scholarly journals Evaluation of gingival and periodontal status in obese and non-obese type II diabetic patients – a cross sectional study

2020 ◽  
Author(s):  
Kenniayan Kumar SriChinthu ◽  
Velusamy Pavithra ◽  
G.S. Kumar ◽  
Harikrishnan Prasad ◽  
Perumal Prema ◽  
...  
Keyword(s):  
Diabetic Group ◽  
Obese Group ◽  
Diabetic Patients ◽  
Type Ii ◽  
Gingival Index ◽  
Periodontal Status ◽  
Periodontal Index ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

Objective. The aim of this study was to evaluate gingival and periodontal status in obese and non-obese type II Diabetic Patients. Methods. The study population comprised of 75 subjects visiting the outpatient department of our institution, divided into three different groups, group 1 (obese diabetic), group 2 (non-obese diabetic), and group 3 (obese, non-diabetic). Diabetic status was assessed with HbA1c values and obesity status was assessed by body mass index (BMI) score greater than or equal to 30 kg/m2. Gingival and periodontal status were assessed using the Gingival Index (GI) and Community Periodontal Index (CPI) respectively. Results. The mean gingival index score in group 1, group 2, and group 3 were 1.58, 1.54, and 1.25, respectively. Gingival status was poor among obese and non-obese diabetic subjects [Groups  1 & 2] when compared with obese non-diabetic patients [Group – 3]. The periodontal status showed that periodontal pockets  were increased in diabetic obese group (15.4%), followed by diabetic non obese (4.66%), and non-diabetic obese (2%) group respectively and loss of attachment was severe in diabetic obese group (60.7%), followed by diabetic non obese (45.9%) and non-diabetic obese (15.3%) respectively. Conclusion. Gingival and periodontal status was poor in the obese diabetic group compared to non-obese diabetic and obese non diabetic group. Hence, the risk of gingivitis and periodontitis in obese diabetic patients should be addressed earlier to prevent further complications and achieve a good oral health status.

scholarly journals The Threshold of Admission Glycemia as a Predictor of Adverse Events in Diabetic and Non-Diabetic Patients with Acute Coronary Syndrome

2009 ◽  
Vol 3 ◽  
pp. CMC.S2289 ◽  
Author(s):  
Taysir S. Garadah ◽  
Salah Kassab ◽  
Qasim M. Al-Shboul ◽  
Abdulhai Alawadi
Keyword(s):  
Acute Coronary Syndrome ◽  
Adverse Events ◽  
Diabetic Patients ◽  
Stress Hyperglycemia ◽  
Coronary Syndrome ◽  
History Of ◽  
Group 3 ◽  
Group 2 ◽  
High Level ◽  
Group 1

Recent studies indicated a high prevalence of hyperglycemia in non-diabetic patients presenting with acute coronary syndrome (ACS). However, the threshold of admission glucose (AG) as a predictor of adverse events in ACS is unclear. Objective The aim of this study was to assess the threshold of admission glucose (AG) as a predictor of adverse events including Major Acute Cardiac Events (MACE) and mortality, during the first week of admitting patients presenting with ACS. Material and Methods The data of 551 patients with ACS were extracted and evaluated. Patients were stratified according to their blood glucose on admission into three groups: group 1: <7 mmol/L (n = 200, 36.3%) and group 2: >7 mmol/L and <15 mmol/L (n = 178, 32.3%) and group 3: ≥15 mmol/L (n = 173, 31.4%). Stress hyperglycemia was arbitrarily defined as AG levels > 7 mmol/L (group 2 and 3). Patients with ACS were sub-divided into two groups: patients with unstable angina (UA, n = 285) and those with ST segment elevation myocardial Infarction (STEMI, n = 266) and data were analyzed separately using multiple regression analysis. Results The mean age of patients was 59.7 ± 14.8 years and 63% were males. The overall mortality in the population was 8.5% (5.4% in STEMI and 3.1% in UA) patients. In STEMI patients, the odds ratio of stress hyperglycemia as predictor of mortality in group 3 compared with group 1 was 3.3 (CI 0.99-10.98, P < 0.05), while in group 2 compared with group 1 was 2.4 (CI: 0.75-8.07, P = 0.065) after adjustment for age and sex. Similarly, in UA patients, the odds ratio of stress hyperglycemia in group 3 compared with group 1 was 2.7 (CI 0.37-18.98, P < 0.05), while in group 2 compared with group 1 was 2.4 (CI: 0.4-15.2, P = 0.344) after adjustment for age and sex. The incidence of more than 2 MACE in both STEMI and UA patients was higher in group 3 compared with the other two groups. Regression analysis showed that history of DM, high level of LDL cholesterol, high level of HbA1c, and anterior infarction were significant predictors of adverse events while other risk factors such as BMI, history of hypertension and smoking were of no significance. Conclusion This study indicates that the stress hyperglycemia on admission is a powerful predictor of increased major adverse events and hospital mortality in patients with acute coronary syndrome.

scholarly journals Estimation of Micronutrients (Magnesium and Iron) in Periodontitis Patients with and without Type-2 Diabetes Mellitus

2021 ◽  
Vol 10 (22) ◽  
pp. 1645-1649
Author(s):  
Pallavi Samatha Yalamanchili ◽  
Nirupa Elisetti ◽  
Janaki Kesipeddy ◽  
Bilwa Bindu A ◽  
Bhagyasree Vegunta
Keyword(s):  
Diabetes Mellitus ◽  
Statistical Significance ◽  
Serum Magnesium ◽  
Serum Levels ◽  
Diabetic Patients ◽  
Healthy Controls ◽  
Type Ii ◽  
Group I ◽  
Group 3 ◽  
Group 2

BACKGROUND The focus of this study was to assess the relationship of nutrients (magnesium, iron) in periodontitis and diabetic patients. Serum magnesium (Mg) and iron (Fe) levels were evaluated in periodontitis patients and were compared between diabetic patients with periodontitis and healthy controls. METHODS Total sixty subjects (18 females and 42 males) were recruited in this cross-sectional study and were divided into three groups - Group I (healthy subjects), Group II (chronic generalized periodontitis), Group III (Type II diabetes mellitus and chronic generalized periodontitis). Loe and Silness gingival index and probing pocket depth were used for categorizing chronic generalized periodontitis patients. Serum levels of magnesium and iron were estimated and then compared among the groups. Statistical analysis was done using one-way analysis of variance (ANOVA) and Newmann-Keuls multiple post-hoc procedures. Statistical significance was accepted for P ≤ 0.05. RESULTS Mean serum levels of magnesium (Mg) were 0.89 in Group 3 (Type II DM + CGP), 1.01 in Group 2 (CGP) against 1.52 in Group 1 (Control), which were statistically significant. Mean Iron (Fe) levels showed 165.56 in Group 3 (Type II DM + CGP), 137.77 in Group 2 (CGP) against 78.17 (Control) which is also statistically significant. CONCLUSIONS In this study, we found statistically significant decrease in magnesium and increase in serum iron levels in Group 3 (Type II DM + CGP) compared to Group 2 (CGP) and healthy controls. These findings suggest that trace elements also play an important role in the progression of periodontal disease. KEY WORDS Chronic Periodontitis, Diabetes Mellitus, Iron, Magnesium

scholarly journals Estimation and correlation of serum and salivary glucose and immunoglobulin A levels and salivary candidal carriage in diabetic and non-diabetic patients

2020 ◽  
Vol 14 (4) ◽  
pp. 206-213
Author(s):  
Shruthi S Hegde ◽  
Atul P Sattur ◽  
Anil Bapu Bargale ◽  
Gayathri S Rao ◽  
Rajeeth S Shetty ◽  
...  
Keyword(s):  
Oral Candidiasis ◽  
Agar Plate ◽  
Serum Glucose ◽  
Diabetic Patients ◽  
Salivary Iga ◽  
Glucose Levels ◽  
Serum Iga ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

Background. A correlation has been noted between diabetes mellitus (DM) and changes in the oral cavity. The present study aimed to estimate, compare, and correlate serum and salivary glucose and IgA levels and salivary candidal carriage in diabetic and non-diabetic individuals. Methods. Eighty-eight subjects were categorized into three groups: group 1 (controlled DM; n=27), group 2 (uncontrolled DM; n=32) and group 3 (non-diabetics; n=29). Serum and salivary glucose levels were estimated by glucose oxidase/peroxidase method, serum and salivary IgA by a diagnostic kit, and candidal colonization by inoculating samples into Sabouraud dextrose agar plate. Statistical analyses were carried out by one-way ANOVA, post hoc Tukey tests, and Pearson’s correlation coefficient. Results. Significant elevation of serum IgA levels was observed in group 2 compared to group 3 and significant decreases in salivary IgA levels in groups 1 and 2. The candidal carriage was significantly higher in group 2 compared to group 3. Serum glucose and salivary IgA levels showed a significant correlation in group 1. There was a positive correlation between serum/ salivary glucose and serum/salivary IgA levels in group 2. In addition, there was a significant correlation between serum glucose and serum IgA levels in group 3. Conclusion. Saliva could be a potential, non-invasive diagnostic tool to estimate glucose levels. The evaluation of salivary components, like IgA, might be useful in diagnosing and managing oral manifestations in diabetic individuals. Elevated salivary glucose levels contribute to elevated candidal carriage, making individuals susceptible to oral candidiasis.

scholarly journals Increased serum interleukin-9 and interleukin-1β are associated with depression in type 2 diabetes patients

2020 ◽  
Vol 78 (5) ◽  
pp. 255-261 ◽  
Author(s):  
Prabhat VARSHNEY ◽  
Rizwana PARVEEN ◽  
Mohd Ashif KHAN ◽  
Sunil KOHLI ◽  
Nidhi B. AGARWAL
Keyword(s):  
Quality Of Life ◽  
Positive Association ◽  
Diabetic Patients ◽  
Serum Samples ◽  
Type 2 Diabetic Patients ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

ABSTRACT Background: Co-morbid diabetes and depression are prevalent chronic conditions negatively affecting quality of life (QoL). Inflammation has been considered as an integral mechanism in patients with both diabetes and depression. Objective: The aim of the present study was to investigate depression and its association with interleukins (IL)-1β and IL-9 in type 2 diabetic patients (T2DM) and controls. The QoL in diabetic patient was also assessed. Methods: Eighty subjects were included, distributed among three groups: Group 1 - Healthy controls; Group 2 - T2DM patients without depression; Group 3 - T2DM patients with depression. Depression and QoL were assessed using Patient Health Questionnaire (PHQ-9) and The Audit of Diabetes-Dependent QoL (ADDQoL), respectively. IL-1β and IL-9 were measured in serum samples of all the patients using ELISA kit. Results: The PHQ score in the Group 3 was significantly higher as compared to Group 1. The ADDQoL scores in the Group 3 were significantly higher as compared to Group 2. Levels of IL-9 and IL-1β were elevated in Group 3, as compared to the other groups. Conclusion: This study showed positive association between depression and IL-1β, IL-9 in T2DM patients. Additionally, the diabetic patients have poorer quality of life, which is further worsened by the presence of depression. Thus, routine assessment for the presence of depression is suggested in T2DM patients.

scholarly journals Distress and Quality of Life among Type II Diabetic Patients: Role of physical activity

2021 ◽  
Vol 16 (1) ◽  
pp. 64-74
Author(s):  
Devaraju Kadari ◽  
Gadiraju Padmaja ◽  
Binod Rajak
Keyword(s):  
Quality Of Life ◽  
Physical Activity ◽  
Diabetes Management ◽  
Diabetic Patients ◽  
Type Ii ◽  
Snowball Sampling ◽  
Type Ii Diabetics ◽  
Group 2 ◽  
Group 1

This study measures the distress and Quality of Life (QoL) among people with type II diabetics in relation to physical exercise.  The study was conducted using diabetic participants chosen from various hospitals, aerobic centres, playgrounds and gyms in the city of Hyderabad in India.  The participants were divided into two groups – group 1 comprising people who did not adopt physical activity as part of their diabetes management strategy and group 2 comprising people who engaged in physical activity. A quasi-experimental study was performed on both groups employing purposive and snowball sampling methods. Pearson r showed that distress is negatively correlated with QoL among type II diabetics in both groups. Independent t-test indicated that participants in group 2 showed better QoL and lower levels of distress compared to their counterparts in group 1.

scholarly journals ROLE OF METFORMIN ON CLOZAPINE INDUCED DYSLIPIDAEMIA IN WISTAR RATS

2018 ◽  
pp. 1-5
Author(s):  
Syed Shoib Md Hussaini ◽  
Akram A Naikwadi ◽  
Narsapur VU
Keyword(s):  
Diabetes Mellitus ◽  
Metabolic Syndrome ◽  
Type Ii Diabetes ◽  
Wistar Rats ◽  
Type Ii Diabetes Mellitus ◽  
Type Ii ◽  
Metabolic Derangement ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

Background: The clinical research in past decade has reported that most second-generation antipsychotics (SGAs) can cause serious metabolic derangement, which substantially increases the risk for type II diabetes mellitus. Several retrospective studies have shown increased in serum triglyceride in patients treated with Clozapine. SGAs induced metabolic syndrome is characterized by weight gain, hyperglycaemia, hypertension, hyperlipidaemia, glucose intolerance and insulin resistance. Metformin is currently used to treat metabolic syndrome and type II diabetes mellitus. It is therefore important to determine whether Metformin is efficacious in treating Clozapine-induced metabolic derangement like dyslipidaemia. Objectives: To evaluate the effect of Metformin in minimizing Clozapine induced metabolic derangement like dyslipidaemia. Methodology: Wistar rats weighing 180-240g either sex were divided into 3 groups of 6 rats each. Group 1 served as control, Group 2 Treated with Clozapine 25mg/kg body weight and Group 3 Treated with Clozapine 25mg + Metformin 100mg/kg body weight for 28 days P.O. Group 2 and group 3 were treated for 28 days. Biochemical investigations: Retro-orbital blood was collected for Lipid profile. Result: Lipid profile of group 2 rats treated with Clozapine showed dyslipidaemia (TG 103.3 ±1.7mg/dl, Tc 113.7 ±1.6mg/dl). Whereas group 3 rats treated with Clozapine 25mg + Metformin showed normal lipid levels (TG 94.7±1.7mg/dl, TC 102.8 ±0.8 mg/dl) comparable to group 1(TG 93.0 ±2.6mg/dl, TC 103.7 ±1.5mg/dl). Conclusion: This study exploring the use of Metformin to prevent metabolic derangement like dyslipidaemias in patients of schizophrenia treated with Clozapine. KEYWORDS: Clozapine; Metformin; Dyslipidaemia.

Oral and Nasal Malodor in Patients with and without Cleft Lip and Palate Who Had Undergone Orthodontic Therapy

2008 ◽  
Vol 45 (5) ◽  
pp. 481-484 ◽  
Author(s):  
Cenk Doruk ◽  
Fırat Öztürk ◽  
Hakan Özdemir ◽  
Ruhi Nalçaci
Keyword(s):  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Therapy Group ◽  
Plaque Index ◽  
Gingival Index ◽  
Oral Malodor ◽  
Orthodontic Therapy ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

Objective: To compare oral and nasal malodor in patients with and without cleft lip and palate (CLP) who had undergone orthodontic therapy. Setting: University of Cumhuriyet, Sivas, Turkey. Patients: The study included 33 patients. Group 1 was composed of 11 patients with CLP. Measurements were taken while they were undergoing treatment with orthodontic fixed appliances. Group 2 included 11 individuals without CLP; measurements were taken during fixed orthodontic therapy. Group 3 consisted of 11 individuals without CLP who did not receive orthodontic therapy. Intervention: Oral malodor, nasal malodor, Gingival Index, Plaque Index, and probing depths were evaluated in each group. Results: Plaque Index, Gingival Index, and probing depths showed no significant differences between groups 1 and 2. In contrast, oral malodor was significantly different between the two groups (p < .05). Groups 2 and 3 showed differences in gingival and plaque indices but not in probing depths and oral malodor. All healthy nostrils in Group 1, Group 2, and Group 3 were significantly different from affected nostrils in the CLP patients. There was significant malodor in affected nostrils when compared with nonaffected nostrils in group 1 (p < .05). Conclusion: Oral malodor was increased in patients with CLP. Nasal malodor level was also higher in affected nostrils of the CLP patients compared to nostrils of healthy subjects.

The Diversity of the Immune Response to the A2 Domain of Human Factor VIII In a Murine Hemophilia A Model

Blood ◽  
2010 ◽  
Vol 116 (21) ◽  
pp. 2223-2223
Author(s):  
John F. Healey ◽  
John (Pete) S. Lollar ◽  
Ernest T Parker ◽  
Shannon Meeks
Keyword(s):  
Amino Acids ◽  
Immune Response ◽  
Hemophilia A ◽  
Type I ◽  
Type Ii ◽  
Chain Cleavage ◽  
Group 3 ◽  
Group 2 ◽  
A2 Domain ◽  
Group 1

Abstract Abstract 2223 Factor VIII (fVIII) inhibitory antibodies (fVIII inhibitors) are a significant source of morbidity in patients with hemophilia A. Approximately 30% of patients with severe hemophilia A will develop inhibitors. Most inhibitors are directed against either the A2 or C2 domains of fVIII. Anti-A2 antibodies have been reported to bind to at least 3 different regions of the A2 domain. Murine anti-human fVIII monoclonal antibody (MAb) MAb413 has an epitope that localizes to amino acids 484–508 and possibly blocks factor IXa binding to fVIII. R8B12 is a minimally inhibitory anti-A2 MAb that recognizes a discontinuous epitope that includes residues 497–510 and 584–593. CLB-Cag 9 is an anti-A2 MAb that recognizes amino acids 713–740 and decreases the rate of light chain cleavage by thrombin and factor Xa. The goal of this study was to investigate the diversity of the humoral immune response to the A2 domain of human fVIII in a murine hemophilia A model. A panel of 10 murine anti-A2 antibodies was obtained, which included 9 MAbs from anti-fVIII hybridomas produced in our laboratory and antibody MAb413. All 10 MAbs were used as primary antibodies in a competition ELISA using human fVIII as the antigen. The same panel was biotinylated and used as secondary antibodies. Antibody pairs were classified as having non-overlapping or overlapping epitopes based on whether the binding of the secondary antibody was present or absent, respectively. The competition ELISA yielded 3 distinct groups of structural epitopes (see Figure). The ability of the MAbs to inhibit porcine/human hybrid fVIII proteins in a one-stage coagulation assay was used to further delineate the position of the structural epitope. Group 1 contained 6 antibodies, including MAb413, with 4 distinct epitopes on the fVIII protein. Group 2 contained 2 MAbs, and the epitope for 2–54 localized to amino acids 508–541. Group 3 contained 2 MAbs, and the epitope for 1D4 localized to amino acids 605–740. Five of the 6 MAbs in Group 1 were Type I inhibitors with titers ranging from 330-40,000 Bethesda units (BU)/mg and one was non-inhibitory (see Table). In Group 2, both antibodies had high inhibitor titers (11,000 and 33,000 BU/mg) but were type II inhibitors with residual activities of ~20% at saturating concentration of antibody. Group 2 MAb 2–54 also was tested in a purified Xase assay and the residual fVIII activity was high (60-70%) at saturating concentration. Of the two MAbs in Group 3, one was non-inhibitory and the other was a Type I inhibitor with a titer of 7000 BU/mg. The concentration dependence of MAb413 (Group 1), 2–54 (Group 2), and 1D4 (Group 3) on fVIII cleavage and activity was tested by SDS-PAGE and the intrinsic Xase assay. With MAb413 a normal cleavage pattern was seen at concentrations that produced complete inhibition in the Xase assay. With 1D4, light chain, but not heavy chain, cleavage was inhibited in a concentration-dependent manner that corresponded to a decrease in Xase activity. This is consistent with CLB-Cag 9 which has a similar epitope at the C terminal end of the A2 domain. With 2–54, cleavage at all thrombin cleavage sites was partially inhibited, which corresponded to 30–40% inhibition in the Xase assay. This MAb represents a novel class of high titer, type II anti-A2 inhibitors that recognizes residues 508–541 and has similar in vitro characteristics to the Group BC anti-C2 MAbs. The elucidation of the structural and functional complexity of the anti-fVIII A2 repertoire should be useful in the characterization of the pathogenicity of A2 inhibitors. Disclosures: No relevant conflicts of interest to declare.

P5663Impact of proteinuria on cardiovascular outcomes in Japanese diabetic patients with atrial fibrillation: the Fushimi AF Registry

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
S Ikeda ◽  
M Iguchi ◽  
H Ogawa ◽  
K Ishigami ◽  
Y Aono ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Renal Dysfunction ◽  
Clinical Outcomes ◽  
Cardiovascular Death ◽  
Diabetic Patients ◽  
Group 4 ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

Abstract Background Previous studies have suggested that proteinuria is independently associated with clinical outcomes in diabetic patients, irrespective of the presence of renal dysfunction. However, data regarding the impact of proteinuria on clinical outcomes in diabetic patients with atrial fibrillation (AF) are limited. Methods The Fushimi AF Registry is a community-based prospective survey of AF patients in our city in Japan. Follow-up data were available in 4,454 patients, and 634 diabetic patients with available data of proteinuria and estimated glomerular filtration rate (eGFR) were examined. We compared the clinical background and outcomes between patients with proteinuria (n=251) and those without (n=383). Then, we divided the patients into 4 subgroups according to the presence of proteinuria and renal dysfunction, and compared the clinical outcomes between groups; group 1 (without proteinuria, eGFR ≥60 ml/min/1.73 m2; n=203), group 2 (with proteinuria, eGFR ≥60; n=96), group 3 (without proteinuria, eGFR <60; n=180), group 4 (with proteinuria, eGFR <60; n=155). Results Age was comparable between patients with or without proteinuria. Patients with proteinuria had higher prevalences of previous heart failure (HF), stroke/systemic embolism, hypertension and renal dysfunction. The prevalences of previous myocardial infarction, and major bleeding were similar between two groups. During the median follow-up of 1,505 days, the incidence rates of HF hospitalization (4.1/100 person-years vs. 2.5/100 person-years; p<0.01) and cardiovascular death (1.8/100 person-years vs. 0.4/100 person-years; p<0.01) were higher in patients with proteinuria. When we divided patients into 4 subgroups, the incidences of HF hospitalization (group 1: 1.8/100 person-years vs. group 2: 3.4/100 person-years vs. group 3: 3.8/100 person-years vs. group 4: 4.9/100 person-years; p<0.01) and cardiovascular death (group 1: 0.3/100 person-years vs. group 2: 1.8/100 person-years vs. group 3: 0.5/100 person-years vs. group 4: 2.2/100 person-years; p<0.01) tended to be higher in not only group 3 and group 4 but also group 2 than group 1 (Figure). Multivariate Cox proportional hazards regression analysis including female gender, age (≥75 years), hypertension, pre-existing HF, renal dysfunction (eGFR <60),low left ventricular ejection fraction (<40%) and proteinuria revealed that proteinuria was an independent determinant of both of HF hospitalization (adjusted hazard ratio [HR]: 1.57, 95% confidence interval [CI]: 1.05–2.34) and cardiovascular death (HR: 3.76, 95% CI: 1.59–8.88). Figure 1 Conclusion In Japanese diabetic patients with AF, proteinuria was associated with higher incidences of HF hospitalization and cardiovascular death, irrespective of the presence of renal dysfunction.

scholarly journals Impact of Diabetes Mellitus on Pulmonary functions in COPD patients

QJM ◽  
2020 ◽  
Vol 113 (Supplement_1) ◽  
Author(s):  
M M Ahmed ◽  
N M M Abdelfattah ◽  
A A Elsherbeny ◽  
S A Afifi
Keyword(s):  
Diabetes Mellitus ◽  
Diabetic Patients ◽  
University Hospitals ◽  
Pulmonary Functions ◽  
Copd Patients ◽  
Lung Functions ◽  
Patients With Diabetes ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

Abstract Introduction COPD is known to be a multisystemic inflammatory disease that goes beyond lung involvement. The association of decreased lung functions and diabetes mellitus has been studied for many years suggesting that the lung could be a target organ in diabetes mellitus. Objective assessment of pulmonary functions in COPD patients with normoglycemia and with diabetes mellitus, and patients with diabetes mellitus. Patients and Methods The study was conducted in Ain shams university hospitals After the inclusion criteria was met, patients were divided into 3 groups, each group was 20 patients,(group 1): diabetes mellitus patients,(group 2): COPD patients, and (group 3): COPD with diabetes mellitus patients. spirometry was performed and results were analyzed. Results In COPD with diabetes mellitus patients (group 3), the lung functions were the least. Diabetes mellitus was also an independent risk factor for reduced lung functions as was seen in nonsmoking diabetic patients (group 1). Conclusion Pulmonary functions are reduced in DM independent of smoking.

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