investigate the effects of 12-week high-intensity- (HIIT) vs. moderate-intensity-interval training (MIIT) on thyroid stimulating hormone (TSH) and thyroxine (T4) and insulin-resistance in overweight/obese adolescent girls.MethodsTwenty four adolescent girls (age 16.5±1.36 yrs) were randomly allocated into three groups: (1) HIIT (2 blocks per session of 6–8 bouts of 30 s runs at 100–110% maximal aerobic speed (MAS), with 30 s active recovery between bouts at 50% MAS; n=8), (2) MIIT (2 blocks per session of 6–8 bouts of 30 s runs at 70–80% MAS, with 30 s active recovery between bouts at 50% MAS; n=8) and (3) control group (no exercise, n=8). Each training groups engaged in three sessions per week during three months. Anthropometric parameters, aerobic capacity, homeostasis model assessment index for insulin resistance (HOMA-IR) as well as plasma TSH and T4 levels were assessed in all subjects before- and after-training.ResultsFollowing both training programs, body mass, body mass index Z-score, waist circumference and body fat decreased, while aerobic capacity increased. However, TSH and T4 concentrations decreased only after the HIIT (−30.47%, p<0.05, ES=1.42 and −12.86%, p<0.05, ES=1.18; respectively). The HOMA-IR decreased in both training groups (−26.25%, p<0.05, ES=1.87 for MIIT and −21.72%, p<0.05, ES=2.14 for HIIT).ConclusionTwelve weeks of HIIT was effective in reducing circulating TSH and T4 levels, unlike MIIT, in overweight/obese adolescent girls. These findings indicated that the stimulation of pituitary-thyroid function is more sensitive to training intensity than training duration. Further studies are needed to confirm this conclusion.

scholarly journals Sprint interval and moderate-intensity cycling training differentially affect adiposity and aerobic capacity in overweight young-adult women

2016 ◽  
Vol 41 (11) ◽  
pp. 1177-1183 ◽  
Author(s):  
Simon Higgins ◽  
Michael V. Fedewa ◽  
Elizabeth D. Hathaway ◽  
Michael D. Schmidt ◽  
Ellen M. Evans
Keyword(s):  
Body Composition ◽  
Energy Expenditure ◽  
Body Mass ◽  
Young Women ◽  
Fat Mass ◽  
Aerobic Capacity ◽  
Moderate Intensity ◽  
Similar Amount ◽  
Adult Women ◽  
Active Recovery

The purpose of the study was to examine the effects of sprint interval training (SIT) and moderate-intensity continuous cycle training (MICT), with equal estimated energy expenditure during training on body composition and aerobic capacity. Body composition measured via dual-energy X-ray absorptiometry and aerobic capacity were assessed following 6 weeks of training in previously inactive overweight/obese young women (n = 52; age, 20.4 ± 1.5 years; body mass index, 30.3 ± 4.5 kg·m−2, 67.3% white). Training was performed in a group-exercise format that mimicked cycling classes offered by commercial fitness facilities, and included 3 weekly sessions of either 30-s “all-out” sprints followed by 4 min of active recovery (SIT), or continuous cycling at 60%–70% heart rate reserve to expend a similar amount of energy. Participants were randomized to SIT or MICT, attended a similar number of sessions (15.0 ± 1.5 sessions vs. 15.8 ± 1.9 sessions, P = 0.097) and expended a similar amount of energy (541.8 ± 104.6 kJ·session−1 vs. 553.5 ± 138.1 kJ·session−1, P = 0.250). Without significant changes in body mass (P > 0.05), greater relative reductions occurred in SIT than in MICT in total fat mass (3.6% ± 5.6% vs. 0.6% ± 3.9%, P = 0.007), and android fat mass (6.6% ± 6.9% vs. 0.7% ± 6.5%, P = 0.002). Aerobic capacity (mL·kg−1·min−1) increased significantly following both interventions (P < 0.05), but the relative increase was 2-fold greater in SIT than in MICT (14.09% ± 10.31% vs. 7.06% ± 7.81%, P < 0.001). In conclusion, sprint-interval cycling reduces adiposity and increases aerobic capacity more than continuous moderate-intensity cycling of equal estimated energy expenditure in overweight/obese young women.

Interval Training with Different Intensities in Overweight/Obese Adolescent Females

2021 ◽  
Author(s):  
Wissal Abassi ◽  
Nejmeddine Ouerghi ◽  
Pantelis T. Nikolaidis ◽  
Lee Hill ◽  
Ghazi Racil ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Body Composition ◽  
Inflammatory Markers ◽  
Interval Training ◽  
Moderate Intensity ◽  
Cardiometabolic Health ◽  
Maximal Heart Rate ◽  
Active Recovery ◽  
Obese Adolescent

AbstractTo compare the effects of 12 weeks of high-intensity interval training (HIIT) versus moderate-intensity interval training (MIIT) on hematological and inflammatory markers in youth females, 38 overweight/obese females (16.4±1.0 yrs.) were randomly assigned to HIIT (2×6–8 repetitions of 30 s at 100–110% maximal aerobic speed (MAS), with 30 s active recovery between repetitions at 50% MAS; n=13), MIIT (2×6–8 repetitions of 30 s at 70–80% MAS, with 30 s active recovery between repetitions at 50% MAS; n=13), and a control group (CG, no intervention; n=12). Body composition, blood pressure, maximal heart rate, hematological and inflammatory markers (C-reactive protein [CRP], and erythrocyte sedimentation rate [ESR]) markers were assessed in all groups before and following the training program. Results revealed a significant (P<0.05) interaction effect for body composition, systolic blood pressure (SBP), MAS, maximal heart rate, and CRP. Within-group analyses for the HIIT and MIIT groups showed significant improvements in body mass (P=0.009 and P=0.025, respectively), BMI Z-score (P=0.011 and P=0.028, respectively), and MAS (P<0.001 and P=0.011, respectively). The HIIT program showed a significant decrease in body fat (P=0.002), waist circumference (P=0.002), maximal heart rate (P=0.003), SBP (P=0.001), and plasma CRP (P=0.004). In both groups, no significant changes were observed in ESR and hematological markers after intervention. No variable changed in CG. HIIT was the effective method to manage cardiometabolic health and inflammatory disorders in obese youth.

scholarly journals Early Adaptations to a Two-Week Uphill Run Sprint Interval Training and Cycle Sprint Interval Training

Sports ◽  
2018 ◽  
Vol 6 (3) ◽  
pp. 72 ◽  
Author(s):  
Mykolas Kavaliauskas ◽  
John Jakeman ◽  
John Babraj
Keyword(s):  
Body Mass ◽  
Ventilatory Threshold ◽  
Interval Training ◽  
Peak Oxygen Uptake ◽  
Time To Exhaustion ◽  
Sprint Interval Training ◽  
Adult Males ◽  
Sprint Training ◽  
Active Recovery ◽  
Training Groups

This study sought to compare early physiological and performance adaptations between a two-week cycle sprint interval training (SIT) and uphill run sprint training (UST) programs. Seventeen recreationally active adult males (age = 28 ± 5 years; body mass (BM) = 78 ± 9 kg) were assigned to either a control (n = 5), SIT (n = 6), or UST (n = 6) group. A discrete group of participants (n = 6, age = 33 ± 6 years, and body mass = 80 ± 9 kg) completed both training protocols to determine acute physiological responses. Intervention groups completed either a run or cycle peak oxygen uptake (VO2peak) test (intervention type dependent) prior to and following two weeks of training. Training comprised of three sessions per week of 4 × 30-s “all-out” sprints with a four-minute active recovery between bouts on a cycle ergometer against 7.5% of body mass in the SIT group and on a 10% slope in the UST group. The VO2peak values remained unchanged in both training groups, but time-to-exhaustion (TTE) was significantly increased only in the UST group (pre—495 ± 40 s, post—551 ± 15 s; p = 0.014) and not in the SIT group (pre—613 ± 130 s, post—634 ± 118 s, p = 0.07). Ventilatory threshold (VT) was significantly increased in both training groups (SIT group: pre—1.94 ± 0.45 L·min−1, post—2.23 ± 0.42 L·min−1; p < 0.005, UST group: pre—2.04 ± 0.40 L·min−1, post—2.33 ± 0.34 L·min−1, p < 0.005). These results indicate that UST may be an effective alternative to SIT in healthy individuals.

scholarly journals Circulating Irisin in Relation to Insulin Resistance and the Metabolic Syndrome

2013 ◽  
Vol 98 (12) ◽  
pp. 4899-4907 ◽  
Author(s):  
Kyung Hee Park ◽  
Lesya Zaichenko ◽  
Mary Brinkoetter ◽  
Bindiya Thakkar ◽  
Ayse Sahin-Efe ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Body Mass Index ◽  
Body Mass ◽  
Model Assessment ◽  
Homeostasis Model Assessment ◽  
Cvd Risk ◽  
Baseline Serum ◽  
The Metabolic Syndrome ◽  
Increased Risk

Context: Irisin, a recently identified hormone, has been proposed to regulate energy homeostasis and obesity in mice. Whether irisin levels are associated with risk of the metabolic syndrome (MetS), cardiometabolic variables, and cardiovascular disease (CVD) risk in humans remains unknown. Objective: Our objective was to assess the associations between baseline serum irisin levels and MetS, cardiometabolic variables, and CVD risk. Design, Setting, and Subjects: We conducted a comparative cross-sectional evaluation of baseline circulating levels of the novel hormone irisin and the established adipokine adiponectin with MetS, cardiometabolic variables, and CVD risk in a sample of 151 subjects. Results: Baseline irisin levels were significantly higher in subjects with MetS than in subjects without MetS. Irisin was associated negatively with adiponectin (r = −0.4, P &lt; .001) and positively with body mass index (r = 0.22, P = .008), systolic (r = 0.17, P = .04) and diastolic (r = 0.27, P = .001) blood pressure, fasting glucose (r = 0.25, P = .002), triglycerides (r = 0.25, P = .003), and homeostasis model assessment for insulin resistance (r = 0.33, P &lt; .001). After adjustment for potential confounders, including body mass index, subjects in the highest tertile of irisin levels were more likely to have MetS (odds ratio [OR] = 9.44, 95% confidence interval [CI] = 2.66–33.44), elevated fasting blood glucose (OR = 5.80, 95% CI = 1.72–19.60), high triglycerides (OR = 3.89, 95% CI = 1.16–13.03), and low high-density lipoprotein cholesterol (OR = 3.30, 95% CI = 1.18–9.20). Irisin was independently associated with homeostasis model assessment for insulin resistance and general Framingham risk profile in multiple linear regression analyses after adjustment for confounders. Adiponectin demonstrated the expected associations with outcomes. Conclusions: Irisin is associated with increased risk of MetS, cardiometabolic variables, and CVD in humans, indicating either increased secretion by adipose/muscle tissue and/or a compensatory increase of irisin to overcome an underlying irisin resistance in these subjects.

scholarly journals Insulin Resistance and Impaired Mitochondrial Function in Obese Adolescent Girls

2014 ◽  
Vol 12 (1) ◽  
pp. 56-61 ◽  
Author(s):  
Meghan J. Slattery ◽  
Miriam A. Bredella ◽  
Hena Thakur ◽  
Martin Torriani ◽  
Madhusmita Misra
Keyword(s):  
Insulin Resistance ◽  
Adolescent Girls ◽  
Mitochondrial Function ◽  
Obese Adolescent

The effects of short-term high-intensity interval training vs. moderate-intensity continuous training on plasma levels of nesfatin-1 and inflammatory markers

2015 ◽  
Vol 21 (3) ◽  
Author(s):  
Sajad Ahmadizad ◽  
Alireza Salimi Avansar ◽  
Khosrow Ebrahim ◽  
Mohsen Avandi ◽  
Mansour Ghasemikaram
Keyword(s):  
Insulin Resistance ◽  
Exercise Training ◽  
Weight Management ◽  
High Intensity ◽  
Inflammatory Markers ◽  
Interval Training ◽  
Moderate Intensity ◽  
High Intensity Interval Training ◽  
Tnf Α ◽  
High Intensity Interval

AbstractExercise training is an effective method of weight management, and knowing about its influence on the hormones involved in the regulation of food intake and inflammation could be useful for body weight management. Therefore, the purpose of this study was to compare the effects of 6 weeks of high-intensity interval training (HIIT) and moderate-intensity continuous exercise training (MCT) on nesfatin-1, interleukin (IL)-6, and tumor necrosis factor alpha (TNF-α).Thirty sedentary overweight men (Mean±SD; age, 25±1 years) were divided into three (n=10) body mass index-matched groups. The participants in the training groups performed either HIIT or MCT protocols 3 days per week for 6 weeks followed by a week of detraining.Plasma IL-6 and TNF-α did not significantly change after training, but nesfatin increased significantly only with HIIT compared with the control group (p<0.05). In addition, fasting glucose, insulin, and homeostasis model estimated insulin resistance (HOMA-IR), decreased significantly following both HIIT and MCT training (p<0.05). After a detraining period, the plasma nesfatin-1 did not return to pre-training levels in the HIIT group.Both the HIIT and MCT groups had similar effects on inflammatory markers and insulin resistance in men who are overweight, but the HIIT seems to have better anorectic effects (as indicated by nesfatin) compared with MCT.

Analysis of candidate genes in Polish families with obesity

2004 ◽  
Vol 42 (5) ◽  
Author(s):  
Malgorzata Malczewska-Malec ◽  
Iwona Wybranska ◽  
Iwona Leszczynska-Golabek ◽  
Lukasz Partyka ◽  
Jadwiga Hartwich ◽  
...  
Keyword(s):  
Risk Factors ◽  
Insulin Resistance ◽  
Insulin Sensitivity ◽  
Body Mass ◽  
Tolerance Test ◽  
Whole Body ◽  
Oral Glucose ◽  
Sensitivity Index ◽  
Model Assessment ◽  
The Metabolic Syndrome

AbstractThis study analyzes the relationship between risk factors related to overweight/obesity, insulin resistance, lipid tolerance, hypertension, endothelial function and genetic polymorphisms associated with: i) appetite regulation (leptin, melanocortin-3-receptor (MCR-3), dopamine receptor 2 (D2R)); ii) adipocyte differentiation and insulin sensitivity (peroxisome proliferator-activated receptor-γThe 122 members of 40 obese Caucasian families from southern Poland participated in the study. The genotypes were analyzed by restriction fragment length polymorphism-polymerase chain reaction (RFLP-PCR) or by direct sequencing. Phenotypes related to obesity (body mass index (BMI), fat/lean body mass composition, waist-to-hip ratio (WHR)), fasting lipids, glucose, leptin and insulin, as well as insulin during oral glucose tolerance test (OGTT) (4 points within 2 hours) and during oral lipid tolerance test (OLTT) (5 points within 8 hours) were assessed. The insulin sensitivity indexes: homeostasis model assessment of insulin resistance, whole body insulin sensitivity index, hepatic insulin sensitivity and early secretory response to an oral glucose load (HOMA-IR, ISI-COMP, ISI-HOMA and DELTA) were calculated.The single gene mutations such as CWe conclude that the polymorphisms we investigated were weakly correlated with obesity but significantly modified the risk factors of the metabolic syndrome.

scholarly journals Ethnic Variation in Fat and Lean Body Mass and the Association with Insulin Resistance

2009 ◽  
Vol 94 (12) ◽  
pp. 4696-4702 ◽  
Author(s):  
Scott A. Lear ◽  
Simi Kohli ◽  
Gregory P. Bondy ◽  
André Tchernof ◽  
Allan D. Sniderman
Keyword(s):  
Insulin Resistance ◽  
Ethnic Groups ◽  
Body Mass ◽  
Body Fat ◽  
South Asian ◽  
Lean Mass ◽  
South Asians ◽  
Model Assessment ◽  
Total Body Fat ◽  
Total Body

Context: Body fat distribution varies among different ethnic groups, yet less is known regarding differences in lean mass and how this may affect insulin resistance. Objective: Our objective was to compare total body fat to lean mass ratio (F:LM) in Aboriginal, Chinese, European, and South Asian individuals with differences in insulin resistance. Participants, Design, and Setting: Aboriginal (196), Chinese (222), European (202), and South Asian (208) individuals were recruited across a range of body mass index to participate in this cross-sectional community study. Main Outcome Measures: Total body fat, lean mass, and insulin resistance were assessed using homeostasis model assessment (HOMA). Results: After adjustment for confounders and at a given body fat, South Asian men had less lean mass than Aboriginal [3.42 kg less; 95% confidence interval (CI) = 1.55–5.29], Chinese (3.01 kg less; 95% CI = 1.33–4.70), and European (3.57 kg less; 95% CI = 1.82–5.33) men, whereas South Asian women had less lean mass than Aboriginal (1.98 kg less; 95% CI = 0.45–3.50), Chinese (2.24 kg less; 95% CI = 0.81–3.68), and European (2.97 kg less; 95% CI = 1.67–4.27) women. In adjusted models, F:LM was higher in South Asian compared with Chinese and European men and higher in South Asian compared with Aboriginal, Chinese, and European women (P &lt; 0.01 for all). Insulin and HOMA were greatest in South Asians after adjustment; however, these differences were no longer apparent when F:LM was considered. Conclusions: South Asians have a phenotype of high fat mass and low lean mass, which may account for greater levels of insulin and HOMA compared with other ethnic groups.

scholarly journals Salutary effects of high-intensity interval training in persons with elevated cardiovascular risk

F1000Research ◽  
2016 ◽  
Vol 5 ◽  
pp. 2254 ◽  
Author(s):  
Jerome L. Fleg
Keyword(s):  
Cardiovascular Risk ◽  
Aerobic Capacity ◽  
High Intensity ◽  
Interval Training ◽  
Aerobic Exercise Training ◽  
Moderate Intensity ◽  
High Intensity Interval Training ◽  
Continuous Training ◽  
Beneficial Effects ◽  
High Intensity Interval

Although moderate-intensity continuous training (MICT) has been the traditional model for aerobic exercise training for over four decades, a growing body of literature has demonstrated equal if not greater improvement in aerobic capacity and similar beneficial effects on body composition, glucose metabolism, blood pressure, and quality of life from high-intensity interval training (HIIT). An advantage of HIIT over MICT is the shorter time required to perform the same amount of energy expenditure. The current brief review summarizes the effects of HIIT on peak aerobic capacity and cardiovascular risk factors in healthy adults and those with various cardiovascular diseases, including coronary artery disease, chronic heart failure, and post heart transplantation.

scholarly journals Body Mass Index Predicts Aldosterone Production in Normotensive Adults on a High-Salt Diet

2007 ◽  
Vol 92 (11) ◽  
pp. 4472-4475 ◽  
Author(s):  
Rhonda Bentley-Lewis ◽  
Gail K. Adler ◽  
Todd Perlstein ◽  
Ellen W. Seely ◽  
Paul N. Hopkins ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Cardiovascular Disease ◽  
Body Mass Index ◽  
Body Mass ◽  
Model Assessment ◽  
High Sodium ◽  
Sodium Diet ◽  
Serum Aldosterone ◽  
Aldosterone Production ◽  
High Sodium Diet

Abstract Context: The mechanisms underlying obesity-mediated cardiovascular disease are not fully understood. Aldosterone and insulin resistance both are associated with obesity and cardiovascular disease. Objectives: The objectives of this study were to test the hypotheses that aldosterone production is elevated and associated with insulin resistance in overweight adults on a high-sodium diet. Participants/Interventions: Healthy normotensive adults were categorized as lean body mass index (BMI) less than 25 kg/m2 (n = 63) or overweight BMI 25 kg/m2 or greater (n = 57). After 7 d of a high-sodium diet, participants fasted overnight and remained supine throughout hemodynamic and laboratory assessments and angiotensin II (AngII) stimulation. Results: The overweight group, compared with the lean group, had higher 24-h urinary aldosterone (9.0 ± 0.8 vs. 6.6 ± 0.5 μg per 24 h; P = 0.003) and higher AngII-stimulated serum aldosterone (11.4 ± 1.0 vs. 9.0 ± 0.6 ng/dl; P = 0.04). There were no differences in 24-h urinary cortisol or sodium or supine measurements of plasma renin activity, serum aldosterone, or serum potassium. The homeostasis model assessment of insulin resistance was predicted by urinary aldosterone excretion (r = 0.32, P = 0.03) and serum aldosterone response to AngII stimulation (r = 0.28, P = 0.02) independent of age and BMI. Conclusion: Urinary aldosterone excretion and AngII-stimulated aldosterone are increased in overweight, compared with lean, normotensive adults. The correlation of these measures of aldosterone production with insulin resistance suggests a potential role for aldosterone in the pathophysiology of obesity-mediated insulin resistance.

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