scholarly journals Therapeutic options for Corona Virus Disease 2019 (COVID-19)

2021 ◽  
Vol 13 (3) ◽  
pp. 129-132
Author(s):  
Ahmet Eroglu ◽  
Seyfi Kartal ◽  
Esra Kongur
Keyword(s):  
Virus Disease ◽  
Specific Treatment ◽  
Review Article ◽  
Therapeutic Options ◽  
Therapeutic Approaches ◽  
Plasma Therapy ◽  
Severity Of Disease ◽  
Stem Cells Therapy ◽  
Inflammatory Drugs ◽  
Respiratory Treatment

The aim of this review article is to put forth the therapeutic options for coronavirus disease 2019 (COVID-19). There is no specific treatment or therapy recommended for COVID-19 up to now. The therapeutic approaches should be ordered according to the severity of disease. These options can be listed from one to ten such as isolation; oxygen support; respiratory treatment; anticoagulant treatment; anti-inflammatory drugs; hydroxychloroquine and combinations therapies; antiviral drugs; convalescent plasma therapy; mesenchymal stem cells therapy and vaccination. According to the severity and stage of the disease, suitable options are recommended.

scholarly journals Potential therapeutic options for COVID-19: an update on current evidence

2022 ◽  
Vol 27 (1) ◽  
Author(s):  
Zahra Niknam ◽  
Ameneh Jafari ◽  
Ali Golchin ◽  
Fahima Danesh Pouya ◽  
Mohadeseh Nemati ◽  
...  
Keyword(s):  
Specific Treatment ◽  
Immunoglobulin Therapy ◽  
Therapeutic Options ◽  
Health Concern ◽  
Current Evidence ◽  
Therapeutic Approaches ◽  
Plasma Therapy ◽  
Efficient Management ◽  
Comprehensive Information ◽  
Novel Coronavirus

AbstractSARS-CoV-2, a novel coronavirus, is the agent responsible for the COVID-19 pandemic and is a major public health concern nowadays. The rapid and global spread of this coronavirus leads to an increase in hospitalizations and thousands of deaths in many countries. To date, great efforts have been made worldwide for the efficient management of this crisis, but there is still no effective and specific treatment for COVID-19. The primary therapies to treat the disease are antivirals, anti-inflammatories and respiratory therapy. In addition, antibody therapies currently have been a many active and essential part of SARS-CoV-2 infection treatment. Ongoing trials are proposed different therapeutic options including various drugs, convalescent plasma therapy, monoclonal antibodies, immunoglobulin therapy, and cell therapy. The present study summarized current evidence of these therapeutic approaches to assess their efficacy and safety for COVID-19 treatment. We tried to provide comprehensive information about the available potential therapeutic approaches against COVID-19 to support researchers and physicians in any current and future progress in treating COVID-19 patients.

Certain important aspects of the prevention of pathologies of labor activity in obstetric practice (Сlinical lecture)

2016 ◽  
pp. 11-18
Author(s):  
L. Nazarenko ◽  
◽  
L. Dubrova ◽  
O. Tarusмna ◽  
◽  
...  
Keyword(s):  
Key Words ◽  
Review Article ◽  
Optimal Time ◽  
Safe Method ◽  
Individual Approach ◽  
Obstetric Practice ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Time To Delivery ◽  
Ripening Of The Cervix

The question of the prevention of pathologies of the labor is currently very important, the answer to them has become the favored formation of «dominants of delivery», choice of the optimal time to delivery, effective and safe method of induction, that promotes the promptness of the female organism and ripening of the cervix, as well as the timely identification and correction of pathological prelмmмnary period. In a review article describes the modern approaches and methods of preventing the pathology of labor activity, presented by the authors ‘ own experience regarding the use of prostaglandins, non-steroidal anti-inflammatory drugs, individual approach to the management of perinatal risk. Key words: childbirth, prevention, induction, prostaglandin, non-steroidal anti-inflammatory drugs.

Multitarget therapeutic approaches for Alzheimer's and Parkinson's diseases: an opportunity or an illusion?

2021 ◽  
Author(s):  
Maria João Matos
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Neurodegenerative Diseases ◽  
Therapeutic Options ◽  
Therapeutic Approaches ◽  
Recent Information ◽  
Temporary Relief ◽  
Parkinson’S Diseases ◽  
Innovative Approaches

Alzheimer's and Parkinson's disease are the most prevalent neurodegenerative diseases and the leading causes of dementia worldwide. The etiology of these multifactorial pathologies is not completely known. The available therapeutic approaches can cause temporary relief of symptoms but cannot slow down their progression or cure them. Life-changing therapeutic solutions are urgently needed, as the number of people suffering from these pathologies has been increasing quickly over the last few decades. Several targets are being studied, and innovative approaches are being pursued to find new therapeutic options. This overview is focused on the most recent information regarding the paradigm of using multitarget compounds to treat both Alzheimer's and Parkinson's disease.

scholarly journals Zika Virus: A Clinical Review

KYAMC Journal ◽  
2017 ◽  
Vol 7 (1) ◽  
pp. 719-725
Author(s):  
Md Daharul Islam ◽  
SM Tajdit Rahman ◽  
Khaleda Akhter ◽  
Md Azizul Hoque ◽  
Anannya Roy ◽  
...  
Keyword(s):  
Yellow Fever ◽  
Zika Virus ◽  
Yellow Fever Virus ◽  
Virus Disease ◽  
Specific Treatment ◽  
Abrupt Onset ◽  
Fever Virus ◽  
Control Measures ◽  
Disease Treatment ◽  
Antibodies Detection

Zika virus is a flavivirus related to Dengue virus, yellow fever virus and West Nile virus. It is considered an emerging arbovirus transmitted by mosquito of the genus Aedes. Its first description took place in 1947 in the Zika Forest in Uganda, isolated on Rhesus monkey used as bait to study the yellow fever virus. Clinical picture is characterized as a 'dengue-like' syndrome, with abrupt onset of fever; and an early onset of evanescent rash, often pruritic. Occasionally the disease has been associated with Guillain-Barré syndrome. The diagnosis can be performed by PCR or by IgG and IgM antibodies detection. No specific treatment or vaccine is available for Zika virus disease. Treatment is generally supportive. Control measures are same for dengue and chikungunya based mostly on health education and vector control.KYAMC Journal Vol. 7, No.-1, Jul 2016, Page 719-725

scholarly journals Current status of therapeutic approaches and vaccines for SARS-CoV-2

2021 ◽  
Author(s):  
Braira Wahid ◽  
Anam Amir ◽  
Ayesha Ameen ◽  
Muhammad Idrees
Keyword(s):  
Clinical Trial ◽  
Clinical Trials ◽  
Review Article ◽  
Experimental Designs ◽  
Current Status ◽  
Therapeutic Approaches ◽  
Efficacious Treatment ◽  
Rapid Pace ◽  
Global Health Challenge

SARS-CoV-2, declared a pandemic in March 2020, is the current global health challenge. The global bioburden of this virus is increasing at a rapid pace. Many antiviral drugs and vaccines have been registered for clinical trials because of their inhibitory activity observed in vitro. Currently, five types of vaccines have successfully passed Phase IV clinical trial and are being administered in populations worldwide. A plethora of experimental designs have been proposed worldwide in order to find a safe and efficacious treatment option. Therefore, it is necessary to provide baseline data and information to clinicians and researchers so that they can review the current status of therapeutics and efficacy of already developed vaccines. This review article summarizes all therapeutic options that may help to combat SARS-CoV-2.

scholarly journals Modern therapeutic options in the treatment of bacterial vaginosis

2020 ◽  
Vol 69 (3) ◽  
pp. 39-45
Author(s):  
Evgeny F. Kira ◽  
Yulia V. Khalturina
Keyword(s):  
Bacterial Vaginosis ◽  
Therapeutic Options ◽  
Diagnosis And Treatment ◽  
Therapeutic Approaches ◽  
Advantages And Disadvantages ◽  
Modern Methods

This article reviews the pathogenetic aspects of bacterial vaginosis and modern methods of diagnosis and treatment of vaginal microbiocenosis disorders. The advantages and disadvantages of the available therapeutic approaches are discussed, and new opportunities and prospects in the treatment of bacterial vaginosis are highlighted.

scholarly journals CARTILAGE AGEING AND TREATMENT POSSIBILITIES

2019 ◽  
Vol 72 (9) ◽  
pp. 1671-1675
Author(s):  
Jaromir Jarecki
Keyword(s):  
Stem Cells ◽  
Metabolic Pathways ◽  
Platelet Rich Plasma ◽  
Cartilage Destruction ◽  
Therapeutic Strategies ◽  
Review Article ◽  
Progressive Degeneration ◽  
Inflammatory Drugs ◽  
Hyaluronic Acids ◽  
Proinflammatory Factors

Osteoarthritis is the disease connected with aging which is characterised by progressive degeneration of all elements building the joint but also influencing the muscles constituting motor unit with the affected joint. The effective and unified therapy has not been yet introduced despite the broad multi-site studies concentrating on metabolic pathways responsible for the development of the disease. The reason of which is probably its multifactorial aetiology. The treatment methods are based on decreasing of cartilage destruction activity, retardation of proinflammatory factors activity and fighting with pain. Physiotherapy, movement rehabilitation, painkillers, anti-inflammatory drugs, glucosamine sulphates and hyaluronic acids are used as therapeutic strategies. The methods recently introduced are platelet rich plasma concentrates and stem cells injected directly into the affected joint. The aim of this review article was the presentation of differential therapeutic options offered to patients in different stages of osteoarthritis.

scholarly journals Convalescent Plasma Therapy in Severe and Critically Ill COVID-19 Patients: A Systematic Review and Meta-Analysis

2021 ◽  
Author(s):  
Penglei Yang ◽  
Jing Wang ◽  
Ruiqiang Zheng ◽  
Rui Tan ◽  
Xianghui Li ◽  
...  
Keyword(s):  
Systematic Review ◽  
Critically Ill ◽  
Virus Disease ◽  
Therapy Group ◽  
Meta Analysis ◽  
Control Group ◽  
Plasma Therapy ◽  
Risk Of Death ◽  
Randomized Controlled ◽  
Randomized Controlled Studies

Abstract Background: Convalescent plasma treatment of severe and critically ill Corona Virus Disease 2019(COVID-19) patients is still controversial.Objective: To evaluate the efficacy and safety of convalescent plasma in patients with severe COVID-19 infection and critically ill patients, We performed a meta-analysis and systematic review of convalescent plasma therapy in severe and critically ill COVID-19 patients.Methods: We conducted a literature search in electronic data and citations of previously published systematic reviews. We included only randomized controlled studies on convalescent plasma for the treatment of severe and critically ill COVID-19 patients. Results: A total of 7 randomized controlled trials and 1363 patients were included in the meta-analysis. Compared to patients of the control group, there was no difference in clinical improvement (Four studies, RR 1.06, 95% CI 0.96 to 1.17, p = 0.22, moderate certainty) and mortality (seven studies, RR 0.86, 95% CI 0.66 to 1.11, p = 0.48, moderate certainty) for patients of convalescent plasma therapy group.Conclusion: Convalescent plasma does not reduce the improvement of symptoms and the risk of death in severely infected and critically ill COVID-19 patients

scholarly journals Daily monitoring of viral load measured as SARS-CoV-2 antigen and RNA in blood, IL-6, CRP and complement C3d predicts outcome in patients hospitalized with COVID-19

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Claus Lohman Brasen ◽  
Henry Christensen ◽  
Dorte A. Olsen ◽  
Søren Kahns ◽  
Rikke F. Andersen ◽  
...  
Keyword(s):  
Viral Antigen ◽  
The Body ◽  
Nuclear Antigen ◽  
Inflammatory Biomarker ◽  
Daily Monitoring ◽  
Severity Of Disease ◽  
Virus Rna ◽  
Edta Plasma ◽  
Respiratory Treatment ◽  
Rna Concentration

Abstract Objectives We hypothesized that the amount of antigen produced in the body during a COVID-19 infection might differ between patients, and that maximum concentrations would predict the degree of both inflammation and outcome for patients. Methods Eighty-four hospitalized and SARS-CoV-2 PCR swab-positive patients, were followed with blood sampling every day until discharge or death. A total of 444 serial EDTA plasma samples were analyzed for a range of biomarkers: SARS-CoV-2 nuclear antigen and RNA concentration, complement activation as well as several inflammatory markers, and KL-6 as a lung marker. The patients were divided into outcome groups depending on need of respiratory support and death/survival. Results Circulating SARS-CoV-2 nuclear antigen levels were above the detection limit in blood in 65 out of 84 COVID-19 PCR swab-positive patients on day one of hospitalization, as was viral RNA in plasma in 30 out of 84. In all patients, complete antigen clearance was observed within 24 days. There were definite statistically significant differences between the groups depending on their biomarkers, showing that the concentrations of virus RNA and antigen were correlated to the inflammatory biomarker levels, respiratory treatment and death. Conclusions Viral antigen is cleared in parallel with the virus RNA levels. The levels of antigens and SARS-CoV-2 RNA in the blood correlates with the level of IL-6, inflammation, respiratory failure and death. We propose that the antigens levels together with RNA in blood can be used to predict the severity of disease, outcome, and the clearance of the virus from the body.

scholarly journals Gene Therapy for Pancreatic Diseases: Current Status

2018 ◽  
Vol 19 (11) ◽  
pp. 3415 ◽  
Author(s):  
Kenya Kamimura ◽  
Takeshi Yokoo ◽  
Shuji Terai
Keyword(s):  
Pancreatic Cancer ◽  
The Body ◽  
Therapeutic Options ◽  
Current Status ◽  
Endocrine Tumors ◽  
Therapeutic Approaches ◽  
Islet Cell Tumors ◽  
Pancreatic Diseases ◽  
Gene Therapies ◽  
New Strategies

The pancreas is a key organ involved in digestion and endocrine functions in the body. The major diseases of the pancreas include pancreatitis, pancreatic cancer, cystic diseases, pancreatic divisum, islet cell tumors, endocrine tumors, diabetes mellitus, and pancreatic pain induced by these diseases. While various therapeutic methodologies have been established to date, however, the improvement of conventional treatments and establishment of novel therapies are essential to improve the efficacy. For example, conventional therapeutic options, including chemotherapy, are not effective against pancreatic cancer, and despite improvements in the last decade, the mortality rate has not declined and is estimated to become the second cause of cancer-related deaths by 2030. Therefore, continuous efforts focus on the development of novel therapeutic options. In this review, we will summarize the progress toward the development of gene therapies for pancreatic diseases, with an emphasis on recent preclinical studies and clinical trials. We aim to identify new areas for improvement of the current methodologies and new strategies that will lead to safe and effective gene therapeutic approaches in pancreatic diseases.

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