scholarly journals "QUALITY BY DESIGN" IN LIPOSOMAL DRUGS CREATION

2020 ◽  
Vol 13 (6) ◽  
pp. 5-12
Author(s):  
Yu. М. Krasnopolsky ◽  
◽  
◽  

Nanobiotechnological preparations creation is one of the promising areas of modern pharmacy, since it allows creating products of a qualitatively new level. The procedure development, based on an understanding of the product characteristics and the technological process, confirmed by reliable scientific data. The article is devoted to the pharmaceutical development of liposomal drugs. On the basis of our own experience in the development of liposomal medicinal forms, as well as on the basis of literature data, the main components in their composition were detected and these components impact on the quality indicators of liposomes were studied. Individual lipids function in nanoparticle membrane and their interaction, which determines the stability both in the technological process and upon storage of the product, were considered. The advantages and disadvantages of cholesterol incorporation into liposomes with hydrophilic and hydrophobic active pharmaceutical ingredients were described. Cryoprotectors and buffer systems role in ensuring nanopreparation stability is discussed.

2020 ◽  
Vol 11 (2) ◽  
pp. 1621-1630
Author(s):  
Ahmad Ainurofiq ◽  
Kezia Esther Dinda ◽  
Maya Widia Pangestika ◽  
Ulia Himawati ◽  
Wening Dyah Wardhani ◽  
...  

Active pharmaceutical ingredients (API) are the main components in the production process of pharmaceutical products. If the API has a good quality, then it will lead to good pharmaceutical products. API consists of more than one different crystal form which, then forms a polymorph through the process of polymorphism. Until now, API polymorphism is still a big challenge in the pharmaceutical industry. That is because the nature of polymorphism is difficult to predict. One of them is by crystallizing molecules in one or many crystalline forms or combining with other molecules to form stable co-crystal. This process will lead to several polymorph forms of one certain API. Sometimes, these forms will have characteristics that differ one to another. Each polymorph has different mechanical, physical, thermal, and chemical properties that will affect the solubility, dissolution, bioavailability, stability, bioequivalence, and manufacturing of the API. Therefore to know the nature of an API, it is necessary to characterize the polymorphic form of the API before. If the form is not incompatible with the formulation, it can cause a failure in the production process. This review will discuss the effect of polymorphism on the physicochemical properties of API. It is hoped that this review can become the basis for improving the stability and effectiveness of pharmaceutical products.


2020 ◽  
Vol 4 (141) ◽  
pp. 114-122
Author(s):  
DAR’YA LEBEDEVA ◽  
◽  
ANNA KARPUNICHEVA

Large forces and significant thermal effects are created on the rolls when rolling sheets. The higher the stability of the rolls, the less downtime during their rerolling and higher productivity. (Research purpose) The research purpose is in analyzing the ways of restoring rolls and choose the most appropriate method for restoring these parts. (Materials and methods) The article presents the analysis of the scientific and technical literature on the topic of rolling production, methods for restoring large-sized machine parts of machine-building and metallurgical industries that work in difficult conditions and are subject to a high degree of wear. Authors try to solve the problem by means of comparative and logical analysis based on theoretical and empirical methods of scientific research. (Results and discussion) The article presents two groups of methods for restoring rolled rolls: banding and surfacing the working layer of the roll. Authors have analyzed each method in terms of technology, equipment, and feasibility. The article presents the advantages and disadvantages of the methods under consideration. (Conclusions) The most acceptable way to restore parts with a high degree of wear is surfacing. It is most efficient to apply submerged surfacing using an additional hot additive. Such surfacing, despite some complication of the equipment design, allows to deposit the metal on the roll with low heat input and in most cases in one pass. Surfacing using an additional hot additive allows to increase the productivity of the process by up to 250 percent while reducing the penetration depth by 2-3 times and saving energy by up to 40 percent.


2019 ◽  
Vol 952 (10) ◽  
pp. 47-54
Author(s):  
A.V. Komissarov ◽  
A.V. Remizov ◽  
M.M. Shlyakhova ◽  
K.K. Yambaev

The authors consider hand-held laser scanners, as a new photogrammetric tool for obtaining three-dimensional models of objects. The principle of their work and the newest optical systems based on various sensors measuring the depth of space are described in detail. The method of simultaneous navigation and mapping (SLAM) used for combining single scans into point cloud is outlined. The formulated tasks and methods for performing studies of the DotProduct (USA) hand-held laser scanner DPI?8X based on a test site survey are presented. The accuracy requirements for determining the coordinates of polygon points are given. The essence of the performed experimental research of the DPI?8X scanner is described, including scanning of a test object at various scanner distances, shooting a test polygon from various scanner positions and building point cloud, repeatedly shooting the same area of the polygon to check the stability of the scanner. The data on the assessment of accuracy and analysis of research results are given. Fields of applying hand-held laser scanners, their advantages and disadvantages are identified.


2021 ◽  
Vol 14 (1) ◽  
pp. 10-16
Author(s):  
Aleksandr Kozyukov ◽  
Vladimir Zolnikov ◽  
Svetlana Evdokimova ◽  
Oleg Kvasov ◽  
Konstantin Yakovlev ◽  
...  

The article discusses algorithmic methods for ensuring the fault tolerance of the electronic component base (ECB). The protection methods used in regular and irregular structures are described. The essence of Hamming code algorithms, composite code, error correction and detection codes is revealed. The advantages and disadvantages of using arithmetic residual code, the method of redundancy at the level of program code fragments, are shown.


2021 ◽  
Vol 9 (1) ◽  
Author(s):  
Yanbing Luo ◽  
Xiujuan Zhang

AbstractNatural yellow plant dyes and traditional medicines were used widely on historical papers in ancient China for religious reasons and conservation considerations. This study aims to evaluate some traditional yellow botanical sources of dyes that contain different chemical colorant compositions in order to understand their effects on the properties of traditional handmade paper. The physical and chemical changes in paper specimens treated with plant dyes were studied by examining properties such as the color, pH, thermogravimetric (TG) characteristics, tensile strength, folding endurance and microstructure by scanning electron microscopy (SEM). The results indicated that different colorants had different toning effects and that the main components, including carboxyl and ketone groups, could affect the paper stability at high temperatures. The results also revealed that the mechanical properties of paper specimens were improved after treatment with plant dyes. The significant improvements in the tensile strength and folding endurance and the slightly higher decomposition temperature of Amur cork tree-dyed paper could be ascribed to the strong interaction between the colorants’ main components and the fibers. The scientific evaluation of the property changes is therefore valuable information for weighing the advantages and disadvantages of the various yellow toning materials for paper conservation treatment.


Author(s):  
K. Al-Durgham ◽  
D. D. Lichti ◽  
I. Detchev ◽  
G. Kuntze ◽  
J. L. Ronsky

A fundamental task in photogrammetry is the temporal stability analysis of a camera/imaging-system’s calibration parameters. This is essential to validate the repeatability of the parameters’ estimation, to detect any behavioural changes in the camera/imaging system and to ensure precise photogrammetric products. Many stability analysis methods exist in the photogrammetric literature; each one has different methodological bases, and advantages and disadvantages. This paper presents a simple and rigorous stability analysis method that can be straightforwardly implemented for a single camera or an imaging system with multiple cameras. The basic collinearity model is used to capture differences between two calibration datasets, and to establish the stability analysis methodology. Geometric simulation is used as a tool to derive image and object space scenarios. Experiments were performed on real calibration datasets from a dual fluoroscopy (DF; X-ray-based) imaging system. The calibration data consisted of hundreds of images and thousands of image observations from six temporal points over a two-day period for a precise evaluation of the DF system stability. The stability of the DF system – for a single camera analysis – was found to be within a range of 0.01 to 0.66 mm in terms of 3D coordinates root-mean-square-error (RMSE), and 0.07 to 0.19 mm for dual cameras analysis. It is to the authors’ best knowledge that this work is the first to address the topic of DF stability analysis.


Author(s):  
Тарас Гриценко ◽  
Жанна Передера ◽  
Анна Теряева

В работе рассматривается возможность формирования в банковском секторе среды, в которой сотрудники смогут самостоятельно реализовывать цифровые инициативы для развития компании и самообучения. Обоснована необходимость её наличия. Проведен анализ соответствия поставленной проблемы российским и мировым трендам на основе изучения федеральных программ и оценок рейтинговых агентств. В результате исследования разработан бизнес-процесс реализации цифровых инициатив, про-веден конкурентный анализ его преимуществ и недостатков перед традиционным подходом к обучению. The article discusses the possibility of forming in the banking business an environment in which employees will be able to in-dependently implement digital initiatives for the development of the company and self-learning. The necessity of its presence is grounded. The analysis of compliance of the problem with the trends in Russia and the world based on the study of Federal programs and ratings agencies. To attract new staff with the necessary knowledge, banks have a number of tools - business classes, sponsorship programs, mentoring, hackathons, man-agement fights, case-championships, etc. It has been revealed that new professionals with technical skills can solve complex problems and generate products. But it’s difficult for them to dive into the banking sector, study its features and offer their own solutions to problems. It was also revealed that the company is interested in product results that are practice oriented. Com-bining product results and training is only possible by creating an environment in which they can discuss their ideas, find sup-port and implement them. As a result, a business process for the implementation of digital initiatives has been formed, a competi-tive analysis of its advantages and disadvantages over the tradi-tional approach to training has been conducted. strategies. The leading method of research is the definitions according grouping to the principles of the matrix method. It was revealed that the economic security concept is disclosed using factors freely com-bined into three groups (includes: sustainability, protection of interests, ensuring sovereignty), and the most common definitions are built using words-markers: state, security, advantage, process. One of the main study results is an algorithm for constructing the definition of the economic security concept, which allows to model and refine the definition of the concept based on the initial categories, consider-ing the economic context. The author's definition is also formulated, which reflects the interrelation of such components as the protection of interests, the impact of threats, the stability preservation, inde-pendence, ensuring development, self-adaptation and self-reproduction.


RSC Advances ◽  
2020 ◽  
Vol 10 (12) ◽  
pp. 7313-7320
Author(s):  
Joanna Wittckind Manoel ◽  
Gabriele Bordignon Primieri ◽  
Lívia Maronesi Bueno ◽  
Nathalie Ribeiro Wingert ◽  
Nádia Maria Volpato ◽  
...  

Analysis of impurities is an important step in the quality control of pharmaceutical ingredients and final products.


2020 ◽  
Vol 103 (5) ◽  
pp. 1394-1399 ◽  
Author(s):  
Congmei Cao ◽  
Wei Liu ◽  
Silva Babajanian ◽  
Yanjun Zhang ◽  
Peter Chang ◽  
...  

Abstract Background Cinnamon is a popular spice used in food products. Its flavor varies by its chemical profile. Cinnamon flavoring powder is a unique form of material with essential oil encapsulated in wall material, which improves the stability and homogeneity but also increases the difficulties for analysis. A specific and rapid method is needed to analyze the main components for its quality and safety. Objective An analytical method for the quantification of cinnamon flavoring powder was developed and validated. The characteristic components for analysis were selected as coumarin, trans-cinnamic acid, trans-cinnamaldehyde, and eugenol. Methods This quantitation method with ultra-performance liquid chromatography coupled with diode array detector analysis was achieved by material extraction followed by chromatographic separation on C18 columns eluted with a gradient acetonitrile-water mobile phase. The detected wavelength was determined as 280 nm. Results Linear regression of calibration curves for each component was validated (R2 > 0.9995). The specificity, LOD and LOQ, precision, accuracy, and ruggedness of the developed method were also evaluated. Conclusions Such an approach is applicable for the simultaneous determination of these four characteristic constituents in cinnamon flavoring powder used in manufacturing and quality control of nutritional products. Highlights This study describes the selection of four components for analysis, the efficient extraction of them from cinnamon flavoring powder, and the rapid quantitation of these four characteristic components in these materials.


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