Bone markers in children with type 1 DM

Over the period of time, human race has evolved and till date the development is going on. There is continuous civilization and change in life style of human being. Due to these changes in life style, human being is constantly struggling against the changing environmental conditions to maintain optimum health and vigor throughout the life. These changes have lead to increase in the disease burden in the society. Juvenile Diabetes is also such condition which is going to increase day by day in children. Children are the most vulnerable community in society. Juvenile diabetes (Insulin Dependent Diabetes Mellitus – IDDM/ Type 1 DM / T1DM) is the most common endocrine/metabolic disorder of childhood and adolescence. The high prevalence data of Juvenile Diabetes is also alarming. Globally, the incidence of Type 1 DM is increasing in children and youth by about 3% per annum. It is characterized by deficient insulin production and requires daily parenteral administration of insulin, otherwise may prove fatal. The cause of type 1 diabetes is not known and it is not preventable with current knowledge. So a survey of 50 diagnosed juvenile diabetes patients in Jamnagar city of Gujarat state was conducted. With this survey study an effort has been done to find out some contributory factors in the manifestation of the disease from an Ayurvedic perspective.

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Care of children with type 1 diabetes mellitus in school – An interventional study

Journal of Pediatric Endocrinology and Metabolism ◽

10.1515/jpem-2020-0334 ◽

2020 ◽

Vol 0 (0) ◽

Author(s):

Umamaheswari Gurunathan ◽

Hemchand Krishna Prasad ◽

Sherline White ◽

Bala Prasanna ◽

Thangavelu Sangaralingam

Keyword(s):

Type 1 Diabetes ◽

Education Program ◽

School Teachers ◽

Post Intervention ◽

Community Based ◽

Structured Education ◽

Type 1 Dm ◽

The Impact ◽

Determining Factor

AbstractObjectivesPaucity of data from India on care of children with Type 1 diabetes in schools. Aims: To study assess the knowledge, attitude, practices and fear of Type 1 diabetes in school teachers and to assess the impact of an educational model on the fear of teachers and care of children in Type 1 DM at school hours.MethodsA community based study, involving school teachers and the intervention being educating them about diabetes conducted. Data pertaining to basic demography, attitude of teachers towards diabetic children, Hypoglycemia fear factor survey- parent version with worries domain and preparedness of school was collected. An education program was conducted on diabetes care in children. Immediately and after three months, the proforma details and HFSP-W scores reassessed.ResultsForty two teachers (mean age: 38.7±5.4; M:F ratio 2:40) participated in the study. Post intervention, a higher willingness to have the diabetic child in class (100 vs. 57.1%; p>0.05), better support in daily care (100 vs. 92%; p>0.05), participation in sports activities (100 vs. 7.1%; p<0.05) observed. HFSP-W scores were 38.8±4.5 (pre-intervention), 22.5±4.3 (immediate post intervention) and 29.5±3.2 (at 3months) (p<0.05). To study the determinants of improvement in HFSP-W a regression analysis was performed: presence of glucometer the most likely determining factor (T=1.999, p=0.05).ConclusionThere is a significant element of fear in the minds of teachers towards hypoglycemia which improves with a structured education program.

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A literature review and meta-analysis of safety profiles of SGLT2 inhibitors in Japanese patients with diabetes mellitus

Scientific Reports ◽

10.1038/s41598-021-92925-2 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Junichi Mukai ◽

Shinya Kanno ◽

Rie Kubota

Keyword(s):

Diabetes Mellitus ◽

Meta Analysis ◽

Japanese Patients ◽

Sglt2 Inhibitors ◽

Patients With Diabetes ◽

Language Restriction ◽

Calculated Risk ◽

Favorable Safety ◽

Type 1 Dm

AbstractThe safety profiles of sodium-glucose co-transporter 2 (SGLT2) inhibitors may depend on races/ethnicities. We aimed to assess the safety profiles of SGLT2 inhibitors in Japanese patients with diabetes mellitus (DM). The electronic databases MEDLINE, CENTRAL, and Ichushi-web were searched for studies with no language restriction from their inception to August 2019. Trials were included in the analysis if they were randomized controlled trials (RCTs) comparing the effects of SGLT2 inhibitors with a placebo in Japanese patients with DM > 18 years and reporting HbA1c and at least 1 adverse event. We calculated risk ratios with 95% CIs and used a random-effects model. Of the 22 RCTs included in our review, only 1 included patients with type 1 DM. The durations of RCTs ranged between 4 and 24 weeks. In comparison with a placebo, SGLT2 inhibitors were associated with similar risks of hypoglycemia, urinary tract infection, genital infection, hypovolemia, and fracture. The outcomes of treatment with SGLT2 inhibitors among Japanese patients with DM suggest favorable safety profiles. However, further evidence from studies with a longer duration, involving more diverse populations, such as patients with different types of DM, or including individual SGLT2 inhibitors is needed to resolve the limitations of the present study.

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Metabolic bone markers can be related to preserved insulin secretion in children with newly diagnosed type 1 diabetes

Pediatric Endocrinology Diabetes and Metabolism ◽

10.5114/pedm.2020.94391 ◽

2020 ◽

Vol 26 (1) ◽

pp. 10-16

Author(s):

Małgorzata Szymańska ◽

Izabela Michałus ◽

Marcin Kaszkowiak ◽

Krystyna Wyka ◽

Danuta Chlebna-Sokół ◽

...

Keyword(s):

Type 1 Diabetes ◽

Insulin Secretion ◽

Bone Markers ◽

Newly Diagnosed ◽

Metabolic Bone

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Simultaneous Juvenile Idiopathic Arthritis and Diabetes Mellitus Type 1 — A Finnish Nationwide Study

The Journal of Rheumatology ◽

10.3899/jrheum.110654 ◽

2011 ◽

Vol 39 (2) ◽

pp. 377-381 ◽

Cited By ~ 12

Author(s):

HEINI POHJANKOSKI ◽

HANNU KAUTIAINEN ◽

MATTI KORPPI ◽

ANNELI SAVOLAINEN

Keyword(s):

Diabetes Mellitus ◽

Juvenile Idiopathic Arthritis ◽

Autoimmune Disease ◽

Diabetes Mellitus Type 1 ◽

Diabetes Mellitus Type ◽

Laboratory Findings ◽

Type 1 Dm ◽

Psychiatric Problems ◽

Rheumatoid Factor Seropositivity

Objective.To describe the occurrence and main clinical and laboratory findings of patients having both juvenile idiopathic arthritis (JIA) and diabetes mellitus type 1 (DM-1) in a period of 30 years.Methods.Eighty-two patients having simultaneous JIA and DM-1 were identified in the reimbursement registers of the Finnish National Institute of Insurance during the period 1976–2005. Data on their clinical histories were collected from patient files.Results.Occurrence of simultaneous JIA and DM-1 increased 4.5-fold between the first (1976-85) and the last (1996–2005) decade. Prevalence of uveitis was 7%, of rheumatoid factor seropositivity 15%; 22% of patients had a third autoimmune disease [autoimmune disease (AID)], and 16% had serious psychiatric problems.Conclusion.The occurrence of patients with the 2 diseases, JIA and DM-1, increased over 3 decades. The prevalence of uveitis was low, the number of seropositive patients was high, and further cases of AID were frequent. Patients had multiple additional problems necessitating multiprofessional care.

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Autoimmune thyroid disease in patients with anti-GAD positive type 1 diabetes mellitus

Open Medicine ◽

10.2478/s11536-009-0080-z ◽

2009 ◽

Vol 4 (4) ◽

pp. 415-422

Author(s):

Kamile Gul ◽

Ihsan Ustun ◽

Yusuf Aydin ◽

Dilek Berker ◽

Halil Erol ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 1 Diabetes ◽

Type 1 Diabetes Mellitus ◽

Statistical Significance ◽

Control Group ◽

Acid Decarboxylase ◽

Thyroid Peroxidase ◽

The Difference ◽

Type 1 Dm

AbstractThe aim of the study was to determine the frequency and titers of anti-thyroid peroxidase (Anti-TPO), anti-thyroglobulin (Anti-TG), and anti-glutamic acid decarboxylase (Anti-GAD) antibodies in Turkish patients with type 1 diabetes mellitus (DM), and to compare the frequency of anti-TPO and anti-TG titers in the presence or absence of anti-GAD. A total of 104 patients including 56 males and 48 females with type 1 DM and their age-, gender-, and body mass index-matched control group, including 31 males and 27 females, 58 cases in total with an age range of 15-50 years, were recruited into this study. In patients with type 1 DM, positive anti-GAD was detected in 30.8% (n=32). In patients with positive anti-GAD, rate of positive anti-TPO was 37.5%; however, in patients with negative anti-GAD, the rate of positive anti-TPO was 9.7% and the difference was statistically significant (p=0.001). In patients with positive anti-GAD, the rate of positive anti-TG was 18.8%. In patients with negative anti-GAD, the rate of positive anti-TG was 2.8%, and the difference between them was statistically significant (p=0.005). In patients with positive and negative anti-GAD, rates of both positive anti-TPO and anti-TG were 15.6% and 1.4%, respectively, with the difference showing statistical significance (p=0.004). Thyroid autoimmunity in type 1 DM patients with positive anti-GAD was apparently higher; therefore, these patients should be followed more frequently and carefully.

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Sa406 PREDICTING POST-PRANDIAL GLYCEMIA FROM GASTRIC EMPTYING IN TYPE 1 DM PATIENTS

Gastroenterology ◽

10.1016/s0016-5085(21)01888-6 ◽

2021 ◽

Vol 160 (6) ◽

pp. S-496

Author(s):

Brototo Deb ◽

Armando Manduca ◽

Yogish C. Kudva ◽

Adil E. Bharucha

Keyword(s):

Gastric Emptying ◽

Type 1 Dm

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