PRIMARY XANTHOMA TUBEROSUM IN CHILDREN

PEDIATRICS ◽  
1959 ◽  
Vol 23 (1) ◽  
pp. 67-75
Author(s):  
Jack E. McCleary ◽  
Louis A. Brunsting ◽  
Roger L. J. Kennedy
Keyword(s):  
Myocardial Infarction ◽  
Cardiovascular Disease ◽  
Angina Pectoris ◽  
Cardiac Disease ◽  
Blood Lipids ◽  
Close Relative ◽  
History Of ◽  
Coronary Blood Vessels ◽  
The One

A brief classification of xanthomatoses is presented. In an attempt to remove some of the confusion contributed by the several different meanings for the term "hyperlipemia," the term "hyperneutralipemia" is introduced to indicate an elevation of the concentrations of neutral fat in the serum. The term "hyperlipemia" is retained to mean an elevation of values for any of the blood lipids. The term "primary xanthoma tuberosum" designates the classic idiopathic form of xanthoma tuberosum associated with hypercholesteremia and without hyperneutralipemia. The primary purpose of this paper is to review the outcome of 11 cases of primary xanthoma tuberosum in children seen at the Mayo Clinic. Five of the eleven are known to be dead from cardiovascular disease, and one other is presumed to be dead. In five of the six patients angina pectoris developed before death. Two patients who are still living have angina pectoris, one having suffered myocardial infarction. Necropsy of four patients showed atheromatous involvement of the coronary blood vessels to be a prominent finding. Three of the patients died before they reached the age of 15 years. Two of the patients were brother and sister. Of the remaining nine patients, four gave a family history of cardiac disease occurring in a close relative early in life and five patients had relatives with cutaneous xanthomas. In the one family studied, all five members had hypercholestenemia.

Abstract P019: A Single Model For Predicting Major Adverse Cardiovascular Events In Individuals With And Without History Of Atherosclerotic Cardiovascular Disease: The Atherosclerosis Risk In Communities (aric) Study

Circulation ◽  
2021 ◽  
Vol 143 (Suppl_1) ◽  
Author(s):  
Yejin Mok ◽  
Lena Mathews ◽  
Ron C Hoogeveen ◽  
Michael J Blaha ◽  
Christie M Ballantyne ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Cardiovascular Disease ◽  
High Risk ◽  
Risk Stratification ◽  
Cardiovascular Events ◽  
Major Adverse Cardiovascular Events ◽  
Atherosclerotic Cardiovascular Disease ◽  
Single Model ◽  
History Of ◽  
Very High

Background: In the 2018 AHA/ACC Cholesterol guideline, risk stratification is an essential element. The use of a Pooled Cohort Equation (PCE) is recommended for individuals without atherosclerotic cardiovascular disease (ASCVD), and the new dichotomous classification of very high-risk vs. high-risk has been introduced for patients with ASCVD. These distinct risk stratification systems mainly rely on traditional risk factors, raising the possibility that a single model can predict major adverse cardiovascular events (MACEs) in persons with and without ASCVD. Methods: We studied 11,335 ARIC participants with (n=885) and without (n=10,450) a history of ASCVD (myocardial infarction, ischemic stroke, and symptomatic peripheral artery disease) at baseline (1996-98). We modeled factors in the PCE and the new classification for ASCVD patients (Figure legend) in a single CVD prediction model. We examined their associations with MACEs (myocardial infarction, stroke, and heart failure) using Cox models and evaluated the discrimination and calibration for a single model including those factors. Results: During a median follow-up of 18.4 years, there were 3,658 MACEs (3,105 in participants without ASCVD). In general, the factors in the PCE and the risk classification system for ASCVD patients were associated similarly with MACEs regardless of baseline ASCVD status, although age and systolic blood pressure showed significant interactions. A single model with these predictors and the relevant interaction terms showed good calibration and discrimination for those with and without ASCVD (c-statistic=0.729 and 0.704, respectively) (Figure). Conclusion: A single CVD prediction model performed well in persons with and without ASCVD. This approach will provide a specific predicted risk to ASCVD patients (instead of dichotomy of very high vs. high risk) and eliminate a practice gap between primary vs. secondary prevention due to different risk prediction tools.

Abstract WP226: The Association of Green Tea and Coffee Consumption With Mortality From Cardiovascular Disease and All Causes Among Persons With and Without History of Stroke or Myocardial Infarction: The JACC Study

Stroke ◽  
2020 ◽  
Vol 51 (Suppl_1) ◽  
Author(s):  
Masayuki Teramoto ◽  
Isao Muraki ◽  
Kokoro Shirai ◽  
Akiko Tamakoshi ◽  
Hiroyasu Iso
Keyword(s):  
Myocardial Infarction ◽  
Cardiovascular Disease ◽  
General Population ◽  
Green Tea ◽  
Coffee Consumption ◽  
Tea Consumption ◽  
Food Frequency ◽  
All Cause Mortality ◽  
History Of

Background: Both green tea and coffee consumption have been associated with lower risks of mortality from cardiovascular disease (CVD) and all causes in general population, but little is known about those impact on persons with history of CVD. We examined the association of those consumption with these mortalities among persons with and without history of stroke or myocardial infarction in general population. Methods: The study subjects were 60,664 participants (896 stroke and 1751 myocardial infarction survivors and 58,017 persons with no history of stroke or myocardial infarction), aged 40-79 years at the baseline (1988-1990), who completed a lifestyle and medical history questionnaire including self-administered food frequency under the Japan Collaborative Cohort Study for Evaluation of Cancer Risk (JACC Study). Results: During the median follow-up of 18.5 years, a total of 12,745 (7,458 men and 5,287 women) deaths including 3,737 CVD deaths were documented. Green tea and coffee consumption were inversely associated with CVD and all-cause mortality among myocardial infarction survivors as well as persons without history of stroke or myocardial infarction. After adjustment for known cardiovascular risk factors, the lower risks of mortality from CVD and all-causes associated with frequent green tea consumption (5-6 and ≥7 cups/day) or coffee consumption (≥2 cups/day) remained statistical. Conclusions: Both green tea and coffee consumption were inversely associated with risks of CVD and all-cause mortality among myocardial infarction survivors and persons without history of stroke or myocardial infarction.

scholarly journals Maternal and paternal history of myocardial infarction and risk of cardiovascular disease in men and women

2002 ◽  
Vol 11 (1) ◽  
pp. 31 ◽  
Author(s):  
H.D Sesso ◽  
I Lee-Min ◽  
M Gaziano ◽  
K.M Rexrode ◽  
R.J Glynn ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Cardiovascular Disease ◽  
Men And Women ◽  
History Of

scholarly journals The Association of Meat Intake With All-Cause Mortality and Acute Myocardial Infarction Is Age-Dependent in Patients With Stable Angina Pectoris

2021 ◽  
Vol 8 ◽  
Author(s):  
Åslaug O. Matre ◽  
Anthea Van Parys ◽  
Thomas Olsen ◽  
Teresa R. Haugsgjerd ◽  
Carl M. Baravelli ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Cardiovascular Disease ◽  
Acute Myocardial Infarction ◽  
Angina Pectoris ◽  
Stable Angina ◽  
Stable Angina Pectoris ◽  
Meat Intake ◽  
Increased Risk ◽  
All Cause Mortality ◽  
Total Meat

Background: Red and processed meat intake have been associated with increased risk of morbidity and mortality, and a restricted intake is encouraged in patients with cardiovascular disease. However, evidence on the association between total meat intake and clinical outcomes in this patient group is lacking.Objectives: To investigate the association between total meat intake and risk of all-cause mortality, acute myocardial infarction, cancer, and gastrointestinal cancer in patients with stable angina pectoris. We also investigated whether age modified these associations.Materials and Methods: This prospective cohort study consisted of 1,929 patients (80% male, mean age 62 years) with stable angina pectoris from the Western Norway B-Vitamin Intervention Trial. Dietary assessment was performed by the administration of a semi-quantitative food frequency questionnaire. Cox proportional hazards models were used to investigate the association between a relative increase in total meat intake and the outcomes of interest.Results: The association per 50 g/1,000 kcal higher intake of total meat with morbidity and mortality were generally inconclusive but indicated an increased risk of acute myocardial infarction [HR: 1.26 (95% CI: 0.98, 1.61)] and gastrointestinal cancer [1.23 (0.70, 2.16)]. However, we observed a clear effect modification by age, where total meat intake was associated with an increased risk of mortality and acute myocardial infarction among younger individuals, but an attenuation, and even reversal of the risk association with increasing age.Conclusion: Our findings support the current dietary guidelines emphasizing a restricted meat intake in cardiovascular disease patients but highlights the need for further research on the association between meat intake and health outcomes in elderly populations. Future studies should investigate different types of meat separately in other CVD-cohorts, in different age-groups, as well as in the general population.

Prevalence of Cardiovascular Risk Factors Among Patients with Acute Myocardial Infarction and New Left Bundle Branch Block in North East Romania

2018 ◽  
Vol 69 (6) ◽  
pp. 1554-1557
Author(s):  
Larisa Anghel ◽  
Catalina Arsenescu Georgescu
Keyword(s):  
Risk Factors ◽  
Myocardial Infarction ◽  
Cardiovascular Disease ◽  
Acute Myocardial Infarction ◽  
Cardiovascular Risk ◽  
Left Bundle Branch Block ◽  
New Left ◽  
Bundle Branch Block ◽  
North East ◽  
History Of

The prevalence of coronary artery disease, a major contributor to cardiovascular disease, is related to the increasing prevalence of modifiable risk factors.The aim of our study was to determine the risk factors for acute myocardial infarction among patients from North East Romania.We evaluated patients with acute myocardial infarction with or without left bundle-branch block, hospitalized in Georgescu Institute of Cardiovascular Disease Iasi for three years. The results of our study show that patients with acute myocardial infarction and new left bundle branch block have a more recent history of hypertension, dyslipidemia and smoker status compared to patients without left bundle branch block. Nearly two thirds of patients included in the study (65.47%) had an elevated cholesterol level, with a high prevalence of dyslipidemia in patients with myocardial infarction and new left bundle branch block. More than two-thirds of patients with new left bundle branch block had a history of arterial hypertension (69.04% vs. 50.0%, p = 0.354), especially grade 2 hypertension, with a slight predominance in those with new left bundle branch block, but without statistically significant differences between the two groups (45.23% vs. 30.95%, p = 0.358). Early identification of modifiable risk factors is vital to set the strategy for prevention and special attention must be paid to smoking. An adequate control of cardiovascular risk factors would result in a significant reduction of coronary events in patients from the North East part of Romania.

DIATOPIC AND DIACHRONIC VARIATION OF VERBAL FORMS (BY FRENCH MANUSCRIPTS OF THE XIII-XIV CENTURIES)

2020 ◽  
Vol 6 (99) ◽  
pp. 130-137
Author(s):  
ANNA Y. LUKINA
Keyword(s):  
The Other ◽  
French Language ◽  
Verb Forms ◽  
History Of ◽  
Characteristic Features ◽  
The One

This article deals with a new diasystemic approach to studying the variation of verb forms in the history of the French language. The author describes two variations - diatopic and diachronic. The new diasystemic approach allows us to build a classification of the verb form variants taking into account the intra- and extralinguistic criteria: historical, geographical and stylistic. Horizontal and vertical studying of variation in verb forms (L. A. Stanova's method) helps to identify the main trends in the evolution of the French language, on the one hand, and the characteristic features inherent in one or another regional written tradition, script, on the other.

Abstract 13941: The Prevalence of Cardiovascular Disease in Patients With Von Willebrand Disease; A Potential Therapeutic Target

Circulation ◽  
2020 ◽  
Vol 142 (Suppl_3) ◽  
Author(s):  
Nawfal Mihyawi ◽  
MUHAMMAD AJMAL ◽  
Jun Hung ◽  
Beeletsega T Yeneneh
Keyword(s):  
Cardiovascular Disease ◽  
Therapeutic Target ◽  
Multivariate Logistic Regression Analysis ◽  
Von Willebrand Disease ◽  
Cvd Risk ◽  
International Classification Of Disease ◽  
History Of ◽  
Von Willebrand ◽  
Willebrand Factor

Introduction: Von Willebrand factor (vWF) plays an important role in the coagulation process at the site of vascular injury. It is unclear whether vWF deficiency is protective against cardiovascular disease (CVD) since investigations are limited in this entity. Hypothesis: Our study assessed the hypothesis that the prevalence of CVD is less in patients with than without Von Willebrand disease (vWD). Methods: We queried the National Inpatient Sample (NIS) from 2009-2014. Entire data was used with exclusion of patients below 18 and over 75-year-old. We defined cardiovascular disease as any event of myocardial infarction or a diagnosis of ischemic heart disease using the International Classification of Disease, 9th edition (ICD-9). The primary outcome of interest was to compare the odds ratio of CVD in patients with and without vWD. Results: A total of 224,475,443 weighted hospital discharge samples were identified. Of these, 82,809 carried a diagnosis of vWD. The odds of CVD were less common in vWD patients (OR 0.54; 95% CI 0.52 - 0.56) (table 1). After multivariate logistic regression analysis, with adjustment for age, gender and the most common CVD risk factors including hypertension, smoking, diabetes, hyperlipidemia, family history of CVD, chronic kidney disease and obesity the likelihood of CVD remained lower in vWD patients (OR 0.65; 95% CI 0.63-0.67) (table 2). Conclusions: Our study, the first to involve a large cohort of patients, demonstrated that vWF deficiency is associated with decreased prevalence of CVD. Hence, vWF could potentially be a therapeutic target in CVD management. More investigations are needed for confirmation of these findings and to determine causation.

Self-Reported Cardiac Risk Factors in Emergency Department Nurses and Paramedics

2000 ◽  
Vol 15 (2) ◽  
pp. 14-17 ◽  
Author(s):  
Tyler W. Barrett ◽  
Valerie C. Norton ◽  
Matthew Busam ◽  
Julie Boyd ◽  
David J. Maron ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Emergency Department ◽  
High Risk ◽  
Cardiac Disease ◽  
Cardiac Risk ◽  
Smoking History ◽  
Cardiac Risk Factors ◽  
History Of ◽  
Very High

AbstractStudy Objective:Our objective was to assess the prevalence of cardiac risk factors in a sample of urban paramedics and emergency department (ED) nurses.Methods:We asked 175 paramedics and ED nurses working at a busy, urban ED to complete a cardiovascular risk assessment. The survey asked subjects to report smoking history, diet, exercise habits, weight, stress levels, medication use, history of hypertension or cardiac disease, family history of cardiovascular disease (CVD), and cholesterol level (if known)Results:129 of 175 surveys were returned (74% return rate) by 85 paramedics and 44 nurses. The percentages of paramedics and nurses at high or very high risk for cardiac disease were 48% and 41%, respectively. Forty-one percent of female respondents and 46% of male respondents were at high or very high risk. Cigarette smoking was reported in 19% of the paramedics and 14% of the nurses. The percentages of paramedics and nurses who reported hypertension were 13% and 11%, respectively. High cholesterol was reported in 31% of paramedics and 16% of nurses.Conclusions:Forty-eight percent of paramedics and 41% of ED nurses at this center are at high or very high risk for cardiovascular disease, by self-report. Efforts should be made to better educate and intervene in this population of health-care providers in order to reduce their cardiac risk.

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