Contributory factors in Juvenile Diabetes manifestation from Ayurvedic View - A Cohort Survey

2017 ◽  
Vol 2 (3) ◽  
Author(s):  
Hetal S. Gusai ◽  
V. K. Kori ◽  
Rajagopala S. ◽  
K. S. Patel ◽  
Ronakgiri V. Gosai
Keyword(s):  
Life Style ◽  
Current Knowledge ◽  
Juvenile Diabetes ◽  
Survey Study ◽  
Dependent Diabetes Mellitus ◽  
Childhood And Adolescence ◽  
Human Being ◽  
Contributory Factors ◽  
Type 1 Dm

Over the period of time, human race has evolved and till date the development is going on. There is continuous civilization and change in life style of human being. Due to these changes in life style, human being is constantly struggling against the changing environmental conditions to maintain optimum health and vigor throughout the life. These changes have lead to increase in the disease burden in the society. Juvenile Diabetes is also such condition which is going to increase day by day in children. Children are the most vulnerable community in society. Juvenile diabetes (Insulin Dependent Diabetes Mellitus – IDDM/ Type 1 DM / T1DM) is the most common endocrine/metabolic disorder of childhood and adolescence. The high prevalence data of Juvenile Diabetes is also alarming. Globally, the incidence of Type 1 DM is increasing in children and youth by about 3% per annum. It is characterized by deficient insulin production and requires daily parenteral administration of insulin, otherwise may prove fatal. The cause of type 1 diabetes is not known and it is not preventable with current knowledge. So a survey of 50 diagnosed juvenile diabetes patients in Jamnagar city of Gujarat state was conducted. With this survey study an effort has been done to find out some contributory factors in the manifestation of the disease from an Ayurvedic perspective.

scholarly journals Genetic susceptibility to type 1 diabetes mellitus in humans

2007 ◽  
pp. 255-266
Author(s):  
D Kantárová ◽  
M Buc
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Current Knowledge ◽  
Insulin Dependent Diabetes Mellitus ◽  
Dependent Diabetes Mellitus ◽  
Immune Mediated ◽  
Insulin Dependent ◽  
Genetically Determined

Type 1 diabetes mellitus (DM 1A) is an autoimmune disease belonging to the most frequent chronic diseases of the childhood and young adults. DM 1A results from immune-mediated destruction of the insulin-producing beta cells of the pancreas. It is a genetically determined disease and many genes or genetic regions were found to be associated with its induction. In addition to the insulin-dependent diabetes mellitus 1 (IDDM1) gene, which marks the HLA region, and IDDM2 which marks the insulin gene, significant associations of DM 1A to other IDMM genes or genetic regions we reported. We shortly review recent achievements in the field, and the state of current knowledge.

Wolfram-like syndrome – another face of a rare disease in children

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Mariusz Smetek ◽  
Karolina Gadzalska ◽  
Paulina Jakiel ◽  
Julia Grzybowska ◽  
Malgorzata Mysliwiec ◽  
...  
Keyword(s):  
De Novo ◽  
Insulin Dependent Diabetes Mellitus ◽  
Wolfram Syndrome ◽  
Dependent Diabetes Mellitus ◽  
Single Mutation ◽  
Pathogenic Variants ◽  
Ophthalmologic Examination ◽  
Insulin Dependent ◽  
Type 1 Dm

Abstract Objectives The presence of two pathogenic variants in the WFS1 gene leads to the occurrence of a rare genetic disease in children – Wolfram syndrome (WFS), which includes insulin-dependent diabetes mellitus (DM), optic atrophy (OA), diabetes insipidus (DI), and deafness (D). However, the presence of a single mutation in the WFS1 gene results in a number of other autosomal dominant inherited diseases, including Wolfram-like syndrome (WFS-like). Case presentation A 10-year-old boy was referred to the Genetic Outpatient Clinic with suspected WFS based on the coexistence of D, type 1 DM, short stature, and abnormalities in ophthalmologic examination (astigmatism and OA due to the optical coherence tomography result). The genetic analysis did not confirm WFS syndrome in the boy but identified a single likely pathogenic de novo variant in the WFS1 gene, which confirmed WFS-like syndrome. Conclusions Currently, the patient is under the care of an endocrinologist, diabetologist, ophthalmologist, audiologist, and also psychologist because of mood disorders.

Bone markers in children with type 1 DM

2014 ◽  
Author(s):  
Abdussalam Elshakmak ◽  
Nuri Shembesh ◽  
Najwa Ali ◽  
Najat Mazig
Keyword(s):  
Bone Markers ◽  
Type 1 Dm

118-LB: Glucose Variability throughout the Menstrual Cycle on Closed-Loop Control in Type 1 DM

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 118-LB
Author(s):  
CAROL J. LEVY ◽  
GRENYE OMALLEY ◽  
SUE A. BROWN ◽  
DAN RAGHINARU ◽  
YOGISH C. KUDVA ◽  
...  
Keyword(s):  
Menstrual Cycle ◽  
Closed Loop ◽  
Glucose Variability ◽  
Closed Loop Control ◽  
Loop Control ◽  
Type 1 Dm

The pseudomalachite-ludjibaite-reichenbachite conundrum: OD description

2019 ◽  
Vol 57 (5) ◽  
pp. 571-581
Author(s):  
Emil Makovicky
Keyword(s):  
Crystal Structures ◽  
Current Knowledge ◽  
The Other ◽  
Crystal Chemical ◽  
Layer System ◽  
Coordination Polyhedra

Abstract Crystal structures of the three polymorphs of Cu5(PO4)2(OH)4, namely pseudomalachite, ludjibaite, and reichenbachite, can be described as being composed of rods perpendicular to their crystal-chemical layering. Two different sorts of rods can be defined. Type 1 rods share rows of Cu coordination polyhedra, forming a series of slabs. Slab boundaries and slab interiors represent alternating geometric OD layers of two kinds, with layer symmetries close to P21/m and , which make up two different stacking schemes of geometric OD layers in the structures of ludjibaite and pseudomalachite. Such OD layers, however, are not developed in reichenbachite. Type 2 rods are defined as having columns of PO4 tetrahedra in the corners of the rods. In the Type 2 slabs composed of these rods, geometric Pg OD layers of glide-arrayed tetrahedra alternate with more complex OD layers; in ludjibaite this system of layers is oriented diagonally with respect to the Type 1 OD layer system. Two different OD stackings of Type 2 OD layers form the ludjibaite and reichenbachite structures but not that of pseudomalachite. Thus, ludjibaite might form disordered intergrowths with either of the other two members of the triplet but reichenbachite and pseudomalachite should not form oriented intergrowths. Current knowledge concerning formation of the three polymorphs is considered.

Care of children with type 1 diabetes mellitus in school – An interventional study

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Umamaheswari Gurunathan ◽  
Hemchand Krishna Prasad ◽  
Sherline White ◽  
Bala Prasanna ◽  
Thangavelu Sangaralingam
Keyword(s):  
Type 1 Diabetes ◽  
Education Program ◽  
School Teachers ◽  
Post Intervention ◽  
Community Based ◽  
Structured Education ◽  
Type 1 Dm ◽  
The Impact ◽  
Determining Factor

AbstractObjectivesPaucity of data from India on care of children with Type 1 diabetes in schools. Aims: To study assess the knowledge, attitude, practices and fear of Type 1 diabetes in school teachers and to assess the impact of an educational model on the fear of teachers and care of children in Type 1 DM at school hours.MethodsA community based study, involving school teachers and the intervention being educating them about diabetes conducted. Data pertaining to basic demography, attitude of teachers towards diabetic children, Hypoglycemia fear factor survey- parent version with worries domain and preparedness of school was collected. An education program was conducted on diabetes care in children. Immediately and after three months, the proforma details and HFSP-W scores reassessed.ResultsForty two teachers (mean age: 38.7±5.4; M:F ratio 2:40) participated in the study. Post intervention, a higher willingness to have the diabetic child in class (100 vs. 57.1%; p>0.05), better support in daily care (100 vs. 92%; p>0.05), participation in sports activities (100 vs. 7.1%; p<0.05) observed. HFSP-W scores were 38.8±4.5 (pre-intervention), 22.5±4.3 (immediate post intervention) and 29.5±3.2 (at 3months) (p<0.05). To study the determinants of improvement in HFSP-W a regression analysis was performed: presence of glucometer the most likely determining factor (T=1.999, p=0.05).ConclusionThere is a significant element of fear in the minds of teachers towards hypoglycemia which improves with a structured education program.

scholarly journals A literature review and meta-analysis of safety profiles of SGLT2 inhibitors in Japanese patients with diabetes mellitus

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Junichi Mukai ◽  
Shinya Kanno ◽  
Rie Kubota
Keyword(s):  
Diabetes Mellitus ◽  
Meta Analysis ◽  
Japanese Patients ◽  
Sglt2 Inhibitors ◽  
Patients With Diabetes ◽  
Language Restriction ◽  
Calculated Risk ◽  
Favorable Safety ◽  
Type 1 Dm

AbstractThe safety profiles of sodium-glucose co-transporter 2 (SGLT2) inhibitors may depend on races/ethnicities. We aimed to assess the safety profiles of SGLT2 inhibitors in Japanese patients with diabetes mellitus (DM). The electronic databases MEDLINE, CENTRAL, and Ichushi-web were searched for studies with no language restriction from their inception to August 2019. Trials were included in the analysis if they were randomized controlled trials (RCTs) comparing the effects of SGLT2 inhibitors with a placebo in Japanese patients with DM > 18 years and reporting HbA1c and at least 1 adverse event. We calculated risk ratios with 95% CIs and used a random-effects model. Of the 22 RCTs included in our review, only 1 included patients with type 1 DM. The durations of RCTs ranged between 4 and 24 weeks. In comparison with a placebo, SGLT2 inhibitors were associated with similar risks of hypoglycemia, urinary tract infection, genital infection, hypovolemia, and fracture. The outcomes of treatment with SGLT2 inhibitors among Japanese patients with DM suggest favorable safety profiles. However, further evidence from studies with a longer duration, involving more diverse populations, such as patients with different types of DM, or including individual SGLT2 inhibitors is needed to resolve the limitations of the present study.

Sign in / Sign up

Export Citation Format

Share Document