Matriptase-2 (TMPRSS6) is directly up-regulated by hypoxia inducible factor-1: identification of a hypoxia-responsive element in the TMPRSS6 promoter region
Keyword(s):
Type Ii
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Abstract The type II transmembrane serine protease matriptase-2 (TMPRSS6) down-regulates the expression of hepcidin, the main regulator of systemic iron homeostasis, and increases in this way iron plasma levels. Matriptase-2 is up-regulated under hypoxic conditions, providing a new link between hypoxia signaling and iron homeostasis. In this study, we have characterized the TMPRSS6 promoter region and identified a functional hypoxia-responsive element (HRE). Mutations of the hypoxia inducible factor (HIF)-binding site located within the HRE abrogate HIF-1α-dependent induction of TMPRSS6 expression. The action of HIF-1α on TMPRSS6 promoter activity reveals a new regulative element for the suppression of hepcidin synthesis.
2021 ◽
Vol 22
(23)
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pp. 13046
Neuroglobin Regulates Hypoxic Response of Neuronal Cells through Hif-1α- and Nrf2-mediated Mechanism
2012 ◽
Vol 32
(6)
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pp. 1046-1060
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2006 ◽
Vol 281
(35)
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pp. 25703-25711
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2010 ◽
Vol 21
(21)
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pp. 3630-3638
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2017 ◽
Vol 8
(1)
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2004 ◽
Vol 51
(3)
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pp. 563-585
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