scholarly journals Protein intake and loss of proteostasis in the eldery

2021 ◽  
Vol 93 (1) ◽  
pp. 30-39
Author(s):  
A. N. Kirana ◽  
◽  
E. Prafiantini ◽  
N. S. Hardiany ◽  
◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Protein Intake ◽  
The Elderly ◽  
Protein Restriction ◽  
Dietary Proteins ◽  
Protein Homeostasis ◽  
Bodily Function ◽  
Resistance To Infection ◽  
Degenerative Disorder ◽  
The Right

Ageing is a process of declining bodily function and a major risk factor of chronic diseases. The declining bodily function in ageing can cause loss of proteostasis (protein homeostasis), which is a balance between protein synthesis, folding, modification and degradation. For the elderly, adequate protein intake is necessary to prevent sarcopenia, frailty, fracture and osteoporosis as well as reduced resistance to infection. However, increasing the protein intake can enhance the risk of oxidized protein formation, loss of proteostasis and degenerative disorder occurrence. On the other hand, several studies show that protein restriction would increase longevity. The aim of this review was to explain the importance of determining the right amount and composition of protein intake for the elderly. Oxidative stress and molecular mechanism of proteostasis loss in ageing cells as well as its suppression pathway by protein restriction are discussed in this review. Keywords: ageing, dietary proteins, mTOR, oxidative stress, proteostasis loss

scholarly journals Relationship among Frailty, Muscle Volume, Protein Intake in Patients with Chronic Kidney Disease (CKD)

2020 ◽  
Vol 1 (2) ◽  
pp. 101-104
Author(s):  
Bando H ◽  
Kato Y
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Muscle Mass ◽  
Protein Intake ◽  
Muscle Protein ◽  
Muscle Protein Synthesis ◽  
The Elderly ◽  
Protein Restriction ◽  
Restriction Diet ◽  
Meta Analyses

Maintenance of muscle mass and protein intake are closely related. Insufficient protein intake in each meal or a total of three meals causes a decrease in muscle mass. For the elderly, protein intake has been insufficient at breakfast and then a large amount of protein is necessary for stimulating muscle protein synthesis. Consequently, there is a need to more actively and consciously take protein in older age. There have been conflicting results concerning the effect of protein restriction diet on glomerular filtration rate (GFR) in patients with chronic kidney disease (CKD) from the data of various meta-analyses. A beneficial effect and also no significant effect was found. One of the perspectives suggested that protein restriction diet may make slower CKD progression in T1DM and non-DM subjects, but not for T2DM patients. However, further studies will be necessary in the future.

scholarly journals The ageing lung under stress

2020 ◽  
Vol 29 (156) ◽  
pp. 200126
Author(s):  
Martina Korfei ◽  
BreAnne MacKenzie ◽  
Silke Meiners
Keyword(s):  
Oxidative Stress ◽  
Stress Responses ◽  
Respiratory Diseases ◽  
Structural Changes ◽  
The Elderly ◽  
Protein Homeostasis ◽  
Control Mechanisms ◽  
Age Related ◽  
Numerous Cell ◽  
Adaptive Stress Response

Healthy ageing of the lung involves structural changes but also numerous cell-intrinsic and cell-extrinsic alterations. Among them are the age-related decline in central cellular quality control mechanisms such as redox and protein homeostasis. In this review, we would like to provide a conceptual framework of how impaired stress responses in the ageing lung, as exemplified by dysfunctional redox and protein homeostasis, may contribute to onset and progression of COPD and idiopathic pulmonary fibrosis (IPF). We propose that age-related imbalanced redox and protein homeostasis acts, amongst others (e.g. cellular senescence), as a “first hit” that challenges the adaptive stress-response pathways of the cell, increases the level of oxidative stress and renders the lung susceptible to subsequent injury and disease. In both COPD and IPF, additional environmental insults such as smoking, air pollution and/or infections then serve as “second hits” which contribute to persistently elevated oxidative stress that overwhelms the already weakened adaptive defence and repair pathways in the elderly towards non-adaptive, irremediable stress thereby promoting development and progression of respiratory diseases. COPD and IPF are thus distinct horns of the same devil, “lung ageing”.

Nachhaltigkeit in Wald und Gesellschaft trotz «Überalterung» und «Unterjüngung» (Essay)

2013 ◽  
Vol 164 (8) ◽  
pp. 236-239
Author(s):  
Werner Schärer
Keyword(s):  
Civil Society ◽  
Technical Progress ◽  
The Elderly ◽  
Human Populations ◽  
Civil Society Organisations ◽  
Care For The Elderly ◽  
Economic Reasoning ◽  
The Right ◽  
Implementation Programme ◽  
Effective Distribution

Sustainability in forest and society despite “overmaturity” and “lack of regeneration” (essay) This essay compares efforts to move towards sustainability in the forests with those in the care for the elderly in Switzerland, and tries to draw conclusions which may promote sustainability. It is wrong, for forests and human populations, to talk of “overmaturity”, as this assumes the primacy of economic reasoning. To guarantee sustainability, the balance between all aspects is crucial. To attain true sustainability, we need binding guidelines and the “right” scale of implementation programme. Civil society organisations have been working for decades – often longer than the state itself – to improve sustainability. In many different areas, good cooperation and effective distribution of tasks between these institutions can be observed. This is important, among other things, because the ever greater speed of technical progress may overwhelm the adaptive capacity of both forests and people, which would influence sustainability in a negative way.

scholarly journals Zone-specific damage of the olfactory epithelium under protein restriction

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Ayinuer Tuerdi ◽  
Shu Kikuta ◽  
Makoto Kinoshita ◽  
Teru Kamogashira ◽  
Kenji Kondo ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Olfactory Epithelium ◽  
Control Diet ◽  
Intervention Strategy ◽  
Protein Restriction ◽  
Outer Hair Cells ◽  
Basal Cells ◽  
Cell Dynamics ◽  
Age Related ◽  
Positive Effect

AbstractOxidative stress causes tissue damage, affecting age-related pathologies. Protein restriction (PR) provides a powerful intervention strategy for reducing oxidative stress, which may have a positive effect on individual organs. However, it is unknown whether PR intervention influences the olfactory system. Here, we investigated how 10 months of PR could affect the cell dynamics of the olfactory epithelium (OE) in mice. We found that PR reduced age-related loss of outer hair cells in the cochlea, providing preventive effects against age-related hearing loss. In contrast, PR resulted in reduced mature olfactory sensory neurons (OSNs), increased proliferative basal cells, and increased apoptotic OSNs in zone 1 (the only area containing neurons expressing NQO1 [quinone dehydrogenase 1]) of the OE in comparison with animals given a control diet. Substantial oxidative stress occurred in NQO1-positive cells and induced apoptotic OSNs in zone 1. These results indicate that in contrast to the positive effect on the auditory system, PR induces oxidative stress and structurally and functionally negative effects on OSNs in zone 1, which is probably involved in the bioactivation of NQO1.

scholarly journals Elderly’s preferences towards rehabilitation robot appearance using electroencephalogram signal

2021 ◽  
Vol 2021 (1) ◽  
Author(s):  
Xinxin Sun ◽  
Wenkui Jin
Keyword(s):  
Assisted Living ◽  
The Elderly ◽  
Rehabilitation Robots ◽  
Subjective Evaluations ◽  
Analysis Experiment ◽  
Prefrontal Region ◽  
Important Means ◽  
The Difference ◽  
Robot Appearance ◽  
The Right

AbstractRehabilitation robots are becoming an important means of assisted living for the elderly, and the appearance of rehabilitation robots directly affects the willingness of the elderly to interact with the robots. Much of the current research on robot appearance preferences relies solely on subjective evaluations, which are relatively cheap, but do not reach deep into the brain to get an accurate grasp of how humans respond to robot appearance. Using electroencephalogram signal and questionnaire survey, we studied the preference of the elderly for abstract and figurative robots. The experimental materials are derived from the pictures of 10 robots in the market. The electroencephalogram signal are collected by BrainVision Recorder and processed by BrainVision Analyzer, as well as SPSS statistical analysis. Experiment shows that the peak of figurative robot pictures is higher and the fluctuation is more intense from 350 ms to 600 ms in the central region and the right half of parietal region. While the peak of abstract robot pictures is higher and the fluctuation is more intense in the prefrontal region, and the difference between abstract robot and figurative robot is not obvious in the occipital region. Based on the electroencephalogram signal and experimental results, it provides the possibility for objective preference evaluation of the elderly to the robot designed features.

Strategies for Teaching Elders From a Human Development Perspective

1996 ◽  
Vol 22 (1) ◽  
pp. 47-52 ◽  
Author(s):  
JESSIE H. AHRONI
Keyword(s):  
Health Status ◽  
Human Development ◽  
Diabetes Education ◽  
The Elderly ◽  
Coping Resources ◽  
Healthcare Team ◽  
Bodily Function ◽  
Development And Aging ◽  
Almost All ◽  
Development Perspective

Diabetes is a disease that challenges all people to learn, change, and develop. Older people can be taught about diabetes from a human development perspective using Erikson's psychosocial theory of development. Developmental changes in appearance, bodily function, and health status confront almost all persons in later years. If an individual does not have coping resources or a history of successful coping, changes in health status during aging can constitute serious crises. It is important to look at and work with individuals from the context of their entire life cycle rather than in a fixed period of time. The diabetes healthcare team can make more effective use of the theories of human development and aging to enhance the effectiveness of diabetes education for the elderly.

scholarly journals Human Nonmercaptalbumin Is a New Biomarker of Motor Function

2021 ◽  
Vol 10 (11) ◽  
pp. 2464
Author(s):  
Sadayuki Ito ◽  
Hiroaki Nakashima ◽  
Kei Ando ◽  
Kazuyoshi Kobayashi ◽  
Masaaki Machino ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Logistic Regression ◽  
Regression Analysis ◽  
Grip Strength ◽  
Motor Function ◽  
Walking Speed ◽  
The Elderly ◽  
Elderly Subjects ◽  
Locomotive Syndrome ◽  
Reduced Mobility

The ratio of human nonmercaptalbumin (HNA) and reduced albumin (HMA) may be a new marker for oxidative stress. Locomotive syndrome (LS) is reduced mobility due to impairment of locomotive organs. We investigated whether the HNA/HMA ratio could be a new biomarker of LS. This study included 306 subjects (mean age 64.24 ± 10.4 years) who underwent LS tests, grip strength, walking speed, and tests for HNA and HMA. Oxidative stress was measured by the ratio of HMA (f(HMA) = (HMA/(HMA + HNA) × 100)), and the subjects were divided into normal (N group; f[HMA] ≥ 70%) and low (L group; f[HMA] < 70%) groups. There were 124 non-elderly (<65 years) and 182 elderly subjects (≥65 years). There were no significant differences in LS, grip strength, and walking speed between the L and N groups in the non-elderly subjects. However, significant differences were found in the elderly subjects. In logistic regression analysis, there was an association between f(HMA) and the LS severity at older ages. LS in the elderly is associated with a decline in HMA and, thus, an increase in oxidative stress. Thus, f(HMA) is a new biomarker of LS.

scholarly journals Optimal Protein Intake in Pre-Dialysis Chronic Kidney Disease Patients with Sarcopenia: An Overview

Nutrients ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 1205
Author(s):  
Yoshitaka Isaka
Keyword(s):  
Chronic Kidney Disease ◽  
High Risk ◽  
Kidney Disease ◽  
Muscle Mass ◽  
Exercise Therapy ◽  
Protein Intake ◽  
Renin Angiotensin System ◽  
Protein Restriction ◽  
Ckd Stage ◽  
End Stage

Multi-factors, such as anorexia, activation of renin-angiotensin system, inflammation, and metabolic acidosis, contribute to malnutrition in chronic kidney disease (CKD) patients. Most of these factors, contributing to the progression of malnutrition, worsen as CKD progresses. Protein restriction, used as a treatment for CKD, can reduce the risk of CKD progression, but may worsen the sarcopenia, a syndrome characterized by a progressive and systemic loss of muscle mass and strength. The concomitant rate of sarcopenia is higher in CKD patients than in the general population. Sarcopenia is also associated with mortality risk in CKD patients. Thus, it is important to determine whether protein restriction should be continued or loosened in CKD patients with sarcopenia. We may prioritize protein restriction in CKD patients with a high risk of end-stage kidney disease (ESKD), classified to stage G4 to G5, but may loosen protein restriction in ESKD-low risk CKD stage G3 patients with proteinuria <0.5 g/day, and rate of eGFR decline <3.0 mL/min/1.73 m2/year. However, the effect of increasing protein intake alone without exercise therapy may be limited in CKD patients with sarcopenia. The combination of exercise therapy and increased protein intake is effective in improving muscle mass and strength in CKD patients with sarcopenia. In the case of loosening protein restriction, it is safe to avoid protein intake of more than 1.5 g/kgBW/day. In CKD patients with high risk in ESKD, 0.8 g/kgBW/day may be a critical point of protein intake.

scholarly journals Effects of ovariectomy on antioxidant defence systems in the right ventricle of female rats with pulmonary arterial hypertension induced by monocrotaline

2018 ◽  
Vol 96 (3) ◽  
pp. 295-303 ◽  
Author(s):  
Rafaela Siqueira ◽  
Rafael Colombo ◽  
Adriana Conzatti ◽  
Alexandre Luz de Castro ◽  
Cristina Campos Carraro ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Pulmonary Arterial Hypertension ◽  
Right Ventricle ◽  
Protein Expression ◽  
Arterial Hypertension ◽  
Female Rats ◽  
Antioxidant Defenses ◽  
Thioredoxin 1 ◽  
Pulmonary Arterial ◽  
The Right

The aim of this study was to evaluate the impact of ovariectomy on oxidative stress in the right ventricle (RV) of female rats with pulmonary arterial hypertension (PAH) induced by monocrotaline (MCT). Rats were divided into 4 groups (n = 6 per group): sham (S), sham + MCT (SM), ovariectomized (O), and ovariectomized + MCT (OM). MCT (60 mg·kg−1 i.p.) was injected 1 week after ovariectomy or sham surgery. Three weeks later, echocardiographic analysis and RV catheterisation were performed. RV morphometric, biochemical, and protein expression analysis through Western blotting were done. MCT promoted a slight increase in pulmonary artery pressure, without differences between the SM and OM groups, but did not induce RV hypertrophy. RV hydrogen peroxide increased in the MCT groups, but SOD, CAT, and GPx activities were also enhanced. Non-classical antioxidant defenses diminished in ovariectomized groups, probably due to a decrease in the nuclear factor Nrf2. Hemoxygenase-1 and thioredoxin-1 protein expression was increased in the OM group compared with SM, being accompanied by an elevation in the estrogen receptor β (ER-β). Hemoxygenase-1 and thioredoxin-1 may be involved in the modulation of oxidative stress in the OM group, and this could be responsible for attenuation of PAH and RV remodeling.

Recurrent Chronic Subdural Hematoma: Clinical and Imaging Risk Factors

2018 ◽  
Vol 15 (01) ◽  
pp. 008-015 ◽  
Author(s):  
Benaissa Abdennebi ◽  
Maher Al Shamiri
Keyword(s):  
Risk Factors ◽  
Subdural Hematoma ◽  
Heart Diseases ◽  
Chronic Subdural Hematoma ◽  
Antiplatelet Agents ◽  
The Elderly ◽  
Imaging Data ◽  
Anticoagulation Agents ◽  
The Right ◽  
Recurrence Group

Abstract Background Chronic subdural hematoma (CSDH) is a major cause of neurosurgical emergencies in the elderly. Despite the use of routine surgical practices, recurrence of this condition is expected. This study was conducted to identify the risk factors (RF) for recurrent CSDH. Methods Between January 2016 and July 2017, 103 consecutive patients suffering from CSDH were admitted to our department. The no-recurrence group (NRG) consisted of 91 patients, and the recurrence group (RG) consisted of 12 patients. To identify the RF involved in recurrent CSDH, we analyzed multiple factors, including patient comorbidities and imaging data. Results Between the two groups, there were no statistical differences (p > 0.05) for head trauma, diabetes mellitus (DM), high blood pressure, heart diseases, anticoagulation agents, or seizures; however, DM was associated with one of the above-mentioned factors. In contrast, there were significant differences for antiplatelet agents (APA) (p < 10–6) and the right side of the hematoma location (p = 0.03). Conclusion Although the literature highlights the controversy regarding RF for CSDH, we detected APA and the right side as RF, whereas DM alone or associated with another comorbidity does not affect the CSDH outcome.

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