scholarly journals Bioglass and its application in modern treatment of osteooncological diseases

Surface ◽  
2021 ◽  
Vol 13(28) ◽  
pp. 206-245
Author(s):  
S. P. Turanska ◽  
◽  
A. P. Kusyak ◽  
A. L. Petranovska ◽  
V. V. Turov ◽  
...  

Bone tumor diseases are one of the main problems in modern clinical practice. After surgery, some of the tumor cells capable of proliferation may remain, leading to tumor recurrence. In addition, surgical ablation of bone tumors creates bone tissue defects. Therefore, the problem of manufacturing specific biomaterials with a dual function of treating bone tumors and regeneration of bone defects has become a priority. The use of methods of targeted delivery and local controlled release of drugs contributes to the creation of the desired therapeutic concentration of drugs in the disease focus and increases their bioavailability. In recent years, promising samples capable of effective controlled release have been developed in which cisplatin, doxorubicin and gemcitabine have been used as model chemotherapeutic drugs. These approaches have been promising and have shown the potential to destroy residual tumor cells, however, they may become resistant to such drugs, which leads to treatment failure. The main purpose of the review is to summarize the latest world experience in the synthesis, research and use of composites based on bioactive ceramic materials and modern antitumor drugs as promising implants, embodying a new generation of complex remedies for targeted delivery with osteoconductive and antitumor properties, prolonged action, for local application. Examples are given of bioglass application with cytotoxic / cytostatic components, as well as results of development of the newest directions of antitumor therapy of bones, in which acquisition of resistance of tumor cells is not observed. The antitumor functions of such multifunctional samples are performed, for example, by chemotherapy, photothermal therapy, magnetic hyperthermia, and photodynamic therapy. These data are of scientific, practical and methodical interest.

2018 ◽  
Vol 6 (5) ◽  
pp. 46-50
Author(s):  
Hemant K. Sharma ◽  
Manish Kumar

Cancer is an extremely multifaceted illness to appreciate, since it entails manifold cellular physiological system. The mainly general cancer treatment is limited to chemotherapy, radiation and surgery. Furthermore, the untimely credit and action of cancer relics a technological block. There is an urgent require to expand novel and originaltechnology thatcould help to define tumor margins, recognize residual tumor cells and micro metastases, and decide whether a tumor has been totally removed or not. Nanotechnology has witnessed significant progress in the past few decades, and its effect is widespread nowadays in every field. Nanoparticles can be modified in numerous ways to prolong circulation, enhance drug localization, increase drug efficacy, and potentially decrease chances of multidrug resis­tance by the use of nanotechnology. Recently, research in the field of cancer nanotechnology has made remarkable advances. In present study review summarizes the application of various nanotechnology-based approaches towards the diagnostics and therapeutics of cancer. Key-Words:Cancer Nanotechnology, Liposomes, Targeted Delivery, Diagnosis, Nano-medicines.


Author(s):  
Krishna Champaneria ◽  
Prajesh Prajapati

Cancer is one of the reason for mortality and its individual and collective impact is substantial. Conventional chemotherapy utilizes drugs that can destroy Tumor cells effectively. But these agents destroy healthy cells along with the tumor cells, leading to many adverse effects which include hypersensitivity reactions, nephrotoxicity, and neurotoxicity. To minimize the adverse effects, various drug delivery systems (DDSs) has been developed. Among them, nanoparticles are attractive platforms for it. So this review paper explores the recent work done on targeted delivery, enhancing tumor accumulation and longer blood circulation using more effective biomaterial that will enhance the properties of nanoparticles. Moreover, various target-specific delivery of drugs like antibody-targeted, targeting delivery through angiogenesis, mitochondria, CD44 receptor are also explained.


2020 ◽  
Vol 22 (1) ◽  
pp. 340
Author(s):  
Ilya Nifant’ev ◽  
Andrei Siniavin ◽  
Eduard Karamov ◽  
Maxim Kosarev ◽  
Sergey Kovalchuk ◽  
...  

Despite the world’s combined efforts, human immunodeficiency virus (HIV), the causative agent of AIDS, remains one of the world’s most serious public health challenges. High genetic variability of HIV complicates the development of anti-HIV vaccine, and there is an actual clinical need for increasing the efficiency of anti-HIV drugs in terms of targeted delivery and controlled release. Tenofovir (TFV), a nucleotide-analog reverse transcriptase inhibitor, has gained wide acceptance as a drug for pre-exposure prophylaxis or treatment of HIV infection. In our study, we explored the potential of tenofovir disoproxil (TFD) adducts with block copolymers of poly(ethylene glycol) monomethyl ether and poly(ethylene phosphoric acid) (mPEG-b-PEPA) as candidates for developing a long-acting/controlled-release formulation of TFV. Two types of mPEG-b-PEPA with numbers of ethylene phosphoric acid (EPA) fragments of 13 and 49 were synthesized by catalytic ring-opening polymerization, and used for preparing four types of adducts with TFD. Antiviral activity of [mPEG-b-PEPA]TFD or tenofovir disoproxil fumarate (TDF) was evaluated using the model of experimental HIV infection in vitro (MT-4/HIV-1IIIB). Judging by the values of the selectivity index (SI), TFD exhibited an up to 14-fold higher anti-HIV activity in the form of mPEG-b-PEPA adducts, thus demonstrating significant promise for further development of long-acting/controlled-release injectable TFV formulations.


2020 ◽  
pp. 100088
Author(s):  
Robin A. Nadar ◽  
Gerben M. Franssen ◽  
Natasja W.M. Van Dijk ◽  
Karlijn Codee-van der Schilden ◽  
Mirjam de Weijert ◽  
...  

2014 ◽  
Vol 29 (2) ◽  
pp. 487-492 ◽  
Author(s):  
Gak Won Yun ◽  
Jie-Hyun Kim ◽  
Yong Chan Lee ◽  
Sang Kil Lee ◽  
Sung Kwan Shin ◽  
...  

Oncotarget ◽  
2015 ◽  
Vol 6 (28) ◽  
pp. 26177-26191 ◽  
Author(s):  
Jun Li ◽  
Shengnan Li ◽  
Songyun Xia ◽  
Jinfeng Feng ◽  
Xuedi Zhang ◽  
...  

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Xiaohua Gu ◽  
Rui Cao ◽  
Fu Li ◽  
Yan Li ◽  
Hongge Jia ◽  
...  

In this study, Typhonium giganteum containing dual-function nanofibers composed of poly(butylene carbonate), polylactic acid, and graphene oxide (PBC/PLA/GO) were successfully fabricated by electrospinning. The results from thermogravimetric analysis (TG), differential scanning calorimetry (DSC), and Fourier-transform infrared spectroscopy (FTIR) indicate that no interactions occurred between PBC and PLA. The nanofiber microstructure upon which graphene oxide was evenly distributed was studied by scanning electron microscopy (SEM) and showed good silk properties. The nanofibers can be used as a drug carrier since loaded Typhonium giganteum fibers possess excellent biocompatibility. Such nanofibers are effective in inhibiting the proliferation of A549 lung cancer cells, and thus they have potential for replacing chemotherapy-based treatments of lung cancer. In addition, the PBC/PLA/GO nanofibers degrade in physiological and natural environments, which is an important feature when engineering tissues and environment-friendly materials.


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