scholarly journals Evaluation of approaches of gestational diabetes screening test in pregnant women

2020 ◽  
Vol 11 (4) ◽  
pp. 179-190
Author(s):  
Nurten Dalgıç ◽  
Zeynep Aşık
Keyword(s):  
Risk Factors ◽  
Gestational Diabetes ◽  
Pregnant Women ◽  
Screening Test ◽  
Risk Group ◽  
Demographic Characteristics ◽  
Type I ◽  
Type Ii ◽  
Previous Pregnancy ◽  
The Media

Objective: The aim of this study to evaluate the approaches of pregnant women to gestational diabetes mellitus (GDM) screening test. Methods: 102 women with gestational age is 24-28 week, at the age of 18 and over, who were not diagnosed with Type I or Type II DM before the pregnancy, with a single pregnancy, were included in the study. Socio-demographic characteristics of pregnant women, risk factors for GDM, whether GDM screening test and the reasons why pregnant women did not have screening test were questioned. Weight, body mass index, plasma glucose measurements and OGTT results of pregnant women with and without GDM risk factors were compared. Results: 53 (51.96%) of 102 pregnant women included in the study did not have GDM screening test. As the reason for not having a test; seven (13.2%) of the pregnant women thought that they should be screened with another method without sugar, six (11.3%) did not recommend by their doctor, six (11.3%) read in the media that test was harmful, six (11.3%) thought that test would harm the baby, and six (11.3%) stated that they did not know about the test. Ten (18,9%) did not report any reason. The rate of women in the risk group for GDM was 87.3%. The highest risk factor was the maternal age above 25 years (79.4%). In addition, 27,4% of pregnant women had first-degree relatives with Type II DM, 8,8% had a history of giving birth more than 4 kg in their previous pregnancy and 3.9% of women were diagnosed with GDM in their previous pregnancy. In pregnant women in the risk group for GDM; the mean age, weight, BMI and 50 g OGTT result were significantly higher than the other group. GDM was detected in six of 49 women had OGTT and all were in the risk group. Conclusion: GDM screening test rates of pregnant women are gradually decreasing. This is not due to educational level or socio-demographic characteristics. Pregnant women receive false information, especially through the media, and the importance of the issue cannot be understood adequately. Health personnel have important duties; risk factors that are proven to be associated with GDM should be questioned at first encounter with pregnant women. Screening test should be performed in early pregnancy in risky pregnant, who do not want to have screening tests should be followed up frequently with blood glucose measurements.

scholarly journals Low Maternal Immunoglobulin G Avidity and Single Parity as Adverse Implications of Human Cytomegalovirus Vertical Transmission in Pregnant Women with Immunoglobulin M Positivity

Viruses ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 866
Author(s):  
Masatoki Kaneko ◽  
Junsuke Muraoka ◽  
Kazumi Kusumoto ◽  
Toshio Minematsu
Keyword(s):  
Risk Factors ◽  
Pregnant Women ◽  
Vertical Transmission ◽  
Human Cytomegalovirus ◽  
Multiple Logistic Regression Analysis ◽  
Clinical Signs ◽  
Immunoglobulin M ◽  
Igg Antibody ◽  
Neurological Sequelae ◽  
Previous Pregnancy

Human cytomegalovirus (CMV) is the leading cause of neurological sequelae in infants. Understanding the risk factors of primary CMV infection is crucial in establishing preventive strategies. Thus, we conducted a retrospective cohort study to identify risk factors of vertical transmission among pregnant women with immunoglobulin (Ig) M positivity. The study included 456 pregnant women with IgM positivity. Information on age, parity, occupation, clinical signs, IgM levels, and IgG avidity index (AI) was collected. The women were divided into infected and non-infected groups. The two groups showed significant differences in IgM level, IgG AI, number of women with low IgG AI, clinical signs, and number of pregnant women with single parity. In the multiple logistic regression analysis, pregnant women with single parity and low IgG AI were independent predictors. Among 40 women who tested negative for IgG antibody in their previous pregnancy, 20 showed low IgG AI in their current pregnancy. Among the 20 women, 4 had vertical transmission. These results provide better understanding of the risk factors of vertical transmission in pregnant women with IgM positivity.

scholarly journals Effect of Gestational Diabetes Mellitus History on Future Pregnancy Behaviors: The Mutaba’ah Study

2020 ◽  
Vol 18 (1) ◽  
pp. 58
Author(s):  
Nasloon Ali ◽  
Aysha S. Aldhaheri ◽  
Hessa H. Alneyadi ◽  
Maha H. Alazeezi ◽  
Sara S. Al Dhaheri ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Previous History ◽  
Previous Pregnancy ◽  
Prenatal Health ◽  
Supplement Use ◽  
History Of ◽  
Future Pregnancy

Gestational diabetes mellitus (GDM) increases the risk of adverse pregnancy outcomes in any pregnancy and recurrence rates are high in future pregnancies. This study aims to investigate the effect of self-reported history of previous GDM on behaviors in a future pregnancy. This is an interim cross-sectional analysis of the pregnant women who participated in the Mutaba’ah Study between May 2017 and March 2020 in the United Arab Emirates. Participants completed a baseline self-administered questionnaire on sociodemographic and pregnancy-related information about the current pregnancy and previous pregnancies. Regression models assessed the relationships between self-reported history of GDM and pre-pregnancy and pregnancy behaviors in the current pregnancy. Out of 5738 pregnant parous women included in this analysis, nearly 30% (n = 1684) reported a history of GDM in a previous pregnancy. Women with a history of previous GDM were less likely to plan their current pregnancies (adjusted odds ratio (aOR): 0.84, 95% confidence interval (CI) 0.74–0.96) and more likely to be worried about childbirth (aOR: 1.18, 95% CI 1.03–1.36). They had shorter interpregnancy intervals between their previous child and current pregnancy (aOR: 0.88, 95% CI 0.82–0.94, per SD increase). There were no significant differences between women with and without a history of GDM in supplement use, sedentary behavior, or physical activity before and during this current pregnancy. Nearly a third of parous pregnant women in this population had a history of GDM in a previous pregnancy. Pregnant women with a previous history of GDM were similar to their counterparts with no history of GDM in the adopted pre-pregnancy and prenatal health behaviors. More intensive and long-term lifestyle counseling, possibly supported by e-health and social media materials, might be required to empower pregnant women with a history of GDM. This may assist in adopting and maintaining healthy prenatal behaviors early during the pregnancy or the preconception phase to minimize the risk of GDM recurrence and the consequential adverse maternal and infant health outcomes.

scholarly journals Pregnant women and risk factors: a cross-sectional study

2020 ◽  
Vol 30 (Supplement_5) ◽  
Author(s):  
V L a Fauci ◽  
R Squeri ◽  
C Genovese ◽  
V Alessi ◽  
A Facciolà
Keyword(s):  
Risk Factors ◽  
Young Adults ◽  
Health Education ◽  
Pregnant Women ◽  
Educational Level ◽  
Demographic Characteristics ◽  
Alcoholic Beverages ◽  
High Educational Level ◽  
Significant Difference ◽  
High Educational

Abstract Background Many investigations have shown the important role played by risk factors such as tobacco and alcohol in the development of congenital anomalies. Methods Through the administration of an hoc questionnaire, we evaluated the attitude towards smoking and alcohol of a sample of 200 pregnant women at the University Hospital of Messina. The questionnaire was structured to collect information about socio-demographic characteristics, type of gynaecological assistance and their lifestyles (smoking and alcohol). Statistical analysis was performed using version 10 of StatSoftVR software. Results 14% of the women continued to smoke despite pregnancy; the majority of these were young adults, divorced, employed and with a high educational level. Correlating the smoking habit with the socio-demographic characteristics of the studied women, we found a statistically significant difference for the marital status, with a higher number of smokers among the single women (p < 0.05).Moreover, we found a statistically significant difference also for the profession with a higher number of smokers in the worker women (p < 0.05). About the drinking habit, the 4.3% declared to be moderate drinkers (occasional use of alcohol equal to 2-3 glasses a week) despite pregnancy, the 34.4% stated they do not drink alcohol during pregnancy and the 56% stated do not usually drink alcohol. Particularly, about the drinkers' socio-demographic characteristics, the 50% of them were 24-25 years old and the 75% were married. About the type of alcoholic beverages consumed, 86% stated they usually drink bier during the weekend. Conclusions Our study shows that the awareness of the women about the importance of these risk factors is still rather poor. In order to improve the awareness of pregnant women on the importance of avoiding these risk factors and prevent CAs, health education campaigns at various levels surely represent the public health cornerstone. Key messages In our sample 14% of the pregnant women continued to smoke and 4.3% to drink despite pregnancy and they generally were young or young adults and with a high educational level. Our results highlight the importance of continuous health education about the risk to smoke and drink during pregnancy.

scholarly journals Calcification in Human Intracranial Aneurysms Is Highly Prevalent and Displays Both Atherosclerotic and Nonatherosclerotic Types

2019 ◽  
Vol 39 (10) ◽  
pp. 2157-2167 ◽  
Author(s):  
Piyusha S. Gade ◽  
Riikka Tulamo ◽  
Kee-won Lee ◽  
Fernando Mut ◽  
Eliisa Ollikainen ◽  
...  
Keyword(s):  
High Resolution ◽  
Vascular Disease ◽  
Intracranial Aneurysms ◽  
Therapeutic Targets ◽  
Type I ◽  
Type Ii ◽  
Cerebral Vascular Disease ◽  
Ruptured Aneurysms ◽  
The Media

Objective: Although the clinical and biological importance of calcification is well recognized for the extracerebral vasculature, its role in cerebral vascular disease, particularly, intracranial aneurysms (IAs), remains poorly understood. Extracerebrally, 2 distinct mechanisms drive calcification, a nonatherosclerotic, rapid mineralization in the media and a slower, inflammation driven, atherosclerotic mechanism in the intima. This study aims to determine the prevalence, distribution, and type (atherosclerotic, nonatherosclerotic) of calcification in IAs and assess differences in occurrence between ruptured and unruptured IAs. Approach and Results: Sixty-five 65 IA specimens (48 unruptured, 17 ruptured) were resected perioperatively. Calcification and lipid pools were analyzed nondestructively in intact samples using high resolution (0.35 μm) microcomputed tomography. Calcification is highly prevalent (78%) appearing as micro (<500 µm), meso (500 µm–1 mm), and macro (>1 mm) calcifications. Calcification manifests in IAs as both nonatherosclerotic (calcification distinct from lipid pools) and atherosclerotic (calcification in the presence of lipid pools) with 3 wall types: Type I—only calcification, no lipid pools (20/51, 39%), Type II—calcification and lipid pools, not colocalized (19/51, 37%), Type III—calcification colocalized with lipid pools (12/51, 24%). Ruptured IAs either had no calcifications or had nonatherosclerotic micro- or meso-calcifications (Type I or II), without macro-calcifications. Conclusions: Calcification in IAs is substantially more prevalent than previously reported and presents as both nonatherosclerotic and atherosclerotic types. Notably, ruptured aneurysms had only nonatherosclerotic calcification, had significantly lower calcification fraction, and did not contain macrocalcifications. Improved understanding of the role of calcification in IA pathology should lead to new therapeutic targets.

scholarly journals Risk Factors for the Requirement of Antenatal Insulin Treatment in Gestational Diabetes Mellitus

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Mayu Watanabe ◽  
Akihiro Katayama ◽  
Hidetoshi Kagawa ◽  
Daisuke Ogawa ◽  
Jun Wada
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Insulin Therapy ◽  
Pregnant Women ◽  
Plasma Glucose ◽  
Insulin Treatment ◽  
Diet Group ◽  
Glucose Levels

Poor maternal glycemic control increases maternal and fetal risk for adverse outcomes, and strict management of gestational diabetes mellitus (GDM) is recommended to prevent neonatal and maternal complications. However, risk factors for the requirement of antenatal insulin treatment (AIT) are not well-investigated in the pregnant women with GDM. We enrolled 37 pregnant women with GDM and investigated the risk for AIT by comparing the patients with AIT (AIT group;n=10) and without insulin therapy (Diet group;n=27). The 1-h and 2-h plasma glucose levels and the number of abnormal values in 75 g OGTT were significantly higher in AIT group compared with Diet group. By logistic regression analysis, plasma glucose level at 1-h was significant predictor for AIT and the odds ratios were 1.115 (1.004–1.239) using forward selection method and 1.192 (1.006–1.413) using backward elimination method. There were no significant differences in obstetrical outcomes and neonatal complications. 1-h plasma glucose levels in 75 g OGTT are useful parameters in predicting the requirement for AIT in GDM. Both maternal and neonatal complications are comparable in GDM patients with and without insulin therapy.

scholarly journals The impacts of maternal iron deficiency and being overweight during pregnancy on neurodevelopment of the offspring

2017 ◽  
Vol 118 (7) ◽  
pp. 533-540 ◽  
Author(s):  
Staffan K. Berglund ◽  
Francisco J. Torres-Espínola ◽  
Luz García-Valdés ◽  
Mª Teresa Segura ◽  
Cristina Martínez-Zaldívar ◽  
...  
Keyword(s):  
Risk Factors ◽  
Iron Deficiency ◽  
Gestational Diabetes ◽  
Observational Study ◽  
Pregnant Women ◽  
Prospective Observational Study ◽  
Infant Neurodevelopment ◽  
Spanish Women ◽  
Independent Effects ◽  
Maternal Iron

AbstractBoth maternal Fe deficiency (ID) and being overweight or obese (Ow/Ob, BMI≥25 kg/m2) may negatively affect offspring brain development. However, the two risk factors correlate and their independent effects on infant neurodevelopment are unclear. PREOBE is a prospective observational study that included 331 pregnant Spanish women, of whom 166 had pre-gestational Ow/Ob. Fe status was analysed at 34 weeks and at delivery, and babies were assessed using Bayley III scales of neurodevelopment at 18 months. In confounder-adjusted analyses, maternal ID at 34 weeks was associated with lower composite motor scores at 18 months (mean 113·3 (sd 9·9) v. 117·1 (sd 9·2), P=0·039). Further, the offspring of mothers with ID at delivery had lower cognitive scores (114·0 (sd 9·7) v. 121·5 (sd 10·9), P=0·039) and lower receptive, expressive and composite (99·5 (sd 8·6) v. 107·6 (sd 8·3), P=0·004) language scores. The negative associations between maternal ID at delivery and Bayley scores remained even when adjusting for maternal Ow/Ob and gestational diabetes. Similarly, maternal Ow/Ob correlated with lower gross motor scores in the offspring (12·3 (sd 2·0) v. 13·0 (sd 2·1), P=0·037), a correlation that remained when adjusting for maternal ID. In conclusion, maternal ID and pre-gestational Ow/Ob are both negatively associated with Bayley scores at 18 months, but independently and on different subscales. These results should be taken into account when considering Fe supplementation for pregnant women.

Changes in plasma lipids and markers of oxidative stress in normal pregnancy and pregnancies complicated by diabetes

2004 ◽  
Vol 106 (1) ◽  
pp. 93-98 ◽  
Author(s):  
V. TOESCU ◽  
S. L. NUTTALL ◽  
U. MARTIN ◽  
P. NIGHTINGALE ◽  
M. J. KENDALL ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Pregnant Women ◽  
Total Cholesterol ◽  
Type Ii Diabetes ◽  
Plasma Lipids ◽  
Lipid Hydroperoxides ◽  
Type I ◽  
Type Ii ◽  
Markers Of Oxidative Stress ◽  
Normal Women

The purpose of the present study was to determine changes in plasma lipids and markers of oxidative stress longitudinally in pregnancy complicated by diabetes compared with non-diabetic pregnancy. This was carried out by following a group of normal pregnant women (n=17) and groups of pregnant women with Type I diabetes (n=19), Type II diabetes (n=12) and gestational diabetes mellitus (n=12) throughout pregnancy, with sampling carried out at the end of each trimester. Serum total cholesterol and triacylglycerols (triglycerides) were determined using standard colorimetric techniques and low-density lipoprotein (LDL) subfraction profile by disc PAGE. Total antioxidant capacity (TAC) was determined by enhanced chemiluminescence and lipid hydroperoxides by the ferrous oxidation of Xylenol Orange method. Total cholesterol and triacylglycerols increased significantly throughout pregnancy in all groups, but there were no significant differences between normal and diabetic women with respect to either. The LDL score was significantly higher (P<0.001) in diabetic women compared with normal women at each point throughout pregnancy, although there were no significant differences between the diabetic groups. There was evidence of greater oxidative stress in diabetic compared with normal women throughout. Corrected TAC was significantly lower (P<0.001) in all diabetic women throughout pregnancy. In addition, lipid hydroperoxides were higher in all diabetic compared with normal women, particularly so in those with Type II diabetes (P<0.05). These changes may have important implications for diabetic women during pregnancy, as an elevated risk of pre-eclampsia is thought to reflect an oxidative stress-related mechanism. In addition, these changes may have important implications for the development of atherosclerosis and the long-term cardiovascular health of women with diabetes.

scholarly journals The Relationship between Gestational Diabetes and Risk Factors in Pregnant Women in Hamadan

2018 ◽  
Vol 17 (1) ◽  
pp. 30-36
Author(s):  
Shiva Borzouei ◽  
Soghra Rabiei ◽  
Farzaneh Esna Ashari ◽  
Zohreh Zareeighane ◽  
Mansooreh Biglari ◽  
...  
Keyword(s):  
Risk Factors ◽  
Gestational Diabetes ◽  
Pregnant Women ◽  
The Relationship

scholarly journals Screen all pregnant women for risk factors for gestational diabetes, says NICE

BMJ ◽  
2008 ◽  
Vol 336 (7646) ◽  
pp. 689.7-689
Author(s):  
Zosia Kmietowicz
Keyword(s):  
Risk Factors ◽  
Gestational Diabetes ◽  
Pregnant Women
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