The Difference in Effect of Arabica Coffee Gayo Beans and Leaf (Coffea Arabica Gayo) Extract on Decreasing Blood Sugar Levels in Healthy Mice

BACKGROUND: High incidence rate of diabetes mellitus (DM) and increased incidence of complications from DM as well as the use of less effective antidiabetic drugs and high financing to treat demands alternative therapy. AIM: This study was conducted to determine the difference in the effect of Arabica coffee gayo bean and leaf extract on blood sugar levels in healthy mice before and after the intervention of extract and fasting and postprandial blood glucose level after consumption of glucose. METHODS: This research is an experimental research study. The study used experimental animals which were divided into 8 groups which are the control group (Aquadest), group given Acarbose, the group given the Arabica coffee gayo bean extract with dosage of 50 mg, 100 mg and 200 mg in healthy mice, the group given the Arabica coffee gayo leaf extract with dosage of 30 mg, 60 mg and 120 mg in healthy mice. RESULTS: The results of the study obtained are before and after the intervention of extract showed the difference of p= 0.523 and after consumption of glucose the fasting and postprandial result showed the difference of p = 0.005. CONCLUSION: The use of Arabica coffee gayo bean and leaf extract showed a high decrease in blood glucose levels (BGL) compared to the control group.

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Lowering blood sugar levels with kersen leaf stew (muntingia calabura l) and black onion (alium sativum) extract in mice (mus musculus)

International Journal of Advanced Nursing Studies ◽

10.14419/ijans.v9i1.30304 ◽

2020 ◽

Vol 9 (1) ◽

pp. 15

Author(s):

Eni Sumarliyah ◽

Dede Nasrullah ◽

Sukadiono . ◽

Desta Pankyano

Keyword(s):

Blood Glucose ◽

Blood Sugar ◽

Mus Musculus ◽

Intervention Group ◽

Control Group ◽

P Value ◽

Control Group Design ◽

Onion Extract ◽

The Difference ◽

Sugar Levels

Diabetes mellitus (DM) is a metabolic disease characterized by an increase in blood sugar levels. Blood sugar levels in patients with DM are mostly challenging to control, and this will threaten the occurrence of complications. Alternative therapies used are active flavonoids in reducing blood glucose. The purpose of this study was to analyze the decrease in blood sugar levels by administering cherry leaves stew and black onions to mice (mus musculus). The design of this study was the Quasy Experimental design (pretest-posttest with control group design). The sample in this study was 32 mice, 16 in the intervention group, and 16 comparison groups. There are independent variables (Kersen Leaf Stew and Black Onion Extract) and the dependent variable (Blood Glucose Level). The data were collected using an observation sheet, then analyzed using the independent sample T-test and Kolmogorov Smirnov test. The results of this study showed that the pre and post administration of cherry leaf decoction was 36.5 mg/dl, and the difference between pre and post administration of black onion extract was 24.3 mg/dl. While the analysis showed p = value 0.98, it showed no difference in the effectiveness of the two extracts in reducing blood sugar levels in mice. Obtained comparative test results from the two extracts were equally effective in lowering blood sugar in mice. Thus further research needs to be done with more samples.

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The Effects of Sambiloto Leaf Extract (Andrographis peniculata) on Blood Sugar Regulation: an In Vivo Study

Eureka Herba Indonesia ◽

10.37275/ehi.v1i1.1 ◽

2020 ◽

Vol 1 (1) ◽

pp. 1-8

Author(s):

Lusia Hayati ◽

Rachmat Hidayat

Keyword(s):

Blood Glucose ◽

Blood Sugar ◽

Leaf Extract ◽

Negative Control ◽

Control Group ◽

Diabetes Group ◽

White Rats ◽

Sugar Regulation ◽

Sugar Levels

Sambiloto (Andrographis peniculata) is one of the most common plants inIndonesia. Sambiloto contains quite varied secondary metabolites, where thisplant is rich in flavonoids, alkaloids, terpenes and glycosides. This study aimsto assess the effect of Sambiloto (Andrographis peniculata) leaf extract on bloodsugar levels and the expression of GLUT4 protein in muscle tissue whichindicates the potential of the test extract's ability to improve blood glucose intaketo cells so that it can maintain blood sugar regulation. The process of extractingsambiloto is carried out by maceration in which 500 grams of simplicia aremacerated with 96% ethanol for 72 hours. After 1 week of adaptation, the micewere randomly divided into the following six groups, each containing 5 animals:Normal control group, diabetes group (negative control), diabetes + metformingroup (Met; 45 mg/kg), Diabetes + ES group (50 mg/kg), diabetes + ES group(100 mg/kg) and diabetes + ES group (200 mg/kg). The treatment with sambilotoextract was able to reduce blood sugar levels significantly, were at the ES 100and 200 mg/kg BW doses it was able to reduce blood sugar levels to reach thetarget below 200 mg/kg BW. The dominant flavonoids in Sambiloto leaf extractare believed to be responsible for the effect of blood glucose regulation. Inconclusion, Sambiloto extract affects lowering blood sugar levels in diabetesmellitus white rats by increasing glucose intake to cells and tissues.

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UJI AKTIVITAS ANTIDIABETES KOMBINASI EKSTRAK ETANOL DAUN ECENG GONDOK (Eichhornia crassipes (Mart.)Solms) DAN DAUN SINTRONG (Crassocephalum crepidioides (Benth.) S. Moore) PADA MENCIT

Jurnal Insan Farmasi Indonesia ◽

10.36387/jifi.v4i1.602 ◽

2021 ◽

Vol 4 (1) ◽

pp. 44-53

Author(s):

Andri Priyoherianto ◽

◽

Panji Ratih Suci ◽

Putri Rizki Cahya Fatimah ◽

Atik Nur Wijayanti

Keyword(s):

Blood Glucose ◽

Blood Sugar ◽

Water Hyacinth ◽

Leaf Extract ◽

Positive Control ◽

Negative Control ◽

Glucose Levels ◽

Normal Limits ◽

Blood Glucose Levels ◽

Sugar Levels

Diabetes mellitus is a chronic metabolic disorder that occurs due to destruction of pancreatic ? cells characterized by blood glucose levels that exceed normal limits. The purpose of this study was to determine the therapeutic effect of the combination of water hyacinth leaf extract and Sintrong leaf in reducing blood glucose levels in alloxan-induced experimental animals. Water hyacinth leaf powder and Sintrong leaves were extracted using the maceration method with 70% ethanol as a solvent. A total of 25 mice were divided into 5 groups, namely negative control CMC-Na 0.5%, positive control glibenclamide 0.00065 mg / g BW, water hyacinth leaf extract 17.5 mg / kg BW, Sintrong leaf extract 10.5 mg/ kg BW and a combination of water hyacinth leaf extract 17.5 mg / kg BW and sintrong leaf 10.5 mg / kg BW. The results showed that a single extract of water hyacinth and Sintrong leaves was able to reduce blood sugar levels for 7 days. The combination dose was effective in reducing blood sugar levels with a combination dose of 17.5 mg/ kg water hyacinth leaf extract in combination for 7 days.

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THE EFFECTS OF CORN FLOUR WITH TEMPEH FLOUR SUPPLEMENTATION FEEDING IN DIABETES MELLITUS WISTAR RATS TOWARD BLOOD GLUCOSE LEVEL

Jurnal Ilmiah Kedokteran Wijaya Kusuma ◽

10.30742/jikw.v4i2.10 ◽

2017 ◽

Vol 4 (2) ◽

pp. 24

Author(s):

Fatifa Asmarani ◽

Bambang Wirjatmadi ◽

Merryana Adriani

Keyword(s):

Diabetes Mellitus ◽

Blood Glucose ◽

Blood Sugar ◽

Wistar Rats ◽

Control Group ◽

Standard Diet ◽

Corn Flour ◽

Glucose Levels ◽

Blood Glucose Levels ◽

Sugar Levels

Background: Diabetes mellitus (DM) is metabolic disorder syndrome characterized by hyperglycemia due to deficiency of insulin secretion. Patients of diabetic patients increases each year, so it needs proper handling. Corn flour is a source of carbohydrates with a low glycemic index to help reduce the rise in blood sugar levels. In addition, supplementation with tempeh flour containing isoflavones act to protect cells from free radical thereby inhibiting damage cells. Fiber in tempeh affect blood glucose levels because it slows the absorption of glucose.Objective: To determine the effect supplementation of corn flour with tempeh flour on blood sugar levels in diabetes mellitus Wistar rats.Methods: The study was true experimental design with Pre-posttest control group design, samples were 20 male Wistar rats aged 2-3 months were then divided into 4 groups (T0, T1, T2, T3.) T0 was injected with alloxan as 30 mg / 150 grams of BB rats are subsequently treated with standard diet; T1 was dministered by standard diet 50% + 50% corn flour; T2 was administered by standard diet 50% + 30% + corn flour tempeh flour 20%; and T3 was administered by standard diet of corn flour 50% + 15% + 35% tempeh flour for 2 weeks. Blood glucose levels were measured with a glucose kit (GOD FS). Research data were analyzed by One Way ANOVA followed by Tukey's Post Hoc test p-value <0.05.Results: There were significant differences on blood sugar levels in all groups (p = 0.000): control group (only dietary standards), T1 (administered by standard diet 50% + corn flour 50%), T2 (administered by a standard diet 50% + cornstarch 30% tempeh flour + 20%) and T3 (administered by standard diet of corn flour 50% + 15% + 35% tempeh flour).Conclusion: corn flour with tempeh flour supplementation effect on decresing of blood sugar levels.

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EFFECT OF HESPERETIN TREATMENT ON BLOOD GLUCOSE LEVEL, SPERMATOZOA QUALITY, AND SPERMATOZOA QUANTITY IN ALLOXAN-INDUCED DIABETIC MICE

Jurnal Kedokteran Hewan - Indonesian Journal of Veterinary Sciences ◽

10.21157/j.ked.hewan.v15i1.18406 ◽

2021 ◽

Vol 15 (1) ◽

Author(s):

Nerdy Nerdy ◽

Linta Meliala ◽

Bunga Rimta Barus ◽

Puji Lestari ◽

Selamat Ginting ◽

...

Keyword(s):

Diabetes Mellitus ◽

Blood Glucose ◽

Blood Sugar ◽

Normal Control ◽

Normal Control Group ◽

Optimum Dose ◽

Control Group ◽

Testicular Weight ◽

Significant Difference ◽

Sugar Levels

Male infertility has occurred rapidly in the last few decades, primarily in developing countries. An antioxidant, hesperetin is a flavonoid that is found in abundance in orange peels. The aims of this research were to determine the effect of hesperetin on blood sugar levels, spermatozoaquality, and spermatozoa quantity. The research structure included induction of diabetes mellitus and treatment for 8 weeks, followed bydetermination of blood sugar levels, spermatozoa quality, and spermatozoa quantity. Hesperetin has the ability to restore blood sugar levels, spermatozoa quantity, seminiferous tubules diameter, and testicular weight, volume, and germinal epithelial layer thickness with significant difference from the normal control group. Hesperetin did not fully restore spermatozoa motility, viability, and morphology with significant difference from the normal control group, nor from the positive control group. However, overall, hesperetin decreased blood glucose levels, increased spermatozoa quantity, and improved the spermatozoa quality in alloxan-induced diabetes mellitus mice. Dose-dependent activity was observed with the optimum dose at 200 mg/kg body weight.

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Pengaruh Pemberian Koro Benguk (Mucuna pruriens L) terhadap Kadar Gula Darah Tikus Diabetes Melitus yang Diinduksi Streptozotocin

Borneo Journal of Medical Laboratory Technology ◽

10.33084/bjmlt.v2i2.1386 ◽

2020 ◽

Vol 2 (2) ◽

pp. 136-140

Author(s):

Endang Widhiyastuti ◽

Mastuti Widi Lestari

Keyword(s):

Blood Glucose ◽

Blood Sugar ◽

Fasting Blood Glucose ◽

Diabetic Rats ◽

Observation Time ◽

The Body ◽

Mucuna Pruriens ◽

Control Group ◽

Sprague Dawley ◽

Sugar Levels

Diabetes which is well-known in the community as diabetes in Indonesia is a chronic disease, which occurs when the pancreas does not produce enough insulin or when the body cannot utilize the insulin produced by its own products. The Provision of antioxidants in DM mice can reduce blood sugar levels. One of the herbs that can be used for control and management of blood sugar in diabetes is swollen koro. Koro Benguk (Mucuna pruriens L) is a plant that can be used as an alternative treatment because it contains antioxidants that can maintain health without causing toxic effects. The purpose of this study was to determine whether there is an effect of giving koro benguk coffee (Mucuna pruriens L) on blood sugar levels of Streptozotocin-induced Diabetes Mellitus Rats. This study is an experimental study of Sprague Dawley mice. A total of 35 male wistar rats were divided into 5 groups each: normal control (K1); diabetes control (K2); diabetic rats were given a large coffee extract 0.63 mg / g BW rat (P1); diabetic rats were given a large infusion of coffee koro 1.26 mg / g BW rats (P2). Diabetic rats were given an infusion of coffee koro benguk20,52 mg / g BW rats. Fasting blood glucose (GDP) levels were analyzed weekly for 3 weeks using the GOD-PAP method. The results of the study showed a decrease in blood sugar for 4 times the observation time in almost all treatment groups except the positive control group. The conclusions in this study were the provision of related coffee (Mucuna pruriens L) can reduce fasting blood glucose levels in Sprague Dawley rats with diabetes models significantly compared to controls.

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Efek Hipogykemia Pemberian Ekstrak Daun Johar Pada Tikus (Mus Musculus) Yang Di Induksi Dengan Streptozotosin

Jurnal Ilmu Kesehatan ◽

10.32831/jik.v1i1.16 ◽

2017 ◽

Vol 1 (1) ◽

Author(s):

Dyah Ika Krisnawati

Keyword(s):

Blood Glucose ◽

Blood Sugar ◽

Dependent Diabetes Mellitus ◽

Control Group ◽

P Value ◽

Homogeneity Test ◽

Test Results ◽

Leaf Extracts ◽

P Values ◽

Sugar Levels

This thesis examines whether there johar leaf extracts hypoglycemic effect in mice made diabetic by induction streptozotosin. This type of research in this thesis is the experimental research, the design used was Pretest and Posttest Control Group Design. By using Federer formula, the number of samples are 24 mice were divided into 4 treatment groups: the 1st group as the control group was given CMC-na 0.5 %, the 2nd group was given a dose of 0.5 g/kgBW of johar extract / kg, the 3rd Group was given johar extract 1 g / kgBW, and the 4th group were given a dose of 2 g johar extract / kgBW. Examination of the blood glucose test was done using NESCO TEST. The results of post-treatment blood sugar outline obtained an increase in blood sugar in group 1 and group 2, while in group 3 and group 4 showed a decrease in blood sugar levels. Normality test results obtained p values> 0.05 is 1165, so it could be said to be normally distributed data. Homogeneity test results obtained p values; 0.05 is 0.106, so the data can be said to be homogeneous. Observations of blood glucose levels in all groups get p value> 0.05 that is 0.708 so it can be said from the time of reduction in blood sugar levels are not significant, while the value obtained from the group of p ;0.05 is 0.020, Its can be significant. The conclusion of this study of johar leaf extract is not so useful when given to the type of insulin-dependent diabetes mellitus.

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EFEKTIVITAS ANTIDIABETES EKSTRAK DAUN RAMBUSA (Passiflora foetida L.) PADA MENCIT (Mus musculus) DENGAN INDUKSI GLUKOSA

Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) ◽

10.22487/j24428744.2015.v1.i2.6240 ◽

2015 ◽

Vol 1 (2) ◽

pp. 99-104

Author(s):

Khildah Khaerati ◽

Ihwan Ihwan ◽

Musdalifah S Maya

Keyword(s):

Blood Sugar ◽

Leaf Extract ◽

Drug Research ◽

Negative Control Group ◽

Positive Control ◽

Negative Control ◽

Control Group ◽

Antidiabetic Drug ◽

Passiflora Foetida ◽

Sugar Levels

Passiflora foetida leaves used by the society for generations as a natural antidiabetic drug research aims to test the effectiveness of the leaf extract of Passiflora foetida with variations of a dose of 250 mg / kg, 500 mg / kg, and 750 mg / kg in lowering blood sugar levels in mice. Passiflora foetida leaves were extracted by sokhletasi method with 70% ethanol, the extract was tested on 15 mice, the test animals were randomized into 5 groups consist of negative control group given 0.5% Na-CMC, positive control group was given glibenclamide 0, 65 mg / kg, and the treatment group were given the leaf extract of Passiflorafoetida with variations of each dose of 250 mg / kg, 500 mg / kg, 750 mg / kg. To increase blood sugar levels in mice induced glucose 50%. Measurement of blood sugar levels in mice were performed using an easy touch glucometer and blood is taken via the lateral tail vein. The results showed that the percentage of blood sugar levels drop to a negative control is 13.1%, for a dose of 250 mg / kg body weight of 29.52%, for a dose of 500 mg / kg was 38.79%, to dosis750 mg / kg was 49, 21%, and 48.1% for the positive control. The results showed that the leaf extract of Passiflorafoetida at a dose of 750 mg / kg is most effective as an antidiabetic

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THE EFFECTIVENESS OF COMBINATION OF YAM BEAN AND TOMATO JUICES AGAINTS SUGAR LEVELS OF DIABETICS MILITUS PATIENTS TYPE 2

Jurnal Sehat Mandiri ◽

10.33761/jsm.v13i2.66 ◽

2018 ◽

Vol 13 (2) ◽

pp. 1-9

Author(s):

Hasneli . ◽

Andrafikar . ◽

Apreriza Putri .

Keyword(s):

Blood Sugar ◽

Metabolic Diseases ◽

Tomato Juice ◽

Primary Data ◽

Control Group ◽

Blood Levels ◽

Significant Difference ◽

Before And After ◽

Sugar Levels

ABSTRACT Diabetics militus is a group of metabolic diseases with hyperglichemic that is caused by abnormality insulin secretion, insulin works, or both of them. One of alternative for decreasing sugar levels is yam bean and tomato juices consumption. The aim of the research is to exposed the influence of yam bean juice and tomato juice againts sugar levels of diabetics militus type 2. This research is experimental study with pretes-posttest with control group design. We used purposive sampling with 18 respondenses. The primary data are intake interview, IMT measurement, and blood sugar levels. And the secondary data are the data resources about diabetics militus. Data are analyzed statically by T-test two mean differences dependent and independent with error degree 5%. The result showed that the avarage of sugar blood levels before and after intervension respectively is 287,6 mg/dl and 220,8 mg/dl. There was the significant difference between blood sugar levels before and after group cases (p<0,05). The avarages of blood sugar levels before and after intervension on control’s group respectively are 317,8 mg/dl and 331,9 mg/dl. There was no significant difference of blood sugar levels in the begining and final of control’s group (p<0,05). There was an influence of yam bean juice and tomato juice supply againts blood sugar levels at a time (p<0,05). This study is expected to suggest the people with diabetes mellitus to consume yam bean and tomato juice as an alternative way to control or to decrease blood level sugar. Key words: Yam bean and tomato juices, blood sugar levels, DM type 2

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Efektifitas Terapi Murottal Al-Quran Terhadap Kadar Gula Darah Pasien Diabetes Mellitus Tipe 2 di RSUD Dr.Rasidin Padang

Jurnal Sehat Mandiri ◽

10.33761/jsm.v15i1.215 ◽

2020 ◽

Vol 15 (1) ◽

pp. 8-17

Author(s):

Wiwi Sartika ◽

Metri Lidya ◽

Alsri Windra Doni

Keyword(s):

Diabetes Mellitus ◽

Blood Sugar ◽

Control Group ◽

Case Group ◽

Heart Attacks ◽

Before And After ◽

Sugar Levels ◽

The Stability ◽

And Control

The condition of high and uncontrolled high blood sugar levels in Diabetes Mellitus patients increases the risk of other diseases, such as; heart attacks, strokes, blindness, kidney failure, gangrene, and even death. Various studies state that there is a relationship between Murottal Al-Qur'an therapy with the stability of blood sugar. The study aims to determine the effectiveness of Murottal Al-Qur'an on Blood Sugar Levels of Diabetes Mellitus Patients in Rasyidin District Hospital, Padang City in 2019. Interventions were conducted during August until September 2019. The population was inpatients diagnosed with Type 2 DM in RSUD Dr. Rasyidin Padang at the time of the study. A sample of 32 people consisted of a case group (given Murottal Al-Quran therapy) and a control group, each with 16 people. Data collection was carried out through observation and examination of blood sugar before and after the intervention. Data were tested by paired sample T-test. The results showed that there were differences in blood sugar levels at both the case and control groups before and after the intervention. The average blood sugar level of the patient in the case group was more controlled, namely 173.94 mg / dl (GDS <200) compared to the control group, namely 226.69 mg / dl (GDS> 200 mg / dl). Murottal Al-Quran therapy can be used as an alternative to maintain blood sugar stability for people with diabetes.

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