Versuche, sedativ-hypnotische Wirkstoffe im Hopfen nachzuweisen, II / Narcotic Action of 2-Methyl-3-butene-2-ol Contained in the Exhalation of Hops

Hops are told to promote sleep; manyfold efforts to detect the soporific principle have been unsuccessful so far. Preliminary pharmacological tests lead to the conclusion that the soporific activity of the exhalation of hops can be explained by its content of 2-methyl-3-butene-2-ol (1) in the volatile fraction. It was found that 1, when given to mices i.p. (0.80 g/kg) produces narcosis for about 8 h; no abnormal behaviour was observed there upon. Due to its water-solubility the concentration of 1 in the essential oil obtained by steam-destination is low; contrary to that, 1, is enriched in the more volatile fraction of hops.

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Physicochemical Characterization and Antinociceptive Effect of β-cyclodextrin/Lippia pedunculosa Essential Oil in Mice

Current Topics in Medicinal Chemistry ◽

10.2174/1568026618666180607081742 ◽

2018 ◽

Vol 18 (9) ◽

pp. 797-807 ◽

Cited By ~ 1

Author(s):

Paula dos Passos Menezes ◽

Francielly de Oliveira Araujo ◽

Tatianny Araujo Andrade ◽

Igor Araujo Santos Trindade ◽

Heitor Gomes de Araujo-Filho ◽

...

Keyword(s):

Essential Oil ◽

Physicochemical Properties ◽

Water Solubility ◽

Therapeutic Potential ◽

Biological Activities ◽

Antinociceptive Effect ◽

Physicochemical Characterization ◽

Good Tool ◽

Main Challenge ◽

Higher Temperature

Background: Some research studies have shown that Lippia pedunculosa essential oil (EOLP) has interesting biological activities. However, its low water solubility is the main challenge to achieve its therapeutic potential. In this context, Cyclodextrins (CDs) have been widely used in order to overcome this problem due to your capability to improve the physicochemical properties of drugs. Objective: In this perspective, the main goal of this study was to investigate how the improvement of the physicochemical properties of inclusion complexes (EOLP and β-CD) enhance the antinociceptive effect in mice. Methods: To achieve that, we prepared samples by Physical Mixture (PM), Paste Complexation (PC) and Slurry Complexation (SC) methods, followed by their physicochemical characterization. In addition, it was evaluated if the use of β-CD enhances the antinociceptive effect of EOLP in mice. Results: The analysis showed that rotundifolone (72.02%) was the major compound of EOLP and we found out based on DSC results that β-CD protected it from oxidation. In addition, TG techniques demonstrated that the best inclusion methods were PC and SC, due to their greater weight loss (10.8 and 11.6%, respectively) in the second stage (171-312°C), indicating that more complexed oil was released at the higher temperature than oil free. Other characteristics, such as changes in the typical crystalline form, and reduced particle size were observed by SEM and laser diffraction, respectively. The SC was the most effective complexation method, once the presence of rotundifolone was detected by FTIR. Based on that, SC method was used in all mice tests. In this regard, the number of paw licks was reduced for both compounds (all doses), but EOLP was more effective in reducing the nociceptive behavior. Conclusion: Therefore, CDs seem not to be a good tool to enhance the pharmacological properties of EOs rich in peroxide compounds such as rotundifolone.

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Characterization and Antioxidant Activity of Essential Oil of Four Sympatric Orchid Species

Molecules ◽

10.3390/molecules24213878 ◽

2019 ◽

Vol 24 (21) ◽

pp. 3878 ◽

Cited By ~ 2

Author(s):

Francesco Saverio Robustelli della Cuna ◽

Jacopo Calevo ◽

Elia Bari ◽

Annalisa Giovannini ◽

Cinzia Boselli ◽

...

Keyword(s):

Antioxidant Activity ◽

Essential Oil ◽

Critical Role ◽

Dimethyl Disulfide ◽

Double Bond Position ◽

Volatile Fraction ◽

Orchid Species ◽

Anacamptis Pyramidalis ◽

Volatiles Compounds ◽

Dose Dependent

The volatile fractions from fresh inflorescences of naturally growing orchids Anacamptis coriophora (L.) R. M. Bateman, Pridgeon & M. W. Chase subsp. fragrans (Pollini), Anacamptis pyramidalis (L.) R. Ophrys holosericea (Burm.) Greuter and Serapias vomeracea (Burm. f.) B. were isolated by steam distillation and analyzed by GC/FID and GC/MS. Saturated hydrocarbons were quantified as the major constituents of the volatile fraction (47.87–81.57% of the total essential oil), of which long-chain monounsaturated hydrocarbons accounted from 9.20% to 32.04% of the total essential oil. Double bond position in linear alkenes was highlighted by dimethyl disulfide derivatization and MS fragmentation. Aldehydes (from 3.45 to 18.18% of the total essential oil), alcohols (from 0.19% to 13.48%), terpenes (from 0.98 to 2.50%) and acids (0.30 to 2.57%) were also detected. These volatiles compounds may represent a particular feature of these plant species, playing a critical role in the interaction with pollinators. DPPH assay evaluating the antioxidant activity of the essential oils was carried out, showing a dose-dependent antioxidant activity.

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Volatile Composition of Jasonia glutinosa D. C.

Zeitschrift für Naturforschung C ◽

10.1515/znc-2003-11-1209 ◽

2003 ◽

Vol 58 (11-12) ◽

pp. 804-806 ◽

Cited By ~ 5

Author(s):

María Angeles González Romero ◽

Lucinda Villaescusa Castillo ◽

Ana María Díaz Lanza ◽

José María Arribas Bricio ◽

Cristina A. Soria Monzón ◽

...

Keyword(s):

Essential Oil ◽

Volatile Compounds ◽

Thermal Desorption ◽

Oil Extraction ◽

Volatile Fraction ◽

Volatile Composition ◽

Fresh Plant ◽

Direct Thermal Desorption ◽

Sample Amount

Abstract Using GC-MS the volatile composition of Jasonia glutinosa D. C., was studied by comparing two different methods for the isolation of a volatile fraction: distillation from the fresh plant in order to obtain the essential oil, and direct thermal desorption (DTD). Compared with essential oil extraction the main advantages of the DTD technique are the smaller sample amount required, and the increased range of volatile compounds which can be subsequently analysed by GC-MS.

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Essential Oils-Loaded Polymer Particles: Preparation, Characterization and Antimicrobial Property

Polymers ◽

10.3390/polym11061017 ◽

2019 ◽

Vol 11 (6) ◽

pp. 1017 ◽

Cited By ~ 14

Author(s):

Francesca Froiio ◽

Lorianne Ginot ◽

Donatella Paolino ◽

Noureddine Lebaz ◽

Abderrazzak Bentaher ◽

...

Keyword(s):

Antibacterial Activity ◽

Essential Oil ◽

Essential Oils ◽

Shelf Life ◽

Orange Juice ◽

Water Solubility ◽

Antimicrobial Property ◽

Storage Period ◽

Orange Essential Oil

In the last few years, essential oils (EOs) derived from plants have aroused great interest due to their well-known antimicrobial activity. Unfortunately, they present several limitations in their use, such as photosensitivity, temperature sensitivity, high volatility, and poor water solubility. The encapsulation technique represents a good solution to these problems and ensures protection of the functional properties of essential oils. In this work, bergamot essential oil (BEO) and sweet orange essential oil (OEO) loaded-Eudragit® RS 100 (EuRS100) nanoparticles (NPs) were prepared by using the nanoprecipitation technique. We obtained nanoparticles characterized by a mean diameter of 57 to 208 nm and a positive surface charge (39 to 74 mV). The antibacterial activity of the obtained systems against Escherichia coli was in vitro investigated. We demonstrated that both orange and bergamot essential oils were successfully encapsulated and our nanoparticles have good antibacterial activity. Finally, in order to evaluate the potential applicability of OEONps to prolong fresh orange juice shelf-life, survival of E. coli during a storage period of one week at 25 °C was investigated: Orange essential oil-loaded nanoparticles (OEONPs) have been able to prolong the orange juice shelf life.

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Antimicrobial Activity and Chemical Composition of Essential Oil of Eupatorium Glutinosum (Lam.)

Natural Product Communications ◽

10.1177/1934578x0600100811 ◽

2006 ◽

Vol 1 (8) ◽

pp. 1934578X0600100

Author(s):

Hesham R. El-Seedi

Keyword(s):

Chemical Composition ◽

Essential Oil ◽

Steam Distillation ◽

Antimicrobial Activities ◽

Plant Residue ◽

Volatile Fraction ◽

Positive Bacterium ◽

Medicinal Uses ◽

Study Support ◽

First Time

The essential oil obtained by steam distillation from the leaves and twigs of Eupatorium glutinosum Lam. (Asteraceae) showed antimicrobial activities against a Gram-positive bacterium, three Gram–negative bacteria and three fungi. The results from this study support the vernacular medicinal uses of the plant in folkloric medicine. The chemical composition of the essential oil was analysed by GC and GC-MS, resulting in the identification of 24 constituents accounting for 92.6% of the total mass. The major active component, carvacrol, was isolated using MPLC and characterized by NMR and MS analysis. β-Glucosidase-treatment of the aqueous plant residue yielded a volatile fraction that did not show antimicrobial activitiy, in which the major components were octen-3-ol and (Z)-hex-2-en-1-ol. The essential oil from the species is reported for the first time.

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Comparison of Eucalyptus cinerea Essential Oils Produced by Hydrodistillation and Supercritical Carbon Dioxide Extraction

Natural Product Communications ◽

10.1177/1934578x1100600125 ◽

2011 ◽

Vol 6 (1) ◽

pp. 1934578X1100600

Author(s):

Tavleen S. Mann ◽

Garikapati D. Kiran Babu ◽

Shailja Guleria ◽

Bikram Singh

Keyword(s):

Carbon Dioxide ◽

Supercritical Carbon Dioxide ◽

Essential Oil ◽

Major Constituent ◽

Volatile Fraction ◽

Eucalyptus Species ◽

Supercritical Carbon Dioxide Extraction ◽

Significant Difference ◽

Carbon Dioxide Extraction ◽

Supercritical Carbon

The essential oil of Eucalyptus cinerea is reported to possess a higher 1,8-cineole content than other Eucalyptus species. Variations in the quantitative and qualitative characteristics of E. cinerea oil produced by hydrodistillation (HD) and supercritical carbon dioxide extraction (SCE) techniques and a comparison between glycoside-bound and free volatile constituents produced by HD have been studied. It was found that HD produced higher oil (free volatiles) content (3.1%) as compared with SCE (1.1%), whereas bound volatiles constituted only about 0.4%. Gas chromatographic (GC) analysis of the oil samples revealed significant difference in their chemical composition. The essential oil (free volatiles) produced by HD contained 1,8-cineole (85.1%) as the major constituent, followed by α-terpineol (7.2%) and limonene (4.4%). In the bound volatile fraction produced by HD, 1,8 cineole (20.6%), α-terpineol (7.6%), p-cymene (6.3%), and limonene (4.5%) were found as major constituents. The extract produced by SCE was dominated by 1,8-cineole (70.4%), α-terpineol (8.6%), globulol (3.1%), aromadendrene (2%), citronellal (1.7%), viridiflorol (1.3%), phytol (1.1%) and terpinen-4-ol (1%). Although HD produced higher oil yields, SCE produced better extract in terms of the number of components detected.

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Optimization of the Supercritical Carbon Dioxide Separation of Bergapten from Bergamot Essential Oil

Journal of AOAC International ◽

10.5740/jaoacint.17-0190 ◽

2018 ◽

Vol 101 (1) ◽

pp. 293-297 ◽

Cited By ~ 1

Author(s):

Vincenzo Sicari

Keyword(s):

Carbon Dioxide ◽

Supercritical Carbon Dioxide ◽

Essential Oil ◽

Volatile Fraction ◽

Carbon Dioxide Separation ◽

Fractionation Tower ◽

Post Process ◽

Bergamot Oil ◽

Cold Pressed ◽

Supercritical Carbon

Abstract The possibility of following traditional cold-press extraction with the post process continuous separation of bergapten from bergamot essential oil was investigated. A fractionation tower was used in an experiment in which cold-pressed bergamot oil was extracted in a continuous countercurrent process by supercritical carbon dioxide under different conditions. Bergapten is fairly soluble in CO2 in its supercritical phase, in particular at a density of 277.90 kg⋅m–3, corresponding to a pressure of 8 MPa and temperature of 40°C. Under these conditions, an extract with 0.198% bergapten was obtained, a figure slightly below the percentage of bergapten contained in cold-pressed oil (0.21%). However, at densities below 200 kg⋅m–3, the amount of bergapten in the extracted oil was negligible. Of all tested conditions for separation, the best was found to be at a pressure of 8 MPa and temperature of 70°C, conditions under which bergapten was not detected. The results of the experiment showed that bergapten, and the non-volatile fraction in general, was extracted only in small quantities and was not extracted at all with at a CO2 pressure of 8 MPa.

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Effects on growth, essential oil content and composition of the volatile fraction of Achillea millefolium L. cultivated in hydroponic systems deficient in macro- and microelements

Scientia Horticulturae ◽

10.1016/j.scienta.2015.09.046 ◽

2015 ◽

Vol 197 ◽

pp. 329-338 ◽

Cited By ~ 9

Author(s):

Ivan Caldeira Almeida Alvarenga ◽

Paulo Fernandes Boldrin ◽

Fernanda Ventorim Pacheco ◽

Sâmia Torres Silva ◽

Suzan Kelly Vilela Bertolucci ◽

...

Keyword(s):

Essential Oil ◽

Oil Content ◽

Achillea Millefolium ◽

Volatile Fraction ◽

Hydroponic Systems

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“Gold” Pressed Essential Oil: An Essay on the Volatile Fragment from Citrus Juice Industry By-Products Chemistry and Bioactivity

BioMed Research International ◽

10.1155/2017/2761461 ◽

2017 ◽

Vol 2017 ◽

pp. 1-8 ◽

Cited By ~ 4

Author(s):

V. N. Kapsaski-Kanelli ◽

E. Evergetis ◽

A. Michaelakis ◽

D. P. Papachristos ◽

E. D. Myrtsi ◽

...

Keyword(s):

Essential Oil ◽

Volatile Fraction ◽

Asian Tiger Mosquito ◽

Phytochemical Content ◽

Water Distillation ◽

Bioactive Natural Products ◽

Asian Tiger ◽

Refinement Process ◽

Cold Pressed ◽

By Products

Present essay explores the potentials of Citrus juice industry’s by-products as alternative bioactive natural products resources. Four crude Cold Pressed Essential Oils (CPEOs), derived from orange, lemon, grapefruit, and mandarin, were studied. All CPEOs were subjected to water distillation, in order to obtain the volatile fragment, which was further fractionated with respect to distillation period in two parts, concluding to eight samples. These samples along with the four original CPEOs were assessed in relation to their phytochemical content and their repellent and larvicidal properties against Asian Tiger Mosquito. The volatiles recovery rates ranged from 74% to 88% of the CPEO. Limonene presented a significant increase in all samples ranging from 8% to 52% of the respective CPEO’s content and peaked in mandarin’s 2nd volatile fragment which comprised 97% of the essential oil. The refinement process presented clear impacts on both bioassays: a significant increase in larvicidal potency was observed, annotated best by the improvement by 1100% and 1300% of the grapefruit volatile fractions; repellence testing provided only one significant result, the decrease of landings by 50% as a response to mandarin’s second volatile fraction. The applied methodology thus may be considered for the improvement of Citrus juice industry’s by-products chemistry and bioactivity.

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